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Spontaneous Preterm Birth

MedGen UID:
820709
•Concept ID:
C3827961
•
Finding

Definition

Preterm birth from 20 weeks to 36 weeks, 6 days of gestation associated with one of the following: classic preterm labor or preterm premature rupture of membranes. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVSpontaneous Preterm Birth

Professional guidelines

PubMed

Society for Maternal-Fetal Medicine Consult Series #71: Management of previable and periviable preterm prelabor rupture of membranes.
Society for Maternal-Fetal Medicine (SMFM), Battarbee AN, Osmundson SS, McCarthy AM, Louis JM; SMFM Publications Committee. Electronic address: pubs@smfm.org
Am J Obstet Gynecol 2024 Oct;231(4):B2-B15. Epub 2024 Jul 16 doi: 10.1016/j.ajog.2024.07.016. PMID: 39025459
Prediction and Prevention of Spontaneous Preterm Birth: ACOG Practice Bulletin, Number 234.
Hoffman MK
Obstet Gynecol 2021 Dec 1;138(6):945-946. doi: 10.1097/AOG.0000000000004612. PMID: 34794160Free PMC Article
Drugs for the Treatment and Prevention of Preterm Labor.
Patel SS, Ludmir J
Clin Perinatol 2019 Jun;46(2):159-172. doi: 10.1016/j.clp.2019.02.001. PMID: 31010553

Recent clinical studies

Etiology

Predicting Spontaneous Preterm Birth Using the Immunome.
Feyaerts D, Marić I, Arck PC, Prins JR, Gomez-Lopez N, Gaudillière B, Stelzer IA
Clin Perinatol 2024 Jun;51(2):441-459. Epub 2024 Apr 4 doi: 10.1016/j.clp.2024.02.013. PMID: 38705651
Cervical pessary versus vaginal progesterone in women with a singleton pregnancy, a short cervix, and no history of spontaneous preterm birth at less than 34 weeks' gestation: open label, multicentre, randomised, controlled trial.
van Dijk CE, van Gils AL, van Zijl MD, Koullali B, van der Weide MC, van den Akker ES, Hermsen BJ, van Baal WM, Visser H, van Drongelen J, Vollebregt KC, Muller M, van der Made FW, Gordijn SJ, de Mooij YM, Oudijk MA, de Boer MA, Mol BW, Kazemier BM, Pajkrt E; Quadruple P Research Group
BMJ 2024 Mar 12;384:e077033. doi: 10.1136/bmj-2023-077033. PMID: 38471724
Interventions to prevent spontaneous preterm birth in women with singleton pregnancy who are at high risk: systematic review and network meta-analysis.
Care A, Nevitt SJ, Medley N, Donegan S, Good L, Hampson L, Tudur Smith C, Alfirevic Z
BMJ 2022 Feb 15;376:e064547. doi: 10.1136/bmj-2021-064547. PMID: 35168930Free PMC Article
Vaginal progesterone is as effective as cervical cerclage to prevent preterm birth in women with a singleton gestation, previous spontaneous preterm birth, and a short cervix: updated indirect comparison meta-analysis.
Conde-Agudelo A, Romero R, Da Fonseca E, O'Brien JM, Cetingoz E, Creasy GW, Hassan SS, Erez O, Pacora P, Nicolaides KH
Am J Obstet Gynecol 2018 Jul;219(1):10-25. Epub 2018 Apr 7 doi: 10.1016/j.ajog.2018.03.028. PMID: 29630885Free PMC Article
Not transabdominal!
Khalifeh A, Berghella V
Am J Obstet Gynecol 2016 Dec;215(6):739-744.e1. doi: 10.1016/j.ajog.2016.07.019. PMID: 27889000

Diagnosis

Pregnancy complications and later life women's health.
McNestry C, Killeen SL, Crowley RK, McAuliffe FM
Acta Obstet Gynecol Scand 2023 May;102(5):523-531. Epub 2023 Feb 17 doi: 10.1111/aogs.14523. PMID: 36799269Free PMC Article
Does vaginal progesterone prevent recurrent preterm birth in women with a singleton gestation and a history of spontaneous preterm birth? Evidence from a systematic review and meta-analysis.
Conde-Agudelo A, Romero R
Am J Obstet Gynecol 2022 Sep;227(3):440-461.e2. Epub 2022 Apr 20 doi: 10.1016/j.ajog.2022.04.023. PMID: 35460628Free PMC Article
Crowdsourcing assessment of maternal blood multi-omics for predicting gestational age and preterm birth.
Tarca AL, Pataki BÁ, Romero R, Sirota M, Guan Y, Kutum R, Gomez-Lopez N, Done B, Bhatti G, Yu T, Andreoletti G, Chaiworapongsa T; DREAM Preterm Birth Prediction Challenge Consortium, Hassan SS, Hsu CD, Aghaeepour N, Stolovitzky G, Csabai I, Costello JC
Cell Rep Med 2021 Jun 15;2(6):100323. doi: 10.1016/j.xcrm.2021.100323. PMID: 34195686Free PMC Article
Predicting Spontaneous Preterm Birth.
Kennedy C, O’Dwyer V
Ir Med J 2019 Aug 1;112(7):964. PMID: 31553145
Cervical cerclage.
Suhag A, Berghella V
Clin Obstet Gynecol 2014 Sep;57(3):557-67. doi: 10.1097/GRF.0000000000000044. PMID: 24979354

Therapy

Vaginal progesterone for the prevention of recurrent spontaneous preterm birth.
Berghella V, Gulersen M, Roman A, Boelig RC
Am J Obstet Gynecol MFM 2023 Oct;5(10):101116. Epub 2023 Aug 3 doi: 10.1016/j.ajogmf.2023.101116. PMID: 37543143
Does vaginal progesterone prevent recurrent preterm birth in women with a singleton gestation and a history of spontaneous preterm birth? Evidence from a systematic review and meta-analysis.
Conde-Agudelo A, Romero R
Am J Obstet Gynecol 2022 Sep;227(3):440-461.e2. Epub 2022 Apr 20 doi: 10.1016/j.ajog.2022.04.023. PMID: 35460628Free PMC Article
Interventions to prevent spontaneous preterm birth in women with singleton pregnancy who are at high risk: systematic review and network meta-analysis.
Care A, Nevitt SJ, Medley N, Donegan S, Good L, Hampson L, Tudur Smith C, Alfirevic Z
BMJ 2022 Feb 15;376:e064547. doi: 10.1136/bmj-2021-064547. PMID: 35168930Free PMC Article
Progesterone and preterm birth.
Norman JE
Int J Gynaecol Obstet 2020 Jul;150(1):24-30. doi: 10.1002/ijgo.13187. PMID: 32524598Free PMC Article
Marijuana Use in Pregnancy and While Breastfeeding.
Metz TD, Borgelt LM
Obstet Gynecol 2018 Nov;132(5):1198-1210. doi: 10.1097/AOG.0000000000002878. PMID: 30234728Free PMC Article

Prognosis

Does vaginal progesterone prevent recurrent preterm birth in women with a singleton gestation and a history of spontaneous preterm birth? Evidence from a systematic review and meta-analysis.
Conde-Agudelo A, Romero R
Am J Obstet Gynecol 2022 Sep;227(3):440-461.e2. Epub 2022 Apr 20 doi: 10.1016/j.ajog.2022.04.023. PMID: 35460628Free PMC Article
Crowdsourcing assessment of maternal blood multi-omics for predicting gestational age and preterm birth.
Tarca AL, Pataki BÁ, Romero R, Sirota M, Guan Y, Kutum R, Gomez-Lopez N, Done B, Bhatti G, Yu T, Andreoletti G, Chaiworapongsa T; DREAM Preterm Birth Prediction Challenge Consortium, Hassan SS, Hsu CD, Aghaeepour N, Stolovitzky G, Csabai I, Costello JC
Cell Rep Med 2021 Jun 15;2(6):100323. doi: 10.1016/j.xcrm.2021.100323. PMID: 34195686Free PMC Article
Predicting Spontaneous Preterm Birth.
Kennedy C, O’Dwyer V
Ir Med J 2019 Aug 1;112(7):964. PMID: 31553145
Vaginal progesterone is as effective as cervical cerclage to prevent preterm birth in women with a singleton gestation, previous spontaneous preterm birth, and a short cervix: updated indirect comparison meta-analysis.
Conde-Agudelo A, Romero R, Da Fonseca E, O'Brien JM, Cetingoz E, Creasy GW, Hassan SS, Erez O, Pacora P, Nicolaides KH
Am J Obstet Gynecol 2018 Jul;219(1):10-25. Epub 2018 Apr 7 doi: 10.1016/j.ajog.2018.03.028. PMID: 29630885Free PMC Article
Epidemiology and causes of preterm birth.
Goldenberg RL, Culhane JF, Iams JD, Romero R
Lancet 2008 Jan 5;371(9606):75-84. doi: 10.1016/S0140-6736(08)60074-4. PMID: 18177778Free PMC Article

Clinical prediction guides

Predicting Spontaneous Preterm Birth Using the Immunome.
Feyaerts D, Marić I, Arck PC, Prins JR, Gomez-Lopez N, Gaudillière B, Stelzer IA
Clin Perinatol 2024 Jun;51(2):441-459. Epub 2024 Apr 4 doi: 10.1016/j.clp.2024.02.013. PMID: 38705651
Does vaginal progesterone prevent recurrent preterm birth in women with a singleton gestation and a history of spontaneous preterm birth? Evidence from a systematic review and meta-analysis.
Conde-Agudelo A, Romero R
Am J Obstet Gynecol 2022 Sep;227(3):440-461.e2. Epub 2022 Apr 20 doi: 10.1016/j.ajog.2022.04.023. PMID: 35460628Free PMC Article
Predicting Spontaneous Preterm Birth.
Kennedy C, O’Dwyer V
Ir Med J 2019 Aug 1;112(7):964. PMID: 31553145
Not transabdominal!
Khalifeh A, Berghella V
Am J Obstet Gynecol 2016 Dec;215(6):739-744.e1. doi: 10.1016/j.ajog.2016.07.019. PMID: 27889000
Prediction of preterm birth.
Borg F, Gravino G, Schembri-Wismayer P, Calleja-Agius J
Minerva Ginecol 2013 Jun;65(3):345-60. PMID: 23689178

Recent systematic reviews

Vaginal progesterone for preventing preterm birth and adverse perinatal outcomes in twin gestations: a systematic review and meta-analysis.
Conde-Agudelo A, Romero R, Rehal A, Brizot ML, Serra V, Da Fonseca E, Cetingoz E, Syngelaki A, Perales A, Hassan SS, Nicolaides KH
Am J Obstet Gynecol 2023 Dec;229(6):599-616.e3. Epub 2023 May 15 doi: 10.1016/j.ajog.2023.05.010. PMID: 37196896Free PMC Article
Does vaginal progesterone prevent recurrent preterm birth in women with a singleton gestation and a history of spontaneous preterm birth? Evidence from a systematic review and meta-analysis.
Conde-Agudelo A, Romero R
Am J Obstet Gynecol 2022 Sep;227(3):440-461.e2. Epub 2022 Apr 20 doi: 10.1016/j.ajog.2022.04.023. PMID: 35460628Free PMC Article
Interventions to prevent spontaneous preterm birth in women with singleton pregnancy who are at high risk: systematic review and network meta-analysis.
Care A, Nevitt SJ, Medley N, Donegan S, Good L, Hampson L, Tudur Smith C, Alfirevic Z
BMJ 2022 Feb 15;376:e064547. doi: 10.1136/bmj-2021-064547. PMID: 35168930Free PMC Article
Vaginal progesterone for preventing preterm birth and adverse perinatal outcomes in singleton gestations with a short cervix: a meta-analysis of individual patient data.
Romero R, Conde-Agudelo A, Da Fonseca E, O'Brien JM, Cetingoz E, Creasy GW, Hassan SS, Nicolaides KH
Am J Obstet Gynecol 2018 Feb;218(2):161-180. Epub 2017 Nov 17 doi: 10.1016/j.ajog.2017.11.576. PMID: 29157866Free PMC Article
Cervical length screening for prevention of preterm birth in singleton pregnancy with threatened preterm labor: systematic review and meta-analysis of randomized controlled trials using individual patient-level data.
Berghella V, Palacio M, Ness A, Alfirevic Z, Nicolaides KH, Saccone G
Ultrasound Obstet Gynecol 2017 Mar;49(3):322-329. Epub 2017 Feb 8 doi: 10.1002/uog.17388. PMID: 27997053

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