U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

End Organ Damage from Diabetes

MedGen UID:
823063
•Concept ID:
C3830315
•
Finding

Definition

Irreparable damage to multiple organs/systems which is the result of chronic complications of diabetes. The affected organs/systems include the cardiovascular system, kidneys, eyes, nervous system, joints and feet. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVEnd Organ Damage from Diabetes

Professional guidelines

PubMed

EASL Clinical Practice Guidelines on haemochromatosis.
European Association for the Study of the Liver. Electronic address: easloffice@easloffice.eu; European Association for the Study of the Liver
J Hepatol 2022 Aug;77(2):479-502. Epub 2022 Jun 1 doi: 10.1016/j.jhep.2022.03.033. PMID: 35662478
Primary Aldosteronism: Practical Approach to Diagnosis and Management.
Byrd JB, Turcu AF, Auchus RJ
Circulation 2018 Aug 21;138(8):823-835. doi: 10.1161/CIRCULATIONAHA.118.033597. PMID: 30359120Free PMC Article
Diabetes Mellitus: Screening and Diagnosis.
Pippitt K, Li M, Gurgle HE
Am Fam Physician 2016 Jan 15;93(2):103-9. PMID: 26926406

Recent clinical studies

Etiology

Primary Aldosteronism: Practical Approach to Diagnosis and Management.
Byrd JB, Turcu AF, Auchus RJ
Circulation 2018 Aug 21;138(8):823-835. doi: 10.1161/CIRCULATIONAHA.118.033597. PMID: 30359120Free PMC Article
Arterial Hypertension.
Jordan J, Kurschat C, Reuter H
Dtsch Arztebl Int 2018 Aug 20;115(33-34):557-568. doi: 10.3238/arztebl.2018.0557. PMID: 30189978Free PMC Article
ASMBS pediatric metabolic and bariatric surgery guidelines, 2018.
Pratt JSA, Browne A, Browne NT, Bruzoni M, Cohen M, Desai A, Inge T, Linden BC, Mattar SG, Michalsky M, Podkameni D, Reichard KW, Stanford FC, Zeller MH, Zitsman J
Surg Obes Relat Dis 2018 Jul;14(7):882-901. Epub 2018 Mar 23 doi: 10.1016/j.soard.2018.03.019. PMID: 30077361Free PMC Article
Common neurodegenerative pathways in obesity, diabetes, and Alzheimer's disease.
Pugazhenthi S, Qin L, Reddy PH
Biochim Biophys Acta Mol Basis Dis 2017 May;1863(5):1037-1045. Epub 2016 May 6 doi: 10.1016/j.bbadis.2016.04.017. PMID: 27156888Free PMC Article
Diabetes Mellitus: Screening and Diagnosis.
Pippitt K, Li M, Gurgle HE
Am Fam Physician 2016 Jan 15;93(2):103-9. PMID: 26926406

Diagnosis

EASL Clinical Practice Guidelines on haemochromatosis.
European Association for the Study of the Liver. Electronic address: easloffice@easloffice.eu; European Association for the Study of the Liver
J Hepatol 2022 Aug;77(2):479-502. Epub 2022 Jun 1 doi: 10.1016/j.jhep.2022.03.033. PMID: 35662478
Proteinuria during pregnancy: definition, pathophysiology, methodology, and clinical significance.
Fishel Bartal M, Lindheimer MD, Sibai BM
Am J Obstet Gynecol 2022 Feb;226(2S):S819-S834. Epub 2020 Sep 1 doi: 10.1016/j.ajog.2020.08.108. PMID: 32882208
Primary Aldosteronism: Practical Approach to Diagnosis and Management.
Byrd JB, Turcu AF, Auchus RJ
Circulation 2018 Aug 21;138(8):823-835. doi: 10.1161/CIRCULATIONAHA.118.033597. PMID: 30359120Free PMC Article
Arterial Hypertension.
Jordan J, Kurschat C, Reuter H
Dtsch Arztebl Int 2018 Aug 20;115(33-34):557-568. doi: 10.3238/arztebl.2018.0557. PMID: 30189978Free PMC Article
Diabetes Mellitus: Screening and Diagnosis.
Pippitt K, Li M, Gurgle HE
Am Fam Physician 2016 Jan 15;93(2):103-9. PMID: 26926406

Therapy

Novel Pharmacological Approaches in the Treatment of Hypertension: A Focus on RNA-Based Therapeutics.
Addison ML, Ranasinghe P, Webb DJ
Hypertension 2023 Nov;80(11):2243-2254. Epub 2023 Sep 14 doi: 10.1161/HYPERTENSIONAHA.122.19430. PMID: 37706295
Research Advances on the Damage Mechanism of Skin Glycation and Related Inhibitors.
Zheng W, Li H, Go Y, Chan XHF, Huang Q, Wu J
Nutrients 2022 Nov 1;14(21) doi: 10.3390/nu14214588. PMID: 36364850Free PMC Article
Primary Aldosteronism: Practical Approach to Diagnosis and Management.
Byrd JB, Turcu AF, Auchus RJ
Circulation 2018 Aug 21;138(8):823-835. doi: 10.1161/CIRCULATIONAHA.118.033597. PMID: 30359120Free PMC Article
Arterial Hypertension.
Jordan J, Kurschat C, Reuter H
Dtsch Arztebl Int 2018 Aug 20;115(33-34):557-568. doi: 10.3238/arztebl.2018.0557. PMID: 30189978Free PMC Article
Diabetes Mellitus: Screening and Diagnosis.
Pippitt K, Li M, Gurgle HE
Am Fam Physician 2016 Jan 15;93(2):103-9. PMID: 26926406

Prognosis

Childhood Obesity: Insight into Kidney Involvement.
Carullo N, Zicarelli M, Michael A, Faga T, Battaglia Y, Pisani A, Perticone M, Costa D, Ielapi N, Coppolino G, Bolignano D, Serra R, Andreucci M
Int J Mol Sci 2023 Dec 12;24(24) doi: 10.3390/ijms242417400. PMID: 38139229Free PMC Article
Proteinuria during pregnancy: definition, pathophysiology, methodology, and clinical significance.
Fishel Bartal M, Lindheimer MD, Sibai BM
Am J Obstet Gynecol 2022 Feb;226(2S):S819-S834. Epub 2020 Sep 1 doi: 10.1016/j.ajog.2020.08.108. PMID: 32882208
ASMBS pediatric metabolic and bariatric surgery guidelines, 2018.
Pratt JSA, Browne A, Browne NT, Bruzoni M, Cohen M, Desai A, Inge T, Linden BC, Mattar SG, Michalsky M, Podkameni D, Reichard KW, Stanford FC, Zeller MH, Zitsman J
Surg Obes Relat Dis 2018 Jul;14(7):882-901. Epub 2018 Mar 23 doi: 10.1016/j.soard.2018.03.019. PMID: 30077361Free PMC Article
Cardiovascular events and target organ damage in primary aldosteronism compared with essential hypertension: a systematic review and meta-analysis.
Monticone S, D'Ascenzo F, Moretti C, Williams TA, Veglio F, Gaita F, Mulatero P
Lancet Diabetes Endocrinol 2018 Jan;6(1):41-50. Epub 2017 Nov 9 doi: 10.1016/S2213-8587(17)30319-4. PMID: 29129575
Hereditary hemochromatosis.
Crownover BK, Covey CJ
Am Fam Physician 2013 Feb 1;87(3):183-90. PMID: 23418762

Clinical prediction guides

Childhood Obesity: Insight into Kidney Involvement.
Carullo N, Zicarelli M, Michael A, Faga T, Battaglia Y, Pisani A, Perticone M, Costa D, Ielapi N, Coppolino G, Bolignano D, Serra R, Andreucci M
Int J Mol Sci 2023 Dec 12;24(24) doi: 10.3390/ijms242417400. PMID: 38139229Free PMC Article
ASMBS pediatric metabolic and bariatric surgery guidelines, 2018.
Pratt JSA, Browne A, Browne NT, Bruzoni M, Cohen M, Desai A, Inge T, Linden BC, Mattar SG, Michalsky M, Podkameni D, Reichard KW, Stanford FC, Zeller MH, Zitsman J
Surg Obes Relat Dis 2018 Jul;14(7):882-901. Epub 2018 Mar 23 doi: 10.1016/j.soard.2018.03.019. PMID: 30077361Free PMC Article
Cardiovascular events and target organ damage in primary aldosteronism compared with essential hypertension: a systematic review and meta-analysis.
Monticone S, D'Ascenzo F, Moretti C, Williams TA, Veglio F, Gaita F, Mulatero P
Lancet Diabetes Endocrinol 2018 Jan;6(1):41-50. Epub 2017 Nov 9 doi: 10.1016/S2213-8587(17)30319-4. PMID: 29129575
Common neurodegenerative pathways in obesity, diabetes, and Alzheimer's disease.
Pugazhenthi S, Qin L, Reddy PH
Biochim Biophys Acta Mol Basis Dis 2017 May;1863(5):1037-1045. Epub 2016 May 6 doi: 10.1016/j.bbadis.2016.04.017. PMID: 27156888Free PMC Article
Diabetic autonomic neuropathy.
Vinik AI, Erbas T
Handb Clin Neurol 2013;117:279-94. doi: 10.1016/B978-0-444-53491-0.00022-5. PMID: 24095132

Recent systematic reviews

Effects of advanced glycation end products (AGEs) on the differentiation potential of primary stem cells: a systematic review.
Xu K, Zhang L, Yu N, Ren Z, Wang T, Zhang Y, Zhao X, Yu T
Stem Cell Res Ther 2023 Apr 11;14(1):74. doi: 10.1186/s13287-023-03324-5. PMID: 37038234Free PMC Article
The mechanisms of saffron (Crocus sativus') on the inflammatory pathways of diabetes mellitus: A systematic review.
Nasimi Doost Azgomi R, Karimi A, Zarshenas MM, Moini Jazani A
Diabetes Metab Syndr 2022 Jan;16(1):102365. Epub 2021 Dec 14 doi: 10.1016/j.dsx.2021.102365. PMID: 34923214
Cardiovascular events and target organ damage in primary aldosteronism compared with essential hypertension: a systematic review and meta-analysis.
Monticone S, D'Ascenzo F, Moretti C, Williams TA, Veglio F, Gaita F, Mulatero P
Lancet Diabetes Endocrinol 2018 Jan;6(1):41-50. Epub 2017 Nov 9 doi: 10.1016/S2213-8587(17)30319-4. PMID: 29129575
A systematic review on the impact of diabetes mellitus on the ocular surface.
Shih KC, Lam KS, Tong L
Nutr Diabetes 2017 Mar 20;7(3):e251. doi: 10.1038/nutd.2017.4. PMID: 28319106Free PMC Article
Type 1 diabetes, diabetic nephropathy, and pregnancy: a systematic review and meta-study.
Piccoli GB, Clari R, Ghiotto S, Castelluccia N, Colombi N, Mauro G, Tavassoli E, Melluzza C, Cabiddu G, Gernone G, Mongilardi E, Ferraresi M, Rolfo A, Todros T
Rev Diabet Stud 2013 Spring;10(1):6-26. Epub 2013 May 10 doi: 10.1900/RDS.2013.10.6. PMID: 24172695Free PMC Article

Supplemental Content

Table of contents

    Practice guidelines

    • PubMed
      See practice and clinical guidelines in PubMed. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.

    Related information

    • PMC Articles
      Related information in PubMed Central Links
    • PubMed
      Related literature resources in PubMed

    Recent activity

    Clear Turn Off Turn On

    Your browsing activity is empty.

    Activity recording is turned off.

    Turn recording back on

    See more...