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Mesenchymal glioblastoma

MedGen UID:
821870
Concept ID:
C3829122
Neoplastic Process
Synonyms: glioblastoma mesenchymal subtype; Mesenchymal Glioblastoma; mesenchymal glioblastoma
 
Monarch Initiative: MONDO:0000459

Definition

A molecular subtype of glioblastoma characterized by the presence of NF1 mutations. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVMesenchymal glioblastoma

Professional guidelines

PubMed

Vo VTA, Kim S, Hua TNM, Oh J, Jeong Y
Commun Biol 2022 Jun 16;5(1):593. doi: 10.1038/s42003-022-03538-y. PMID: 35710828Free PMC Article

Recent clinical studies

Etiology

Shoji T, Hayashi M, Sumi C, Kusunoki M, Uba T, Matsuo Y, Hirota K
Medicina (Kaunas) 2022 Nov 8;58(11) doi: 10.3390/medicina58111614. PMID: 36363571Free PMC Article
Bhawe K, Das JK, Yoo C, Felty Q, Gong Z, Deoraj A, Liuzzi JP, Ehtesham NZ, Hasnain SE, Singh VP, Mohapatra I, Komotar RJ, Roy D
J Cancer Res Clin Oncol 2022 Jul;148(7):1641-1682. Epub 2022 Apr 20 doi: 10.1007/s00432-022-03987-2. PMID: 35441887
Chen YH, Cimino PJ, Luo J, Dahiya S, Gutmann DH
Oncotarget 2016 Apr 26;7(17):23416-24. doi: 10.18632/oncotarget.8030. PMID: 26981778Free PMC Article
Herrlinger U, Jones DTW, Glas M, Hattingen E, Gramatzki D, Stuplich M, Felsberg J, Bähr O, Gielen GH, Simon M, Wiewrodt D, Schabet M, Hovestadt V, Capper D, Steinbach JP, von Deimling A, Lichter P, Pfister SM, Weller M, Reifenberger G
Acta Neuropathol 2016 Feb;131(2):309-319. Epub 2015 Oct 22 doi: 10.1007/s00401-015-1495-z. PMID: 26493382
Reifenberger G, Weber RG, Riehmer V, Kaulich K, Willscher E, Wirth H, Gietzelt J, Hentschel B, Westphal M, Simon M, Schackert G, Schramm J, Matschke J, Sabel MC, Gramatzki D, Felsberg J, Hartmann C, Steinbach JP, Schlegel U, Wick W, Radlwimmer B, Pietsch T, Tonn JC, von Deimling A, Binder H, Weller M, Loeffler M; German Glioma Network
Int J Cancer 2014 Oct 15;135(8):1822-31. Epub 2014 Mar 28 doi: 10.1002/ijc.28836. PMID: 24615357

Diagnosis

Su IC, Su YK, Setiawan SA, Yadav VK, Fong IH, Yeh CT, Lin CM, Liu HW
Int J Mol Sci 2023 Apr 22;24(9) doi: 10.3390/ijms24097706. PMID: 37175412Free PMC Article
Pieri V, Gallotti AL, Drago D, Cominelli M, Pagano I, Conti V, Valtorta S, Coliva A, Lago S, Michelatti D, Massimino L, Ungaro F, Perani L, Spinelli A, Castellano A, Falini A, Zippo A, Poliani PL, Moresco RM, Andolfo A, Galli R
Cancer Res 2023 Jan 18;83(2):195-218. doi: 10.1158/0008-5472.CAN-22-0677. PMID: 36409826
Keller M, Blom M, Conze LL, Guo M, Hägerstrand D, Aspenström P
Sci Rep 2022 Jun 14;12(1):9838. doi: 10.1038/s41598-022-14063-7. PMID: 35701472Free PMC Article
Wang Z, Zhang H, Xu S, Liu Z, Cheng Q
Signal Transduct Target Ther 2021 Mar 23;6(1):124. doi: 10.1038/s41392-021-00491-w. PMID: 33753720Free PMC Article
Wang Q, Cai J, Fang C, Yang C, Zhou J, Tan Y, Wang Y, Li Y, Meng X, Zhao K, Yi K, Zhang S, Zhang J, Jiang C, Zhang J, Kang C
Theranostics 2018;8(17):4733-4749. Epub 2018 Sep 9 doi: 10.7150/thno.26550. PMID: 30279734Free PMC Article

Therapy

Su IC, Su YK, Setiawan SA, Yadav VK, Fong IH, Yeh CT, Lin CM, Liu HW
Int J Mol Sci 2023 Apr 22;24(9) doi: 10.3390/ijms24097706. PMID: 37175412Free PMC Article
Yuan Y, Zhao Q, Zhao S, Zhang P, Zhao H, Li Z, Du Y, Tian X, Lu J
Cancer Med 2019 Jul;8(8):3811-3821. Epub 2019 May 29 doi: 10.1002/cam4.2312. PMID: 31140757Free PMC Article
Bell JB, Eckerdt FD, Alley K, Magnusson LP, Hussain H, Bi Y, Arslan AD, Clymer J, Alvarez AA, Goldman S, Cheng SY, Nakano I, Horbinski C, Davuluri RV, James CD, Platanias LC
Mol Cancer Res 2016 Oct;14(10):984-993. Epub 2016 Jun 30 doi: 10.1158/1541-7786.MCR-16-0172. PMID: 27364770Free PMC Article

Prognosis

Weidner L, Lorenz J, Quach S, Braun FK, Rothhammer-Hampl T, Ammer LM, Vollmann-Zwerenz A, Bartos LM, Dekorsy FJ, Holzgreve A, Kirchleitner SV, Thon N, Greve T, Ruf V, Herms J, Bader S, Milenkovic VM, von Baumgarten L, Menevse AN, Hussein A, Sax J, Wetzel CH, Rupprecht R, Proescholdt M, Schmidt NO, Beckhove P, Hau P, Tonn JC, Bartenstein P, Brendel M, Albert NL, Riemenschneider MJ
Acta Neuropathol Commun 2023 Sep 11;11(1):147. doi: 10.1186/s40478-023-01651-5. PMID: 37697350Free PMC Article
Shoji T, Hayashi M, Sumi C, Kusunoki M, Uba T, Matsuo Y, Hirota K
Medicina (Kaunas) 2022 Nov 8;58(11) doi: 10.3390/medicina58111614. PMID: 36363571Free PMC Article
Vo VTA, Kim S, Hua TNM, Oh J, Jeong Y
Commun Biol 2022 Jun 16;5(1):593. doi: 10.1038/s42003-022-03538-y. PMID: 35710828Free PMC Article
Keller M, Blom M, Conze LL, Guo M, Hägerstrand D, Aspenström P
Sci Rep 2022 Jun 14;12(1):9838. doi: 10.1038/s41598-022-14063-7. PMID: 35701472Free PMC Article
Wei J, Marisetty A, Schrand B, Gabrusiewicz K, Hashimoto Y, Ott M, Grami Z, Kong LY, Ling X, Caruso H, Zhou S, Wang YA, Fuller GN, Huse J, Gilboa E, Kang N, Huang X, Verhaak R, Li S, Heimberger AB
J Clin Invest 2019 Jan 2;129(1):137-149. Epub 2018 Nov 19 doi: 10.1172/JCI121266. PMID: 30307407Free PMC Article

Clinical prediction guides

Jain S, Rick JW, Joshi RS, Beniwal A, Spatz J, Gill S, Chang AC, Choudhary N, Nguyen AT, Sudhir S, Chalif EJ, Chen JS, Chandra A, Haddad AF, Wadhwa H, Shah SS, Choi S, Hayes JL, Wang L, Yagnik G, Costello JF, Diaz A, Heiland DH, Aghi MK
J Clin Invest 2023 Mar 1;133(5) doi: 10.1172/JCI147087. PMID: 36856115Free PMC Article
Pieri V, Gallotti AL, Drago D, Cominelli M, Pagano I, Conti V, Valtorta S, Coliva A, Lago S, Michelatti D, Massimino L, Ungaro F, Perani L, Spinelli A, Castellano A, Falini A, Zippo A, Poliani PL, Moresco RM, Andolfo A, Galli R
Cancer Res 2023 Jan 18;83(2):195-218. doi: 10.1158/0008-5472.CAN-22-0677. PMID: 36409826
Shoji T, Hayashi M, Sumi C, Kusunoki M, Uba T, Matsuo Y, Hirota K
Medicina (Kaunas) 2022 Nov 8;58(11) doi: 10.3390/medicina58111614. PMID: 36363571Free PMC Article
Bhawe K, Das JK, Yoo C, Felty Q, Gong Z, Deoraj A, Liuzzi JP, Ehtesham NZ, Hasnain SE, Singh VP, Mohapatra I, Komotar RJ, Roy D
J Cancer Res Clin Oncol 2022 Jul;148(7):1641-1682. Epub 2022 Apr 20 doi: 10.1007/s00432-022-03987-2. PMID: 35441887
Amemiya T, Hata N, Mizoguchi M, Yokokawa R, Kawamura Y, Hatae R, Sangatsuda Y, Kuga D, Fujioka Y, Takigawa K, Akagi Y, Yoshimoto K, Iihara K, Miura T
Mol Biol Rep 2021 Jan;48(1):395-403. Epub 2021 Jan 2 doi: 10.1007/s11033-020-06061-7. PMID: 33387197Free PMC Article

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