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Cystadenoma

MedGen UID:
8221
•Concept ID:
C0010633
•
Neoplastic Process
Synonym: Cystadenomas
SNOMED CT: Cystadenoma (47620003); Cystoma (47620003)
 
Monarch Initiative: MONDO:0002369

Definition

A benign or borderline cystic epithelial neoplasm arising from the glandular epithelium. The epithelial cells line the cystic spaces which contain serous or mucinous fluid. Representative examples include ovarian and pancreatic cystadenomas. [from NCI]

Professional guidelines

PubMed

Adnexal masses during pregnancy: diagnosis, treatment, and prognosis.
Cathcart AM, Nezhat FR, Emerson J, Pejovic T, Nezhat CH, Nezhat CR
Am J Obstet Gynecol 2023 Jun;228(6):601-612. Epub 2022 Nov 19 doi: 10.1016/j.ajog.2022.11.1291. PMID: 36410423
Updates in diagnosis and management of pancreatic cysts.
Lee LS
World J Gastroenterol 2021 Sep 14;27(34):5700-5714. doi: 10.3748/wjg.v27.i34.5700. PMID: 34629795Free PMC Article
Cystic and ductal tumors of the pancreas: diagnosis and management.
Scoazec JY, Vullierme MP, Barthet M, Gonzalez JM, Sauvanet A
J Visc Surg 2013 Apr;150(2):69-84. Epub 2013 Mar 19 doi: 10.1016/j.jviscsurg.2013.02.003. PMID: 23518192

Recent clinical studies

Etiology

Mucinous Ovarian Tumors.
Mills AM, Shanes ED
Surg Pathol Clin 2019 Jun;12(2):565-585. doi: 10.1016/j.path.2019.01.008. PMID: 31097115
Cystic Pancreatic Tumors.
Burk KS, Knipp D, Sahani DV
Magn Reson Imaging Clin N Am 2018 Aug;26(3):405-420. doi: 10.1016/j.mric.2018.03.006. PMID: 30376978
ACG Clinical Guideline: Diagnosis and Management of Pancreatic Cysts.
Elta GH, Enestvedt BK, Sauer BG, Lennon AM
Am J Gastroenterol 2018 Apr;113(4):464-479. Epub 2018 Feb 27 doi: 10.1038/ajg.2018.14. PMID: 29485131
Pancreatic Cystic Lesions: Diagnostic, Management and Indications for Operation. Part I.
Bauer F
Chirurgia (Bucur) 2017 Mar-Apr;112(2):97-109. doi: 10.21614/chirurgia.112.2.97. PMID: 28463669
Diagnosis and treatment of cystic pancreatic tumors.
Al-Haddad M, Schmidt MC, Sandrasegaran K, Dewitt J
Clin Gastroenterol Hepatol 2011 Aug;9(8):635-48. Epub 2011 Mar 11 doi: 10.1016/j.cgh.2011.03.005. PMID: 21397725

Diagnosis

Insights into the Pathogenesis of Pancreatic Cystic Neoplasms.
Sethi V, Giri B, Saluja A, Dudeja V
Dig Dis Sci 2017 Jul;62(7):1778-1786. Epub 2017 May 12 doi: 10.1007/s10620-017-4603-1. PMID: 28500587Free PMC Article
Pancreatic cytology: standardised terminology and nomenclature.
Perez-Machado MA
Cytopathology 2016 Jun;27(3):157-60. doi: 10.1111/cyt.12347. PMID: 27221751
Management of pancreatic cysts: a review of the current guidelines.
Hol L, Signoretti M, Poley JW
Minerva Gastroenterol Dietol 2015 Jun;61(2):87-99. Epub 2015 Feb 5 PMID: 25651835
Diagnosis and treatment of cystic pancreatic tumors.
Al-Haddad M, Schmidt MC, Sandrasegaran K, Dewitt J
Clin Gastroenterol Hepatol 2011 Aug;9(8):635-48. Epub 2011 Mar 11 doi: 10.1016/j.cgh.2011.03.005. PMID: 21397725
Management of pancreatic serous cystadenomas.
Wargo JA, Fernandez-del-Castillo C, Warshaw AL
Adv Surg 2009;43:23-34. doi: 10.1016/j.yasu.2009.03.001. PMID: 19845167

Therapy

Exosomal microRNAs as tumor markers in epithelial ovarian cancer.
Pan C, Stevic I, Müller V, Ni Q, Oliveira-Ferrer L, Pantel K, Schwarzenbach H
Mol Oncol 2018 Nov;12(11):1935-1948. Epub 2018 Oct 9 doi: 10.1002/1878-0261.12371. PMID: 30107086Free PMC Article
Clinical approach to incidental pancreatic cysts.
Chiang AL, Lee LS
World J Gastroenterol 2016 Jan 21;22(3):1236-45. doi: 10.3748/wjg.v22.i3.1236. PMID: 26811661Free PMC Article
Management and outcomes of pancreatic cystic lesions.
Brugge WR
Dig Liver Dis 2008 Nov;40(11):854-9. Epub 2008 May 27 doi: 10.1016/j.dld.2008.03.023. PMID: 18502709
Tracheobronchial gland tumors.
Gaissert HA, Mark EJ
Cancer Control 2006 Oct;13(4):286-94. doi: 10.1177/107327480601300406. PMID: 17075566
Laparoscopic appendectomy.
Agarwala N, Liu CY
J Am Assoc Gynecol Laparosc 2003 May;10(2):166-8. doi: 10.1016/s1074-3804(05)60292-7. PMID: 12732765

Prognosis

Mucinous Cystadenoma of the Urachus and Review of Current Classification of Urachal Mucinous Cystic Neoplasms.
Wang D, Sule N
Arch Pathol Lab Med 2019 Feb;143(2):258-263. Epub 2018 Nov 6 doi: 10.5858/arpa.2017-0319-RS. PMID: 30398914
Exosomal microRNAs as tumor markers in epithelial ovarian cancer.
Pan C, Stevic I, Müller V, Ni Q, Oliveira-Ferrer L, Pantel K, Schwarzenbach H
Mol Oncol 2018 Nov;12(11):1935-1948. Epub 2018 Oct 9 doi: 10.1002/1878-0261.12371. PMID: 30107086Free PMC Article
Papillary cystadenoma of the epididymis.
Odrzywolski KJ, Mukhopadhyay S
Arch Pathol Lab Med 2010 Apr;134(4):630-3. doi: 10.5858/134.4.630. PMID: 20367315
Multilocular cystadenoma and cystadenocarcinoma of the prostate.
Tuziak T, Spiess PE, Abrahams NA, Wrona A, Tu SM, Czerniak B
Urol Oncol 2007 Jan-Feb;25(1):19-25. doi: 10.1016/j.urolonc.2006.01.011. PMID: 17208134
Laparoscopic appendectomy.
Agarwala N, Liu CY
J Am Assoc Gynecol Laparosc 2003 May;10(2):166-8. doi: 10.1016/s1074-3804(05)60292-7. PMID: 12732765

Clinical prediction guides

Adnexal masses during pregnancy: diagnosis, treatment, and prognosis.
Cathcart AM, Nezhat FR, Emerson J, Pejovic T, Nezhat CH, Nezhat CR
Am J Obstet Gynecol 2023 Jun;228(6):601-612. Epub 2022 Nov 19 doi: 10.1016/j.ajog.2022.11.1291. PMID: 36410423
Molecular Diagnosis of Cystic Neoplasms of the Pancreas: a Review.
Chen JC, Beal EW, Pawlik TM, Cloyd J, Dillhoff ME
J Gastrointest Surg 2020 May;24(5):1201-1214. Epub 2020 Mar 3 doi: 10.1007/s11605-020-04537-2. PMID: 32128679
Morphologic, Immunophenotypic, and Molecular Features of Epithelial Ovarian Cancer.
Ramalingam P
Oncology (Williston Park) 2016 Feb;30(2):166-76. PMID: 26892153
A Consensus for Classification and Pathologic Reporting of Pseudomyxoma Peritonei and Associated Appendiceal Neoplasia: The Results of the Peritoneal Surface Oncology Group International (PSOGI) Modified Delphi Process.
Carr NJ, Cecil TD, Mohamed F, Sobin LH, Sugarbaker PH, González-Moreno S, Taflampas P, Chapman S, Moran BJ; Peritoneal Surface Oncology Group International
Am J Surg Pathol 2016 Jan;40(1):14-26. doi: 10.1097/PAS.0000000000000535. PMID: 26492181
Evaluation of hepatic cystic lesions.
Lantinga MA, Gevers TJ, Drenth JP
World J Gastroenterol 2013 Jun 21;19(23):3543-54. doi: 10.3748/wjg.v19.i23.3543. PMID: 23801855Free PMC Article

Recent systematic reviews

Diagnosis and Treatment of a Mixed Epithelial Stromal Tumor of the Seminal Vesicle: A Systematic Review.
Babar M, Matloubieh J, Macdonald E, Cheng J, Aboumohamed A, Watts K
Urology 2022 Sep;167:13-18. Epub 2022 Feb 26 doi: 10.1016/j.urology.2022.02.012. PMID: 35231450
Benign parotid mass and facial palsy: systematic review.
Stewart KE, Bannon R, Bannister M
Ann R Coll Surg Engl 2021 Jan;103(1):47-52. Epub 2020 Sep 24 doi: 10.1308/rcsann.2020.0194. PMID: 32969265Free PMC Article
Clinicopathological Features and Management of Appendiceal Mucoceles: A Systematic Review.
Morano WF, Gleeson EM, Sullivan SH, Padmanaban V, Mapow BL, Shewokis PA, Esquivel J, Bowne WB
Am Surg 2018 Feb 1;84(2):273-281. PMID: 29580358
Pancreatic lesions in von Hippel-Lindau disease? A systematic review and meta-synthesis of the literature.
Charlesworth M, Verbeke CS, Falk GA, Walsh M, Smith AM, Morris-Stiff G
J Gastrointest Surg 2012 Jul;16(7):1422-8. Epub 2012 Feb 28 doi: 10.1007/s11605-012-1847-0. PMID: 22370733
The management of simple hepatic cysts: sclerotherapy or laparoscopic fenestration.
Moorthy K, Mihssin N, Houghton PW
Ann R Coll Surg Engl 2001 Nov;83(6):409-14. PMID: 11777137Free PMC Article

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