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Toxic Erythema of Chemotherapy

MedGen UID:
819957
•Concept ID:
C3827209
•
Finding

Definition

Painful red or purple patches, edematous plaques or blisters on the hands, feet, extremities or intertriginous regions; the onset can occur days to months after receiving chemotherapy. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVToxic Erythema of Chemotherapy

Professional guidelines

PubMed

High-dose oral vitamin D: An emerging therapeutic for skin toxicities associated with cancer treatment.
Choi S, Iriarte C
J Am Acad Dermatol 2024 Sep;91(3):596-597. Epub 2024 May 18 doi: 10.1016/j.jaad.2024.05.027. PMID: 38763290
High-Dose Vitamin D for the Management of Toxic Erythema of Chemotherapy in Hospitalized Patients.
Nguyen CV, Zheng L, Zhou XA, Ernst MK, Kye Y, Choi JN, Lu KQ
JAMA Dermatol 2023 Feb 1;159(2):219-222. doi: 10.1001/jamadermatol.2022.5397. PMID: 36542397Free PMC Article
Enhanced skin toxicity associated with the combination of clofarabine plus cytarabine for the treatment of acute leukemia.
Zhang B, Bolognia J, Marks P, Podoltsev N
Cancer Chemother Pharmacol 2014 Aug;74(2):303-7. Epub 2014 Jun 8 doi: 10.1007/s00280-014-2504-y. PMID: 24908437

Recent clinical studies

Etiology

Clinical and Histopathologic Spectrum of Toxic Erythema of Chemotherapy: A Series of 56 Cases From a Single Institution.
Cole DW, Menge TD, Lowe L, Chan MP, Bresler SC
Am J Dermatopathol 2024 Jun 1;46(6):337-345. Epub 2023 Dec 13 doi: 10.1097/DAD.0000000000002450. PMID: 38133527
Cutaneous manifestations in pediatric oncology patients.
Özkur E, Sert C, Kıvanç Altunay İ, Yıldırırmak ZY, Genç DB, Vural S, Erdem Y
Pediatr Dermatol 2021 Jan;38(1):58-65. Epub 2020 Nov 12 doi: 10.1111/pde.14375. PMID: 33179835
Atypical features and systemic associations in extensive cases of Grover disease: A systematic review.
Gantz M, Butler D, Goldberg M, Ryu J, McCalmont T, Shinkai K
J Am Acad Dermatol 2017 Nov;77(5):952-957.e1. Epub 2017 Sep 14 doi: 10.1016/j.jaad.2017.06.041. PMID: 28918973
Baboon syndrome and toxic erythema of chemotherapy: Fold (intertriginous) dermatoses.
Wolf R, Tüzün Y
Clin Dermatol 2015 Jul-Aug;33(4):462-5. Epub 2015 Apr 7 doi: 10.1016/j.clindermatol.2015.04.008. PMID: 26051062
Toxic erythema of chemotherapy following i.v. BU plus fludarabine for allogeneic PBSC transplant.
Parker TL, Cooper DL, Seropian SE, Bolognia JL
Bone Marrow Transplant 2013 May;48(5):646-50. Epub 2012 Nov 19 doi: 10.1038/bmt.2012.218. PMID: 23165491

Diagnosis

Toxic erythema of chemotherapy induced by liposomal doxorubicin, a clinical case.
Esperanca-Martins M, Lobo-Martins S, Sanches M, Brazao C, Pena B, Correia C, Aguado-Lobo M, Espinosa-Lara P, Costa L, Soares-de-Almeida L, Fernandes I
Dermatol Online J 2022 Jan 15;28(1) doi: 10.5070/D328157060. PMID: 35499414
Cutaneous manifestations in pediatric oncology patients.
Özkur E, Sert C, Kıvanç Altunay İ, Yıldırırmak ZY, Genç DB, Vural S, Erdem Y
Pediatr Dermatol 2021 Jan;38(1):58-65. Epub 2020 Nov 12 doi: 10.1111/pde.14375. PMID: 33179835
Baboon syndrome and toxic erythema of chemotherapy: Fold (intertriginous) dermatoses.
Wolf R, Tüzün Y
Clin Dermatol 2015 Jul-Aug;33(4):462-5. Epub 2015 Apr 7 doi: 10.1016/j.clindermatol.2015.04.008. PMID: 26051062
Toxic erythema of chemotherapy.
Repass TS, Wetter DA, Camilleri MJ
Am J Hematol 2012 Sep;87(9):923. Epub 2011 Nov 10 doi: 10.1002/ajh.22200. PMID: 22072527
Toxic erythema of chemotherapy: a useful clinical term.
Bolognia JL, Cooper DL, Glusac EJ
J Am Acad Dermatol 2008 Sep;59(3):524-9. doi: 10.1016/j.jaad.2008.05.018. PMID: 18694683

Therapy

Capecitabine-induced palmo-plantar erythrodysesthesia (toxic erythema of chemotherapy).
Pugalia N, Singh R, Madke B, Rusia K, Jaiswal S
Dermatol Online J 2023 Feb 15;29(1) doi: 10.5070/D329160225. PMID: 37040922
Baboon syndrome and toxic erythema of chemotherapy: Fold (intertriginous) dermatoses.
Wolf R, Tüzün Y
Clin Dermatol 2015 Jul-Aug;33(4):462-5. Epub 2015 Apr 7 doi: 10.1016/j.clindermatol.2015.04.008. PMID: 26051062
Tec.
McCalmont TH
J Cutan Pathol 2013 Sep;40(9):785-7. doi: 10.1111/cup.12207. PMID: 23962116
Toxic erythema of chemotherapy.
Repass TS, Wetter DA, Camilleri MJ
Am J Hematol 2012 Sep;87(9):923. Epub 2011 Nov 10 doi: 10.1002/ajh.22200. PMID: 22072527
Toxic erythema of chemotherapy: a useful clinical term.
Bolognia JL, Cooper DL, Glusac EJ
J Am Acad Dermatol 2008 Sep;59(3):524-9. doi: 10.1016/j.jaad.2008.05.018. PMID: 18694683

Prognosis

Toxic Skin Reactions Should Be Differentiated from Allergic Reactions to Chemotherapeutic Drugs in Children: A Case Series and Review of the Literature.
Özhan AK, Demirhan A, Arikoglu T, Karahan F, Satıcı FEG, Tokmeci N, Gündoğan BD, Yalaki Aİ, Akbey V, Karabulut YY, Ünal S, Kuyucu S
Dermatitis 2024 May-Jun;35(3):275-287. Epub 2024 Jan 3 doi: 10.1089/derm.2023.0258. PMID: 38165639
Enfortumab Vedotin-Associated Toxic Epidermal Necrolysis-like Toxic Erythema of Chemotherapy.
Birmingham SW, Moon DJ, Kraus CN, Lee BA
Am J Dermatopathol 2022 Dec 1;44(12):933-935. Epub 2022 Jul 19 doi: 10.1097/DAD.0000000000002255. PMID: 35925560
Atypical features and systemic associations in extensive cases of Grover disease: A systematic review.
Gantz M, Butler D, Goldberg M, Ryu J, McCalmont T, Shinkai K
J Am Acad Dermatol 2017 Nov;77(5):952-957.e1. Epub 2017 Sep 14 doi: 10.1016/j.jaad.2017.06.041. PMID: 28918973
Baboon syndrome and toxic erythema of chemotherapy: Fold (intertriginous) dermatoses.
Wolf R, Tüzün Y
Clin Dermatol 2015 Jul-Aug;33(4):462-5. Epub 2015 Apr 7 doi: 10.1016/j.clindermatol.2015.04.008. PMID: 26051062
Intertriginous pattern of toxic erythema of chemotherapy.
Carvalho R, Macias V, Marques-Pinto G, Afonso A, Cardoso J
Cutan Ocul Toxicol 2011 Dec;30(4):309-11. Epub 2011 Apr 18 doi: 10.3109/15569527.2011.572572. PMID: 21501039

Clinical prediction guides

Cutaneous manifestations in pediatric oncology patients.
Özkur E, Sert C, Kıvanç Altunay İ, Yıldırırmak ZY, Genç DB, Vural S, Erdem Y
Pediatr Dermatol 2021 Jan;38(1):58-65. Epub 2020 Nov 12 doi: 10.1111/pde.14375. PMID: 33179835
Generalized benign cutaneous reaction to cytarabine.
Ruben BS, Yu WY, Liu F, Truong SV, Wang KC, Fox LP
J Am Acad Dermatol 2015 Nov;73(5):821-8. Epub 2015 Aug 29 doi: 10.1016/j.jaad.2015.07.010. PMID: 26321388
Enhanced skin toxicity associated with the combination of clofarabine plus cytarabine for the treatment of acute leukemia.
Zhang B, Bolognia J, Marks P, Podoltsev N
Cancer Chemother Pharmacol 2014 Aug;74(2):303-7. Epub 2014 Jun 8 doi: 10.1007/s00280-014-2504-y. PMID: 24908437
Demodex folliculitis mimicking acute graft-vs-host disease.
Cotliar J, Frankfurt O
JAMA Dermatol 2013 Dec;149(12):1407-9. doi: 10.1001/jamadermatol.2013.5891. PMID: 24132559
Toxic erythema of chemotherapy following i.v. BU plus fludarabine for allogeneic PBSC transplant.
Parker TL, Cooper DL, Seropian SE, Bolognia JL
Bone Marrow Transplant 2013 May;48(5):646-50. Epub 2012 Nov 19 doi: 10.1038/bmt.2012.218. PMID: 23165491

Recent systematic reviews

Atypical features and systemic associations in extensive cases of Grover disease: A systematic review.
Gantz M, Butler D, Goldberg M, Ryu J, McCalmont T, Shinkai K
J Am Acad Dermatol 2017 Nov;77(5):952-957.e1. Epub 2017 Sep 14 doi: 10.1016/j.jaad.2017.06.041. PMID: 28918973

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