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Chondrosarcoma, Grade 3

MedGen UID:
824654
Concept ID:
C3838808
Neoplastic Process
Synonyms: Chondrosarcoma, grade 3; Grade III Chondrosarcoma; High Grade Chondrosarcoma; High-Grade Chondrosarcoma
SNOMED CT: Chondrosarcoma, grade 3 (703700004)

Definition

A high-grade chondrosarcoma arising in the medulla of bone or within the cartilaginous cap of a pre-existing osteochondroma. It is characterized by the presence of increased cellularity and a greater degree of nuclear atypia, hyperchromasia, and mitotic activity as compared to grade 2 chondrosarcoma. [from NCI]

Term Hierarchy

Professional guidelines

PubMed

Kozawa E, Nishida Y, Kawai A, Hayakawa K, Setsu N, Kawashima H, Iwata S, Tsuchiya H, Tsukushi S, Takenaka S, Imanishi J, Baba I, Nagano A, Morii T, Shirai T, Shimizu K, Kawano H
Cancer Sci 2022 Jul;113(7):2397-2408. Epub 2022 May 18 doi: 10.1111/cas.15382. PMID: 35485870Free PMC Article

Recent clinical studies

Etiology

Tong Y, Cui Y, Jiang L, Pi Y, Gong Y, Zhao D
Front Public Health 2022;10:901680. Epub 2022 Jun 30 doi: 10.3389/fpubh.2022.901680. PMID: 35844853Free PMC Article
Beena D, Kattoor J, Mathews A, P Nair S, M V, T P, N G
Gulf J Oncolog 2021 Jan;1(35):54-58. PMID: 33716213
Tawbi HA, Burgess M, Bolejack V, Van Tine BA, Schuetze SM, Hu J, D'Angelo S, Attia S, Riedel RF, Priebat DA, Movva S, Davis LE, Okuno SH, Reed DR, Crowley J, Butterfield LH, Salazar R, Rodriguez-Canales J, Lazar AJ, Wistuba II, Baker LH, Maki RG, Reinke D, Patel S
Lancet Oncol 2017 Nov;18(11):1493-1501. Epub 2017 Oct 4 doi: 10.1016/S1470-2045(17)30624-1. PMID: 28988646Free PMC Article
Skubitz KM, D'Adamo DR
Mayo Clin Proc 2007 Nov;82(11):1409-32. doi: 10.4065/82.11.1409. PMID: 17976362
Mercuri M, Picci P, Campanacci L, Rulli E
Skeletal Radiol 1995 Aug;24(6):409-16. doi: 10.1007/BF00941235. PMID: 7481896

Diagnosis

Tong Y, Cui Y, Jiang L, Pi Y, Gong Y, Zhao D
Front Public Health 2022;10:901680. Epub 2022 Jun 30 doi: 10.3389/fpubh.2022.901680. PMID: 35844853Free PMC Article
Sesboue C, Le Loarer F
Semin Diagn Pathol 2021 May;38(3):183-194. Epub 2021 Jan 12 doi: 10.1053/j.semdp.2020.12.002. PMID: 33451916
Engel H, Herget GW, Füllgraf H, Sutter R, Benndorf M, Bamberg F, Jungmann PM
Rofo 2021 Mar;193(3):262-275. Epub 2020 Nov 5 doi: 10.1055/a-1288-1209. PMID: 33152784
Skubitz KM, D'Adamo DR
Mayo Clin Proc 2007 Nov;82(11):1409-32. doi: 10.4065/82.11.1409. PMID: 17976362
Mercuri M, Picci P, Campanacci L, Rulli E
Skeletal Radiol 1995 Aug;24(6):409-16. doi: 10.1007/BF00941235. PMID: 7481896

Therapy

Subbiah V, Chawla SP, Conley AP, Wilky BA, Tolcher A, Lakhani NJ, Berz D, Andrianov V, Crago W, Holcomb M, Hussain A, Veldstra C, Kalabus J, O'Neill B, Senne L, Rowell E, Heidt AB, Willis KM, Eckelman BP
Clin Cancer Res 2023 Aug 15;29(16):2988-3003. doi: 10.1158/1078-0432.CCR-23-0974. PMID: 37265425Free PMC Article
Tong Y, Cui Y, Jiang L, Pi Y, Gong Y, Zhao D
Front Public Health 2022;10:901680. Epub 2022 Jun 30 doi: 10.3389/fpubh.2022.901680. PMID: 35844853Free PMC Article
Zarei M, Hue JJ, Hajihassani O, Graor HJ, Katayama ES, Loftus AW, Bajor D, Rothermel LD, Vaziri-Gohar A, Winter JM
Cancer Treat Rev 2022 Feb;103:102334. Epub 2021 Dec 28 doi: 10.1016/j.ctrv.2021.102334. PMID: 34974243
Tawbi HA, Burgess M, Bolejack V, Van Tine BA, Schuetze SM, Hu J, D'Angelo S, Attia S, Riedel RF, Priebat DA, Movva S, Davis LE, Okuno SH, Reed DR, Crowley J, Butterfield LH, Salazar R, Rodriguez-Canales J, Lazar AJ, Wistuba II, Baker LH, Maki RG, Reinke D, Patel S
Lancet Oncol 2017 Nov;18(11):1493-1501. Epub 2017 Oct 4 doi: 10.1016/S1470-2045(17)30624-1. PMID: 28988646Free PMC Article
Skubitz KM, D'Adamo DR
Mayo Clin Proc 2007 Nov;82(11):1409-32. doi: 10.4065/82.11.1409. PMID: 17976362

Prognosis

Subbiah V, Chawla SP, Conley AP, Wilky BA, Tolcher A, Lakhani NJ, Berz D, Andrianov V, Crago W, Holcomb M, Hussain A, Veldstra C, Kalabus J, O'Neill B, Senne L, Rowell E, Heidt AB, Willis KM, Eckelman BP
Clin Cancer Res 2023 Aug 15;29(16):2988-3003. doi: 10.1158/1078-0432.CCR-23-0974. PMID: 37265425Free PMC Article
Tong Y, Cui Y, Jiang L, Pi Y, Gong Y, Zhao D
Front Public Health 2022;10:901680. Epub 2022 Jun 30 doi: 10.3389/fpubh.2022.901680. PMID: 35844853Free PMC Article
Tawbi HA, Burgess M, Bolejack V, Van Tine BA, Schuetze SM, Hu J, D'Angelo S, Attia S, Riedel RF, Priebat DA, Movva S, Davis LE, Okuno SH, Reed DR, Crowley J, Butterfield LH, Salazar R, Rodriguez-Canales J, Lazar AJ, Wistuba II, Baker LH, Maki RG, Reinke D, Patel S
Lancet Oncol 2017 Nov;18(11):1493-1501. Epub 2017 Oct 4 doi: 10.1016/S1470-2045(17)30624-1. PMID: 28988646Free PMC Article
Skubitz KM, D'Adamo DR
Mayo Clin Proc 2007 Nov;82(11):1409-32. doi: 10.4065/82.11.1409. PMID: 17976362
Mercuri M, Picci P, Campanacci L, Rulli E
Skeletal Radiol 1995 Aug;24(6):409-16. doi: 10.1007/BF00941235. PMID: 7481896

Clinical prediction guides

Zhou H, He S, Zhang D, Wang J, Yang X, Jiao J, Xu W, Yang J, Xiao J
Medicine (Baltimore) 2023 Oct 27;102(43):e34231. doi: 10.1097/MD.0000000000034231. PMID: 37904412Free PMC Article
Wang W, Zhen J
Orthop Surg 2023 Dec;15(12):3288-3299. Epub 2023 Oct 24 doi: 10.1111/os.13916. PMID: 37875420Free PMC Article
Tong Y, Cui Y, Jiang L, Pi Y, Gong Y, Zhao D
Front Public Health 2022;10:901680. Epub 2022 Jun 30 doi: 10.3389/fpubh.2022.901680. PMID: 35844853Free PMC Article
Shemesh SS, Pretell-Mazzini J, Quartin PAJ, Rutenberg TF, Conway SA
Arch Orthop Trauma Surg 2019 Dec;139(12):1659-1666. Epub 2019 Apr 24 doi: 10.1007/s00402-019-03184-w. PMID: 31020410
Choi J, Dharmarajan H, Victores A, Wenaas A, Ongkasuwan J
J Voice 2018 Jul;32(4):484-487. Epub 2017 Aug 16 doi: 10.1016/j.jvoice.2017.07.014. PMID: 28822621

Recent systematic reviews

Tsukamoto S, Mavrogenis AF, Nitta Y, Righi A, Masunaga T, Honoki K, Fujii H, Kido A, Tanaka Y, Tanaka Y, Errani C
Curr Oncol 2024 Jan 19;31(1):566-578. doi: 10.3390/curroncol31010040. PMID: 38275833Free PMC Article
Vuong HG, Ngo TNM, Dunn IF
Cancer Med 2021 Jul;10(13):4415-4423. Epub 2021 Jun 3 doi: 10.1002/cam4.4019. PMID: 34085407Free PMC Article
Lu VM, O'Connor KP, Mahajan A, Carlson ML, Van Gompel JJ
J Neurooncol 2020 May;147(3):503-513. Epub 2020 Mar 23 doi: 10.1007/s11060-020-03464-1. PMID: 32206977
Chin OY, Dubal PM, Sheikh AB, Unsal AA, Park RC, Baredes S, Eloy JA
Laryngoscope 2017 Feb;127(2):430-439. Epub 2016 Jun 12 doi: 10.1002/lary.26068. PMID: 27291822
Yamazaki T, McLoughlin GS, Patel S, Rhines LD, Fourney DR
Spine (Phila Pa 1976) 2009 Oct 15;34(22 Suppl):S31-8. doi: 10.1097/BRS.0b013e3181b8b796. PMID: 19829275

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