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Juvenile polymyositis

MedGen UID:
819736
•Concept ID:
C3826988
•
Disease or Syndrome
Synonym: Juvenile myositis
SNOMED CT: Juvenile polymyositis (738526005)
 
Monarch Initiative: MONDO:0019734
Orphanet: ORPHA93568

Definition

A rare type of juvenile idiopathic inflammatory myopathy with onset before 18 years of age of chronic skeletal muscle inflammation, manifesting as progressive, proximal and distal muscle weakness and atrophy. [from SNOMEDCT_US]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVJuvenile polymyositis

Professional guidelines

PubMed

Developments in the classification and treatment of the juvenile idiopathic inflammatory myopathies.
Rider LG, Katz JD, Jones OY
Rheum Dis Clin North Am 2013 Nov;39(4):877-904. Epub 2013 Sep 19 doi: 10.1016/j.rdc.2013.06.001. PMID: 24182859Free PMC Article
Idiopathic inflammatory myopathies: current trends in pathogenesis, clinical features, and up-to-date treatment recommendations.
Ernste FC, Reed AM
Mayo Clin Proc 2013 Jan;88(1):83-105. doi: 10.1016/j.mayocp.2012.10.017. PMID: 23274022
Treatment of inflammatory myopathies.
Mastaglia FL, Laing BA, Zilko P
Baillieres Clin Neurol 1993 Nov;2(3):717-40. PMID: 8156149

Recent clinical studies

Etiology

Lung involvement in juvenile idiopathic inflammatory myopathy: A systematic review.
Abu-Rumeileh S, Marrani E, Maniscalco V, Maccora I, Pagnini I, Mastrolia MV, Rouster-Stevens K, Simonini G
Autoimmun Rev 2023 Oct;22(10):103416. Epub 2023 Aug 22 doi: 10.1016/j.autrev.2023.103416. PMID: 37611886
Juvenile Idiopathic Inflammatory Myopathies.
Huber AM
Pediatr Clin North Am 2018 Aug;65(4):739-756. doi: 10.1016/j.pcl.2018.04.006. PMID: 30031496
The juvenile idiopathic inflammatory myopathies: pathogenesis, clinical and autoantibody phenotypes, and outcomes.
Rider LG, Nistala K
J Intern Med 2016 Jul;280(1):24-38. Epub 2016 Mar 30 doi: 10.1111/joim.12444. PMID: 27028907Free PMC Article
Developments in the classification and treatment of the juvenile idiopathic inflammatory myopathies.
Rider LG, Katz JD, Jones OY
Rheum Dis Clin North Am 2013 Nov;39(4):877-904. Epub 2013 Sep 19 doi: 10.1016/j.rdc.2013.06.001. PMID: 24182859Free PMC Article
Clinical and laboratory features distinguishing juvenile polymyositis and muscular dystrophy.
Mamyrova G, Katz JD, Jones RV, Targoff IN, Lachenbruch PA, Jones OY, Miller FW, Rider LG; Childhood Myositis Heterogeneity Collaborative Study Group
Arthritis Care Res (Hoboken) 2013 Dec;65(12):1969-75. doi: 10.1002/acr.22088. PMID: 23925923Free PMC Article

Diagnosis

Lung involvement in juvenile idiopathic inflammatory myopathy: A systematic review.
Abu-Rumeileh S, Marrani E, Maniscalco V, Maccora I, Pagnini I, Mastrolia MV, Rouster-Stevens K, Simonini G
Autoimmun Rev 2023 Oct;22(10):103416. Epub 2023 Aug 22 doi: 10.1016/j.autrev.2023.103416. PMID: 37611886
Environmental factors associated with juvenile idiopathic inflammatory myopathy clinical and serologic phenotypes.
Scalabrini JC, Schiffenbauer AI, Farhadi PN, Volochayev R, Bayat N, Jansen A, Targoff IN, Miller FW, Rider LG
Pediatr Rheumatol Online J 2022 Apr 12;20(1):28. doi: 10.1186/s12969-022-00684-9. PMID: 35414090Free PMC Article
Juvenile Idiopathic Inflammatory Myopathies.
Huber AM
Pediatr Clin North Am 2018 Aug;65(4):739-756. doi: 10.1016/j.pcl.2018.04.006. PMID: 30031496
Clinical and laboratory features distinguishing juvenile polymyositis and muscular dystrophy.
Mamyrova G, Katz JD, Jones RV, Targoff IN, Lachenbruch PA, Jones OY, Miller FW, Rider LG; Childhood Myositis Heterogeneity Collaborative Study Group
Arthritis Care Res (Hoboken) 2013 Dec;65(12):1969-75. doi: 10.1002/acr.22088. PMID: 23925923Free PMC Article
Myositis in children.
Reed AM
Curr Opin Rheumatol 2001 Sep;13(5):428-33. doi: 10.1097/00002281-200109000-00015. PMID: 11604600

Therapy

Juvenile Idiopathic Inflammatory Myopathies.
Huber AM
Pediatr Clin North Am 2018 Aug;65(4):739-756. doi: 10.1016/j.pcl.2018.04.006. PMID: 30031496
Clinical course and outcomes of Iranian children with juvenile dermatomyositis and polymyositis.
Malek A, Raeeskarami SR, Ziaee V, Aghighi Y, Moradinejad MH
Clin Rheumatol 2014 Aug;33(8):1113-8. Epub 2014 May 31 doi: 10.1007/s10067-014-2675-2. PMID: 24878926
Developments in the classification and treatment of the juvenile idiopathic inflammatory myopathies.
Rider LG, Katz JD, Jones OY
Rheum Dis Clin North Am 2013 Nov;39(4):877-904. Epub 2013 Sep 19 doi: 10.1016/j.rdc.2013.06.001. PMID: 24182859Free PMC Article
Clinical and laboratory features distinguishing juvenile polymyositis and muscular dystrophy.
Mamyrova G, Katz JD, Jones RV, Targoff IN, Lachenbruch PA, Jones OY, Miller FW, Rider LG; Childhood Myositis Heterogeneity Collaborative Study Group
Arthritis Care Res (Hoboken) 2013 Dec;65(12):1969-75. doi: 10.1002/acr.22088. PMID: 23925923Free PMC Article
Treatment of inflammatory myopathies.
Mastaglia FL, Laing BA, Zilko P
Baillieres Clin Neurol 1993 Nov;2(3):717-40. PMID: 8156149

Prognosis

Juvenile Idiopathic Inflammatory Myopathies.
Huber AM
Pediatr Clin North Am 2018 Aug;65(4):739-756. doi: 10.1016/j.pcl.2018.04.006. PMID: 30031496
The juvenile idiopathic inflammatory myopathies: pathogenesis, clinical and autoantibody phenotypes, and outcomes.
Rider LG, Nistala K
J Intern Med 2016 Jul;280(1):24-38. Epub 2016 Mar 30 doi: 10.1111/joim.12444. PMID: 27028907Free PMC Article
Clinical course and outcomes of Iranian children with juvenile dermatomyositis and polymyositis.
Malek A, Raeeskarami SR, Ziaee V, Aghighi Y, Moradinejad MH
Clin Rheumatol 2014 Aug;33(8):1113-8. Epub 2014 May 31 doi: 10.1007/s10067-014-2675-2. PMID: 24878926
Developments in the classification and treatment of the juvenile idiopathic inflammatory myopathies.
Rider LG, Katz JD, Jones OY
Rheum Dis Clin North Am 2013 Nov;39(4):877-904. Epub 2013 Sep 19 doi: 10.1016/j.rdc.2013.06.001. PMID: 24182859Free PMC Article
Clinical and laboratory features distinguishing juvenile polymyositis and muscular dystrophy.
Mamyrova G, Katz JD, Jones RV, Targoff IN, Lachenbruch PA, Jones OY, Miller FW, Rider LG; Childhood Myositis Heterogeneity Collaborative Study Group
Arthritis Care Res (Hoboken) 2013 Dec;65(12):1969-75. doi: 10.1002/acr.22088. PMID: 23925923Free PMC Article

Clinical prediction guides

Dysferlinopathy misdiagnosed with juvenile polymyositis in the pre-symptomatic stage of hyperCKemia: a case report and literature review.
Contreras-Cubas C, Barajas-Olmos F, Frayre-Martínez MI, Siordia-Reyes G, Guízar-Sánchez CC, García-Ortiz H, Orozco L, Baca V
BMC Med Genomics 2022 Jun 20;15(1):139. doi: 10.1186/s12920-022-01284-y. PMID: 35725460Free PMC Article
Development and Preliminary Validation of an Electromyography-Scoring Protocol for the Assessment and Grading of Muscle Involvement in Patients With Juvenile Idiopathic Inflammatory Myopathies.
Cappellari AM, Minoia F, Consonni D, Petaccia A, Picca I, Filocamo G
Pediatr Neurol 2021 Nov;124:6-10. Epub 2021 Aug 6 doi: 10.1016/j.pediatrneurol.2021.07.017. PMID: 34507251
Spectrum of paediatric rheumatic diseases in Nigeria.
Olaosebikan BH, Adelowo OO, Animashaun BA, Akintayo RO
Pediatr Rheumatol Online J 2017 Jan 31;15(1):7. doi: 10.1186/s12969-017-0139-3. PMID: 28143550Free PMC Article
Clinical analysis and outcome of interstitial lung disease complicated with juvenile dermatomyositis and juvenile polymyositis.
Sato S, Uejima Y, Nanbu M, Suganuma E, Takano T, Tanaka R, Kabuki T, Oguma E, Oh-Ishi T, Kawano Y
Mod Rheumatol 2017 Jul;27(4):652-656. Epub 2016 Sep 20 doi: 10.1080/14397595.2016.1231102. PMID: 27588444
Clinical and laboratory features distinguishing juvenile polymyositis and muscular dystrophy.
Mamyrova G, Katz JD, Jones RV, Targoff IN, Lachenbruch PA, Jones OY, Miller FW, Rider LG; Childhood Myositis Heterogeneity Collaborative Study Group
Arthritis Care Res (Hoboken) 2013 Dec;65(12):1969-75. doi: 10.1002/acr.22088. PMID: 23925923Free PMC Article

Recent systematic reviews

Lung involvement in juvenile idiopathic inflammatory myopathy: A systematic review.
Abu-Rumeileh S, Marrani E, Maniscalco V, Maccora I, Pagnini I, Mastrolia MV, Rouster-Stevens K, Simonini G
Autoimmun Rev 2023 Oct;22(10):103416. Epub 2023 Aug 22 doi: 10.1016/j.autrev.2023.103416. PMID: 37611886

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