U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Candidiasis, familial, 8(CANDF8)

MedGen UID:
811541
•Concept ID:
C3714992
•
Disease or Syndrome
Synonym: CANDF8
 
Gene (location): TRAF3IP2 (6q21)
 
Monarch Initiative: MONDO:0014230
OMIM®: 615527

Definition

Chronic mucocutaneous candidiasis is characterized by recurrent or persistent infections of the skin, nails, and oral and genital mucosae with Candida albicans, and sometimes by staphylococcal skin infections (summary by Boisson et al., 2013). For a discussion of genetic heterogeneity of familial candidiasis, see CANDF1 (114580). [from OMIM]

Clinical features

From HPO
Blepharitis
MedGen UID:
598
•Concept ID:
C0005741
•
Disease or Syndrome
Inflammation of the eyelids.
See: Feature record | Search on this feature
Seborrheic dermatitis
MedGen UID:
19912
•Concept ID:
C0036508
•
Disease or Syndrome
Seborrheic dermatitis is a form of eczema which is closely related to dandruff. It causes dry or greasy peeling of the scalp, eyebrows, and face, and sometimes trunk.
See: Feature record | Search on this feature
Onychomycosis
MedGen UID:
11825
•Concept ID:
C0040261
•
Disease or Syndrome
A fungal infection of the toenails or fingernails that tends to cause the nails to thicken, discolor, disfigure, and split.
See: Feature record | Search on this feature
Chronic oral candidiasis
MedGen UID:
870166
•Concept ID:
C4024599
•
Disease or Syndrome
Chronic accumulation and overgrowth of the fungus Candida albicans on the mucous membranes of the mouth, generally manifested as associated with creamy white lesions on the tongue or inner cheeks, occasionally spreading to the gums, tonsils, palate or oropharynx.
See: Feature record | Search on this feature
Cheilitis
MedGen UID:
3349
•Concept ID:
C0007971
•
Disease or Syndrome
Inflammation of the lip.
See: Feature record | Search on this feature
Macroglossia
MedGen UID:
44236
•Concept ID:
C0024421
•
Disease or Syndrome
Increased length and width of the tongue.
See: Feature record | Search on this feature
Show allHide all

Professional guidelines

PubMed

Survey of healthcare providers' testing practices for vulvovaginal candidiasis and treatment outcomes-United States, 2021.
Benedict K, Moret R, Molinari NAM, Jackson BR
PLoS One 2022;17(12):e0278630. Epub 2022 Dec 30 doi: 10.1371/journal.pone.0278630. PMID: 36584109Free PMC Article
APECED-Associated Hepatitis: Clinical, Biochemical, Histological and Treatment Data From a Large, Predominantly American Cohort.
Chascsa DM, Ferré EMN, Hadjiyannis Y, Alao H, Natarajan M, Quinones M, Kleiner DE, Simcox TL, Chitsaz E, Rose SR, Hallgren A, Kampe O, Marko J, Ali RO, Auh S, Koh C, Belkaid Y, Lionakis MS, Heller T
Hepatology 2021 Mar;73(3):1088-1104. doi: 10.1002/hep.31421. PMID: 32557834Free PMC Article
Molecular background and genotype-phenotype correlation in autoimmune-polyendocrinopathy-candidiasis-ectodermal-distrophy patients from Campania and in their relatives.
Capalbo D, Mazza C, Giordano R, Improda N, Arvat E, Cervato S, Morlin L, Pignata C, Betterle C, Salerno M
J Endocrinol Invest 2012 Feb;35(2):169-73. Epub 2011 Apr 20 doi: 10.3275/7677. PMID: 21508664

Recent clinical studies

Etiology

Lactobacillus probiotics restore vaginal and gut microbiota of pregnant women with vaginal candidiasis.
Ang XY, Roslan NS, Ahmad N, Yusof SM, Abdullah N, Nik Ab Rahman NN, Woon JJ, Teh CS, Todorov SD, Liu G, Liong MT
Benef Microbes 2023 Nov 23;14(5):421-431. doi: 10.1163/18762891-20220103. PMID: 38350486
Correlation between postpartum pelvic floor dysfunction and vaginal microecological imbalance in late pregnancy.
Cheng C, Guo B, Li R, Wu W, Mi C, Li X
Zhong Nan Da Xue Xue Bao Yi Xue Ban 2022 Nov 28;47(11):1608-1614. doi: 10.11817/j.issn.1672-7347.2022.220100. PMID: 36481640Free PMC Article
Multicenter Prospective Study of Biomarkers for Diagnosis of Invasive Candidiasis in Children and Adolescents.
Fisher BT, Boge CLK, Xiao R, Shuster S, Chin-Quee D, Allen J, Shaheen S, Hayden R, Suganda S, Zaoutis TE, Chang YC, Yin DE, Huppler AR, Danziger-Isakov L, Muller WJ, Roilides E, Romero J, Sue PK, Berman D, Wattier RL, Halasa N, Pong A, Maron G, Soler-Palacin P, Hutto SC, Gonzalez BE, Salvatore CM, Rajan S, Green M, Doby Knackstedt E, Hauger SB, Steinbach WJ
Clin Infect Dis 2022 Aug 25;75(2):248-259. doi: 10.1093/cid/ciab928. PMID: 35134165Free PMC Article
Vulvar pain: The revealing scenario of leading comorbidities in 1183 cases.
Graziottin A, Murina F, Gambini D, Taraborrelli S, Gardella B, Campo M; VuNet Study Group
Eur J Obstet Gynecol Reprod Biol 2020 Sep;252:50-55. Epub 2020 May 30 doi: 10.1016/j.ejogrb.2020.05.052. PMID: 32563924
Incidence of Opportunistic Infections and the Impact of Antiretroviral Therapy Among HIV-Infected Adults in Low- and Middle-Income Countries: A Systematic Review and Meta-analysis.
Low A, Gavriilidis G, Larke N, B-Lajoie MR, Drouin O, Stover J, Muhe L, Easterbrook P
Clin Infect Dis 2016 Jun 15;62(12):1595-1603. Epub 2016 Mar 6 doi: 10.1093/cid/ciw125. PMID: 26951573Free PMC Article

Diagnosis

Scoping review of cytolytic vaginosis literature.
Kraut R, Carvallo FD, Golonka R, Campbell SM, Rehmani A, Babenko O, Lee MC, Vieira-Baptista P
PLoS One 2023;18(1):e0280954. Epub 2023 Jan 26 doi: 10.1371/journal.pone.0280954. PMID: 36701339Free PMC Article
Correlation between postpartum pelvic floor dysfunction and vaginal microecological imbalance in late pregnancy.
Cheng C, Guo B, Li R, Wu W, Mi C, Li X
Zhong Nan Da Xue Xue Bao Yi Xue Ban 2022 Nov 28;47(11):1608-1614. doi: 10.11817/j.issn.1672-7347.2022.220100. PMID: 36481640Free PMC Article
Multicenter Prospective Study of Biomarkers for Diagnosis of Invasive Candidiasis in Children and Adolescents.
Fisher BT, Boge CLK, Xiao R, Shuster S, Chin-Quee D, Allen J, Shaheen S, Hayden R, Suganda S, Zaoutis TE, Chang YC, Yin DE, Huppler AR, Danziger-Isakov L, Muller WJ, Roilides E, Romero J, Sue PK, Berman D, Wattier RL, Halasa N, Pong A, Maron G, Soler-Palacin P, Hutto SC, Gonzalez BE, Salvatore CM, Rajan S, Green M, Doby Knackstedt E, Hauger SB, Steinbach WJ
Clin Infect Dis 2022 Aug 25;75(2):248-259. doi: 10.1093/cid/ciab928. PMID: 35134165Free PMC Article
Cytometric analysis and clinical features in a Moroccan cohort with severe combined immunodeficiency.
El Allam A, El Fakihi S, Tahoune H, Sahmoudi K, Bousserhane H, Bakri Y, El Hafidi N, Seghrouchni F
Hum Antibodies 2022;30(2):67-77. doi: 10.3233/HAB-211510. PMID: 35094990
Evaluation of vaginal complaints.
Anderson MR, Klink K, Cohrssen A
JAMA 2004 Mar 17;291(11):1368-79. doi: 10.1001/jama.291.11.1368. PMID: 15026404

Therapy

Lactobacillus probiotics restore vaginal and gut microbiota of pregnant women with vaginal candidiasis.
Ang XY, Roslan NS, Ahmad N, Yusof SM, Abdullah N, Nik Ab Rahman NN, Woon JJ, Teh CS, Todorov SD, Liu G, Liong MT
Benef Microbes 2023 Nov 23;14(5):421-431. doi: 10.1163/18762891-20220103. PMID: 38350486
Incidence of Opportunistic Infections and the Impact of Antiretroviral Therapy Among HIV-Infected Adults in Low- and Middle-Income Countries: A Systematic Review and Meta-analysis.
Low A, Gavriilidis G, Larke N, B-Lajoie MR, Drouin O, Stover J, Muhe L, Easterbrook P
Clin Infect Dis 2016 Jun 15;62(12):1595-1603. Epub 2016 Mar 6 doi: 10.1093/cid/ciw125. PMID: 26951573Free PMC Article
Nipple pain, damage, and vasospasm in the first 8 weeks postpartum.
Buck ML, Amir LH, Cullinane M, Donath SM; CASTLE Study Team
Breastfeed Med 2014 Mar;9(2):56-62. Epub 2013 Dec 31 doi: 10.1089/bfm.2013.0106. PMID: 24380583Free PMC Article
Prevalence and risk factors of trichomoniasis, bacterial vaginosis, and candidiasis for married women of child-bearing age in rural Shandong.
Fang X, Zhou Y, Yang Y, Diao Y, Li H
Jpn J Infect Dis 2007 Sep;60(5):257-61. PMID: 17881863
Paediatric HIV infection.
Friesen H
P N G Med J 1996 Sep;39(3):183-9. PMID: 9795560

Prognosis

Multicenter Prospective Study of Biomarkers for Diagnosis of Invasive Candidiasis in Children and Adolescents.
Fisher BT, Boge CLK, Xiao R, Shuster S, Chin-Quee D, Allen J, Shaheen S, Hayden R, Suganda S, Zaoutis TE, Chang YC, Yin DE, Huppler AR, Danziger-Isakov L, Muller WJ, Roilides E, Romero J, Sue PK, Berman D, Wattier RL, Halasa N, Pong A, Maron G, Soler-Palacin P, Hutto SC, Gonzalez BE, Salvatore CM, Rajan S, Green M, Doby Knackstedt E, Hauger SB, Steinbach WJ
Clin Infect Dis 2022 Aug 25;75(2):248-259. doi: 10.1093/cid/ciab928. PMID: 35134165Free PMC Article
Autosomal Dominant Hyper-IgE Syndrome in the USIDNET Registry.
Gernez Y, Freeman AF, Holland SM, Garabedian E, Patel NC, Puck JM, Sullivan KE, Akhter J, Secord E, Chen K, Buckley R, Haddad E, Ochs HD, Fuleihan R, Routes J, Muskat M, Lugar P, Mancini J, Cunningham-Rundles C
J Allergy Clin Immunol Pract 2018 May-Jun;6(3):996-1001. Epub 2017 Sep 19 doi: 10.1016/j.jaip.2017.06.041. PMID: 28939137Free PMC Article
Incidence of Opportunistic Infections and the Impact of Antiretroviral Therapy Among HIV-Infected Adults in Low- and Middle-Income Countries: A Systematic Review and Meta-analysis.
Low A, Gavriilidis G, Larke N, B-Lajoie MR, Drouin O, Stover J, Muhe L, Easterbrook P
Clin Infect Dis 2016 Jun 15;62(12):1595-1603. Epub 2016 Mar 6 doi: 10.1093/cid/ciw125. PMID: 26951573Free PMC Article
Evaluation of vaginal complaints.
Anderson MR, Klink K, Cohrssen A
JAMA 2004 Mar 17;291(11):1368-79. doi: 10.1001/jama.291.11.1368. PMID: 15026404
Paediatric HIV infection.
Friesen H
P N G Med J 1996 Sep;39(3):183-9. PMID: 9795560

Clinical prediction guides

Scoping review of cytolytic vaginosis literature.
Kraut R, Carvallo FD, Golonka R, Campbell SM, Rehmani A, Babenko O, Lee MC, Vieira-Baptista P
PLoS One 2023;18(1):e0280954. Epub 2023 Jan 26 doi: 10.1371/journal.pone.0280954. PMID: 36701339Free PMC Article
Multicenter Prospective Study of Biomarkers for Diagnosis of Invasive Candidiasis in Children and Adolescents.
Fisher BT, Boge CLK, Xiao R, Shuster S, Chin-Quee D, Allen J, Shaheen S, Hayden R, Suganda S, Zaoutis TE, Chang YC, Yin DE, Huppler AR, Danziger-Isakov L, Muller WJ, Roilides E, Romero J, Sue PK, Berman D, Wattier RL, Halasa N, Pong A, Maron G, Soler-Palacin P, Hutto SC, Gonzalez BE, Salvatore CM, Rajan S, Green M, Doby Knackstedt E, Hauger SB, Steinbach WJ
Clin Infect Dis 2022 Aug 25;75(2):248-259. doi: 10.1093/cid/ciab928. PMID: 35134165Free PMC Article
Cytometric analysis and clinical features in a Moroccan cohort with severe combined immunodeficiency.
El Allam A, El Fakihi S, Tahoune H, Sahmoudi K, Bousserhane H, Bakri Y, El Hafidi N, Seghrouchni F
Hum Antibodies 2022;30(2):67-77. doi: 10.3233/HAB-211510. PMID: 35094990
Molecular and clinical characterization of autoimmune polyendocrinopathy-candidiasis-ectodermal dystrophy syndrome (APECED) in Iranian non-Jewish patients: report of two novel AIRE gene pathogenic variants.
Setoodeh A, Panjeh-Shahi S, Bahmani F, Vand-Rajabpour F, Jalilian N, Sayarifard F, Abbasi F, Sayarifard A, Rostami P, Parvaneh N, Akhavan-Niaki H, Ahmadifard M, Tabrizi M
Orphanet J Rare Dis 2022 Jan 6;17(1):10. doi: 10.1186/s13023-021-02170-z. PMID: 34991662Free PMC Article
Evaluation of vaginal complaints.
Anderson MR, Klink K, Cohrssen A
JAMA 2004 Mar 17;291(11):1368-79. doi: 10.1001/jama.291.11.1368. PMID: 15026404

Recent systematic reviews

Screening for Bacterial Vaginosis in Pregnant Adolescents and Women to Prevent Preterm Delivery: Updated Evidence Report and Systematic Review for the US Preventive Services Task Force.
Kahwati LC, Clark R, Berkman N, Urrutia R, Patel SV, Zeng J, Viswanathan M
JAMA 2020 Apr 7;323(13):1293-1309. doi: 10.1001/jama.2020.0233. PMID: 32259235
Incidence of Opportunistic Infections and the Impact of Antiretroviral Therapy Among HIV-Infected Adults in Low- and Middle-Income Countries: A Systematic Review and Meta-analysis.
Low A, Gavriilidis G, Larke N, B-Lajoie MR, Drouin O, Stover J, Muhe L, Easterbrook P
Clin Infect Dis 2016 Jun 15;62(12):1595-1603. Epub 2016 Mar 6 doi: 10.1093/cid/ciw125. PMID: 26951573Free PMC Article

Supplemental Content

Table of contents

    Clinical resources

    Practice guidelines

    • PubMed
      See practice and clinical guidelines in PubMed. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.
    • Bookshelf
      See practice and clinical guidelines in NCBI Bookshelf. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.

    Reviews

    Related information

    • ClinVar
      Related medical variations
    • Gene
      Related information in NCBI Gene
    • GTR
      Related information in GTR
    • GTR(Clinical)
      Clinical tests in GTR
    • OMIM
      Related records in OMIM
    • OMIM(Genes)
      OMIM records containing genes associated with phenotypes registered in MedGen
    • PMC Articles
      Related information in PubMed Central Links
    • PubMed
      Related literature resources in PubMed
    • PubMed (OMIM)
      Related literature resources in PubMed

    Recent activity

    Clear Turn Off Turn On

    Your browsing activity is empty.

    Activity recording is turned off.

    Turn recording back on

    See more...