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Pseudomyogenic hemangioendothelioma

MedGen UID:
826097
Concept ID:
C3840252
Neoplastic Process
Synonyms: Pseudomyogenic (epithelioid sarcoma-like) hemangioendothelioma; Pseudomyogenic (Epithelioid Sarcoma-Like) Hemangioendothelioma; Pseudomyogenic Hemangioendothelioma; pseudomyogenic hemangioendothelioma
SNOMED CT: Pseudomyogenic (epithelioid sarcoma-like) hemangioendothelioma (703658006)
 
Monarch Initiative: MONDO:0975754

Definition

An intermediate, rarely metastasizing blood vessel neoplasm that more frequently affects young adult males and usually arises in the lower limbs. In approximately half of the affected patients the tumor is painful and in two-thirds of the patients the tumor is multifocal. Morphologically it is characterized by the presence of sheets and fascicles of spindle cells with abundant eosinophilic cytoplasm and vesicular nuclei. Cytologic atypia is usually mild. Approximately 60% of the patients develop local recurrences or additional tumors in the same anatomic region. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVPseudomyogenic hemangioendothelioma

Professional guidelines

PubMed

Burke AB, Dong C, Chandra SR
Oral Maxillofac Surg Clin North Am 2024 Feb;36(1):93-102. Epub 2023 Oct 29 doi: 10.1016/j.coms.2023.09.004. PMID: 37903662

Recent clinical studies

Etiology

Folpe AL
Hum Pathol 2024 May;147:114-128. Epub 2024 Feb 13 doi: 10.1016/j.humpath.2024.01.014. PMID: 38360216
Warmke LM, Collier CD, Davis JL
Genes Chromosomes Cancer 2023 Nov;62(11):655-662. Epub 2023 Jun 16 doi: 10.1002/gcc.23186. PMID: 37326138
Yang N, Huang Y, Yang P, Yan W, Zhang S, Li N, Feng Z
Diagn Pathol 2023 Feb 20;18(1):25. doi: 10.1186/s13000-023-01309-9. PMID: 36803395Free PMC Article
Schaefer IM, Hornick JL
Adv Anat Pathol 2018 Nov;25(6):400-412. doi: 10.1097/PAP.0000000000000204. PMID: 30134255Free PMC Article
Brooks JS, Lee S
J Surg Oncol 2015 Apr;111(5):513-9. Epub 2015 Feb 17 doi: 10.1002/jso.23853. PMID: 25689920

Diagnosis

Kallen ME, Hornick JL
Am J Surg Pathol 2021 Jan;45(1):e1-e23. doi: 10.1097/PAS.0000000000001552. PMID: 32796172
Caballero GA, Roitman PD
Arch Pathol Lab Med 2020 Apr;144(4):529-533. Epub 2019 Apr 24 doi: 10.5858/arpa.2018-0395-RS. PMID: 31017450
Ansai SI, Morimoto M, Akaishi S
J Nippon Med Sch 2019;86(2):126-130. doi: 10.1272/jnms.JNMS.2019_86-209. PMID: 31130564
Al-Qaderi A, Mansour AT
Arch Pathol Lab Med 2019 Jun;143(6):763-767. Epub 2018 Dec 21 doi: 10.5858/arpa.2017-0430-RS. PMID: 30576238
Horan NA, DiMaio DJ
Cutis 2017 Dec;100(6):E13-E16. PMID: 29360904

Therapy

Brance ML, Cóccaro NM, Roitman P, Castiglioni A, Agostinis F, Spense M, Scheitlin B, Rene N, Brun LR
Arch Osteoporos 2022 Feb 1;17(1):28. doi: 10.1007/s11657-022-01062-4. PMID: 35106633
Pranteda G, Magri F, Muscianese M, Pigliacelli F, D'Arino A, Federico A, Pranteda G, Bartolazzi A
Dermatol Ther 2018 Nov;31(6):e12725. Epub 2018 Sep 21 doi: 10.1111/dth.12725. PMID: 30239066
van IJzendoorn DGP, Sleijfer S, Gelderblom H, Eskens FALM, van Leenders GJLH, Szuhai K, Bovée JVMG
Clin Cancer Res 2018 Jun 1;24(11):2678-2687. Epub 2018 Mar 6 doi: 10.1158/1078-0432.CCR-17-3512. PMID: 29511030
Gabor KM, Sapi Z, Tiszlavicz LG, Fige A, Bereczki C, Bartyik K
Pediatr Blood Cancer 2018 Feb;65(2) Epub 2017 Aug 26 doi: 10.1002/pbc.26781. PMID: 28843050
Sugita S, Hasegawa T
J Orthop Sci 2017 Jul;22(4):601-612. Epub 2017 Mar 6 doi: 10.1016/j.jos.2017.02.004. PMID: 28274512

Prognosis

Yang N, Huang Y, Yang P, Yan W, Zhang S, Li N, Feng Z
Diagn Pathol 2023 Feb 20;18(1):25. doi: 10.1186/s13000-023-01309-9. PMID: 36803395Free PMC Article
Kallen ME, Hornick JL
Am J Surg Pathol 2021 Jan;45(1):e1-e23. doi: 10.1097/PAS.0000000000001552. PMID: 32796172
Caballero GA, Roitman PD
Arch Pathol Lab Med 2020 Apr;144(4):529-533. Epub 2019 Apr 24 doi: 10.5858/arpa.2018-0395-RS. PMID: 31017450
Al-Qaderi A, Mansour AT
Arch Pathol Lab Med 2019 Jun;143(6):763-767. Epub 2018 Dec 21 doi: 10.5858/arpa.2017-0430-RS. PMID: 30576238
Squillaci S, Pitino A, Spairani C, Rassu PC, Chiapuzzo E, Kutzner H
Pathologica 2018 Sep;110(2):96-101. PMID: 30546145

Clinical prediction guides

Yang N, Huang Y, Yang P, Yan W, Zhang S, Li N, Feng Z
Diagn Pathol 2023 Feb 20;18(1):25. doi: 10.1186/s13000-023-01309-9. PMID: 36803395Free PMC Article
Ge Y, Lin X, Zhang F, Xu F, Luo L, Huang W, Liu Z, Liu Y, Li Z
Diagn Pathol 2019 Jul 17;14(1):79. doi: 10.1186/s13000-019-0857-6. PMID: 31311568Free PMC Article
Squillaci S, Pitino A, Spairani C, Rassu PC, Chiapuzzo E, Kutzner H
Pathologica 2018 Sep;110(2):96-101. PMID: 30546145
Pranteda G, Magri F, Muscianese M, Pigliacelli F, D'Arino A, Federico A, Pranteda G, Bartolazzi A
Dermatol Ther 2018 Nov;31(6):e12725. Epub 2018 Sep 21 doi: 10.1111/dth.12725. PMID: 30239066
Schaefer IM, Hornick JL
Adv Anat Pathol 2018 Nov;25(6):400-412. doi: 10.1097/PAP.0000000000000204. PMID: 30134255Free PMC Article

Recent systematic reviews

Brance ML, Cóccaro NM, Roitman P, Castiglioni A, Agostinis F, Spense M, Scheitlin B, Rene N, Brun LR
Arch Osteoporos 2022 Feb 1;17(1):28. doi: 10.1007/s11657-022-01062-4. PMID: 35106633

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