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Testicular sex cord-stromal neoplasm

MedGen UID:
825921
Concept ID:
C3840076
Neoplastic Process
Synonym: Sex cord-stromal tumor of testis
SNOMED CT: Sex cord stromal tumor of testis (702406000)
 
Monarch Initiative: MONDO:0003125
Orphanet: ORPHA363489

Definition

A group of rare tumors of testis comprising neoplasms of pure sex cord or pure stromal type, or neoplasms with admixtures of both components in various proportions and degree of differentiation. The tumors usually present as a painless testicular mass, although some may be associated with endocrine manifestations such as precocious puberty, gynecomastia, or erectile dysfunction. Malignant behavior is seen only in a small percentage of these tumors. [from ORDO]

Professional guidelines

PubMed

Fankhauser CD, Grogg JB, Hayoz S, Wettstein MS, Dieckmann KP, Sulser T, Bode PK, Clarke NW, Beyer J, Hermanns T
J Urol 2020 May;203(5):949-956. Epub 2019 Dec 17 doi: 10.1097/JU.0000000000000705. PMID: 31845841
Narula HS, Carlson HE
Nat Rev Endocrinol 2014 Nov;10(11):684-98. Epub 2014 Aug 12 doi: 10.1038/nrendo.2014.139. PMID: 25112235
Acar C, Gurocak S, Sozen S
Urology 2009 Jun;73(6):1165-71. Epub 2009 Apr 10 doi: 10.1016/j.urology.2008.10.036. PMID: 19362328

Recent clinical studies

Etiology

Colecchia M, Raspollini MR, Bremmer F, Pini GM
Curr Opin Urol 2022 Jul 1;32(4):339-343. Epub 2022 Jun 27 doi: 10.1097/MOU.0000000000001001. PMID: 35749781
Shang B, Cao C, Jiang W, Shi H, Bi X, Cui C, Shou J, Zheng S, Zhang J, Zhou A, Li C, Ma J
Front Immunol 2021;12:720359. Epub 2022 Jan 10 doi: 10.3389/fimmu.2021.720359. PMID: 35082775Free PMC Article
Al-Obaidy KI, Idrees MT
Adv Anat Pathol 2021 Jul 1;28(4):258-275. doi: 10.1097/PAP.0000000000000302. PMID: 33871428
Chávarri-Guerra Y, González-Ochoa E, De-la-Mora-Molina H, Soto-Perez-de-Celis E
Chin Clin Oncol 2020 Aug;9(4):52. Epub 2020 Jul 28 doi: 10.21037/cco-20-36. PMID: 32787339
Fankhauser CD, Grogg JB, Hayoz S, Wettstein MS, Dieckmann KP, Sulser T, Bode PK, Clarke NW, Beyer J, Hermanns T
J Urol 2020 May;203(5):949-956. Epub 2019 Dec 17 doi: 10.1097/JU.0000000000000705. PMID: 31845841

Diagnosis

Dashora A, Wagner T, Berney DM
Surg Pathol Clin 2022 Dec;15(4):729-743. Epub 2022 Oct 13 doi: 10.1016/j.path.2022.07.007. PMID: 36344186
Berney DM, Cree I, Rao V, Moch H, Srigley JR, Tsuzuki T, Amin MB, Comperat EM, Hartmann A, Menon S, Netto GJ, Rubin MA, Turajlic S, Raspollini MR, Tickoo SK
Histopathology 2022 Oct;81(4):459-466. Epub 2022 Jul 1 doi: 10.1111/his.14675. PMID: 35502823Free PMC Article
Al-Obaidy KI, Idrees MT
Adv Anat Pathol 2021 Jul 1;28(4):258-275. doi: 10.1097/PAP.0000000000000302. PMID: 33871428
Fankhauser CD, Grogg JB, Hayoz S, Wettstein MS, Dieckmann KP, Sulser T, Bode PK, Clarke NW, Beyer J, Hermanns T
J Urol 2020 May;203(5):949-956. Epub 2019 Dec 17 doi: 10.1097/JU.0000000000000705. PMID: 31845841
Peckham MJ, McElwain TJ
Clin Endocrinol Metab 1975 Nov;4(3):665-92. doi: 10.1016/s0300-595x(75)80052-1. PMID: 58746

Therapy

Hendricks M, Cois A, Geel J, van Heerden J, Naidu G, du Plessis J, Bassingthwaighte M, van Zyl A, Uys R, Bϋchner A, Rowe B, Omar F, Mahlachana N, Thomas K, Vermeulen J, Davidson A, Donald KA, Kruger M
J Pediatr Hematol Oncol 2021 Jul 1;43(5):e619-e624. doi: 10.1097/MPH.0000000000002076. PMID: 33560080
Naouar S, Braiek S, El Kamel R
Presse Med 2017 Jun;46(6 Pt 1):572-578. Epub 2017 May 23 doi: 10.1016/j.lpm.2017.05.006. PMID: 28549629
Fresneau B, Orbach D, Faure-Conter C, Verité C, Castex MP, Kalfa N, Martelli H, Patte C
Pediatr Blood Cancer 2015 Dec;62(12):2114-9. Epub 2015 Jul 23 doi: 10.1002/pbc.25614. PMID: 26206391
Hofmann M, Schlegel PG, Hippert F, Schmidt P, von-Schweinitz D, Leuschner I, Göbel U, Calaminus G, Schneider DT; MAKEI study group
Pediatr Blood Cancer 2013 Oct;60(10):1651-5. Epub 2013 Jun 3 doi: 10.1002/pbc.24607. PMID: 23733594
Peckham MJ, McElwain TJ
Clin Endocrinol Metab 1975 Nov;4(3):665-92. doi: 10.1016/s0300-595x(75)80052-1. PMID: 58746

Prognosis

Berney DM, Cree I, Rao V, Moch H, Srigley JR, Tsuzuki T, Amin MB, Comperat EM, Hartmann A, Menon S, Netto GJ, Rubin MA, Turajlic S, Raspollini MR, Tickoo SK
Histopathology 2022 Oct;81(4):459-466. Epub 2022 Jul 1 doi: 10.1111/his.14675. PMID: 35502823Free PMC Article
Shang B, Cao C, Jiang W, Shi H, Bi X, Cui C, Shou J, Zheng S, Zhang J, Zhou A, Li C, Ma J
Front Immunol 2021;12:720359. Epub 2022 Jan 10 doi: 10.3389/fimmu.2021.720359. PMID: 35082775Free PMC Article
Chávarri-Guerra Y, González-Ochoa E, De-la-Mora-Molina H, Soto-Perez-de-Celis E
Chin Clin Oncol 2020 Aug;9(4):52. Epub 2020 Jul 28 doi: 10.21037/cco-20-36. PMID: 32787339
Fankhauser CD, Grogg JB, Hayoz S, Wettstein MS, Dieckmann KP, Sulser T, Bode PK, Clarke NW, Beyer J, Hermanns T
J Urol 2020 May;203(5):949-956. Epub 2019 Dec 17 doi: 10.1097/JU.0000000000000705. PMID: 31845841
Gigantino V, La Mantia E, Franco R, Cecere S, Rossetti S, Di Napoli M, Pisano C, Berretta M, Galzerano A, Botti G, Pignata S, Facchini G
Anticancer Drugs 2013 Mar;24(3):228-36. doi: 10.1097/CAD.0b013e32835a3598. PMID: 23059385

Clinical prediction guides

Fankhauser CD, Grogg JB, Hayoz S, Wettstein MS, Dieckmann KP, Sulser T, Bode PK, Clarke NW, Beyer J, Hermanns T
J Urol 2020 May;203(5):949-956. Epub 2019 Dec 17 doi: 10.1097/JU.0000000000000705. PMID: 31845841
Schultz KA, Harris AK, Schneider DT, Young RH, Brown J, Gershenson DM, Dehner LP, Hill DA, Messinger YH, Frazier AL
J Oncol Pract 2016 Oct;12(10):940-946. doi: 10.1200/JOP.2016.016261. PMID: 27858560Free PMC Article
Silberstein JL, Bazzi WM, Vertosick E, Carver BS, Bosl GJ, Feldman DR, Bajorin DF, Motzer RJ, Al-Ahmadie H, Reuter VE, Sheinfeld J
J Urol 2014 Aug;192(2):415-9. Epub 2014 Feb 8 doi: 10.1016/j.juro.2014.01.104. PMID: 24518791Free PMC Article
Gigantino V, La Mantia E, Franco R, Cecere S, Rossetti S, Di Napoli M, Pisano C, Berretta M, Galzerano A, Botti G, Pignata S, Facchini G
Anticancer Drugs 2013 Mar;24(3):228-36. doi: 10.1097/CAD.0b013e32835a3598. PMID: 23059385
Kennedy GL Jr, Butenhoff JL, Olsen GW, O'Connor JC, Seacat AM, Perkins RG, Biegel LB, Murphy SR, Farrar DG
Crit Rev Toxicol 2004 Jul-Aug;34(4):351-84. doi: 10.1080/10408440490464705. PMID: 15328768

Recent systematic reviews

Bois JI, Vagni RL, de Badiola FI, Moldes JM, Losty PD, Lobos PA
Pediatr Surg Int 2021 May;37(5):607-616. Epub 2021 Jan 17 doi: 10.1007/s00383-020-04850-6. PMID: 33454815
Renne SL, Valeri M, Tosoni A, Bertolotti A, Rossi R, Renne G, Colecchia M
Virchows Arch 2021 Apr;478(4):727-734. Epub 2020 Nov 2 doi: 10.1007/s00428-020-02957-8. PMID: 33140129
Grogg JB, Schneider K, Bode PK, Kranzbühler B, Eberli D, Sulser T, Beyer J, Lorch A, Hermanns T, Fankhauser CD
J Cancer Res Clin Oncol 2020 Nov;146(11):2829-2841. Epub 2020 Jul 27 doi: 10.1007/s00432-020-03326-3. PMID: 32719989Free PMC Article
Grogg J, Schneider K, Bode PK, Kranzbühler B, Eberli D, Sulser T, Lorch A, Beyer J, Hermanns T, Fankhauser CD
Oncologist 2020 Jul;25(7):585-590. Epub 2020 Feb 11 doi: 10.1634/theoncologist.2019-0692. PMID: 32043680Free PMC Article
Bozzini G, Ratti D, Carmignani L; en representación de Young Academic Urologists (YAU) Men's Health Group
Actas Urol Esp 2017 Apr;41(3):146-154. Epub 2016 Nov 25 doi: 10.1016/j.acuro.2016.04.014. PMID: 27890492

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