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Invasive Encapsulated Follicular Variant Thyroid Gland Papillary Carcinoma

MedGen UID:
825497
•Concept ID:
C3839652
•
Neoplastic Process
Synonyms: Follicular Variant Thyroid Gland Papillary Carcinoma, Encapsulated Subtype with Invasion; Invasive Encapsulated Follicular Variant Papillary Carcinoma; Solid papillary carcinoma with invasion
SNOMED CT: Solid papillary carcinoma with invasion (703594003)

Definition

A papillary carcinoma of the thyroid gland which is encapsulated and resembles an encapsulated follicular neoplasm. Capsular invasion is present. The malignant follicular cells display the nuclear features that characterize the papillary adenocarcinomas of the thyroid gland. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVInvasive Encapsulated Follicular Variant Thyroid Gland Papillary Carcinoma

Professional guidelines

PubMed

Application of Strict Criteria for Noninvasive Follicular Thyroid Neoplasm with Papillary-Like Nuclear Features and Encapsulated Follicular Variant Papillary Thyroid Carcinoma: a Retrospective Study of 50 Tumors Previously Diagnosed as Follicular Variant PTC.
Point du Jour K, du Jour KP, Schmitt AC, Chen AY, Griffith CC
Endocr Pathol 2018 Mar;29(1):35-42. doi: 10.1007/s12022-017-9509-0. PMID: 29368294
Evolution of the histologic classification of thyroid neoplasms and its impact on clinical management.
Xu B, Ghossein R
Eur J Surg Oncol 2018 Mar;44(3):338-347. Epub 2017 May 18 doi: 10.1016/j.ejso.2017.05.002. PMID: 28554832Free PMC Article
American Thyroid Association Guidelines on the Management of Thyroid Nodules and Differentiated Thyroid Cancer Task Force Review and Recommendation on the Proposed Renaming of Encapsulated Follicular Variant Papillary Thyroid Carcinoma Without Invasion to Noninvasive Follicular Thyroid Neoplasm with Papillary-Like Nuclear Features.
Haugen BR, Sawka AM, Alexander EK, Bible KC, Caturegli P, Doherty GM, Mandel SJ, Morris JC, Nassar A, Pacini F, Schlumberger M, Schuff K, Sherman SI, Somerset H, Sosa JA, Steward DL, Wartofsky L, Williams MD
Thyroid 2017 Apr;27(4):481-483. Epub 2017 Feb 21 doi: 10.1089/thy.2016.0628. PMID: 28114862

Recent clinical studies

Etiology

Thyroid Nodules and Follicular Cell-Derived Thyroid Carcinomas in Children.
Slack JC, Hollowell M, Barletta JA
Endocr Pathol 2023 Jun;34(2):165-175. Epub 2023 May 9 doi: 10.1007/s12022-023-09764-2. PMID: 37160531
Update from the 2022 World Health Organization Classification of Thyroid Tumors: A Standardized Diagnostic Approach.
Jung CK, Bychkov A, Kakudo K
Endocrinol Metab (Seoul) 2022 Oct;37(5):703-718. Epub 2022 Oct 4 doi: 10.3803/EnM.2022.1553. PMID: 36193717Free PMC Article
Overview of the 2022 WHO Classification of Thyroid Neoplasms.
Baloch ZW, Asa SL, Barletta JA, Ghossein RA, Juhlin CC, Jung CK, LiVolsi VA, Papotti MG, Sobrinho-Simões M, Tallini G, Mete O
Endocr Pathol 2022 Mar;33(1):27-63. Epub 2022 Mar 14 doi: 10.1007/s12022-022-09707-3. PMID: 35288841
The thyroid cancer epidemic, 2017 perspective.
Roman BR, Morris LG, Davies L
Curr Opin Endocrinol Diabetes Obes 2017 Oct;24(5):332-336. doi: 10.1097/MED.0000000000000359. PMID: 28692457Free PMC Article
Nomenclature Revision for Encapsulated Follicular Variant of Papillary Thyroid Carcinoma: A Paradigm Shift to Reduce Overtreatment of Indolent Tumors.
Nikiforov YE, Seethala RR, Tallini G, Baloch ZW, Basolo F, Thompson LD, Barletta JA, Wenig BM, Al Ghuzlan A, Kakudo K, Giordano TJ, Alves VA, Khanafshar E, Asa SL, El-Naggar AK, Gooding WE, Hodak SP, Lloyd RV, Maytal G, Mete O, Nikiforova MN, Nosé V, Papotti M, Poller DN, Sadow PM, Tischler AS, Tuttle RM, Wall KB, LiVolsi VA, Randolph GW, Ghossein RA
JAMA Oncol 2016 Aug 1;2(8):1023-9. doi: 10.1001/jamaoncol.2016.0386. PMID: 27078145Free PMC Article

Diagnosis

Update from the 2022 World Health Organization Classification of Thyroid Tumors: A Standardized Diagnostic Approach.
Jung CK, Bychkov A, Kakudo K
Endocrinol Metab (Seoul) 2022 Oct;37(5):703-718. Epub 2022 Oct 4 doi: 10.3803/EnM.2022.1553. PMID: 36193717Free PMC Article
Overview of the 2022 WHO Classification of Thyroid Neoplasms.
Baloch ZW, Asa SL, Barletta JA, Ghossein RA, Juhlin CC, Jung CK, LiVolsi VA, Papotti MG, Sobrinho-Simões M, Tallini G, Mete O
Endocr Pathol 2022 Mar;33(1):27-63. Epub 2022 Mar 14 doi: 10.1007/s12022-022-09707-3. PMID: 35288841
A closer look at NIFTP.
Dhanushika T, Priyani AAH, Ranaweera MEM, Ranaweera GG, de Silva MVC, Dassanayake RS
Hormones (Athens) 2020 Sep;19(3):285-290. Epub 2020 May 16 doi: 10.1007/s42000-020-00206-w. PMID: 32415648
The thyroid cancer epidemic, 2017 perspective.
Roman BR, Morris LG, Davies L
Curr Opin Endocrinol Diabetes Obes 2017 Oct;24(5):332-336. doi: 10.1097/MED.0000000000000359. PMID: 28692457Free PMC Article
Nomenclature Revision for Encapsulated Follicular Variant of Papillary Thyroid Carcinoma: A Paradigm Shift to Reduce Overtreatment of Indolent Tumors.
Nikiforov YE, Seethala RR, Tallini G, Baloch ZW, Basolo F, Thompson LD, Barletta JA, Wenig BM, Al Ghuzlan A, Kakudo K, Giordano TJ, Alves VA, Khanafshar E, Asa SL, El-Naggar AK, Gooding WE, Hodak SP, Lloyd RV, Maytal G, Mete O, Nikiforova MN, Nosé V, Papotti M, Poller DN, Sadow PM, Tischler AS, Tuttle RM, Wall KB, LiVolsi VA, Randolph GW, Ghossein RA
JAMA Oncol 2016 Aug 1;2(8):1023-9. doi: 10.1001/jamaoncol.2016.0386. PMID: 27078145Free PMC Article

Therapy

Large (>4 cm) Intrathyroidal Encapsulated Well-Differentiated Follicular Cell-Derived Carcinoma Without Vascular Invasion May Have Negligible Risk of Recurrence Even When Treated with Lobectomy Alone.
Ghossein R, Ganly I, Tuttle RM, Xu B
Thyroid 2023 May;33(5):586-592. Epub 2023 Apr 18 doi: 10.1089/thy.2023.0032. PMID: 36884299Free PMC Article
Noninvasive Follicular Thyroid Neoplasm with Papillary-Like Nuclear Features: Can Cytology Face the Challenge of Diagnosis in the Light of the New Classification?
Díaz Del Arco C, Fernández Aceñero MJ
Acta Cytol 2018;62(4):265-272. Epub 2018 Jun 1 doi: 10.1159/000488579. PMID: 29860249
Noninvasive Encapsulated Follicular Variant of Papillary Thyroid Cancer: Clinical Lessons from a Community-Based Endocrine Surgical Practice.
Golding A, Shively D, Bimston DN, Harrell RM
Int J Surg Oncol 2017;2017:4689465. Epub 2017 Apr 13 doi: 10.1155/2017/4689465. PMID: 28487771Free PMC Article
Outcome of Large Noninvasive Follicular Thyroid Neoplasm with Papillary-Like Nuclear Features.
Xu B, Tallini G, Scognamiglio T, Roman BR, Tuttle RM, Ghossein RA
Thyroid 2017 Apr;27(4):512-517. Epub 2017 Feb 24 doi: 10.1089/thy.2016.0649. PMID: 28136139Free PMC Article
NONINVASIVE FOLLICULAR TUMOR WITH PAPILLARY-LIKE NUCLEAR FEATURES: NOT A TEMPEST IN A TEAPOT.
Agrawal N, Abbott CE, Liu C, Kang S, Tipton L, Patel K, Persky M, King L, Deng FM, Bannan M, Ogilvie JB, Heller K, Hodak SP
Endocr Pract 2017 Apr 2;23(4):451-457. Epub 2017 Jan 17 doi: 10.4158/EP161632.OR. PMID: 28095037

Prognosis

Thyroid Nodules and Follicular Cell-Derived Thyroid Carcinomas in Children.
Slack JC, Hollowell M, Barletta JA
Endocr Pathol 2023 Jun;34(2):165-175. Epub 2023 May 9 doi: 10.1007/s12022-023-09764-2. PMID: 37160531
Overview of the 2022 WHO Classification of Thyroid Neoplasms.
Baloch ZW, Asa SL, Barletta JA, Ghossein RA, Juhlin CC, Jung CK, LiVolsi VA, Papotti MG, Sobrinho-Simões M, Tallini G, Mete O
Endocr Pathol 2022 Mar;33(1):27-63. Epub 2022 Mar 14 doi: 10.1007/s12022-022-09707-3. PMID: 35288841
Non-invasive follicular thyroid neoplasm with papillary-like nuclearfeatures (NIFTP): a review and update.
Geramizadeh B, Maleki Z
Endocrine 2019 Jun;64(3):433-440. Epub 2019 Mar 13 doi: 10.1007/s12020-019-01887-z. PMID: 30868412
An update on noninvasive follicular thyroid neoplasm with papillary-like nuclear features.
Range DE, Jiang XS
Curr Opin Oncol 2018 Jan;30(1):1-7. doi: 10.1097/CCO.0000000000000416. PMID: 29049050
Encapsulated Thyroid Carcinoma of Follicular Cell Origin.
Xu B, Ghossein R
Endocr Pathol 2015 Sep;26(3):191-9. doi: 10.1007/s12022-015-9376-5. PMID: 26003547

Clinical prediction guides

Large (>4 cm) Intrathyroidal Encapsulated Well-Differentiated Follicular Cell-Derived Carcinoma Without Vascular Invasion May Have Negligible Risk of Recurrence Even When Treated with Lobectomy Alone.
Ghossein R, Ganly I, Tuttle RM, Xu B
Thyroid 2023 May;33(5):586-592. Epub 2023 Apr 18 doi: 10.1089/thy.2023.0032. PMID: 36884299Free PMC Article
Noninvasive follicular thyroid neoplasm with papillary-like nuclear features (NIFTP): a review for clinicians.
Rosario PW, Mourão GF
Endocr Relat Cancer 2019 May 1;26(5):R259-R266. doi: 10.1530/ERC-19-0048. PMID: 30913533
Non-invasive follicular thyroid neoplasm with papillary-like nuclearfeatures (NIFTP): a review and update.
Geramizadeh B, Maleki Z
Endocrine 2019 Jun;64(3):433-440. Epub 2019 Mar 13 doi: 10.1007/s12020-019-01887-z. PMID: 30868412
Non-invasive follicular thyroid neoplasm with papillary-like nuclear features (NIFTP): impact on the reclassification of thyroid nodules.
Amendoeira I, Maia T, Sobrinho-Simões M
Endocr Relat Cancer 2018 Apr;25(4):R247-R258. Epub 2018 Feb 9 doi: 10.1530/ERC-17-0513. PMID: 29439059
Nomenclature Revision for Encapsulated Follicular Variant of Papillary Thyroid Carcinoma: A Paradigm Shift to Reduce Overtreatment of Indolent Tumors.
Nikiforov YE, Seethala RR, Tallini G, Baloch ZW, Basolo F, Thompson LD, Barletta JA, Wenig BM, Al Ghuzlan A, Kakudo K, Giordano TJ, Alves VA, Khanafshar E, Asa SL, El-Naggar AK, Gooding WE, Hodak SP, Lloyd RV, Maytal G, Mete O, Nikiforova MN, Nosé V, Papotti M, Poller DN, Sadow PM, Tischler AS, Tuttle RM, Wall KB, LiVolsi VA, Randolph GW, Ghossein RA
JAMA Oncol 2016 Aug 1;2(8):1023-9. doi: 10.1001/jamaoncol.2016.0386. PMID: 27078145Free PMC Article

Recent systematic reviews

Pathological findings of the retrospective diagnosis of NIFTP (non-invasive follicular thyroid neoplasm with papillary-like nuclear features) in 84 cases from Turkey and systematic review.
Turan G, Özkara SK
Ann Diagn Pathol 2021 Aug;53:151764. Epub 2021 Jun 9 doi: 10.1016/j.anndiagpath.2021.151764. PMID: 34118581

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