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End Organ Damage from Diabetes

MedGen UID:
823063
•Concept ID:
C3830315
•
Finding

Definition

Irreparable damage to multiple organs/systems which is the result of chronic complications of diabetes. The affected organs/systems include the cardiovascular system, kidneys, eyes, nervous system, joints and feet. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVEnd Organ Damage from Diabetes

Professional guidelines

PubMed

EASL Clinical Practice Guidelines on haemochromatosis.
European Association for the Study of the Liver. Electronic address: easloffice@easloffice.eu; European Association for the Study of the Liver
J Hepatol 2022 Aug;77(2):479-502. Epub 2022 Jun 1 doi: 10.1016/j.jhep.2022.03.033. PMID: 35662478
Primary Aldosteronism: Practical Approach to Diagnosis and Management.
Byrd JB, Turcu AF, Auchus RJ
Circulation 2018 Aug 21;138(8):823-835. doi: 10.1161/CIRCULATIONAHA.118.033597. PMID: 30359120Free PMC Article
Diabetes Mellitus: Screening and Diagnosis.
Pippitt K, Li M, Gurgle HE
Am Fam Physician 2016 Jan 15;93(2):103-9. PMID: 26926406

Recent clinical studies

Etiology

The Signaling of Cellular Senescence in Diabetic Nephropathy.
Xiong Y, Zhou L
Oxid Med Cell Longev 2019;2019:7495629. Epub 2019 Oct 3 doi: 10.1155/2019/7495629. PMID: 31687085Free PMC Article
Arterial Hypertension.
Jordan J, Kurschat C, Reuter H
Dtsch Arztebl Int 2018 Aug 20;115(33-34):557-568. doi: 10.3238/arztebl.2018.0557. PMID: 30189978Free PMC Article
ASMBS pediatric metabolic and bariatric surgery guidelines, 2018.
Pratt JSA, Browne A, Browne NT, Bruzoni M, Cohen M, Desai A, Inge T, Linden BC, Mattar SG, Michalsky M, Podkameni D, Reichard KW, Stanford FC, Zeller MH, Zitsman J
Surg Obes Relat Dis 2018 Jul;14(7):882-901. Epub 2018 Mar 23 doi: 10.1016/j.soard.2018.03.019. PMID: 30077361Free PMC Article
Common neurodegenerative pathways in obesity, diabetes, and Alzheimer's disease.
Pugazhenthi S, Qin L, Reddy PH
Biochim Biophys Acta Mol Basis Dis 2017 May;1863(5):1037-1045. Epub 2016 May 6 doi: 10.1016/j.bbadis.2016.04.017. PMID: 27156888Free PMC Article
Diabetes Mellitus: Screening and Diagnosis.
Pippitt K, Li M, Gurgle HE
Am Fam Physician 2016 Jan 15;93(2):103-9. PMID: 26926406

Diagnosis

EASL Clinical Practice Guidelines on haemochromatosis.
European Association for the Study of the Liver. Electronic address: easloffice@easloffice.eu; European Association for the Study of the Liver
J Hepatol 2022 Aug;77(2):479-502. Epub 2022 Jun 1 doi: 10.1016/j.jhep.2022.03.033. PMID: 35662478
Proteinuria during pregnancy: definition, pathophysiology, methodology, and clinical significance.
Fishel Bartal M, Lindheimer MD, Sibai BM
Am J Obstet Gynecol 2022 Feb;226(2S):S819-S834. Epub 2020 Sep 1 doi: 10.1016/j.ajog.2020.08.108. PMID: 32882208
Arterial Hypertension.
Jordan J, Kurschat C, Reuter H
Dtsch Arztebl Int 2018 Aug 20;115(33-34):557-568. doi: 10.3238/arztebl.2018.0557. PMID: 30189978Free PMC Article
ASMBS pediatric metabolic and bariatric surgery guidelines, 2018.
Pratt JSA, Browne A, Browne NT, Bruzoni M, Cohen M, Desai A, Inge T, Linden BC, Mattar SG, Michalsky M, Podkameni D, Reichard KW, Stanford FC, Zeller MH, Zitsman J
Surg Obes Relat Dis 2018 Jul;14(7):882-901. Epub 2018 Mar 23 doi: 10.1016/j.soard.2018.03.019. PMID: 30077361Free PMC Article
Diabetes Mellitus: Screening and Diagnosis.
Pippitt K, Li M, Gurgle HE
Am Fam Physician 2016 Jan 15;93(2):103-9. PMID: 26926406

Therapy

Hypertension in childhood obesity.
Wühl E
Acta Paediatr 2019 Jan;108(1):37-43. Epub 2018 Sep 19 doi: 10.1111/apa.14551. PMID: 30144170
Primary Aldosteronism: Practical Approach to Diagnosis and Management.
Byrd JB, Turcu AF, Auchus RJ
Circulation 2018 Aug 21;138(8):823-835. doi: 10.1161/CIRCULATIONAHA.118.033597. PMID: 30359120Free PMC Article
Arterial Hypertension.
Jordan J, Kurschat C, Reuter H
Dtsch Arztebl Int 2018 Aug 20;115(33-34):557-568. doi: 10.3238/arztebl.2018.0557. PMID: 30189978Free PMC Article
SGLT2 inhibitor dapagliflozin limits podocyte damage in proteinuric nondiabetic nephropathy.
Cassis P, Locatelli M, Cerullo D, Corna D, Buelli S, Zanchi C, Villa S, Morigi M, Remuzzi G, Benigni A, Zoja C
JCI Insight 2018 Aug 9;3(15) doi: 10.1172/jci.insight.98720. PMID: 30089717Free PMC Article
Diabetes Mellitus: Screening and Diagnosis.
Pippitt K, Li M, Gurgle HE
Am Fam Physician 2016 Jan 15;93(2):103-9. PMID: 26926406

Prognosis

Proteinuria during pregnancy: definition, pathophysiology, methodology, and clinical significance.
Fishel Bartal M, Lindheimer MD, Sibai BM
Am J Obstet Gynecol 2022 Feb;226(2S):S819-S834. Epub 2020 Sep 1 doi: 10.1016/j.ajog.2020.08.108. PMID: 32882208
Hypertension in childhood obesity.
Wühl E
Acta Paediatr 2019 Jan;108(1):37-43. Epub 2018 Sep 19 doi: 10.1111/apa.14551. PMID: 30144170
ASMBS pediatric metabolic and bariatric surgery guidelines, 2018.
Pratt JSA, Browne A, Browne NT, Bruzoni M, Cohen M, Desai A, Inge T, Linden BC, Mattar SG, Michalsky M, Podkameni D, Reichard KW, Stanford FC, Zeller MH, Zitsman J
Surg Obes Relat Dis 2018 Jul;14(7):882-901. Epub 2018 Mar 23 doi: 10.1016/j.soard.2018.03.019. PMID: 30077361Free PMC Article
Cardiovascular events and target organ damage in primary aldosteronism compared with essential hypertension: a systematic review and meta-analysis.
Monticone S, D'Ascenzo F, Moretti C, Williams TA, Veglio F, Gaita F, Mulatero P
Lancet Diabetes Endocrinol 2018 Jan;6(1):41-50. Epub 2017 Nov 9 doi: 10.1016/S2213-8587(17)30319-4. PMID: 29129575
Hereditary hemochromatosis.
Crownover BK, Covey CJ
Am Fam Physician 2013 Feb 1;87(3):183-90. PMID: 23418762

Clinical prediction guides

Classical and Nonclassical Manifestations of Primary Hyperparathyroidism.
El-Hajj Fuleihan G, Chakhtoura M, Cipriani C, Eastell R, Karonova T, Liu JM, Minisola S, Mithal A, Moreira CA, Peacock M, Schini M, Silva B, Walker M, El Zein O, Marcocci C
J Bone Miner Res 2022 Nov;37(11):2330-2350. Epub 2022 Oct 17 doi: 10.1002/jbmr.4679. PMID: 36245249
Oxidative Stress and Advanced Lipoxidation and Glycation End Products (ALEs and AGEs) in Aging and Age-Related Diseases.
Moldogazieva NT, Mokhosoev IM, Mel'nikova TI, Porozov YB, Terentiev AA
Oxid Med Cell Longev 2019;2019:3085756. Epub 2019 Aug 14 doi: 10.1155/2019/3085756. PMID: 31485289Free PMC Article
ASMBS pediatric metabolic and bariatric surgery guidelines, 2018.
Pratt JSA, Browne A, Browne NT, Bruzoni M, Cohen M, Desai A, Inge T, Linden BC, Mattar SG, Michalsky M, Podkameni D, Reichard KW, Stanford FC, Zeller MH, Zitsman J
Surg Obes Relat Dis 2018 Jul;14(7):882-901. Epub 2018 Mar 23 doi: 10.1016/j.soard.2018.03.019. PMID: 30077361Free PMC Article
Cardiovascular events and target organ damage in primary aldosteronism compared with essential hypertension: a systematic review and meta-analysis.
Monticone S, D'Ascenzo F, Moretti C, Williams TA, Veglio F, Gaita F, Mulatero P
Lancet Diabetes Endocrinol 2018 Jan;6(1):41-50. Epub 2017 Nov 9 doi: 10.1016/S2213-8587(17)30319-4. PMID: 29129575
Common neurodegenerative pathways in obesity, diabetes, and Alzheimer's disease.
Pugazhenthi S, Qin L, Reddy PH
Biochim Biophys Acta Mol Basis Dis 2017 May;1863(5):1037-1045. Epub 2016 May 6 doi: 10.1016/j.bbadis.2016.04.017. PMID: 27156888Free PMC Article

Recent systematic reviews

The mechanisms of saffron (Crocus sativus') on the inflammatory pathways of diabetes mellitus: A systematic review.
Nasimi Doost Azgomi R, Karimi A, Zarshenas MM, Moini Jazani A
Diabetes Metab Syndr 2022 Jan;16(1):102365. Epub 2021 Dec 14 doi: 10.1016/j.dsx.2021.102365. PMID: 34923214
Predictors of mortality in hospitalized COVID-19 patients: A systematic review and meta-analysis.
Tian W, Jiang W, Yao J, Nicholson CJ, Li RH, Sigurslid HH, Wooster L, Rotter JI, Guo X, Malhotra R
J Med Virol 2020 Oct;92(10):1875-1883. Epub 2020 Jul 11 doi: 10.1002/jmv.26050. PMID: 32441789Free PMC Article
Cardiovascular events and target organ damage in primary aldosteronism compared with essential hypertension: a systematic review and meta-analysis.
Monticone S, D'Ascenzo F, Moretti C, Williams TA, Veglio F, Gaita F, Mulatero P
Lancet Diabetes Endocrinol 2018 Jan;6(1):41-50. Epub 2017 Nov 9 doi: 10.1016/S2213-8587(17)30319-4. PMID: 29129575
A systematic review on the impact of diabetes mellitus on the ocular surface.
Shih KC, Lam KS, Tong L
Nutr Diabetes 2017 Mar 20;7(3):e251. doi: 10.1038/nutd.2017.4. PMID: 28319106Free PMC Article
Type 1 diabetes, diabetic nephropathy, and pregnancy: a systematic review and meta-study.
Piccoli GB, Clari R, Ghiotto S, Castelluccia N, Colombi N, Mauro G, Tavassoli E, Melluzza C, Cabiddu G, Gernone G, Mongilardi E, Ferraresi M, Rolfo A, Todros T
Rev Diabet Stud 2013 Spring;10(1):6-26. Epub 2013 May 10 doi: 10.1900/RDS.2013.10.6. PMID: 24172695Free PMC Article

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