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Developmental dysplasia of the hip 2(DDH2)

MedGen UID:
811575
Concept ID:
C3715079
Disease or Syndrome
Synonym: DDH2
 
Monarch Initiative: MONDO:0014277
OMIM®: 615612

Definition

Developmental dysplasia of the hip (DDH) is a debilitating condition characterized by incomplete formation of the acetabulum leading to dislocation of the femur, suboptimal joint function, and accelerated wear of the articular cartilage, resulting in arthritis. Undetected hip dysplasia is the leading cause of osteoarthritis of the hip in young individuals, causing over 40% of cases in that age group (summary by Feldman et al., 2013). For discussion of genetic heterogeneity of developmental dysplasia of the hip, see DDH1 (142700). [from OMIM]

Clinical features

From HPO
Hip pain
MedGen UID:
1643075
Concept ID:
C4551516
Sign or Symptom
An unpleasant sensation characterized by physical discomfort (such as pricking, throbbing, or aching) localized to the hip.
Coxa valga
MedGen UID:
116080
Concept ID:
C0239137
Finding
Coxa valga is a deformity of the hip in which the angle between the femoral shaft and the femoral neck is increased compared to age-adjusted values (about 150 degrees in newborns gradually reducing to 120-130 degrees in adults).
Arthritis
MedGen UID:
2043
Concept ID:
C0003864
Disease or Syndrome
Inflammation of a joint.
Osteoarthritis of hip
MedGen UID:
14530
Concept ID:
C0029410
Disease or Syndrome
Osteoarthritis of the hip joint.
Hip dysplasia
MedGen UID:
1640560
Concept ID:
C4551649
Congenital Abnormality
The presence of developmental dysplasia of the hip.

Professional guidelines

PubMed

Kuitunen I, Uimonen MM, Haapanen M, Sund R, Helenius I, Ponkilainen VT
JAMA Netw Open 2022 Aug 1;5(8):e2227638. doi: 10.1001/jamanetworkopen.2022.27638. PMID: 35980635Free PMC Article
Husum HC, Thomsen JL, Kold S, Maimburg RD, Rahbek O
Dan Med J 2022 Jan 5;69(2) PMID: 35088700
Al-Essa RS, Aljahdali FH, Alkhilaiwi RM, Philip W, Jawadi AH, Khoshhal KI
J Orthop Surg (Hong Kong) 2017 May-Aug;25(2):2309499017717197. doi: 10.1177/2309499017717197. PMID: 28659058

Recent clinical studies

Etiology

Dwan K, Kirkham J, Paton RW, Morley E, Newton AW, Perry DC
Cochrane Database Syst Rev 2022 Oct 10;10(10):CD012717. doi: 10.1002/14651858.CD012717.pub2. PMID: 36214650Free PMC Article
Ulziibat M, Munkhuu B, Bataa AE, Schmid R, Baumann T, Essig S
BMC Pediatr 2021 Oct 13;21(1):450. doi: 10.1186/s12887-021-02910-x. PMID: 34641800Free PMC Article
Zhang S, Doudoulakis KJ, Khurwal A, Sarraf KM
Br J Hosp Med (Lond) 2020 Jul 2;81(7):1-8. Epub 2020 Jul 6 doi: 10.12968/hmed.2020.0223. PMID: 32730146
Parcells BW
Pediatr Clin North Am 2020 Feb;67(1):139-152. doi: 10.1016/j.pcl.2019.09.003. PMID: 31779829
de Hundt M, Vlemmix F, Bais JM, Hutton EK, de Groot CJ, Mol BW, Kok M
Eur J Obstet Gynecol Reprod Biol 2012 Nov;165(1):8-17. Epub 2012 Jul 21 doi: 10.1016/j.ejogrb.2012.06.030. PMID: 22824571

Diagnosis

Dwan K, Kirkham J, Paton RW, Morley E, Newton AW, Perry DC
Cochrane Database Syst Rev 2022 Oct 10;10(10):CD012717. doi: 10.1002/14651858.CD012717.pub2. PMID: 36214650Free PMC Article
Kuitunen I, Uimonen MM, Haapanen M, Sund R, Helenius I, Ponkilainen VT
JAMA Netw Open 2022 Aug 1;5(8):e2227638. doi: 10.1001/jamanetworkopen.2022.27638. PMID: 35980635Free PMC Article
Zhang S, Doudoulakis KJ, Khurwal A, Sarraf KM
Br J Hosp Med (Lond) 2020 Jul 2;81(7):1-8. Epub 2020 Jul 6 doi: 10.12968/hmed.2020.0223. PMID: 32730146
Shaw BA, Segal LS; SECTION ON ORTHOPAEDICS
Pediatrics 2016 Dec;138(6) Epub 2016 Nov 21 doi: 10.1542/peds.2016-3107. PMID: 27940740
Bancroft LW, Merinbaum DJ, Zaleski CG, Peterson JJ, Kransdorf MJ, Berquist TH
Semin Musculoskelet Radiol 2007 Jun;11(2):126-36. doi: 10.1055/s-2007-1001878. PMID: 18095245

Therapy

Tønning LU, O'Brien M, Semciw A, Stewart C, Kemp JL, Mechlenburg I
Arch Orthop Trauma Surg 2023 Jun;143(6):3637-3648. Epub 2022 Sep 30 doi: 10.1007/s00402-022-04627-7. PMID: 36175675
Dwan K, Kirkham J, Paton RW, Morley E, Newton AW, Perry DC
Cochrane Database Syst Rev 2022 Oct 10;10(10):CD012717. doi: 10.1002/14651858.CD012717.pub2. PMID: 36214650Free PMC Article
Kuitunen I, Uimonen MM, Haapanen M, Sund R, Helenius I, Ponkilainen VT
JAMA Netw Open 2022 Aug 1;5(8):e2227638. doi: 10.1001/jamanetworkopen.2022.27638. PMID: 35980635Free PMC Article
Ulziibat M, Munkhuu B, Bataa AE, Schmid R, Baumann T, Essig S
BMC Pediatr 2021 Oct 13;21(1):450. doi: 10.1186/s12887-021-02910-x. PMID: 34641800Free PMC Article
Carsi B, Al-Hallao S, Wahed K, Page J, Clarke NM
Acta Orthop 2014 Feb;85(1):66-70. Epub 2014 Jan 24 doi: 10.3109/17453674.2014.886030. PMID: 24460107Free PMC Article

Prognosis

Kuitunen I, Uimonen MM, Haapanen M, Sund R, Helenius I, Ponkilainen VT
JAMA Netw Open 2022 Aug 1;5(8):e2227638. doi: 10.1001/jamanetworkopen.2022.27638. PMID: 35980635Free PMC Article
Shaw BA, Segal LS; SECTION ON ORTHOPAEDICS
Pediatrics 2016 Dec;138(6) Epub 2016 Nov 21 doi: 10.1542/peds.2016-3107. PMID: 27940740
Ge Y, Cai H, Wang Z
Hip Int 2016 Jul 25;26(4):355-9. Epub 2016 May 16 doi: 10.5301/hipint.5000348. PMID: 27198970
Carsi B, Al-Hallao S, Wahed K, Page J, Clarke NM
Acta Orthop 2014 Feb;85(1):66-70. Epub 2014 Jan 24 doi: 10.3109/17453674.2014.886030. PMID: 24460107Free PMC Article
de Hundt M, Vlemmix F, Bais JM, Hutton EK, de Groot CJ, Mol BW, Kok M
Eur J Obstet Gynecol Reprod Biol 2012 Nov;165(1):8-17. Epub 2012 Jul 21 doi: 10.1016/j.ejogrb.2012.06.030. PMID: 22824571

Clinical prediction guides

Kuitunen I, Uimonen MM, Haapanen M, Sund R, Helenius I, Ponkilainen VT
JAMA Netw Open 2022 Aug 1;5(8):e2227638. doi: 10.1001/jamanetworkopen.2022.27638. PMID: 35980635Free PMC Article
Gyurkovits Z, Sohár G, Baricsa A, Németh G, Orvos H, Dubs B
Hip Int 2021 May;31(3):424-429. Epub 2019 Sep 30 doi: 10.1177/1120700019879687. PMID: 31566007
Parcells BW
Pediatr Clin North Am 2020 Feb;67(1):139-152. doi: 10.1016/j.pcl.2019.09.003. PMID: 31779829
Shaw BA, Segal LS; SECTION ON ORTHOPAEDICS
Pediatrics 2016 Dec;138(6) Epub 2016 Nov 21 doi: 10.1542/peds.2016-3107. PMID: 27940740
Carsi B, Al-Hallao S, Wahed K, Page J, Clarke NM
Acta Orthop 2014 Feb;85(1):66-70. Epub 2014 Jan 24 doi: 10.3109/17453674.2014.886030. PMID: 24460107Free PMC Article

Recent systematic reviews

Savoye-Laurens T, Verdier N, Wettstein M, Baulot E, Gédouin JE, Martz P
Orthop Traumatol Surg Res 2023 Jun;109(4):103539. Epub 2022 Dec 29 doi: 10.1016/j.otsr.2022.103539. PMID: 36587762
Dwan K, Kirkham J, Paton RW, Morley E, Newton AW, Perry DC
Cochrane Database Syst Rev 2022 Oct 10;10(10):CD012717. doi: 10.1002/14651858.CD012717.pub2. PMID: 36214650Free PMC Article
Kuitunen I, Uimonen MM, Haapanen M, Sund R, Helenius I, Ponkilainen VT
JAMA Netw Open 2022 Aug 1;5(8):e2227638. doi: 10.1001/jamanetworkopen.2022.27638. PMID: 35980635Free PMC Article
Kuroda Y, Saito M, Sunil Kumar KH, Malviya A, Khanduja V
Arthroscopy 2020 Sep;36(9):2550-2567.e1. Epub 2020 Jun 4 doi: 10.1016/j.arthro.2020.05.035. PMID: 32505709
de Hundt M, Vlemmix F, Bais JM, Hutton EK, de Groot CJ, Mol BW, Kok M
Eur J Obstet Gynecol Reprod Biol 2012 Nov;165(1):8-17. Epub 2012 Jul 21 doi: 10.1016/j.ejogrb.2012.06.030. PMID: 22824571

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