U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Endometrial Atypical Hyperplasia/Endometrioid Intraepithelial Neoplasia

MedGen UID:
818206
•Concept ID:
C3812874
•
Neoplastic Process
Synonyms: Atypical Endometrial Hyperplasia; Atypical Hyperplasia of Endometrium; Atypical hyperplasia of the endometrium; Atypical Hyperplasia of the Endometrium; Atypical Hyperplasia/Endometrioid Intraepithelial Neoplasm; EIN - endometrial intraepithelial neoplasia; Endometrial Glandular Dysplasia; Endometrial Hyperplasia with Atypia; Endometrial Intraepithelial Neoplasia; Endometrial intraepithelial neoplasia; Endometrioid intraepithelial neoplasia
SNOMED CT: Endometrial intraepithelial neoplasia (419327006); EIN - endometrial intraepithelial neoplasia (419327006); Atypical hyperplasia of the endometrium (703548001); Endometrioid intraepithelial neoplasia (703548001)

Definition

A neoplastic clonal expansion of endometrial glands characterized by cytologic changes of the epithelium and the presence of an increased number of endometrial glands. The glands form crowded aggregates with tubular or branching patterns which are cytologically distinct from the background architectural and cytological pattern. It is associated with molecular changes seen in endometrioid endometrial carcinoma, including microsatellite instability, PAX2 inactivation, and PTEN, KRAS, and CTNNB1 gene mutations. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVEndometrial Atypical Hyperplasia/Endometrioid Intraepithelial Neoplasia

Professional guidelines

PubMed

PTEN immunohistochemistry in endometrial hyperplasia: which are the optimal criteria for the diagnosis of precancer?
Travaglino A, Raffone A, Saccone G, Mascolo M, Pignatiello S, Mollo A, De Placido G, Insabato L, Zullo F
APMIS 2019 Apr;127(4):161-169. doi: 10.1111/apm.12938. PMID: 30803040

Recent clinical studies

Etiology

Reliable Identification of Endometrial Precancers Through Combined Pax2, β-Catenin, and Pten Immunohistochemistry.
Aguilar M, Chen H, Rivera-Colon G, Niu S, Carrick K, Gwin K, Cuevas IC, Sahoo SS, Li HD, Zhang S, Zheng W, Lucas E, Castrillon DH
Am J Surg Pathol 2022 Mar 1;46(3):404-414. doi: 10.1097/PAS.0000000000001810. PMID: 34545858Free PMC Article

Diagnosis

YTHDF2 is a novel diagnostic marker of endometrial adenocarcinoma and endometrial atypical hyperplasia/ intraepithelial neoplasia.
Bian PP, Liu SY, Luo QP, Xiong ZT
Pathol Res Pract 2022 Jun;234:153919. Epub 2022 Apr 28 doi: 10.1016/j.prp.2022.153919. PMID: 35512522
Reliable Identification of Endometrial Precancers Through Combined Pax2, β-Catenin, and Pten Immunohistochemistry.
Aguilar M, Chen H, Rivera-Colon G, Niu S, Carrick K, Gwin K, Cuevas IC, Sahoo SS, Li HD, Zhang S, Zheng W, Lucas E, Castrillon DH
Am J Surg Pathol 2022 Mar 1;46(3):404-414. doi: 10.1097/PAS.0000000000001810. PMID: 34545858Free PMC Article
Endometrial carcinoma: molecular subtypes, precursors and the role of pathology in early diagnosis.
Huvila J, Pors J, Thompson EF, Gilks CB
J Pathol 2021 Apr;253(4):355-365. Epub 2021 Feb 6 doi: 10.1002/path.5608. PMID: 33368243

Prognosis

Clinicopathologic Evaluation and Molecular Profiling of Recurrent Stage IA Endometrial Endometrioid Carcinoma: A Case-control Study.
Sharma AE, Moran A, Somasegar S, Steinhardt G, Chapel DB, Lastra RR, Lee NK, Ritterhouse LL, Bennett JA
Int J Gynecol Pathol 2023 Jan 1;42(1):26-34. Epub 2022 Feb 4 doi: 10.1097/PGP.0000000000000856. PMID: 35125405
Endometrial carcinoma: molecular subtypes, precursors and the role of pathology in early diagnosis.
Huvila J, Pors J, Thompson EF, Gilks CB
J Pathol 2021 Apr;253(4):355-365. Epub 2021 Feb 6 doi: 10.1002/path.5608. PMID: 33368243

Supplemental Content

Table of contents

    Practice guidelines

    • PubMed
      See practice and clinical guidelines in PubMed. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.

    Related information

    • PMC Articles
      Related information in PubMed Central Links
    • PubMed
      Related literature resources in PubMed

    Recent activity

    Clear Turn Off Turn On

    Your browsing activity is empty.

    Activity recording is turned off.

    Turn recording back on

    See more...