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Small Cell Neuroendocrine Carcinoma

MedGen UID:
82650
•Concept ID:
C0262584
•
Neoplastic Process
Synonyms: Carcinoma, Oat Cell; Carcinoma, Small Cell; Carcinomas, Oat Cell; Carcinomas, Small Cell; Oat Cell Carcinoma; Oat Cell Carcinomas; Small Cell Carcinoma; Small Cell Carcinomas
SNOMED CT: SCC - Small cell carcinoma (74364000); Small cell carcinoma (74364000); Reserve cell carcinoma (74364000); Round cell carcinoma (74364000); Oat cell carcinoma (76817009); Small cell neuroendocrine carcinoma (719105002); Small cell carcinoma (11010461000119101)

Definition

An aggressive, high-grade, and poorly differentiated carcinoma with neuroendocrine differentiation. It is composed of malignant small cells. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVSmall Cell Neuroendocrine Carcinoma

Professional guidelines

PubMed

Recent Advances in the Management of Small Cell Carcinoma of the Uterine Cervix.
Miyoshi AI, Ueda Y, Kurita T, Kimura T, Yoshino K
Anticancer Res 2023 Apr;43(4):1397-1405. doi: 10.21873/anticanres.16288. PMID: 36974776
How phenotype guides management of the neuroendocrine carcinomas of the larynx.
López F, Hunt JL, Nixon IJ, Rinaldo A, Williams MD, Cardesa A, Ferlito A
J Laryngol Otol 2018 Jul;132(7):568-574. Epub 2018 Jun 18 doi: 10.1017/S0022215118000968. PMID: 29909787
Clinical recommendations on the treatment of neuroendocrine carcinoma of the larynx: A meta-analysis of 436 reported cases.
van der Laan TP, Plaat BE, van der Laan BF, Halmos GB
Head Neck 2015 May;37(5):707-15. Epub 2014 Jun 18 doi: 10.1002/hed.23666. PMID: 24596175

Recent clinical studies

Etiology

Small Cell (Neuroendocrine) Carcinoma of the Cervix: An Analysis for 19 Cases and Literature Review.
Lu J, Li Y, Wang J
Front Cell Infect Microbiol 2022;12:916506. Epub 2022 Jul 13 doi: 10.3389/fcimb.2022.916506. PMID: 35909972Free PMC Article
Primary small-cell neuroendocrine carcinoma of the bladder: Case report and literature review.
Olivieri V, Fortunati V, Bellei L, Massarelli M, Ruggiero G, Abate D, Serra N, Griffa D, Forte F, Corongiu E
Arch Ital Urol Androl 2020 Oct 2;92(3) doi: 10.4081/aiua.2020.3.211. PMID: 33016048
Neuroendocrine tumors of genitourinary tract: Recent advances.
Shehabeldin AN, Ro JY
Ann Diagn Pathol 2019 Oct;42:48-58. Epub 2019 Jun 21 doi: 10.1016/j.anndiagpath.2019.06.009. PMID: 31306859
Small cell neuroendocrine carcinoma of nose and paranasal sinuses: The Shaukat Khanum Memorial Cancer Hospital experience and review of literature.
Faisal M, Haider I, Adeel M, Waqas O, Hussain R, Jamshed A
J Pak Med Assoc 2018 Jan;68(1):133-136. PMID: 29371736
Small cell neuroendocrine carcinoma of larynx: case series and literature review.
Iqbal MS, Paleri V, Moor J, Dobrowsky W, Kelly C, Kovarik J
J Laryngol Otol 2015 Sep;129(9):910-5. Epub 2015 Jul 15 doi: 10.1017/S0022215115001668. PMID: 26173932

Diagnosis

Non-squamous Laryngeal Cancer.
MacNeil SD
Otolaryngol Clin North Am 2023 Apr;56(2):345-359. doi: 10.1016/j.otc.2023.01.003. PMID: 37030947
Small Cell (Neuroendocrine) Carcinoma of the Cervix: An Analysis for 19 Cases and Literature Review.
Lu J, Li Y, Wang J
Front Cell Infect Microbiol 2022;12:916506. Epub 2022 Jul 13 doi: 10.3389/fcimb.2022.916506. PMID: 35909972Free PMC Article
Imaging and staging of neuroendocrine cervical cancer.
Elsherif S, Odisio EGLC, Faria S, Javadi S, Yedururi S, Frumovitz M, Ramalingam P, Bhosale P
Abdom Radiol (NY) 2018 Dec;43(12):3468-3478. doi: 10.1007/s00261-018-1667-0. PMID: 29974177
Should patients with laryngeal small cell neuroendocrine carcinoma receive prophylactic cranial irradiation?
Coca-Pelaz A, Devaney KO, Rodrigo JP, Halmos GB, Strojan P, Mendenhall WM, Eisbruch A, Smee R, Kusafuka K, Rinaldo A, Ferlito A
Eur Arch Otorhinolaryngol 2016 Oct;273(10):2925-30. Epub 2015 Nov 3 doi: 10.1007/s00405-015-3799-y. PMID: 26530293
Small cell neuroendocrine carcinoma of larynx: case series and literature review.
Iqbal MS, Paleri V, Moor J, Dobrowsky W, Kelly C, Kovarik J
J Laryngol Otol 2015 Sep;129(9):910-5. Epub 2015 Jul 15 doi: 10.1017/S0022215115001668. PMID: 26173932

Therapy

Small cell neuroendocrine carcinoma of the cervix: From molecular basis to therapeutic advances.
Chao A, Wu RC, Lin CY, Chang TC, Lai CH
Biomed J 2023 Oct;46(5):100633. Epub 2023 Jul 17 doi: 10.1016/j.bj.2023.100633. PMID: 37467967Free PMC Article
Small Cell Neuroendocrine of the Head and Neck: A Rare Presentation and Review of the Literature.
Niforatos S, Sandhu M, Kallem M, Serinelli S, Curtiss C, Akhtar K
J Investig Med High Impact Case Rep 2022 Jan-Dec;10:23247096221127792. doi: 10.1177/23247096221127792. PMID: 36165297Free PMC Article
Pre-existing Castration-resistant Prostate Cancer-like Cells in Primary Prostate Cancer Promote Resistance to Hormonal Therapy.
Cheng Q, Butler W, Zhou Y, Zhang H, Tang L, Perkinson K, Chen X, Jiang XS, McCall SJ, Inman BA, Huang J
Eur Urol 2022 May;81(5):446-455. Epub 2022 Jan 17 doi: 10.1016/j.eururo.2021.12.039. PMID: 35058087Free PMC Article
Systemic therapy in non-conventional cancers of the larynx.
Tan E, Mody MD, Saba NF
Oral Oncol 2018 Jul;82:61-68. Epub 2018 May 26 doi: 10.1016/j.oraloncology.2018.05.005. PMID: 29909903
Small cell carcinoma of the urinary bladder: changing trends in the current literature.
Erdem GU, Özdemir NY, Demirci NS, Şahin S, Bozkaya Y, Zengin N
Curr Med Res Opin 2016 Jun;32(6):1013-21. Epub 2016 Mar 17 doi: 10.1185/03007995.2016.1155982. PMID: 26889739

Prognosis

Non-squamous Laryngeal Cancer.
MacNeil SD
Otolaryngol Clin North Am 2023 Apr;56(2):345-359. doi: 10.1016/j.otc.2023.01.003. PMID: 37030947
Small Cell (Neuroendocrine) Carcinoma of the Cervix: An Analysis for 19 Cases and Literature Review.
Lu J, Li Y, Wang J
Front Cell Infect Microbiol 2022;12:916506. Epub 2022 Jul 13 doi: 10.3389/fcimb.2022.916506. PMID: 35909972Free PMC Article
Pre-existing Castration-resistant Prostate Cancer-like Cells in Primary Prostate Cancer Promote Resistance to Hormonal Therapy.
Cheng Q, Butler W, Zhou Y, Zhang H, Tang L, Perkinson K, Chen X, Jiang XS, McCall SJ, Inman BA, Huang J
Eur Urol 2022 May;81(5):446-455. Epub 2022 Jan 17 doi: 10.1016/j.eururo.2021.12.039. PMID: 35058087Free PMC Article
Reprogramming normal human epithelial tissues to a common, lethal neuroendocrine cancer lineage.
Park JW, Lee JK, Sheu KM, Wang L, Balanis NG, Nguyen K, Smith BA, Cheng C, Tsai BL, Cheng D, Huang J, Kurdistani SK, Graeber TG, Witte ON
Science 2018 Oct 5;362(6410):91-95. doi: 10.1126/science.aat5749. PMID: 30287662Free PMC Article
Small cell neuroendocrine carcinoma of larynx: case series and literature review.
Iqbal MS, Paleri V, Moor J, Dobrowsky W, Kelly C, Kovarik J
J Laryngol Otol 2015 Sep;129(9):910-5. Epub 2015 Jul 15 doi: 10.1017/S0022215115001668. PMID: 26173932

Clinical prediction guides

Radiomics in pulmonary neuroendocrine tumours (NETs).
Cozzi D, Bicci E, Cavigli E, Danti G, Bettarini S, Tortoli P, Mazzoni LN, Busoni S, Pradella S, Miele V
Radiol Med 2022 Jun;127(6):609-615. Epub 2022 May 10 doi: 10.1007/s11547-022-01494-5. PMID: 35538389Free PMC Article
Neuroendocrine Neoplasms of the Larynx: A Clinicopathologic Analysis of 27 Neuroendocrine Tumors and Neuroendocrine Carcinomas.
Bal M, Sharma A, Rane SU, Mittal N, Chaukar D, Prabhash K, Patil A
Head Neck Pathol 2022 Jun;16(2):375-387. Epub 2021 Aug 16 doi: 10.1007/s12105-021-01367-9. PMID: 34401980Free PMC Article
Small-cell neuroendocrine carcinoma of the ileum: case report and literature review.
Lee JE, Hong SH, Jung HI, Son MW, Ahn TS, Han SW, Cho JH
BMC Surg 2019 Sep 12;19(1):135. doi: 10.1186/s12893-019-0591-8. PMID: 31510991Free PMC Article
A clinical analysis of small-cell neuroendocrine carcinoma of the gynecologic tract: report of 20 cases.
He Y, Zhao H, Li XM, Yin CH, Wu YM
Arch Gynecol Obstet 2019 Feb;299(2):543-549. Epub 2018 Nov 8 doi: 10.1007/s00404-018-4960-9. PMID: 30411160
Models of neuroendocrine prostate cancer.
Berman-Booty LD, Knudsen KE
Endocr Relat Cancer 2015 Feb;22(1):R33-49. Epub 2014 Oct 27 doi: 10.1530/ERC-14-0393. PMID: 25349195Free PMC Article

Recent systematic reviews

Diagnostic value of four neuroendocrine markers in small cell neuroendocrine carcinomas of the cervix: a meta-analysis.
Huang R, Yu L, Zheng C, Liang Q, Suye S, Yang X, Yin H, Ren Z, Shi L, Zhang Z, Chen H, Fu C
Sci Rep 2020 Sep 11;10(1):14975. doi: 10.1038/s41598-020-72055-x. PMID: 32917946Free PMC Article
Neuroendocrine cells of prostate cancer: biologic functions and molecular mechanisms.
Huang YH, Zhang YQ, Huang JT
Asian J Androl 2019 May-Jun;21(3):291-295. doi: 10.4103/aja.aja_128_18. PMID: 30924452Free PMC Article
A systematic review and meta-analysis on the attribution of human papillomavirus (HPV) in neuroendocrine cancers of the cervix.
Castle PE, Pierz A, Stoler MH
Gynecol Oncol 2018 Feb;148(2):422-429. Epub 2017 Dec 14 doi: 10.1016/j.ygyno.2017.12.001. PMID: 29248196
Neuroendrocrine tumors of the uterine cervix: A therapeutic challenge for gynecologic oncologists.
Gadducci A, Carinelli S, Aletti G
Gynecol Oncol 2017 Mar;144(3):637-646. Epub 2017 Jan 3 doi: 10.1016/j.ygyno.2016.12.003. PMID: 28057354
Sinonasal small cell neuroendocrine carcinoma: a systematic review of 80 patients.
Rivero A, Liang J
Int Forum Allergy Rhinol 2016 Jul;6(7):744-51. Epub 2016 Feb 16 doi: 10.1002/alr.21734. PMID: 26880574

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