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Non-Index Lesion

MedGen UID:
820014
•Concept ID:
C3827266
•
Finding

Definition

Any tumor lesion other than the largest tumor lesion targeted by therapy. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVNon-Index Lesion

Recent clinical studies

Etiology

Sensitivity of multiparametric MRI and targeted biopsy for detection of adverse pathologies (Cribriform gleason pattern 4 and intraductal carcinoma): Correlation of detected and missed prostate cancer foci with whole mount histopathology.
Cai Q, Costa DN, Metter CK, Goldberg K, Roehrborn CG, Cadeddu J, Pedrosa I, Meng X, Mostardeiro TR, Shah RB
Urol Oncol 2022 Oct;40(10):452.e1-452.e8. Epub 2022 Aug 23 doi: 10.1016/j.urolonc.2022.07.012. PMID: 36008255
Detection of Clinically Significant Index Prostate Cancer Using Micro-ultrasound: Correlation With Radical Prostatectomy.
Callejas MF, Klein EA, Truong M, Thomas L, McKenney JK, Ghai S
Urology 2022 Nov;169:150-155. Epub 2022 Jul 16 doi: 10.1016/j.urology.2022.07.002. PMID: 35843353
The role of perilesional and multiparametric resonance imaging-targeted biopsies to reduce the risk of upgrading at radical prostatectomy pathology: A retrospective monocentric study.
Diamand R, Hollans M, Lefebvre Y, Sirtaine N, Limani K, Hawaux E, Abou Zahr R, Mattlet A, Albisinni S, Roumeguère T, Peltier A
Urol Oncol 2022 May;40(5):192.e11-192.e17. Epub 2022 Feb 27 doi: 10.1016/j.urolonc.2022.01.011. PMID: 35236622
Possible Dose-Response Relationship in Palliative Radiotherapy for Non-bone Painful Lesions.
Saito T, Tomitaka E, Toya R, Oya N
Clin Oncol (R Coll Radiol) 2019 Jun;31(6):391-398. Epub 2019 Apr 5 doi: 10.1016/j.clon.2019.03.042. PMID: 30955989
Radiologists' preferences regarding content of prostate MRI reports: a survey of the Society of Abdominal Radiology.
Spilseth B, Margolis DJ, Ghai S, Patel NU, Rosenkrantz AB
Abdom Radiol (NY) 2018 Jul;43(7):1807-1812. doi: 10.1007/s00261-017-1393-z. PMID: 29128994

Diagnosis

Sensitivity of multiparametric MRI and targeted biopsy for detection of adverse pathologies (Cribriform gleason pattern 4 and intraductal carcinoma): Correlation of detected and missed prostate cancer foci with whole mount histopathology.
Cai Q, Costa DN, Metter CK, Goldberg K, Roehrborn CG, Cadeddu J, Pedrosa I, Meng X, Mostardeiro TR, Shah RB
Urol Oncol 2022 Oct;40(10):452.e1-452.e8. Epub 2022 Aug 23 doi: 10.1016/j.urolonc.2022.07.012. PMID: 36008255
Detection of Clinically Significant Index Prostate Cancer Using Micro-ultrasound: Correlation With Radical Prostatectomy.
Callejas MF, Klein EA, Truong M, Thomas L, McKenney JK, Ghai S
Urology 2022 Nov;169:150-155. Epub 2022 Jul 16 doi: 10.1016/j.urology.2022.07.002. PMID: 35843353
The role of perilesional and multiparametric resonance imaging-targeted biopsies to reduce the risk of upgrading at radical prostatectomy pathology: A retrospective monocentric study.
Diamand R, Hollans M, Lefebvre Y, Sirtaine N, Limani K, Hawaux E, Abou Zahr R, Mattlet A, Albisinni S, Roumeguère T, Peltier A
Urol Oncol 2022 May;40(5):192.e11-192.e17. Epub 2022 Feb 27 doi: 10.1016/j.urolonc.2022.01.011. PMID: 35236622
Possible Dose-Response Relationship in Palliative Radiotherapy for Non-bone Painful Lesions.
Saito T, Tomitaka E, Toya R, Oya N
Clin Oncol (R Coll Radiol) 2019 Jun;31(6):391-398. Epub 2019 Apr 5 doi: 10.1016/j.clon.2019.03.042. PMID: 30955989
Clinical findings and outcomes of MRI staging of breast cancer in a diverse population.
Raghavendra A, Wecsler J, Ji L, Sheth P, Ricker C, Church T, Sposto R, Lang J, Sener S, Larsen L, Tripathy D
Breast Cancer Res Treat 2019 Apr;174(2):315-324. Epub 2018 Dec 12 doi: 10.1007/s10549-018-05084-w. PMID: 30542816Free PMC Article

Therapy

The impact of drainage pathways on the detection of nodal metastases in prostate cancer: a phase II randomized comparison of intratumoral vs intraprostatic tracer injection for sentinel node detection.
Wit EMK, van Beurden F, Kleinjan GH, Grivas N, de Korne CM, Buckle T, Donswijk ML, Bekers EM, van Leeuwen FWB, van der Poel HG
Eur J Nucl Med Mol Imaging 2022 Apr;49(5):1743-1753. Epub 2021 Nov 8 doi: 10.1007/s00259-021-05580-0. PMID: 34748059
Quality-of-life after bile duct injury: intraoperative detection is crucial. A national case-control study.
Rystedt JM, Montgomery AK
HPB (Oxford) 2016 Dec;18(12):1010-1016. Epub 2016 Oct 20 doi: 10.1016/j.hpb.2016.09.003. PMID: 27773464Free PMC Article
Dedicated paclitaxel-eluting bifurcation stent BiOSS® (bifurcation optimisation stent system): 12-month results from a prospective registry of consecutive all-comers population.
Gil RJ, Vassilev D, Michalek A, Kern A, Formuszewicz R, Dobrzycki S, Wójcik J, Lesiak M, Kardaszewicz P, Lekston A
EuroIntervention 2012 Jul 20;8(3):316-24. doi: 10.4244/EIJV8I3A50. PMID: 22829507
Quantitative bone marrow lesion size in osteoarthritic knees correlates with cartilage damage and predicts longitudinal cartilage loss.
Driban JB, Lo GH, Lee JY, Ward RJ, Miller E, Pang J, Price LL, McAlindon TE
BMC Musculoskelet Disord 2011 Sep 30;12:217. doi: 10.1186/1471-2474-12-217. PMID: 21961433Free PMC Article

Prognosis

Sensitivity of multiparametric MRI and targeted biopsy for detection of adverse pathologies (Cribriform gleason pattern 4 and intraductal carcinoma): Correlation of detected and missed prostate cancer foci with whole mount histopathology.
Cai Q, Costa DN, Metter CK, Goldberg K, Roehrborn CG, Cadeddu J, Pedrosa I, Meng X, Mostardeiro TR, Shah RB
Urol Oncol 2022 Oct;40(10):452.e1-452.e8. Epub 2022 Aug 23 doi: 10.1016/j.urolonc.2022.07.012. PMID: 36008255
The role of perilesional and multiparametric resonance imaging-targeted biopsies to reduce the risk of upgrading at radical prostatectomy pathology: A retrospective monocentric study.
Diamand R, Hollans M, Lefebvre Y, Sirtaine N, Limani K, Hawaux E, Abou Zahr R, Mattlet A, Albisinni S, Roumeguère T, Peltier A
Urol Oncol 2022 May;40(5):192.e11-192.e17. Epub 2022 Feb 27 doi: 10.1016/j.urolonc.2022.01.011. PMID: 35236622
Possible Dose-Response Relationship in Palliative Radiotherapy for Non-bone Painful Lesions.
Saito T, Tomitaka E, Toya R, Oya N
Clin Oncol (R Coll Radiol) 2019 Jun;31(6):391-398. Epub 2019 Apr 5 doi: 10.1016/j.clon.2019.03.042. PMID: 30955989
Dedicated paclitaxel-eluting bifurcation stent BiOSS® (bifurcation optimisation stent system): 12-month results from a prospective registry of consecutive all-comers population.
Gil RJ, Vassilev D, Michalek A, Kern A, Formuszewicz R, Dobrzycki S, Wójcik J, Lesiak M, Kardaszewicz P, Lekston A
EuroIntervention 2012 Jul 20;8(3):316-24. doi: 10.4244/EIJV8I3A50. PMID: 22829507
Histological characteristics of the index lesion in whole-mount radical prostatectomy specimens: implications for focal therapy.
Karavitakis M, Winkler M, Abel P, Livni N, Beckley I, Ahmed HU
Prostate Cancer Prostatic Dis 2011 Mar;14(1):46-52. Epub 2010 May 25 doi: 10.1038/pcan.2010.16. PMID: 20498680

Clinical prediction guides

Sensitivity of multiparametric MRI and targeted biopsy for detection of adverse pathologies (Cribriform gleason pattern 4 and intraductal carcinoma): Correlation of detected and missed prostate cancer foci with whole mount histopathology.
Cai Q, Costa DN, Metter CK, Goldberg K, Roehrborn CG, Cadeddu J, Pedrosa I, Meng X, Mostardeiro TR, Shah RB
Urol Oncol 2022 Oct;40(10):452.e1-452.e8. Epub 2022 Aug 23 doi: 10.1016/j.urolonc.2022.07.012. PMID: 36008255
Detection of Clinically Significant Index Prostate Cancer Using Micro-ultrasound: Correlation With Radical Prostatectomy.
Callejas MF, Klein EA, Truong M, Thomas L, McKenney JK, Ghai S
Urology 2022 Nov;169:150-155. Epub 2022 Jul 16 doi: 10.1016/j.urology.2022.07.002. PMID: 35843353
The role of perilesional and multiparametric resonance imaging-targeted biopsies to reduce the risk of upgrading at radical prostatectomy pathology: A retrospective monocentric study.
Diamand R, Hollans M, Lefebvre Y, Sirtaine N, Limani K, Hawaux E, Abou Zahr R, Mattlet A, Albisinni S, Roumeguère T, Peltier A
Urol Oncol 2022 May;40(5):192.e11-192.e17. Epub 2022 Feb 27 doi: 10.1016/j.urolonc.2022.01.011. PMID: 35236622
Possible Dose-Response Relationship in Palliative Radiotherapy for Non-bone Painful Lesions.
Saito T, Tomitaka E, Toya R, Oya N
Clin Oncol (R Coll Radiol) 2019 Jun;31(6):391-398. Epub 2019 Apr 5 doi: 10.1016/j.clon.2019.03.042. PMID: 30955989
Clinical findings and outcomes of MRI staging of breast cancer in a diverse population.
Raghavendra A, Wecsler J, Ji L, Sheth P, Ricker C, Church T, Sposto R, Lang J, Sener S, Larsen L, Tripathy D
Breast Cancer Res Treat 2019 Apr;174(2):315-324. Epub 2018 Dec 12 doi: 10.1007/s10549-018-05084-w. PMID: 30542816Free PMC Article

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