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Chondrosarcoma, Grade 2

MedGen UID:
824797
Concept ID:
C3838951
Neoplastic Process
Synonyms: Chondrosarcoma, grade 2; Grade II Chondrosarcoma; Intermediate Grade Chondrosarcoma; Intermediate-Grade Chondrosarcoma
SNOMED CT: Chondrosarcoma, grade 2 (703699000)

Definition

An intermediate-grade chondrosarcoma arising in the medulla of bone or within the cartilaginous cap of a pre-existing osteochondroma. It is characterized by the presence of increased cellularity and a greater degree of nuclear atypia and hyperchromasia as compared to grade 1 chondrosarcoma. Mitotic activity is present. [from NCI]

Term Hierarchy

Professional guidelines

PubMed

Deloin X, Dumaine V, Biau D, Karoubi M, Babinet A, Tomeno B, Anract P
Orthop Traumatol Surg Res 2009 Oct;95(6):393-401. Epub 2009 Oct 3 doi: 10.1016/j.otsr.2009.05.004. PMID: 19801212

Recent clinical studies

Etiology

Kask G, Laitinen MK, Stevenson J, Evans S, Jeys LM, Parry MC
Bone Joint J 2021 Mar;103-B(3):562-568. doi: 10.1302/0301-620X.103B3.BJJ-2020-1337.R1. PMID: 33641425
Duffaud F, Mir O, Boudou-Rouquette P, Piperno-Neumann S, Penel N, Bompas E, Delcambre C, Kalbacher E, Italiano A, Collard O, Chevreau C, Saada E, Isambert N, Delaye J, Schiffler C, Bouvier C, Vidal V, Chabaud S, Blay JY; French Sarcoma Group
Lancet Oncol 2019 Jan;20(1):120-133. Epub 2018 Nov 23 doi: 10.1016/S1470-2045(18)30742-3. PMID: 30477937
Chow WA
F1000Res 2018;7 Epub 2018 Nov 20 doi: 10.12688/f1000research.15953.1. PMID: 30519452Free PMC Article
Tawbi HA, Burgess M, Bolejack V, Van Tine BA, Schuetze SM, Hu J, D'Angelo S, Attia S, Riedel RF, Priebat DA, Movva S, Davis LE, Okuno SH, Reed DR, Crowley J, Butterfield LH, Salazar R, Rodriguez-Canales J, Lazar AJ, Wistuba II, Baker LH, Maki RG, Reinke D, Patel S
Lancet Oncol 2017 Nov;18(11):1493-1501. Epub 2017 Oct 4 doi: 10.1016/S1470-2045(17)30624-1. PMID: 28988646Free PMC Article
Skubitz KM, D'Adamo DR
Mayo Clin Proc 2007 Nov;82(11):1409-32. doi: 10.4065/82.11.1409. PMID: 17976362

Diagnosis

Tlemsani C, Larousserie F, De Percin S, Audard V, Hadjadj D, Chen J, Biau D, Anract P, Terris B, Goldwasser F, Pasmant E, Boudou-Rouquette P
Int J Mol Sci 2023 Jan 10;24(2) doi: 10.3390/ijms24021361. PMID: 36674874Free PMC Article
Hameed M
Surg Pathol Clin 2021 Dec;14(4):605-617. Epub 2021 Oct 7 doi: 10.1016/j.path.2021.06.005. PMID: 34742483
Whelan JS, Davis LE
J Clin Oncol 2018 Jan 10;36(2):188-193. Epub 2017 Dec 8 doi: 10.1200/JCO.2017.75.1743. PMID: 29220289
Mendonça V, Jorge M, Monteiro-Grillo I, Palhano MJ, Feijó S
Clin Transl Oncol 2010 Aug;12(8):576-80. doi: 10.1007/s12094-010-0557-x. PMID: 20709656
Skubitz KM, D'Adamo DR
Mayo Clin Proc 2007 Nov;82(11):1409-32. doi: 10.4065/82.11.1409. PMID: 17976362

Therapy

Tap WD, Villalobos VM, Cote GM, Burris H, Janku F, Mir O, Beeram M, Wagner AJ, Jiang L, Wu B, Choe S, Yen K, Gliser C, Fan B, Agresta S, Pandya SS, Trent JC
J Clin Oncol 2020 May 20;38(15):1693-1701. Epub 2020 Mar 24 doi: 10.1200/JCO.19.02492. PMID: 32208957Free PMC Article
Duffaud F, Mir O, Boudou-Rouquette P, Piperno-Neumann S, Penel N, Bompas E, Delcambre C, Kalbacher E, Italiano A, Collard O, Chevreau C, Saada E, Isambert N, Delaye J, Schiffler C, Bouvier C, Vidal V, Chabaud S, Blay JY; French Sarcoma Group
Lancet Oncol 2019 Jan;20(1):120-133. Epub 2018 Nov 23 doi: 10.1016/S1470-2045(18)30742-3. PMID: 30477937
Tawbi HA, Burgess M, Bolejack V, Van Tine BA, Schuetze SM, Hu J, D'Angelo S, Attia S, Riedel RF, Priebat DA, Movva S, Davis LE, Okuno SH, Reed DR, Crowley J, Butterfield LH, Salazar R, Rodriguez-Canales J, Lazar AJ, Wistuba II, Baker LH, Maki RG, Reinke D, Patel S
Lancet Oncol 2017 Nov;18(11):1493-1501. Epub 2017 Oct 4 doi: 10.1016/S1470-2045(17)30624-1. PMID: 28988646Free PMC Article
Fujii T, Khawaja MR, DiNardo CD, Atkins JT, Janku F
Discov Med 2016 May;21(117):373-80. PMID: 27355333
Skubitz KM, D'Adamo DR
Mayo Clin Proc 2007 Nov;82(11):1409-32. doi: 10.4065/82.11.1409. PMID: 17976362

Prognosis

Hameed M
Surg Pathol Clin 2021 Dec;14(4):605-617. Epub 2021 Oct 7 doi: 10.1016/j.path.2021.06.005. PMID: 34742483
Kask G, Laitinen MK, Stevenson J, Evans S, Jeys LM, Parry MC
Bone Joint J 2021 Mar;103-B(3):562-568. doi: 10.1302/0301-620X.103B3.BJJ-2020-1337.R1. PMID: 33641425
Chow WA
F1000Res 2018;7 Epub 2018 Nov 20 doi: 10.12688/f1000research.15953.1. PMID: 30519452Free PMC Article
Tawbi HA, Burgess M, Bolejack V, Van Tine BA, Schuetze SM, Hu J, D'Angelo S, Attia S, Riedel RF, Priebat DA, Movva S, Davis LE, Okuno SH, Reed DR, Crowley J, Butterfield LH, Salazar R, Rodriguez-Canales J, Lazar AJ, Wistuba II, Baker LH, Maki RG, Reinke D, Patel S
Lancet Oncol 2017 Nov;18(11):1493-1501. Epub 2017 Oct 4 doi: 10.1016/S1470-2045(17)30624-1. PMID: 28988646Free PMC Article
Skubitz KM, D'Adamo DR
Mayo Clin Proc 2007 Nov;82(11):1409-32. doi: 10.4065/82.11.1409. PMID: 17976362

Clinical prediction guides

Tilden W, Andrei V, O'Donnell P, Saifuddin A
Skeletal Radiol 2022 Jun;51(6):1189-1199. Epub 2021 Oct 29 doi: 10.1007/s00256-021-03947-w. PMID: 34714386
Hameed M
Surg Pathol Clin 2021 Dec;14(4):605-617. Epub 2021 Oct 7 doi: 10.1016/j.path.2021.06.005. PMID: 34742483
Kask G, Laitinen MK, Stevenson J, Evans S, Jeys LM, Parry MC
Bone Joint J 2021 Mar;103-B(3):562-568. doi: 10.1302/0301-620X.103B3.BJJ-2020-1337.R1. PMID: 33641425
Compton ML, Cates JMM
Am J Surg Pathol 2020 Jan;44(1):111-119. doi: 10.1097/PAS.0000000000001397. PMID: 31651521
Fujii T, Khawaja MR, DiNardo CD, Atkins JT, Janku F
Discov Med 2016 May;21(117):373-80. PMID: 27355333

Recent systematic reviews

Dong M, Liu R, Zhang Q, Luo H, Wang D, Wang Y, Chen J, Ou Y, Wang X
Radiat Oncol 2022 Oct 25;17(1):172. doi: 10.1186/s13014-022-02089-0. PMID: 36284346Free PMC Article
Baba A, Kurokawa R, Kurokawa M, Ota Y, Lobo R, Srinivasan A
J Neuroimaging 2022 Mar;32(2):213-222. Epub 2022 Jan 12 doi: 10.1111/jon.12963. PMID: 35019171
Deckers C, Steyvers MJ, Hannink G, Schreuder HWB, de Rooy JWJ, Van Der Geest ICM
Acta Orthop 2020 Aug;91(4):471-478. Epub 2020 May 20 doi: 10.1080/17453674.2020.1763717. PMID: 32429792Free PMC Article
Shemesh SS, Acevedo-Nieves JD, Pretell-Mazzini J
Musculoskelet Surg 2018 Aug;102(2):95-109. Epub 2017 Oct 6 doi: 10.1007/s12306-017-0507-7. PMID: 28986742
Chin OY, Dubal PM, Sheikh AB, Unsal AA, Park RC, Baredes S, Eloy JA
Laryngoscope 2017 Feb;127(2):430-439. Epub 2016 Jun 12 doi: 10.1002/lary.26068. PMID: 27291822

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