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Chondrosarcoma, Grade 3

MedGen UID:
824654
Concept ID:
C3838808
Neoplastic Process
Synonyms: Chondrosarcoma, grade 3; Grade III Chondrosarcoma; High Grade Chondrosarcoma; High-Grade Chondrosarcoma
SNOMED CT: Chondrosarcoma, grade 3 (703700004)

Definition

A high-grade chondrosarcoma arising in the medulla of bone or within the cartilaginous cap of a pre-existing osteochondroma. It is characterized by the presence of increased cellularity and a greater degree of nuclear atypia, hyperchromasia, and mitotic activity as compared to grade 2 chondrosarcoma. [from NCI]

Term Hierarchy

Professional guidelines

PubMed

Kozawa E, Nishida Y, Kawai A, Hayakawa K, Setsu N, Kawashima H, Iwata S, Tsuchiya H, Tsukushi S, Takenaka S, Imanishi J, Baba I, Nagano A, Morii T, Shirai T, Shimizu K, Kawano H
Cancer Sci 2022 Jul;113(7):2397-2408. Epub 2022 May 18 doi: 10.1111/cas.15382. PMID: 35485870Free PMC Article

Recent clinical studies

Etiology

Kozawa E, Nishida Y, Kawai A, Hayakawa K, Setsu N, Kawashima H, Iwata S, Tsuchiya H, Tsukushi S, Takenaka S, Imanishi J, Baba I, Nagano A, Morii T, Shirai T, Shimizu K, Kawano H
Cancer Sci 2022 Jul;113(7):2397-2408. Epub 2022 May 18 doi: 10.1111/cas.15382. PMID: 35485870Free PMC Article
Kask G, Laitinen MK, Stevenson J, Evans S, Jeys LM, Parry MC
Bone Joint J 2021 Mar;103-B(3):562-568. doi: 10.1302/0301-620X.103B3.BJJ-2020-1337.R1. PMID: 33641425
Duffaud F, Mir O, Boudou-Rouquette P, Piperno-Neumann S, Penel N, Bompas E, Delcambre C, Kalbacher E, Italiano A, Collard O, Chevreau C, Saada E, Isambert N, Delaye J, Schiffler C, Bouvier C, Vidal V, Chabaud S, Blay JY; French Sarcoma Group
Lancet Oncol 2019 Jan;20(1):120-133. Epub 2018 Nov 23 doi: 10.1016/S1470-2045(18)30742-3. PMID: 30477937
Tawbi HA, Burgess M, Bolejack V, Van Tine BA, Schuetze SM, Hu J, D'Angelo S, Attia S, Riedel RF, Priebat DA, Movva S, Davis LE, Okuno SH, Reed DR, Crowley J, Butterfield LH, Salazar R, Rodriguez-Canales J, Lazar AJ, Wistuba II, Baker LH, Maki RG, Reinke D, Patel S
Lancet Oncol 2017 Nov;18(11):1493-1501. Epub 2017 Oct 4 doi: 10.1016/S1470-2045(17)30624-1. PMID: 28988646Free PMC Article
Skubitz KM, D'Adamo DR
Mayo Clin Proc 2007 Nov;82(11):1409-32. doi: 10.4065/82.11.1409. PMID: 17976362

Diagnosis

Sesboue C, Le Loarer F
Semin Diagn Pathol 2021 May;38(3):183-194. Epub 2021 Jan 12 doi: 10.1053/j.semdp.2020.12.002. PMID: 33451916
Engel H, Herget GW, Füllgraf H, Sutter R, Benndorf M, Bamberg F, Jungmann PM
Rofo 2021 Mar;193(3):262-275. Epub 2020 Nov 5 doi: 10.1055/a-1288-1209. PMID: 33152784
Mavrogenis AF, Gambarotti M, Angelini A, Palmerini E, Staals EL, Ruggieri P, Papagelopoulos PJ
Orthopedics 2012 Mar 7;35(3):e379-90. doi: 10.3928/01477447-20120222-30. PMID: 22385450
Skubitz KM, D'Adamo DR
Mayo Clin Proc 2007 Nov;82(11):1409-32. doi: 10.4065/82.11.1409. PMID: 17976362
Mercuri M, Picci P, Campanacci L, Rulli E
Skeletal Radiol 1995 Aug;24(6):409-16. doi: 10.1007/BF00941235. PMID: 7481896

Therapy

Tap WD, Villalobos VM, Cote GM, Burris H, Janku F, Mir O, Beeram M, Wagner AJ, Jiang L, Wu B, Choe S, Yen K, Gliser C, Fan B, Agresta S, Pandya SS, Trent JC
J Clin Oncol 2020 May 20;38(15):1693-1701. Epub 2020 Mar 24 doi: 10.1200/JCO.19.02492. PMID: 32208957Free PMC Article
Duffaud F, Mir O, Boudou-Rouquette P, Piperno-Neumann S, Penel N, Bompas E, Delcambre C, Kalbacher E, Italiano A, Collard O, Chevreau C, Saada E, Isambert N, Delaye J, Schiffler C, Bouvier C, Vidal V, Chabaud S, Blay JY; French Sarcoma Group
Lancet Oncol 2019 Jan;20(1):120-133. Epub 2018 Nov 23 doi: 10.1016/S1470-2045(18)30742-3. PMID: 30477937
Mery B, Espenel S, Guy JB, Rancoule C, Vallard A, Aloy MT, Rodriguez-Lafrasse C, Magné N
Crit Rev Oncol Hematol 2018 Jun;126:32-36. Epub 2018 Mar 22 doi: 10.1016/j.critrevonc.2018.03.009. PMID: 29759564
Tawbi HA, Burgess M, Bolejack V, Van Tine BA, Schuetze SM, Hu J, D'Angelo S, Attia S, Riedel RF, Priebat DA, Movva S, Davis LE, Okuno SH, Reed DR, Crowley J, Butterfield LH, Salazar R, Rodriguez-Canales J, Lazar AJ, Wistuba II, Baker LH, Maki RG, Reinke D, Patel S
Lancet Oncol 2017 Nov;18(11):1493-1501. Epub 2017 Oct 4 doi: 10.1016/S1470-2045(17)30624-1. PMID: 28988646Free PMC Article
Skubitz KM, D'Adamo DR
Mayo Clin Proc 2007 Nov;82(11):1409-32. doi: 10.4065/82.11.1409. PMID: 17976362

Prognosis

Kask G, Laitinen MK, Stevenson J, Evans S, Jeys LM, Parry MC
Bone Joint J 2021 Mar;103-B(3):562-568. doi: 10.1302/0301-620X.103B3.BJJ-2020-1337.R1. PMID: 33641425
Duffaud F, Mir O, Boudou-Rouquette P, Piperno-Neumann S, Penel N, Bompas E, Delcambre C, Kalbacher E, Italiano A, Collard O, Chevreau C, Saada E, Isambert N, Delaye J, Schiffler C, Bouvier C, Vidal V, Chabaud S, Blay JY; French Sarcoma Group
Lancet Oncol 2019 Jan;20(1):120-133. Epub 2018 Nov 23 doi: 10.1016/S1470-2045(18)30742-3. PMID: 30477937
Tawbi HA, Burgess M, Bolejack V, Van Tine BA, Schuetze SM, Hu J, D'Angelo S, Attia S, Riedel RF, Priebat DA, Movva S, Davis LE, Okuno SH, Reed DR, Crowley J, Butterfield LH, Salazar R, Rodriguez-Canales J, Lazar AJ, Wistuba II, Baker LH, Maki RG, Reinke D, Patel S
Lancet Oncol 2017 Nov;18(11):1493-1501. Epub 2017 Oct 4 doi: 10.1016/S1470-2045(17)30624-1. PMID: 28988646Free PMC Article
Skubitz KM, D'Adamo DR
Mayo Clin Proc 2007 Nov;82(11):1409-32. doi: 10.4065/82.11.1409. PMID: 17976362
DiFrancesco LM, Davanzo Castillo CA, Temple WJ
Arch Pathol Lab Med 2006 Dec;130(12):1871-4. doi: 10.5858/2006-130-1871-EC. PMID: 17149966

Clinical prediction guides

Baba A, Kurokawa R, Kurokawa M, Ota Y, Lobo R, Srinivasan A
J Neuroimaging 2022 Mar;32(2):213-222. Epub 2022 Jan 12 doi: 10.1111/jon.12963. PMID: 35019171
Tilden W, Andrei V, O'Donnell P, Saifuddin A
Skeletal Radiol 2022 Jun;51(6):1189-1199. Epub 2021 Oct 29 doi: 10.1007/s00256-021-03947-w. PMID: 34714386
Talati VM, Urban MJ, Patel TR, Wojcik C, Tajudeen BA, Stenson K, Bhayani MK, Al-Khudari S, Husain IA
Otolaryngol Head Neck Surg 2022 Jan;166(1):101-108. Epub 2021 Apr 13 doi: 10.1177/01945998211004578. PMID: 33848444
Kask G, Laitinen MK, Stevenson J, Evans S, Jeys LM, Parry MC
Bone Joint J 2021 Mar;103-B(3):562-568. doi: 10.1302/0301-620X.103B3.BJJ-2020-1337.R1. PMID: 33641425
Chen X, Yu LJ, Peng HM, Jiang C, Ye CH, Zhu SB, Qian WW
Eur J Surg Oncol 2017 Sep;43(9):1718-1726. Epub 2017 Jun 14 doi: 10.1016/j.ejso.2017.05.022. PMID: 28666625

Recent systematic reviews

Dong M, Liu R, Zhang Q, Luo H, Wang D, Wang Y, Chen J, Ou Y, Wang X
Radiat Oncol 2022 Oct 25;17(1):172. doi: 10.1186/s13014-022-02089-0. PMID: 36284346Free PMC Article
Baba A, Kurokawa R, Kurokawa M, Ota Y, Lobo R, Srinivasan A
J Neuroimaging 2022 Mar;32(2):213-222. Epub 2022 Jan 12 doi: 10.1111/jon.12963. PMID: 35019171
Shemesh SS, Acevedo-Nieves JD, Pretell-Mazzini J
Musculoskelet Surg 2018 Aug;102(2):95-109. Epub 2017 Oct 6 doi: 10.1007/s12306-017-0507-7. PMID: 28986742
Chen X, Yu LJ, Peng HM, Jiang C, Ye CH, Zhu SB, Qian WW
Eur J Surg Oncol 2017 Sep;43(9):1718-1726. Epub 2017 Jun 14 doi: 10.1016/j.ejso.2017.05.022. PMID: 28666625
Chin OY, Dubal PM, Sheikh AB, Unsal AA, Park RC, Baredes S, Eloy JA
Laryngoscope 2017 Feb;127(2):430-439. Epub 2016 Jun 12 doi: 10.1002/lary.26068. PMID: 27291822

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