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Normal melanin content in melanocytes

MedGen UID:
816121
•Concept ID:
C3809791
•
Finding

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVNormal melanin content in melanocytes

Professional guidelines

PubMed

Effects of combined treatment with interferon and mezerein on melanogenesis and growth in human melanoma cells.
Fisher PB, Prignoli DR, Hermo H Jr, Weinstein IB, Pestka S
J Interferon Res 1985 Winter;5(1):11-22. doi: 10.1089/jir.1985.5.11. PMID: 3989332

Recent clinical studies

Etiology

Glutathione amino acid precursors protect skin from UVB-induced damage and improve skin tone.
Cui X, Mi T, Zhang H, Gao P, Xiao X, Lee J, Guelakis M, Gu X
J Eur Acad Dermatol Venereol 2024 Jan;38 Suppl 3:12-20. doi: 10.1111/jdv.19718. PMID: 38189671
Chlortetracycline and melanin biopolymer - The risk of accumulation and implications for phototoxicity: An in vitro study on normal human melanocytes.
Rok J, Rzepka Z, Respondek M, Beberok A, Wrześniok D
Chem Biol Interact 2019 Apr 25;303:27-34. Epub 2019 Feb 12 doi: 10.1016/j.cbi.2019.02.005. PMID: 30768968
Antimelanogenic Efficacy of Melasolv (3,4,5-Trimethoxycinnamate Thymol Ester) in Melanocytes and Three-Dimensional Human Skin Equivalent.
Lee JH, Lee ES, Bae IH, Hwang JA, Kim SH, Kim DY, Park NH, Rho HS, Kim YJ, Oh SG, Lee CS
Skin Pharmacol Physiol 2017;30(4):190-196. Epub 2017 Jun 30 doi: 10.1159/000477356. PMID: 28662511
Effect of fluoroquinolones on melanogenesis in normal human melanocytes HEMn-DP: a comparative in vitro study.
Beberok A, Wrześniok D, Rzepka Z, Rok J, Delijewski M, Otręba M, Respondek M, Buszman E
Cutan Ocul Toxicol 2017 Jun;36(2):169-175. Epub 2016 Sep 28 doi: 10.1080/15569527.2016.1229674. PMID: 27572617
Modulation of Melanogenesis and Antioxidant Status of Melanocytes in Response to Phototoxic Action of Doxycycline.
Rok J, Buszman E, Beberok A, Delijewski M, Otręba M, Wrześniok D
Photochem Photobiol 2015 Nov;91(6):1429-34. Epub 2015 Aug 13 doi: 10.1111/php.12497. PMID: 26189561

Diagnosis

Phototoxic Reactions Inducted by Hydrochlorothiazide and Furosemide in Normal Skin Cells-In Vitro Studies on Melanocytes and Fibroblasts.
Karkoszka M, Rok J, Rzepka Z, Banach K, Kowalska J, Wrześniok D
Int J Mol Sci 2024 Jan 24;25(3) doi: 10.3390/ijms25031432. PMID: 38338717Free PMC Article
The melanogenic effects and underlying mechanism of paeoniflorin in human melanocytes and vitiligo mice.
Hu M, Chen C, Liu J, Cai L, Shao J, Chen Z, Lin L, Zheng T, Ding X, Li Z
Fitoterapia 2020 Jan;140:104416. Epub 2019 Nov 5 doi: 10.1016/j.fitote.2019.104416. PMID: 31704261
Gentamicin affects melanogenesis in normal human melanocytes.
Wrześniok D, Beberok A, Otręba M, Buszman E
Cutan Ocul Toxicol 2015;34(2):107-11. Epub 2014 Jun 18 doi: 10.3109/15569527.2014.910803. PMID: 24938455
Progressive cribriform and zosteriform hyperpigmentation: a clinicopathologic study.
Cho E, Cho SH, Lee JD
Int J Dermatol 2012 Apr;51(4):399-405. doi: 10.1111/j.1365-4632.2011.04988.x. PMID: 22435426
Tuberous sclerosis and guttate leukodermas.
Jimbow K
Semin Cutan Med Surg 1997 Mar;16(1):30-5. doi: 10.1016/s1085-5629(97)80033-8. PMID: 9125763

Therapy

The melanogenic effects and underlying mechanism of paeoniflorin in human melanocytes and vitiligo mice.
Hu M, Chen C, Liu J, Cai L, Shao J, Chen Z, Lin L, Zheng T, Ding X, Li Z
Fitoterapia 2020 Jan;140:104416. Epub 2019 Nov 5 doi: 10.1016/j.fitote.2019.104416. PMID: 31704261
Fargesin inhibits melanin synthesis in murine malignant and immortalized melanocytes by regulating PKA/CREB and P38/MAPK signaling pathways.
Fu T, Chai B, Shi Y, Dang Y, Ye X
J Dermatol Sci 2019 Apr;94(1):213-219. Epub 2019 Mar 28 doi: 10.1016/j.jdermsci.2019.03.004. PMID: 30956031
In vitro melanogenesis inhibition by fluphenazine and prochlorperazine in normal human melanocytes lightly pigmented.
Otręba M, Beberok A, Wrześniok D, Buszman E
Daru 2018 Sep;26(1):85-89. Epub 2018 Jul 24 doi: 10.1007/s40199-018-0206-4. PMID: 30159761Free PMC Article
Methylquercetins stimulate melanin biosynthesis in a three-dimensional skin model.
Yamauchi K, Mitsunaga T
J Nat Med 2018 Mar;72(2):563-569. Epub 2018 Feb 13 doi: 10.1007/s11418-018-1175-0. PMID: 29442220
Melanogenesis and antioxidant defense system in normal human melanocytes cultured in the presence of chlorpromazine.
Otreba M, Wrześniok D, Beberok A, Rok J, Buszman E
Toxicol In Vitro 2015 Feb;29(1):221-7. doi: 10.1016/j.tiv.2014.10.016. PMID: 25449126

Prognosis

Biphasic pro-melanogenic and pro-apoptotic effects of all-trans-retinoic acid (ATRA) on human melanocytes: time-course study.
Baldea I, Costin GE, Shellman Y, Kechris K, Olteanu ED, Filip A, Cosgarea MR, Norris DA, Birlea SA
J Dermatol Sci 2013 Nov;72(2):168-76. Epub 2013 Jun 21 doi: 10.1016/j.jdermsci.2013.06.004. PMID: 23867358
Abrogating effect of a xanthophyll carotenoid astaxanthin on the stem cell factor-induced stimulation of human epidermal pigmentation.
Nakajima H, Fukazawa K, Wakabayashi Y, Wakamatsu K, Senda K, Imokawa G
Arch Dermatol Res 2012 Dec;304(10):803-16. Epub 2012 May 26 doi: 10.1007/s00403-012-1248-y. PMID: 22639095
Comprehensive understanding of idiopathic guttate hypomelanosis: clinical and histopathological correlation.
Kim SK, Kim EH, Kang HY, Lee ES, Sohn S, Kim YC
Int J Dermatol 2010 Feb;49(2):162-6. doi: 10.1111/j.1365-4632.2009.04209.x. PMID: 20465639
TRPM1 forms ion channels associated with melanin content in melanocytes.
Oancea E, Vriens J, Brauchi S, Jun J, Splawski I, Clapham DE
Sci Signal 2009 May 12;2(70):ra21. doi: 10.1126/scisignal.2000146. PMID: 19436059Free PMC Article
High frequency of tetraploidy detected in malignant melanoma of Japanese patients by fluorescence in situ hybridization.
Satoh S, Hashimoto-Tamaoki T, Furuyama J, Mihara K, Namba M, Kitano Y
Int J Oncol 2000 Oct;17(4):707-15. doi: 10.3892/ijo.17.4.707. PMID: 10995881

Clinical prediction guides

In vitro melanogenesis inhibition by fluphenazine and prochlorperazine in normal human melanocytes lightly pigmented.
Otręba M, Beberok A, Wrześniok D, Buszman E
Daru 2018 Sep;26(1):85-89. Epub 2018 Jul 24 doi: 10.1007/s40199-018-0206-4. PMID: 30159761Free PMC Article
Novel regulation of melanogenesis by adiponectin via the AMPK/CRTC pathway.
Bang S, Won KH, Moon HR, Yoo H, Hong A, Song Y, Chang SE
Pigment Cell Melanoma Res 2017 Jan;30(6):553-557. Epub 2017 Jul 14 doi: 10.1111/pcmr.12596. PMID: 28481450
Melanogenesis and antioxidant defense system in normal human melanocytes cultured in the presence of chlorpromazine.
Otreba M, Wrześniok D, Beberok A, Rok J, Buszman E
Toxicol In Vitro 2015 Feb;29(1):221-7. doi: 10.1016/j.tiv.2014.10.016. PMID: 25449126
Interferon-γ induces senescence in normal human melanocytes.
Wang S, Zhou M, Lin F, Liu D, Hong W, Lu L, Zhu Y, Xu A
PLoS One 2014;9(3):e93232. Epub 2014 Mar 28 doi: 10.1371/journal.pone.0093232. PMID: 24681574Free PMC Article
Tuberous sclerosis and guttate leukodermas.
Jimbow K
Semin Cutan Med Surg 1997 Mar;16(1):30-5. doi: 10.1016/s1085-5629(97)80033-8. PMID: 9125763

Supplemental Content

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    Practice guidelines

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