U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Cytomegalovirus infection

MedGen UID:
8239
Concept ID:
C0010823
Disease or Syndrome
Synonym: CMV infection
SNOMED CT: CMV - Cytomegalovirus infection (28944009); Disease due to Cytomegalovirus (28944009); Cytomegalovirus disease (28944009); Cytomegalovirus infection (28944009); Cytomegalic inclusion disease (28944009)
 
Monarch Initiative: MONDO:0005132

Definition

A herpesvirus infection caused by Cytomegalovirus. Healthy individuals generally do not produce symptoms. However, the infection may be life-threatening in affected immunocompromised patients. The virus may cause retinitis, esophagitis, gastritis, and colitis. Morphologically, it is characterized by the presence of intranuclear inclusion bodies. [from NCI]

Professional guidelines

PubMed

Pesch MH, Saunders NA, Abdelnabi S
J Midwifery Womens Health 2021 May;66(3):397-402. Epub 2021 May 24 doi: 10.1111/jmwh.13228. PMID: 34031974
Ljungman P, de la Camara R, Robin C, Crocchiolo R, Einsele H, Hill JA, Hubacek P, Navarro D, Cordonnier C, Ward KN; 2017 European Conference on Infections in Leukaemia group
Lancet Infect Dis 2019 Aug;19(8):e260-e272. Epub 2019 May 29 doi: 10.1016/S1473-3099(19)30107-0. PMID: 31153807
Rawlinson WD, Boppana SB, Fowler KB, Kimberlin DW, Lazzarotto T, Alain S, Daly K, Doutré S, Gibson L, Giles ML, Greenlee J, Hamilton ST, Harrison GJ, Hui L, Jones CA, Palasanthiran P, Schleiss MR, Shand AW, van Zuylen WJ
Lancet Infect Dis 2017 Jun;17(6):e177-e188. Epub 2017 Mar 11 doi: 10.1016/S1473-3099(17)30143-3. PMID: 28291720

Recent clinical studies

Etiology

Chatzakis C, Shahar-Nissan K, Faure-Bardon V, Picone O, Hadar E, Amir J, Egloff C, Vivanti A, Sotiriadis A, Leruez-Ville M, Ville Y
Am J Obstet Gynecol 2024 Feb;230(2):109-117.e2. Epub 2023 Jul 18 doi: 10.1016/j.ajog.2023.07.022. PMID: 37473793
Pinninti S, Boppana S
Curr Opin Infect Dis 2022 Oct 1;35(5):436-441. Epub 2022 Aug 19 doi: 10.1097/QCO.0000000000000874. PMID: 35984001Free PMC Article
Hakki M, Aitken SL, Danziger-Isakov L, Michaels MG, Carpenter PA, Chemaly RF, Papanicolaou GA, Boeckh M, Marty FM
Transplant Cell Ther 2021 Sep;27(9):707-719. doi: 10.1016/j.jtct.2021.05.001. PMID: 34452721
Shahar-Nissan K, Pardo J, Peled O, Krause I, Bilavsky E, Wiznitzer A, Hadar E, Amir J
Lancet 2020 Sep 12;396(10253):779-785. doi: 10.1016/S0140-6736(20)31868-7. PMID: 32919517
Nicloux M, Peterman L, Parodi M, Magny JF
Arch Pediatr 2020 Apr;27(3):160-165. Epub 2020 Feb 29 doi: 10.1016/j.arcped.2020.01.006. PMID: 32127242

Diagnosis

Corazzi V, Hatzopoulos S, Bianchini C, Skarżyńska MB, Pelucchi S, Skarżyński PH, Ciorba A
Int J Pediatr Otorhinolaryngol 2022 Jan;152:111005. Epub 2021 Dec 7 doi: 10.1016/j.ijporl.2021.111005. PMID: 34894538
Hakki M, Aitken SL, Danziger-Isakov L, Michaels MG, Carpenter PA, Chemaly RF, Papanicolaou GA, Boeckh M, Marty FM
Transplant Cell Ther 2021 Sep;27(9):707-719. doi: 10.1016/j.jtct.2021.05.001. PMID: 34452721
Andronaco DW
J Obstet Gynecol Neonatal Nurs 2020 May;49(3):293-304. Epub 2020 Apr 4 doi: 10.1016/j.jogn.2020.02.005. PMID: 32259513
Nicloux M, Peterman L, Parodi M, Magny JF
Arch Pediatr 2020 Apr;27(3):160-165. Epub 2020 Feb 29 doi: 10.1016/j.arcped.2020.01.006. PMID: 32127242
Daniel Y, Gull I, Peyser MR, Lessing JB
Eur J Obstet Gynecol Reprod Biol 1995 Nov;63(1):7-16. doi: 10.1016/0301-2115(95)02198-g. PMID: 8674570

Therapy

Struble EB, Murata H, Komatsu T, Scott D
Int J Mol Sci 2021 Aug 13;22(16) doi: 10.3390/ijms22168728. PMID: 34445434Free PMC Article
Limaye AP, Babu TM, Boeckh M
Clin Microbiol Rev 2020 Dec 16;34(1) Epub 2020 Oct 28 doi: 10.1128/CMR.00043-19. PMID: 33115722Free PMC Article
Shahar-Nissan K, Pardo J, Peled O, Krause I, Bilavsky E, Wiznitzer A, Hadar E, Amir J
Lancet 2020 Sep 12;396(10253):779-785. doi: 10.1016/S0140-6736(20)31868-7. PMID: 32919517
Zammarchi L, Lazzarotto T, Andreoni M, Campolmi I, Pasquini L, Di Tommaso M, Simonazzi G, Tomasoni LR, Castelli F, Galli L, Borchi B, Clerici P, Bartoloni A, Tavio M, Trotta M
Clin Microbiol Infect 2020 Sep;26(9):1151-1154. Epub 2020 Apr 11 doi: 10.1016/j.cmi.2020.04.006. PMID: 32289479
Berger SP, Sommerer C, Witzke O, Tedesco H, Chadban S, Mulgaonkar S, Qazi Y, de Fijter JW, Oppenheimer F, Cruzado JM, Watarai Y, Massari P, Legendre C, Citterio F, Henry M, Srinivas TR, Vincenti F, Gutierrez MPH, Marti AM, Bernhardt P, Pascual J; TRANSFORM investigators
Am J Transplant 2019 Nov;19(11):3018-3034. Epub 2019 Jul 1 doi: 10.1111/ajt.15480. PMID: 31152476

Prognosis

Hughes BL, Clifton RG, Rouse DJ, Saade GR, Dinsmoor MJ, Reddy UM, Pass R, Allard D, Mallett G, Fette LM, Gyamfi-Bannerman C, Varner MW, Goodnight WH, Tita ATN, Costantine MM, Swamy GK, Gibbs RS, Chien EK, Chauhan SP, El-Sayed YY, Casey BM, Parry S, Simhan HN, Napolitano PG, Macones GA; Eunice Kennedy Shriver National Institute of Child Health and Human Development Maternal–Fetal Medicine Units Network
N Engl J Med 2021 Jul 29;385(5):436-444. doi: 10.1056/NEJMoa1913569. PMID: 34320288Free PMC Article
Goldsmith SR, Abid MB, Auletta JJ, Bashey A, Beitinjaneh A, Castillo P, Chemaly RF, Chen M, Ciurea S, Dandoy CE, Díaz MÁ, Fuchs E, Ganguly S, Kanakry CG, Kanakry JA, Kim S, Komanduri KV, Krem MM, Lazarus HM, Liu H, Ljungman P, Masiarz R, Mulroney C, Nathan S, Nishihori T, Page KM, Perales MA, Taplitz R, Romee R, Riches M
Blood 2021 Jun 10;137(23):3291-3305. doi: 10.1182/blood.2020009362. PMID: 33657221Free PMC Article
Keymeulen A, De Leenheer E, Goderis J, Dhooge I, Smets K; Flemish Society of Pediatrics’ Neonatology and Perinatal Epidemiology Working Group for cCMV infection
Acta Clin Belg 2021 Jun;76(3):169-176. Epub 2019 Oct 23 doi: 10.1080/17843286.2019.1683262. PMID: 31645217
Berger SP, Sommerer C, Witzke O, Tedesco H, Chadban S, Mulgaonkar S, Qazi Y, de Fijter JW, Oppenheimer F, Cruzado JM, Watarai Y, Massari P, Legendre C, Citterio F, Henry M, Srinivas TR, Vincenti F, Gutierrez MPH, Marti AM, Bernhardt P, Pascual J; TRANSFORM investigators
Am J Transplant 2019 Nov;19(11):3018-3034. Epub 2019 Jul 1 doi: 10.1111/ajt.15480. PMID: 31152476
Marsico C, Kimberlin DW
Ital J Pediatr 2017 Apr 17;43(1):38. doi: 10.1186/s13052-017-0358-8. PMID: 28416012Free PMC Article

Clinical prediction guides

Mastroianni A, Mauro MV
Clin Neuropathol 2022 May-Jun;41(3):135-144. doi: 10.5414/NP301409. PMID: 35142284
Linder KA, Kovacs C, Mullane KM, Wolfe C, Clark NM, La Hoz RM, Smith J, Kotton CN, Limaye AP, Malinis M, Hakki M, Mishkin A, Gonzalez AA, Prono MD, Ostrander D, Avery R, Kaul DR
Transpl Infect Dis 2021 Aug;23(4):e13687. Epub 2021 Jul 20 doi: 10.1111/tid.13687. PMID: 34251742
Lee SM, Mitchell R, Knight JA, Mazzulli T, Relton C, Khodayari Moez E, Hung RJ
Int J Epidemiol 2021 May 17;50(2):538-549. doi: 10.1093/ije/dyaa232. PMID: 33306803
Nicloux M, Peterman L, Parodi M, Magny JF
Arch Pediatr 2020 Apr;27(3):160-165. Epub 2020 Feb 29 doi: 10.1016/j.arcped.2020.01.006. PMID: 32127242
Leruez-Ville M, Foulon I, Pass R, Ville Y
Am J Obstet Gynecol 2020 Sep;223(3):330-349. Epub 2020 Feb 24 doi: 10.1016/j.ajog.2020.02.018. PMID: 32105678

Recent systematic reviews

D'Antonio F, Marinceu D, Prasad S, Khalil A
Ultrasound Obstet Gynecol 2023 Apr;61(4):436-444. doi: 10.1002/uog.26136. PMID: 36484439
Tang Y, Guo J, Li J, Zhou J, Mao X, Qiu T
Transpl Immunol 2022 Oct;74:101677. Epub 2022 Jul 25 doi: 10.1016/j.trim.2022.101677. PMID: 35901951
Périllaud-Dubois C, Belhadi D, Laouénan C, Mandelbrot L, Picone O, Vauloup-Fellous C
PLoS One 2021;16(12):e0261011. Epub 2021 Dec 3 doi: 10.1371/journal.pone.0261011. PMID: 34860861Free PMC Article
Du Y, Zhang G, Liu Z
Virol J 2018 Feb 6;15(1):31. doi: 10.1186/s12985-018-0937-3. PMID: 29409508Free PMC Article
Rafailidis PI, Mourtzoukou EG, Varbobitis IC, Falagas ME
Virol J 2008 Mar 27;5:47. doi: 10.1186/1743-422X-5-47. PMID: 18371229Free PMC Article

Supplemental Content

Table of contents

    Genetic Testing Registry

    Clinical resources

    Practice guidelines

    • PubMed
      See practice and clinical guidelines in PubMed. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.
    • Bookshelf
      See practice and clinical guidelines in NCBI Bookshelf. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.

    Consumer resources

    Recent activity

    Your browsing activity is empty.

    Activity recording is turned off.

    Turn recording back on

    See more...