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Hyperpigmentation in sun-exposed areas

MedGen UID:
812207
Concept ID:
C3805877
Finding
Synonym: Hyperpigmentation of exposed areas
 
HPO: HP:0005586

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVHyperpigmentation in sun-exposed areas

Conditions with this feature

Familial porphyria cutanea tarda
MedGen UID:
75669
Concept ID:
C0268323
Disease or Syndrome
Familial porphyria cutanea tarda (F-PCT) is characterized by: skin findings including blistering over the dorsal aspects of the hands and other sun-exposed areas of skin, skin friability after minor trauma, facial hypertrichosis and hyperpigmentation, and severe thickening of affected skin areas (pseudoscleroderma); and an increased risk for hepatocellular carcinoma (HCC).
Hereditary spastic paraplegia 23
MedGen UID:
167094
Concept ID:
C0796019
Disease or Syndrome
Spastic paraplegia-23 (SPG23) is an autosomal recessive neurologic disorder characterized by childhood-onset spastic paraplegia resulting in gait difficulties and associated with pigmentary abnormalities, including premature graying of the hair and vitiligo-like or hyperpigmented skin lesions. Some patients may also have a peripheral neuropathy (summary by Lee et al., 2017).

Professional guidelines

PubMed

Kerns ML, Chien AL, Kang S
Plast Reconstr Surg 2021 Dec 1;148(6S):27S-31S. doi: 10.1097/PRS.0000000000008783. PMID: 34847095
Sofen B, Prado G, Emer J
Skin Therapy Lett 2016 Jan;21(1):1-7. PMID: 27224897
Tanaka Y, Tsunemi Y, Kawashima M
Lasers Surg Med 2016 Jan;48(1):30-5. Epub 2015 Oct 14 doi: 10.1002/lsm.22433. PMID: 26462982Free PMC Article

Recent clinical studies

Etiology

Coricciati L, Gabellone M, Donne PD, Pennati BM, Zingoni T
Skin Res Technol 2023 Aug;29(8):e13434. doi: 10.1111/srt.13434. PMID: 37632189Free PMC Article
Konisky H, Balazic E, Jaller JA, Khanna U, Kobets K
J Cosmet Dermatol 2023 Apr;22(4):1197-1206. Epub 2023 Jan 6 doi: 10.1111/jocd.15589. PMID: 36606378
Austin E, Nguyen JK, Jagdeo J
J Drugs Dermatol 2019 Nov 1;18(11) PMID: 31741361
Robles-Méndez JC, Rizo-Frías P, Herz-Ruelas ME, Pandya AG, Ocampo Candiani J
Int J Dermatol 2018 May;57(5):505-514. Epub 2017 Oct 26 doi: 10.1111/ijd.13806. PMID: 29076159
Handel AC, Miot LD, Miot HA
An Bras Dermatol 2014 Sep-Oct;89(5):771-82. doi: 10.1590/abd1806-4841.20143063. PMID: 25184917Free PMC Article

Diagnosis

Murthy AB, Palaniappan V, Karthikeyan K, Anbarasan V
Int J Dermatol 2023 Oct;62(10):1218-1227. Epub 2023 Aug 27 doi: 10.1111/ijd.16817. PMID: 37634201
Arrowitz C, Schoelermann AM, Mann T, Jiang LI, Weber T, Kolbe L
J Invest Dermatol 2019 Aug;139(8):1691-1698.e6. Epub 2019 Feb 27 doi: 10.1016/j.jid.2019.02.013. PMID: 30825454
Robles-Méndez JC, Rizo-Frías P, Herz-Ruelas ME, Pandya AG, Ocampo Candiani J
Int J Dermatol 2018 May;57(5):505-514. Epub 2017 Oct 26 doi: 10.1111/ijd.13806. PMID: 29076159
Wu IB, Lambert C, Lotti TM, Hercogová J, Sintim-Damoa A, Schwartz RA
G Ital Dermatol Venereol 2012 Aug;147(4):413-8. PMID: 23007216
Kumar P, Sharma PK, Gautam RK, Jain RK, Kar HK
Int J Dermatol 2007 May;46(5):492-3. doi: 10.1111/j.1365-4632.2007.03248.x. PMID: 17472679

Therapy

Konisky H, Balazic E, Jaller JA, Khanna U, Kobets K
J Cosmet Dermatol 2023 Apr;22(4):1197-1206. Epub 2023 Jan 6 doi: 10.1111/jocd.15589. PMID: 36606378
Austin E, Nguyen JK, Jagdeo J
J Drugs Dermatol 2019 Nov 1;18(11) PMID: 31741361
Arrowitz C, Schoelermann AM, Mann T, Jiang LI, Weber T, Kolbe L
J Invest Dermatol 2019 Aug;139(8):1691-1698.e6. Epub 2019 Feb 27 doi: 10.1016/j.jid.2019.02.013. PMID: 30825454
Kwon SH, Hwang YJ, Lee SK, Park KC
Int J Mol Sci 2016 May 26;17(6) doi: 10.3390/ijms17060824. PMID: 27240341Free PMC Article
Sofen B, Prado G, Emer J
Skin Therapy Lett 2016 Jan;21(1):1-7. PMID: 27224897

Prognosis

Thiem A, Schummer P, Ueberschaar S, Kerstan A, Kneitz H, Schrama D, Appenzeller S, Meierjohann S, Schilling B, Goebeler M, Gesierich A
Melanoma Res 2018 Oct;28(5):465-468. doi: 10.1097/CMR.0000000000000458. PMID: 29781871
Robles-Méndez JC, Rizo-Frías P, Herz-Ruelas ME, Pandya AG, Ocampo Candiani J
Int J Dermatol 2018 May;57(5):505-514. Epub 2017 Oct 26 doi: 10.1111/ijd.13806. PMID: 29076159
Vachiramon V, Panmanee W, Techapichetvanich T, Chanprapaph K
Lasers Surg Med 2016 Apr;48(4):354-9. Epub 2016 Jan 12 doi: 10.1002/lsm.22472. PMID: 27096729
Yu HS, Lee CH, Jee SH, Ho CK, Guo YL
J Dermatol 2001 Nov;28(11):628-31. doi: 10.1111/j.1346-8138.2001.tb00049.x. PMID: 11770720
Kumar P, Rao KS, Shashikala P, Chandrashekar HR, Banapurmath CR
Indian J Pediatr 2000 Aug;67(8):595-7. doi: 10.1007/BF02758492. PMID: 10985003

Clinical prediction guides

Murthy AB, Palaniappan V, Karthikeyan K, Anbarasan V
Int J Dermatol 2023 Oct;62(10):1218-1227. Epub 2023 Aug 27 doi: 10.1111/ijd.16817. PMID: 37634201
Konisky H, Balazic E, Jaller JA, Khanna U, Kobets K
J Cosmet Dermatol 2023 Apr;22(4):1197-1206. Epub 2023 Jan 6 doi: 10.1111/jocd.15589. PMID: 36606378
Arrowitz C, Schoelermann AM, Mann T, Jiang LI, Weber T, Kolbe L
J Invest Dermatol 2019 Aug;139(8):1691-1698.e6. Epub 2019 Feb 27 doi: 10.1016/j.jid.2019.02.013. PMID: 30825454
Kwon SH, Hwang YJ, Lee SK, Park KC
Int J Mol Sci 2016 May 26;17(6) doi: 10.3390/ijms17060824. PMID: 27240341Free PMC Article
Bolanca I, Bolanca Z, Kuna K, Vuković A, Tuckar N, Herman R, Grubisić G
Coll Antropol 2008 Oct;32 Suppl 2:139-41. PMID: 19140277

Recent systematic reviews

Austin E, Nguyen JK, Jagdeo J
J Drugs Dermatol 2019 Nov 1;18(11) PMID: 31741361

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