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Morning sickness

MedGen UID:
81435
Concept ID:
C0312416
Sign or Symptom
Synonyms: Morning Sickness; Sickness, Morning
SNOMED CT: Morning sickness (51885006)

Definition

The nausea and vomiting that accompanies early pregnancy. [from NCI]

Professional guidelines

PubMed

Committee on Practice Bulletins-Obstetrics
Obstet Gynecol 2018 Jan;131(1):e15-e30. doi: 10.1097/AOG.0000000000002456. PMID: 29266076
Obstet Gynecol 2018 Jan;131(1):190-193. doi: 10.1097/AOG.0000000000002450. PMID: 29266070
Obstet Gynecol 2015 Sep;126(3):e12-e24. doi: 10.1097/AOG.0000000000001048. PMID: 26287788

Recent clinical studies

Etiology

Abe M, Yamaguchi T, Fujita Y, Nishimura T, Kitagawa K, Inui N, Hirano K, Sakata Y, Iihara H, Shibuya Y, Suzuki K, Shibata K, Hori K, Daga H, Nakayama T, Sakata Y, Takahashi TY, Zenda S, Hashimoto H
JAMA Netw Open 2023 May 1;6(5):e2310894. doi: 10.1001/jamanetworkopen.2023.10894. PMID: 37129897Free PMC Article
Mohd Nafiah NA, Chieng WK, Zainuddin AA, Chew KT, Kalok A, Abu MA, Ng BK, Mohamed Ismail NA, Nur Azurah AG
Int J Environ Res Public Health 2022 Sep 1;19(17) doi: 10.3390/ijerph191710886. PMID: 36078602Free PMC Article
Gadsby R, Ivanova D, Trevelyan E, Hutton JL, Johnson S
Br J Gen Pract 2020 Aug;70(697):e534-e539. Epub 2020 Jul 30 doi: 10.3399/bjgp20X710885. PMID: 32601054Free PMC Article
Sarrafpour S, Urits I, Powell J, Nguyen D, Callan J, Orhurhu V, Simopoulos T, Viswanath O, Kaye AD, Kaye RJ, Cornett EM, Yazdi C
Curr Pain Headache Rep 2020 Jun 10;24(7):38. doi: 10.1007/s11916-020-00872-w. PMID: 32524214
Matthews A, Haas DM, O'Mathúna DP, Dowswell T
Cochrane Database Syst Rev 2015 Sep 8;2015(9):CD007575. doi: 10.1002/14651858.CD007575.pub4. PMID: 26348534Free PMC Article

Diagnosis

Vanderziel A, Anthony JC, Barondess D, Kerver JM, Alshaarawy O
Am J Obstet Gynecol MFM 2023 Dec;5(12):101171. Epub 2023 Sep 29 doi: 10.1016/j.ajogmf.2023.101171. PMID: 37778699Free PMC Article
Pontius E, Vieth JT
Emerg Med Clin North Am 2019 May;37(2):219-237. doi: 10.1016/j.emc.2019.01.004. PMID: 30940368
Committee on Practice Bulletins-Obstetrics
Obstet Gynecol 2018 Jan;131(1):e15-e30. doi: 10.1097/AOG.0000000000002456. PMID: 29266076
Dean E
Nurs Stand 2016 Aug 10;30(50):15. doi: 10.7748/ns.30.50.15.s16. PMID: 27507366
Summers A
Emerg Nurse 2012 Jul;20(4):24-8. doi: 10.7748/en2012.07.20.4.24.c9206. PMID: 22876404

Therapy

Sarrafpour S, Urits I, Powell J, Nguyen D, Callan J, Orhurhu V, Simopoulos T, Viswanath O, Kaye AD, Kaye RJ, Cornett EM, Yazdi C
Curr Pain Headache Rep 2020 Jun 10;24(7):38. doi: 10.1007/s11916-020-00872-w. PMID: 32524214
Borner T, Shaulson ED, Ghidewon MY, Barnett AB, Horn CC, Doyle RP, Grill HJ, Hayes MR, De Jonghe BC
Cell Metab 2020 Feb 4;31(2):351-362.e5. Epub 2020 Jan 9 doi: 10.1016/j.cmet.2019.12.004. PMID: 31928886Free PMC Article
Committee on Practice Bulletins-Obstetrics
Obstet Gynecol 2018 Jan;131(1):e15-e30. doi: 10.1097/AOG.0000000000002456. PMID: 29266076
Matthews A, Haas DM, O'Mathúna DP, Dowswell T
Cochrane Database Syst Rev 2015 Sep 8;2015(9):CD007575. doi: 10.1002/14651858.CD007575.pub4. PMID: 26348534Free PMC Article
Vargesson N
Birth Defects Res C Embryo Today 2015 Jun;105(2):140-56. Epub 2015 Jun 4 doi: 10.1002/bdrc.21096. PMID: 26043938Free PMC Article

Prognosis

Nelson-Piercy C, Dean C, Shehmar M, Gadsby R, O'Hara M, Hodson K, Nana M; Royal College of Obstetricians and Gynaecologists
BJOG 2024 Jun;131(7):e1-e30. Epub 2024 Feb 4 doi: 10.1111/1471-0528.17739. PMID: 38311315
Smit T, Kotze I, du Plessis J
Ann Palliat Med 2021 Mar;10(3):2679-2686. Epub 2021 Jan 30 doi: 10.21037/apm-19-453. PMID: 33549001
Sturt J, Ali S, Robertson W, Metcalfe D, Grove A, Bourne C, Bridle C
Br J Gen Pract 2012 Nov;62(604):e757-64. doi: 10.3399/bjgp12X658287. PMID: 23211179Free PMC Article
Marcus DM, Snodgrass WR
Obstet Gynecol 2005 May;105(5 Pt 1):1119-22. doi: 10.1097/01.AOG.0000158858.79134.ea. PMID: 15863553
Quinla JD, Hill DA
Am Fam Physician 2003 Jul 1;68(1):121-8. PMID: 12887118

Clinical prediction guides

Nelson-Piercy C, Dean C, Shehmar M, Gadsby R, O'Hara M, Hodson K, Nana M; Royal College of Obstetricians and Gynaecologists
BJOG 2024 Jun;131(7):e1-e30. Epub 2024 Feb 4 doi: 10.1111/1471-0528.17739. PMID: 38311315
Mohd Nafiah NA, Chieng WK, Zainuddin AA, Chew KT, Kalok A, Abu MA, Ng BK, Mohamed Ismail NA, Nur Azurah AG
Int J Environ Res Public Health 2022 Sep 1;19(17) doi: 10.3390/ijerph191710886. PMID: 36078602Free PMC Article
Smit T, Kotze I, du Plessis J
Ann Palliat Med 2021 Mar;10(3):2679-2686. Epub 2021 Jan 30 doi: 10.21037/apm-19-453. PMID: 33549001
Khorasani F, Aryan H, Sobhi A, Aryan R, Abavi-Sani A, Ghazanfarpour M, Saeidi M, Rajab Dizavandi F
J Obstet Gynaecol 2020 Jan;40(1):10-19. Epub 2019 Jun 19 doi: 10.1080/01443615.2019.1587392. PMID: 31215276
Flaxman SM, Sherman PW
Q Rev Biol 2000 Jun;75(2):113-48. doi: 10.1086/393377. PMID: 10858967

Recent systematic reviews

Nijsten K, van der Minnen L, Wiegers HMG, Koot MH, Middeldorp S, Roseboom TJ, Grooten IJ, Painter RC
Br J Nutr 2022 Jul 14;128(1):30-42. Epub 2021 Jul 30 doi: 10.1017/S0007114521002865. PMID: 34325760Free PMC Article
Khorasani F, Aryan H, Sobhi A, Aryan R, Abavi-Sani A, Ghazanfarpour M, Saeidi M, Rajab Dizavandi F
J Obstet Gynaecol 2020 Jan;40(1):10-19. Epub 2019 Jun 19 doi: 10.1080/01443615.2019.1587392. PMID: 31215276
Matthews A, Haas DM, O'Mathúna DP, Dowswell T
Cochrane Database Syst Rev 2015 Sep 8;2015(9):CD007575. doi: 10.1002/14651858.CD007575.pub4. PMID: 26348534Free PMC Article
Matthews A, Haas DM, O'Mathúna DP, Dowswell T, Doyle M
Cochrane Database Syst Rev 2014 Mar 21;(3):CD007575. doi: 10.1002/14651858.CD007575.pub3. PMID: 24659261
Sturt J, Ali S, Robertson W, Metcalfe D, Grove A, Bourne C, Bridle C
Br J Gen Pract 2012 Nov;62(604):e757-64. doi: 10.3399/bjgp12X658287. PMID: 23211179Free PMC Article

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