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Approximately 10% of cases are paraneoplastic

MedGen UID:
812338
•Concept ID:
C3806008
•
Finding

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVApproximately 10% of cases are paraneoplastic

Professional guidelines

PubMed

A systematic review of paraneoplastic syndromes associated with thymoma: Treatment modalities, recurrence, and outcomes in resected cases.
Zhao J, Bhatnagar V, Ding L, Atay SM, David EA, McFadden PM, Stamnes S, Lechtholz-Zey E, Wightman SC, Detterbeck FC, Kim AW
J Thorac Cardiovasc Surg 2020 Jul;160(1):306-314.e14. Epub 2019 Dec 2 doi: 10.1016/j.jtcvs.2019.11.052. PMID: 31982129

Recent clinical studies

Etiology

Comparison of (18) F-FDG PET/CT and (68) Ga-DOTATATE PET/CT in the Targeted Imaging of Culprit Tumors Causing Osteomalacia.
Yu HN, Liu L, Chen QS, He Q, Li YS, Wang Y, Gao S
Orthop Surg 2021 May;13(3):791-798. Epub 2021 Mar 11 doi: 10.1111/os.12980. PMID: 33709632Free PMC Article
Cranial Nerve Disorders Associated With Immune Checkpoint Inhibitors.
Vogrig A, Muñiz-Castrillo S, Joubert B, Picard G, Rogemond V, Skowron F, Egri M, Desestret V, Tilikete C, Psimaras D, Ducray F, Honnorat J
Neurology 2021 Feb 9;96(6):e866-e875. Epub 2020 Dec 14 doi: 10.1212/WNL.0000000000011340. PMID: 33318162
Management of the ectopic ACTH syndrome due to thoracic carcinoids.
Pass HI, Doppman JL, Nieman L, Stovroff M, Vetto J, Norton JA, Travis W, Chrousos GP, Oldfield EH, Cutler GB Jr
Ann Thorac Surg 1990 Jul;50(1):52-7. doi: 10.1016/0003-4975(90)90085-k. PMID: 2164362
Small cell lung cancer.
Goodman GE, Livingston RB
Dis Mon 1989 Dec;35(12):769-861. doi: 10.1016/0011-5029(89)90023-0. PMID: 2556255
Small cell lung cancer.
Goodman GE, Livingston RB
Curr Probl Cancer 1989 Jan-Feb;13(1):1-54. PMID: 2539953

Diagnosis

Comparison of (18) F-FDG PET/CT and (68) Ga-DOTATATE PET/CT in the Targeted Imaging of Culprit Tumors Causing Osteomalacia.
Yu HN, Liu L, Chen QS, He Q, Li YS, Wang Y, Gao S
Orthop Surg 2021 May;13(3):791-798. Epub 2021 Mar 11 doi: 10.1111/os.12980. PMID: 33709632Free PMC Article
Cranial Nerve Disorders Associated With Immune Checkpoint Inhibitors.
Vogrig A, Muñiz-Castrillo S, Joubert B, Picard G, Rogemond V, Skowron F, Egri M, Desestret V, Tilikete C, Psimaras D, Ducray F, Honnorat J
Neurology 2021 Feb 9;96(6):e866-e875. Epub 2020 Dec 14 doi: 10.1212/WNL.0000000000011340. PMID: 33318162
Paraneoplastic Cushing syndrome, case-series and review of the literature.
Deldycke A, Haenebalcke C, Taes Y
Acta Clin Belg 2018 Aug;73(4):298-304. Epub 2017 Sep 12 doi: 10.1080/17843286.2017.1373927. PMID: 28895465
Management of the ectopic ACTH syndrome due to thoracic carcinoids.
Pass HI, Doppman JL, Nieman L, Stovroff M, Vetto J, Norton JA, Travis W, Chrousos GP, Oldfield EH, Cutler GB Jr
Ann Thorac Surg 1990 Jul;50(1):52-7. doi: 10.1016/0003-4975(90)90085-k. PMID: 2164362
Small cell lung cancer.
Goodman GE, Livingston RB
Dis Mon 1989 Dec;35(12):769-861. doi: 10.1016/0011-5029(89)90023-0. PMID: 2556255

Therapy

Cranial Nerve Disorders Associated With Immune Checkpoint Inhibitors.
Vogrig A, Muñiz-Castrillo S, Joubert B, Picard G, Rogemond V, Skowron F, Egri M, Desestret V, Tilikete C, Psimaras D, Ducray F, Honnorat J
Neurology 2021 Feb 9;96(6):e866-e875. Epub 2020 Dec 14 doi: 10.1212/WNL.0000000000011340. PMID: 33318162
Acquired Haemophilia A Associated with Subsequent Hepatocellular Carcinoma.
Pacholczak R, Bazan-Socha S, Zdziarska J, Iwaniec T, Walocha JA, Musiał J, Dropiński J
Hamostaseologie 2019 Feb;39(1):95-99. Epub 2018 Aug 15 doi: 10.1055/s-0038-1668570. PMID: 30112740
Acquired Hemophilia of Unknown Etiology in an Elderly Man: Case Report.
Stephen SE, Loong JLX, Hoong CK, Lim SM, Botross NP
Am J Case Rep 2018 Jul 23;19:858-863. doi: 10.12659/AJCR.909228. PMID: 30033442Free PMC Article
Pathogenesis and therapy of neuropathies associated with monoclonal gammopathies.
Latov N
Ann Neurol 1995 May;37 Suppl 1:S32-42. doi: 10.1002/ana.410370705. PMID: 8968215
Small cell lung cancer.
Goodman GE, Livingston RB
Dis Mon 1989 Dec;35(12):769-861. doi: 10.1016/0011-5029(89)90023-0. PMID: 2556255

Prognosis

Cranial Nerve Disorders Associated With Immune Checkpoint Inhibitors.
Vogrig A, Muñiz-Castrillo S, Joubert B, Picard G, Rogemond V, Skowron F, Egri M, Desestret V, Tilikete C, Psimaras D, Ducray F, Honnorat J
Neurology 2021 Feb 9;96(6):e866-e875. Epub 2020 Dec 14 doi: 10.1212/WNL.0000000000011340. PMID: 33318162
A retrospective review of acute encephalitis in adults in Auckland over a five-year period (2005-2009).
Child N, Croxson MC, Rahnama F, Anderson NE
J Clin Neurosci 2012 Nov;19(11):1483-5. Epub 2012 Aug 25 doi: 10.1016/j.jocn.2012.03.010. PMID: 22925416
Amyopathic dermatomyositis: a review by the Italian Group of Immunodermatology.
Caproni M, Cardinali C, Parodi A, Giomi B, Papini M, Vaccaro M, Marzano A, De Simone C, Fazio M, Rebora A, Fabbri P
Arch Dermatol 2002 Jan;138(1):23-7. doi: 10.1001/archderm.138.1.23. PMID: 11790163
Pulmonary and thymic carcinoid tumors.
Dusmet ME, McKneally MF
World J Surg 1996 Feb;20(2):189-95. doi: 10.1007/s002689900029. PMID: 8661816
Management of the ectopic ACTH syndrome due to thoracic carcinoids.
Pass HI, Doppman JL, Nieman L, Stovroff M, Vetto J, Norton JA, Travis W, Chrousos GP, Oldfield EH, Cutler GB Jr
Ann Thorac Surg 1990 Jul;50(1):52-7. doi: 10.1016/0003-4975(90)90085-k. PMID: 2164362

Clinical prediction guides

Characteristics of Opsoclonus-Myoclonus Syndrome in Patients of the Largest Pediatric Hospital in Latin America.
Zeny MS, do Valle DA, Santos MLSF, Bara TS, Cordeiro ML
Pediatr Neurol 2024 May;154:9-14. Epub 2024 Jan 5 doi: 10.1016/j.pediatrneurol.2023.12.028. PMID: 38430891
Comparison of (18) F-FDG PET/CT and (68) Ga-DOTATATE PET/CT in the Targeted Imaging of Culprit Tumors Causing Osteomalacia.
Yu HN, Liu L, Chen QS, He Q, Li YS, Wang Y, Gao S
Orthop Surg 2021 May;13(3):791-798. Epub 2021 Mar 11 doi: 10.1111/os.12980. PMID: 33709632Free PMC Article
Paraneoplastic Dermatomyositis in a Patient with Metastatic Gastric Carcinoma.
Pozharashka J, Dourmishev L, Rusinova D, Balabanova M, Miteva L
Acta Dermatovenerol Croat 2020 Aug;28(2):120-122. PMID: 32876041
A systematic review of paraneoplastic syndromes associated with thymoma: Treatment modalities, recurrence, and outcomes in resected cases.
Zhao J, Bhatnagar V, Ding L, Atay SM, David EA, McFadden PM, Stamnes S, Lechtholz-Zey E, Wightman SC, Detterbeck FC, Kim AW
J Thorac Cardiovasc Surg 2020 Jul;160(1):306-314.e14. Epub 2019 Dec 2 doi: 10.1016/j.jtcvs.2019.11.052. PMID: 31982129

Recent systematic reviews

Cranial Nerve Disorders Associated With Immune Checkpoint Inhibitors.
Vogrig A, Muñiz-Castrillo S, Joubert B, Picard G, Rogemond V, Skowron F, Egri M, Desestret V, Tilikete C, Psimaras D, Ducray F, Honnorat J
Neurology 2021 Feb 9;96(6):e866-e875. Epub 2020 Dec 14 doi: 10.1212/WNL.0000000000011340. PMID: 33318162
A systematic review of paraneoplastic syndromes associated with thymoma: Treatment modalities, recurrence, and outcomes in resected cases.
Zhao J, Bhatnagar V, Ding L, Atay SM, David EA, McFadden PM, Stamnes S, Lechtholz-Zey E, Wightman SC, Detterbeck FC, Kim AW
J Thorac Cardiovasc Surg 2020 Jul;160(1):306-314.e14. Epub 2019 Dec 2 doi: 10.1016/j.jtcvs.2019.11.052. PMID: 31982129

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