Full Report

Format

Full Report
Summary (Text)
Summary (XML)

Send to:

Choose Destination

File
Clipboard
Collections

Discordant Twin

MedGen UID:: 811053
•Concept ID:: C2609166
•: Pathologic Function

Synonym:

Discordant Growth

Definition

A twin whose estimated fetal weight is determined to have 20% or greater difference from its sibling. [from NCI]

Term Hierarchy

GTR
MeSH

CClinical test, RResearch test, OOMIM, GGeneReviews, VClinVar

CROGVDiscordant Twin

Pathological Conditions, Signs and Symptoms
- Clinical finding
  - Finding by Cause
    - Complication
      - Pregnancy Complication
        Discordant Twin

Professional guidelines

PubMed

Neonatal Screening for Congenital Hypothyroidism: What Can We Learn From Discordant Twins?

Medda E, Vigone MC, Cassio A, Calaciura F, Costa P, Weber G, de Filippis T, Gelmini G, Di Frenna M, Caiulo S, Ortolano R, Rotondi D, Bartolucci M, Gelsomino R, De Angelis S, Gabbianelli M, Persani L, Olivieri A
J Clin Endocrinol Metab 2019 Dec 1;104(12):5765-5779. doi: 10.1210/jc.2019-00900. PMID: 31287502

Non-invasive prenatal diagnosis of single gene disorders: how close are we?

Norbury G, Norbury CJ
Semin Fetal Neonatal Med 2008 Apr;13(2):76-83. Epub 2008 Jan 29 doi: 10.1016/j.siny.2007.12.008. PMID: 18234572

The definition, diagnosis, and management of growth-discordant twins: an international census survey.

Blickstein I
Acta Genet Med Gemellol (Roma) 1991;40(3-4):345-51. doi: 10.1017/s0001566000003536. PMID: 1821511

See all (4)

Recent clinical studies

Etiology

Cancer in twin pairs discordant for smoking: The Nordic Twin Study of Cancer.

Korhonen T, Hjelmborg J, Harris JR, Clemmensen S, Adami HO, Kaprio J; Nordic Twin Study of Cancer (NorTwinCan) collaboration
Int J Cancer 2022 Jul 1;151(1):33-43. Epub 2022 Feb 24 doi: 10.1002/ijc.33963. PMID: 35143046 Free PMC Article

Concordance and comorbidities among monozygotic twins with tic disorders.

Pedersen JH, Skytthe A, Bybjerg-Grauholm J, Kucukyildiz AS, Skov L, Debes NM, Tümer Z
J Psychiatr Res 2022 Feb;146:297-303. Epub 2021 Nov 9 doi: 10.1016/j.jpsychires.2021.11.019. PMID: 34794811

Disease-discordant twin structural MRI studies on affective disorders.

Delvecchio G, Pigoni A, Bauer IE, Soares JC, Brambilla P
Neurosci Biobehav Rev 2020 Jan;108:459-471. Epub 2019 Nov 29 doi: 10.1016/j.neubiorev.2019.11.023. PMID: 31790709

Fetal growth disorders in twin gestations.

Breathnach FM, Malone FD
Semin Perinatol 2012 Jun;36(3):175-81. doi: 10.1053/j.semperi.2012.02.002. PMID: 22713498

The growth discordant twin.

Blickstein I, Lancet M
Obstet Gynecol Surv 1988 Sep;43(9):509-15. doi: 10.1097/00006254-198809000-00002. PMID: 3062515

See all (254)

Diagnosis

Childhood trauma and borderline personality disorder traits: A discordant twin study.

Skaug E, Czajkowski NO, Waaktaar T, Torgersen S
J Psychopathol Clin Sci 2022 May;131(4):365-374. Epub 2022 Apr 4 doi: 10.1037/abn0000755. PMID: 35377676

Cancer in twin pairs discordant for smoking: The Nordic Twin Study of Cancer.

Concordance and comorbidities among monozygotic twins with tic disorders.

Pedersen JH, Skytthe A, Bybjerg-Grauholm J, Kucukyildiz AS, Skov L, Debes NM, Tümer Z
J Psychiatr Res 2022 Feb;146:297-303. Epub 2021 Nov 9 doi: 10.1016/j.jpsychires.2021.11.019. PMID: 34794811

Femoral-facial syndrome: A review of the literature and 14 additional patients including a monozygotic discordant twin pair.

Lacarrubba-Flores MDJ, Carvalho DR, Ribeiro EM, Moreno CA, Esposito AC, Marson FAL, Loureiro T, Cavalcanti DP
Am J Med Genet A 2018 Sep;176(9):1917-1928. Epub 2018 Aug 2 doi: 10.1002/ajmg.a.40425. PMID: 30070764

What you need to know when managing twins: 10 key facts.

Simpson LL
Obstet Gynecol Clin North Am 2015 Jun;42(2):225-39. Epub 2015 Mar 9 doi: 10.1016/j.ogc.2015.01.002. PMID: 26002163

See all (102)

Therapy

Cancer in twin pairs discordant for smoking: The Nordic Twin Study of Cancer.

Childhood maltreatment and disordered gambling in adulthood: disentangling causal and familial influences.

Dash GF, Martin NG, Slutske WS
Psychol Med 2022 Apr;52(5):979-988. Epub 2020 Aug 3 doi: 10.1017/S0033291720002743. PMID: 32744192 Free PMC Article

Smoking Causes Fatal Subarachnoid Hemorrhage: A Case-Control Study of Finnish Twins.

Rautalin I, Korja M, Kaprio J
Stroke 2020 Oct;51(10):3018-3022. Epub 2020 Sep 17 doi: 10.1161/STROKEAHA.120.031231. PMID: 32938311

Early-life antibiotic use and risk of asthma and eczema: results of a discordant twin study.

Slob EMA, Brew BK, Vijverberg SJH, Kats CJAR, Longo C, Pijnenburg MW, van Beijsterveldt TCEM, Dolan CV, Bartels M, Magnusson P, Lichtenstein P, Gong T, Koppelman GH, Almqvist C, Boomsma DI, Maitland-van der Zee AH
Eur Respir J 2020 Apr;55(4) Epub 2020 Apr 23 doi: 10.1183/13993003.02021-2019. PMID: 32139457

Early onset alcohol use and self-harm: a discordant twin analysis.

Few LR, Werner KB, Sartor CE, Grant JD, Trull TJ, Nock MK, Bucholz KK, Deitz SK, Glowinski AL, Martin NG, Nelson EC, Statham DJ, Madden PA, Heath AC, Lynskey MT, Agrawal A
Alcohol Clin Exp Res 2015 Nov;39(11):2134-42. Epub 2015 Oct 14 doi: 10.1111/acer.12889. PMID: 26463647 Free PMC Article

See all (45)

Prognosis

Neonatal outcomes between discordant monochorionic and dichorionic twins.

Park YH, Kim YN, Im DH, Kim DH, Byun JM, Jeong DH, Lee KB, Sung MS
J Matern Fetal Neonatal Med 2021 Jul;34(13):2080-2088. Epub 2019 Aug 28 doi: 10.1080/14767058.2019.1657085. PMID: 31416367

Drinking and mortality: long-term follow-up of drinking-discordant twin pairs.

Sipilä P, Rose RJ, Kaprio J
Addiction 2016 Feb;111(2):245-54. Epub 2015 Nov 13 doi: 10.1111/add.13152. PMID: 26359785 Free PMC Article

Understanding coronary artery disease using twin studies.

Mangino M, Spector T
Heart 2013 Mar;99(6):373-5. Epub 2012 Nov 10 doi: 10.1136/heartjnl-2012-303001. PMID: 23142714

Fetal growth disorders in twin gestations.

Breathnach FM, Malone FD
Semin Perinatol 2012 Jun;36(3):175-81. doi: 10.1053/j.semperi.2012.02.002. PMID: 22713498

The growth discordant twin.

Blickstein I, Lancet M
Obstet Gynecol Surv 1988 Sep;43(9):509-15. doi: 10.1097/00006254-198809000-00002. PMID: 3062515

See all (104)

Clinical prediction guides

Differences in DNA Methylation-Based Age Prediction Within Twin Pairs Discordant for Cancer.

Bode HF, Heikkinen A, Lundgren S, Kaprio J, Ollikainen M
Twin Res Hum Genet 2022 Oct;25(4-5):171-179. Epub 2022 Sep 8 doi: 10.1017/thg.2022.32. PMID: 36073160

Broader Epstein-Barr virus-specific T cell receptor repertoire in patients with multiple sclerosis.

Schneider-Hohendorf T, Gerdes LA, Pignolet B, Gittelman R, Ostkamp P, Rubelt F, Raposo C, Tackenberg B, Riepenhausen M, Janoschka C, Wünsch C, Bucciarelli F, Flierl-Hecht A, Beltrán E, Kümpfel T, Anslinger K, Gross CC, Chapman H, Kaplan I, Brassat D, Wekerle H, Kerschensteiner M, Klotz L, Lünemann JD, Hohlfeld R, Liblau R, Wiendl H, Schwab N
J Exp Med 2022 Nov 7;219(11) Epub 2022 Sep 1 doi: 10.1084/jem.20220650. PMID: 36048016 Free PMC Article

Femoral-facial syndrome: A review of the literature and 14 additional patients including a monozygotic discordant twin pair.

Fetal growth disorders in twin gestations.

Breathnach FM, Malone FD
Semin Perinatol 2012 Jun;36(3):175-81. doi: 10.1053/j.semperi.2012.02.002. PMID: 22713498

The growth discordant twin.

Blickstein I, Lancet M
Obstet Gynecol Surv 1988 Sep;43(9):509-15. doi: 10.1097/00006254-198809000-00002. PMID: 3062515

See all (145)