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Abnormal nipple morphology

MedGen UID:
824919
•Concept ID:
C3839073
•
Finding
Synonym: Nipple abnormalities
SNOMED CT: Nipple abnormality (700153004); Abnormal nipple (700153004)
 
HPO: HP:0004404

Definition

An abnormality of the nipple. [from HPO]

Professional guidelines

PubMed

Treatment of the benign inverted nipple: A systematic review and recommendations for future therapy.
Hernandez Yenty QM, Jurgens WJ, van Zuijlen PP, de Vet HC, Verhaegen PD
Breast 2016 Oct;29:82-9. Epub 2016 Jul 29 doi: 10.1016/j.breast.2016.07.011. PMID: 27476082
Diagnosis and surgical treatment of nipple adenoma.
Wang C, Wang X, Ma R
ANZ J Surg 2015 Jun;85(6):444-7. Epub 2014 Jun 27 doi: 10.1111/ans.12744. PMID: 24975720
Prevalence, diagnosis, and treatment of ankyloglossia: methodologic review.
Segal LM, Stephenson R, Dawes M, Feldman P
Can Fam Physician 2007 Jun;53(6):1027-33. PMID: 17872781Free PMC Article

Recent clinical studies

Etiology

Typical and atypical presenting symptoms of breast cancer and their associations with diagnostic intervals: Evidence from a national audit of cancer diagnosis.
Koo MM, von Wagner C, Abel GA, McPhail S, Rubin GP, Lyratzopoulos G
Cancer Epidemiol 2017 Jun;48:140-146. Epub 2017 May 23 doi: 10.1016/j.canep.2017.04.010. PMID: 28549339Free PMC Article
Benign breast disorders.
Onstad M, Stuckey A
Obstet Gynecol Clin North Am 2013 Sep;40(3):459-73. Epub 2013 Jul 24 doi: 10.1016/j.ogc.2013.05.004. PMID: 24021252
Dermatopathology of the female breast.
Peters MS, Lehman JS, Comfere NI
Am J Dermatopathol 2013 May;35(3):289-304; quiz 305-7. doi: 10.1097/DAD.0b013e318267caa3. PMID: 23598853
Male breast cancer.
Reis LO, Dias FG, Castro MA, Ferreira U
Aging Male 2011 Jun;14(2):99-109. Epub 2011 Jan 4 doi: 10.3109/13685538.2010.535048. PMID: 21204612
Benign breast disease.
Miltenburg DM, Speights VO Jr
Obstet Gynecol Clin North Am 2008 Jun;35(2):285-300, ix. doi: 10.1016/j.ogc.2008.03.008. PMID: 18486842

Diagnosis

Skin diseases of the breast and nipple: Benign and malignant tumors.
Waldman RA, Finch J, Grant-Kels JM, Stevenson C, Whitaker-Worth D
J Am Acad Dermatol 2019 Jun;80(6):1467-1481. Epub 2018 Nov 16 doi: 10.1016/j.jaad.2018.08.066. PMID: 30452954
Typical and atypical presenting symptoms of breast cancer and their associations with diagnostic intervals: Evidence from a national audit of cancer diagnosis.
Koo MM, von Wagner C, Abel GA, McPhail S, Rubin GP, Lyratzopoulos G
Cancer Epidemiol 2017 Jun;48:140-146. Epub 2017 May 23 doi: 10.1016/j.canep.2017.04.010. PMID: 28549339Free PMC Article
Benign breast disorders.
Onstad M, Stuckey A
Obstet Gynecol Clin North Am 2013 Sep;40(3):459-73. Epub 2013 Jul 24 doi: 10.1016/j.ogc.2013.05.004. PMID: 24021252
Male breast cancer.
Reis LO, Dias FG, Castro MA, Ferreira U
Aging Male 2011 Jun;14(2):99-109. Epub 2011 Jan 4 doi: 10.3109/13685538.2010.535048. PMID: 21204612
Benign breast disease.
Miltenburg DM, Speights VO Jr
Obstet Gynecol Clin North Am 2008 Jun;35(2):285-300, ix. doi: 10.1016/j.ogc.2008.03.008. PMID: 18486842

Therapy

Nipple-Areola Complex Reconstruction.
Sisti A
Medicina (Kaunas) 2020 Jun 16;56(6) doi: 10.3390/medicina56060296. PMID: 32560062Free PMC Article
Breast Pathology That Contributes to Dysfunction of Human Lactation: a Spotlight on Nipple Blebs.
Mitchell KB, Johnson HM
J Mammary Gland Biol Neoplasia 2020 Jun;25(2):79-83. Epub 2020 Jun 3 doi: 10.1007/s10911-020-09450-7. PMID: 32495215
Mammary Dysbiosis and Nipple Blebs Treated With Intravenous Daptomycin and Dalbavancin.
Mitchell KB, Eglash A, Bamberger ET
J Hum Lact 2020 May;36(2):365-368. Epub 2019 Jul 16 doi: 10.1177/0890334419862214. PMID: 31310726
Treatment of the benign inverted nipple: A systematic review and recommendations for future therapy.
Hernandez Yenty QM, Jurgens WJ, van Zuijlen PP, de Vet HC, Verhaegen PD
Breast 2016 Oct;29:82-9. Epub 2016 Jul 29 doi: 10.1016/j.breast.2016.07.011. PMID: 27476082
Management of Recurrent or Persistent Macromastia.
Austin RE, Lista F, Ahmad J
Clin Plast Surg 2016 Apr;43(2):383-93. Epub 2016 Feb 11 doi: 10.1016/j.cps.2015.12.004. PMID: 27012797

Prognosis

The investigation and management of unilateral nipple discharge.
Clark SE, Agrawal A, Laws S, Graja T, Sheehan LA, Laban C, Scutt F
Ann R Coll Surg Engl 2020 May;102(5):369-374. Epub 2020 Apr 1 doi: 10.1308/rcsann.2020.0036. PMID: 32233847Free PMC Article
Skin diseases of the breast and nipple: Benign and malignant tumors.
Waldman RA, Finch J, Grant-Kels JM, Stevenson C, Whitaker-Worth D
J Am Acad Dermatol 2019 Jun;80(6):1467-1481. Epub 2018 Nov 16 doi: 10.1016/j.jaad.2018.08.066. PMID: 30452954
Cat eye syndrome.
Sharma D, Murki S, Pratap T, Vasikarla M
BMJ Case Rep 2014 May 19;2014 doi: 10.1136/bcr-2014-203923. PMID: 24842361Free PMC Article
Dermatopathology of the female breast.
Peters MS, Lehman JS, Comfere NI
Am J Dermatopathol 2013 May;35(3):289-304; quiz 305-7. doi: 10.1097/DAD.0b013e318267caa3. PMID: 23598853
Male breast cancer.
Reis LO, Dias FG, Castro MA, Ferreira U
Aging Male 2011 Jun;14(2):99-109. Epub 2011 Jan 4 doi: 10.3109/13685538.2010.535048. PMID: 21204612

Clinical prediction guides

The investigation and management of unilateral nipple discharge.
Clark SE, Agrawal A, Laws S, Graja T, Sheehan LA, Laban C, Scutt F
Ann R Coll Surg Engl 2020 May;102(5):369-374. Epub 2020 Apr 1 doi: 10.1308/rcsann.2020.0036. PMID: 32233847Free PMC Article
Inverted Nipple Treatment and Poliglecaprone Spacer.
Dessena L, Dast S, Perez S, Mercut R, Herlin C, Sinna R
Aesthetic Plast Surg 2018 Aug;42(4):958-963. Epub 2018 May 1 doi: 10.1007/s00266-018-1139-5. PMID: 29717339
Dermatopathology of the female breast.
Peters MS, Lehman JS, Comfere NI
Am J Dermatopathol 2013 May;35(3):289-304; quiz 305-7. doi: 10.1097/DAD.0b013e318267caa3. PMID: 23598853
Diseases of the male nipple and areola.
Krause W
J Dtsch Dermatol Ges 2011 Dec;9(12):1004-9. Epub 2011 Jun 9 doi: 10.1111/j.1610-0387.2011.07720.x. PMID: 21651722
Clinical and pathological features of pachyonychia congenita.
Leachman SA, Kaspar RL, Fleckman P, Florell SR, Smith FJ, McLean WH, Lunny DP, Milstone LM, van Steensel MA, Munro CS, O'Toole EA, Celebi JT, Kansky A, Lane EB
J Investig Dermatol Symp Proc 2005 Oct;10(1):3-17. doi: 10.1111/j.1087-0024.2005.10202.x. PMID: 16250204

Recent systematic reviews

Role of duct excision surgery in the treatment of pathological nipple discharge and detection of breast carcinoma: systematic review.
Makineli S, van Wijnbergen JWM, Vriens MR, van Diest PJ, Witkamp AJ
BJS Open 2023 Jul 10;7(4) doi: 10.1093/bjsopen/zrad066. PMID: 37459137Free PMC Article
Diagnostic Performance of MRI Versus Galactography in Women With Pathologic Nipple Discharge: A Systematic Review and Meta-Analysis.
Berger N, Luparia A, Di Leo G, Carbonaro LA, Trimboli RM, Ambrogi F, Sardanelli F
AJR Am J Roentgenol 2017 Aug;209(2):465-471. Epub 2017 May 24 doi: 10.2214/AJR.16.16682. PMID: 28537847
Treatment of the benign inverted nipple: A systematic review and recommendations for future therapy.
Hernandez Yenty QM, Jurgens WJ, van Zuijlen PP, de Vet HC, Verhaegen PD
Breast 2016 Oct;29:82-9. Epub 2016 Jul 29 doi: 10.1016/j.breast.2016.07.011. PMID: 27476082
Systematic review and meta-analysis of the diagnostic accuracy of ductoscopy in patients with pathological nipple discharge.
Waaijer L, Simons JM, Borel Rinkes IH, van Diest PJ, Verkooijen HM, Witkamp AJ
Br J Surg 2016 May;103(6):632-643. Epub 2016 Mar 23 doi: 10.1002/bjs.10125. PMID: 27004588
Proliferative epithelial disease identified in nipple aspirate fluid and risk of developing breast cancer: a systematic review.
Hornberger J, Chen SC, Li Q, Kakad P, Quay SC
Curr Med Res Opin 2015 Feb;31(2):253-62. Epub 2014 Dec 3 doi: 10.1185/03007995.2014.988209. PMID: 25405383

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