U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Near-Haploidy

MedGen UID:
821591
•Concept ID:
C3828843
•
Cell or Molecular Dysfunction
Synonym: Near-Haploid

Definition

A chromosomal abnormality in which there are less than thirty chromosomes in a cell. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVNear-Haploidy

Recent clinical studies

Etiology

Next-generation-sequencing-based risk stratification and identification of new genes involved in structural and sequence variations in near haploid lymphoblastic leukemia.
Chen C, Bartenhagen C, Gombert M, Okpanyi V, Binder V, Röttgers S, Bradtke J, Teigler-Schlegel A, Harbott J, Ginzel S, Thiele R, Fischer U, Dugas M, Hu J, Borkhardt A
Genes Chromosomes Cancer 2013 Jun;52(6):564-79. Epub 2013 Mar 18 doi: 10.1002/gcc.22054. PMID: 23508829
Hyperhaploid plasma cell myeloma.
Hoctor VT, Campbell LJ
Cancer Genet 2012 Jul-Aug;205(7-8):414-8. doi: 10.1016/j.cancergen.2012.05.004. PMID: 22868003
Disease-associated patterns of disomic chromosomes in hyperhaploid neoplasms.
Mandahl N, Johansson B, Mertens F, Mitelman F
Genes Chromosomes Cancer 2012 Jun;51(6):536-44. Epub 2012 Feb 15 doi: 10.1002/gcc.21947. PMID: 22334476
Acute lymphoblastic leukaemia.
Harrison CJ
Best Pract Res Clin Haematol 2001 Sep;14(3):593-607. doi: 10.1053/beha.2001.0156. PMID: 11640871
The genetics of childhood acute lymphoblastic leukaemia.
Harrison CJ
Baillieres Best Pract Res Clin Haematol 2000 Sep;13(3):427-39. doi: 10.1053/beha.2000.0086. PMID: 11030043

Diagnosis

Adult acute lymphoblastic leukemia with near haploidy, hyperdiploidy and Ph positive lines: a rare entity with poor prognosis.
Sunil SK, Prakash PN, Hariharan S, Vinod G, Preethi RT, Geetha N, Ankathil R
Leuk Lymphoma 2006 Mar;47(3):561-3. doi: 10.1080/10428190500361094. PMID: 16396782
Cytogenetics and molecular genetics of acute lymphoblastic leukemia.
Harrison CJ, Foroni L
Rev Clin Exp Hematol 2002 Jun;6(2):91-113; discussion 200-2. doi: 10.1046/j.1468-0734.2002.00069.x. PMID: 12196211
Acute lymphoblastic leukaemia.
Harrison CJ
Best Pract Res Clin Haematol 2001 Sep;14(3):593-607. doi: 10.1053/beha.2001.0156. PMID: 11640871
Near haploid childhood acute lymphoblastic leukemia masked by hyperdiploid line: detection by fluorescence in situ hybridization.
Stark B, Jeison M, Gobuzov R, Krug H, Glaser-Gabay L, Luria D, El-Hasid R, Harush MB, Avrahami G, Fisher S, Stein J, Zaizov R, Yaniv I
Cancer Genet Cytogenet 2001 Jul 15;128(2):108-13. doi: 10.1016/s0165-4608(01)00411-3. PMID: 11463448
The genetics of childhood acute lymphoblastic leukaemia.
Harrison CJ
Baillieres Best Pract Res Clin Haematol 2000 Sep;13(3):427-39. doi: 10.1053/beha.2000.0086. PMID: 11030043

Therapy

Adult acute lymphoblastic leukemia with near haploidy, hyperdiploidy and Ph positive lines: a rare entity with poor prognosis.
Sunil SK, Prakash PN, Hariharan S, Vinod G, Preethi RT, Geetha N, Ankathil R
Leuk Lymphoma 2006 Mar;47(3):561-3. doi: 10.1080/10428190500361094. PMID: 16396782
The role of bone marrow transplantation in first remission of paediatric all.
Chessells JM
Front Biosci 2001 Aug 1;6:G38-42. doi: 10.2741/a717. PMID: 11502486
Determinants of outcome after intensified therapy of childhood lymphoblastic leukaemia: results from Medical Research Council United Kingdom acute lymphoblastic leukaemia XI protocol.
Hann I, Vora A, Harrison G, Harrison C, Eden O, Hill F, Gibson B, Richards S; UK Medical Research Council's Working Party on Childhood Leukaemia
Br J Haematol 2001 Apr;113(1):103-14. doi: 10.1046/j.1365-2141.2001.02668.x. PMID: 11328289
Near-haploidy and subsequent polyploidization characterize the progression of peripheral chondrosarcoma.
Bovée JV, van Royen M, Bardoel AF, Rosenberg C, Cornelisse CJ, Cleton-Jansen AM, Hogendoorn PC
Am J Pathol 2000 Nov;157(5):1587-95. doi: 10.1016/S0002-9440(10)64796-7. PMID: 11073818Free PMC Article
Cytogenetics and prognosis in childhood lymphoblastic leukaemia: results of MRC UKALL X. Medical Research Council Working Party in Childhood Leukaemia.
Chessels JM, Swansbury GJ, Reeves B, Bailey CC, Richards SM
Br J Haematol 1997 Oct;99(1):93-100. doi: 10.1046/j.1365-2141.1997.3493163.x. PMID: 9359508

Prognosis

Next-generation-sequencing-based risk stratification and identification of new genes involved in structural and sequence variations in near haploid lymphoblastic leukemia.
Chen C, Bartenhagen C, Gombert M, Okpanyi V, Binder V, Röttgers S, Bradtke J, Teigler-Schlegel A, Harbott J, Ginzel S, Thiele R, Fischer U, Dugas M, Hu J, Borkhardt A
Genes Chromosomes Cancer 2013 Jun;52(6):564-79. Epub 2013 Mar 18 doi: 10.1002/gcc.22054. PMID: 23508829
Hyperhaploid plasma cell myeloma.
Hoctor VT, Campbell LJ
Cancer Genet 2012 Jul-Aug;205(7-8):414-8. doi: 10.1016/j.cancergen.2012.05.004. PMID: 22868003
Cytogenetics and molecular genetics of acute lymphoblastic leukemia.
Harrison CJ, Foroni L
Rev Clin Exp Hematol 2002 Jun;6(2):91-113; discussion 200-2. doi: 10.1046/j.1468-0734.2002.00069.x. PMID: 12196211
Acute lymphoblastic leukaemia.
Harrison CJ
Best Pract Res Clin Haematol 2001 Sep;14(3):593-607. doi: 10.1053/beha.2001.0156. PMID: 11640871
The genetics of childhood acute lymphoblastic leukaemia.
Harrison CJ
Baillieres Best Pract Res Clin Haematol 2000 Sep;13(3):427-39. doi: 10.1053/beha.2000.0086. PMID: 11030043

Clinical prediction guides

Genome-Wide Single-Nucleotide Polymorphism Array Analysis Improves Prognostication of Acute Lymphoblastic Leukemia/Lymphoma.
Wang Y, Miller S, Roulston D, Bixby D, Shao L
J Mol Diagn 2016 Jul;18(4):595-603. Epub 2016 May 6 doi: 10.1016/j.jmoldx.2016.03.004. PMID: 27161658
Next-generation-sequencing-based risk stratification and identification of new genes involved in structural and sequence variations in near haploid lymphoblastic leukemia.
Chen C, Bartenhagen C, Gombert M, Okpanyi V, Binder V, Röttgers S, Bradtke J, Teigler-Schlegel A, Harbott J, Ginzel S, Thiele R, Fischer U, Dugas M, Hu J, Borkhardt A
Genes Chromosomes Cancer 2013 Jun;52(6):564-79. Epub 2013 Mar 18 doi: 10.1002/gcc.22054. PMID: 23508829
Hyperhaploid plasma cell myeloma.
Hoctor VT, Campbell LJ
Cancer Genet 2012 Jul-Aug;205(7-8):414-8. doi: 10.1016/j.cancergen.2012.05.004. PMID: 22868003
Near haploid childhood acute lymphoblastic leukemia masked by hyperdiploid line: detection by fluorescence in situ hybridization.
Stark B, Jeison M, Gobuzov R, Krug H, Glaser-Gabay L, Luria D, El-Hasid R, Harush MB, Avrahami G, Fisher S, Stein J, Zaizov R, Yaniv I
Cancer Genet Cytogenet 2001 Jul 15;128(2):108-13. doi: 10.1016/s0165-4608(01)00411-3. PMID: 11463448
Near haploidy in breast cancer: a particular pathway of chromosome evolution.
Flagiello D, Gerbault-Seureau M, Padoy E, Dutrillaux B
Cancer Genet Cytogenet 1998 Apr 1;102(1):54-8. doi: 10.1016/s0165-4608(97)00297-5. PMID: 9530341

Supplemental Content

Table of contents

    Practice guidelines

    • Bookshelf
      See practice and clinical guidelines in NCBI Bookshelf. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.

    Related information

    • PMC Articles
      Related information in PubMed Central Links
    • PubMed
      Related literature resources in PubMed

    Recent activity

    Clear Turn Off Turn On

    Your browsing activity is empty.

    Activity recording is turned off.

    Turn recording back on

    See more...