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Small Cell Neuroendocrine Carcinoma

MedGen UID:
82650
•Concept ID:
C0262584
•
Neoplastic Process
Synonyms: Carcinoma, Oat Cell; Carcinoma, Small Cell; Carcinomas, Oat Cell; Carcinomas, Small Cell; Oat Cell Carcinoma; Oat Cell Carcinomas; Small Cell Carcinoma; Small Cell Carcinomas
SNOMED CT: SCC - Small cell carcinoma (74364000); Small cell carcinoma (74364000); Reserve cell carcinoma (74364000); Round cell carcinoma (74364000); Oat cell carcinoma (76817009); Small cell neuroendocrine carcinoma (719105002); Small cell carcinoma (11010461000119101)

Definition

An aggressive, high-grade, and poorly differentiated carcinoma with neuroendocrine differentiation. It is composed of malignant small cells. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVSmall Cell Neuroendocrine Carcinoma

Professional guidelines

PubMed

Recent Advances in the Management of Small Cell Carcinoma of the Uterine Cervix.
Miyoshi AI, Ueda Y, Kurita T, Kimura T, Yoshino K
Anticancer Res 2023 Apr;43(4):1397-1405. doi: 10.21873/anticanres.16288. PMID: 36974776
How phenotype guides management of the neuroendocrine carcinomas of the larynx.
López F, Hunt JL, Nixon IJ, Rinaldo A, Williams MD, Cardesa A, Ferlito A
J Laryngol Otol 2018 Jul;132(7):568-574. Epub 2018 Jun 18 doi: 10.1017/S0022215118000968. PMID: 29909787
Merkel cell carcinoma (primary cutaneous neuroendocrine carcinoma): an overview on management.
Veness MJ
Australas J Dermatol 2006 Aug;47(3):160-5. doi: 10.1111/j.1440-0960.2006.00263.x. PMID: 16866994

Recent clinical studies

Etiology

Small-cell neuroendocrine carcinoma of the female genital tract: A comprehensive overview.
Saraei P, Heshmati A, Hosseini S
J Neuroendocrinol 2024 Jun;36(6):e13394. Epub 2024 Apr 16 doi: 10.1111/jne.13394. PMID: 38626758
Small Cell (Neuroendocrine) Carcinoma of the Cervix: An Analysis for 19 Cases and Literature Review.
Lu J, Li Y, Wang J
Front Cell Infect Microbiol 2022;12:916506. Epub 2022 Jul 13 doi: 10.3389/fcimb.2022.916506. PMID: 35909972Free PMC Article
Small Cell Neuroendocrine Carcinoma of Paranasal Sinuses: Radiologic Features in 14 Cases.
Lin N, Qi M, Wang Z, Luo S, Pan Y, Zhang F, Sha Y
J Comput Assist Tomogr 2021 Jan-Feb 01;45(1):135-141. doi: 10.1097/RCT.0000000000001065. PMID: 32649429Free PMC Article
Neuroendocrine tumors of genitourinary tract: Recent advances.
Shehabeldin AN, Ro JY
Ann Diagn Pathol 2019 Oct;42:48-58. Epub 2019 Jun 21 doi: 10.1016/j.anndiagpath.2019.06.009. PMID: 31306859
Small cell neuroendocrine carcinoma of larynx: case series and literature review.
Iqbal MS, Paleri V, Moor J, Dobrowsky W, Kelly C, Kovarik J
J Laryngol Otol 2015 Sep;129(9):910-5. Epub 2015 Jul 15 doi: 10.1017/S0022215115001668. PMID: 26173932

Diagnosis

Small-cell neuroendocrine carcinoma of the female genital tract: A comprehensive overview.
Saraei P, Heshmati A, Hosseini S
J Neuroendocrinol 2024 Jun;36(6):e13394. Epub 2024 Apr 16 doi: 10.1111/jne.13394. PMID: 38626758
Non-squamous Laryngeal Cancer.
MacNeil SD
Otolaryngol Clin North Am 2023 Apr;56(2):345-359. doi: 10.1016/j.otc.2023.01.003. PMID: 37030947
Small Cell (Neuroendocrine) Carcinoma of the Cervix: An Analysis for 19 Cases and Literature Review.
Lu J, Li Y, Wang J
Front Cell Infect Microbiol 2022;12:916506. Epub 2022 Jul 13 doi: 10.3389/fcimb.2022.916506. PMID: 35909972Free PMC Article
Small-cell neuroendocrine carcinoma of the cervix accompanied by adenocarcinoma and high-grade squamous intraepithelial lesion.
Okabe A, Ishida M, Noda Y, Okano K, Sandoh K, Fukuda H, Kita M, Okada H, Tsuta K
Diagn Cytopathol 2022 Oct;50(10):E285-E288. Epub 2022 Jun 2 doi: 10.1002/dc.24997. PMID: 35652304
Imaging and staging of neuroendocrine cervical cancer.
Elsherif S, Odisio EGLC, Faria S, Javadi S, Yedururi S, Frumovitz M, Ramalingam P, Bhosale P
Abdom Radiol (NY) 2018 Dec;43(12):3468-3478. doi: 10.1007/s00261-018-1667-0. PMID: 29974177

Therapy

Small cell neuroendocrine carcinoma of the cervix: From molecular basis to therapeutic advances.
Chao A, Wu RC, Lin CY, Chang TC, Lai CH
Biomed J 2023 Oct;46(5):100633. Epub 2023 Jul 17 doi: 10.1016/j.bj.2023.100633. PMID: 37467967Free PMC Article
Recent Advances in the Management of Small Cell Carcinoma of the Uterine Cervix.
Miyoshi AI, Ueda Y, Kurita T, Kimura T, Yoshino K
Anticancer Res 2023 Apr;43(4):1397-1405. doi: 10.21873/anticanres.16288. PMID: 36974776
Pre-existing Castration-resistant Prostate Cancer-like Cells in Primary Prostate Cancer Promote Resistance to Hormonal Therapy.
Cheng Q, Butler W, Zhou Y, Zhang H, Tang L, Perkinson K, Chen X, Jiang XS, McCall SJ, Inman BA, Huang J
Eur Urol 2022 May;81(5):446-455. Epub 2022 Jan 17 doi: 10.1016/j.eururo.2021.12.039. PMID: 35058087Free PMC Article
Systemic therapy in non-conventional cancers of the larynx.
Tan E, Mody MD, Saba NF
Oral Oncol 2018 Jul;82:61-68. Epub 2018 May 26 doi: 10.1016/j.oraloncology.2018.05.005. PMID: 29909903
Small cell carcinoma of the urinary bladder: changing trends in the current literature.
Erdem GU, Özdemir NY, Demirci NS, Şahin S, Bozkaya Y, Zengin N
Curr Med Res Opin 2016 Jun;32(6):1013-21. Epub 2016 Mar 17 doi: 10.1185/03007995.2016.1155982. PMID: 26889739

Prognosis

Small cell neuroendocrine carcinoma of the cervix: From molecular basis to therapeutic advances.
Chao A, Wu RC, Lin CY, Chang TC, Lai CH
Biomed J 2023 Oct;46(5):100633. Epub 2023 Jul 17 doi: 10.1016/j.bj.2023.100633. PMID: 37467967Free PMC Article
Non-squamous Laryngeal Cancer.
MacNeil SD
Otolaryngol Clin North Am 2023 Apr;56(2):345-359. doi: 10.1016/j.otc.2023.01.003. PMID: 37030947
Small Cell (Neuroendocrine) Carcinoma of the Cervix: An Analysis for 19 Cases and Literature Review.
Lu J, Li Y, Wang J
Front Cell Infect Microbiol 2022;12:916506. Epub 2022 Jul 13 doi: 10.3389/fcimb.2022.916506. PMID: 35909972Free PMC Article
Pre-existing Castration-resistant Prostate Cancer-like Cells in Primary Prostate Cancer Promote Resistance to Hormonal Therapy.
Cheng Q, Butler W, Zhou Y, Zhang H, Tang L, Perkinson K, Chen X, Jiang XS, McCall SJ, Inman BA, Huang J
Eur Urol 2022 May;81(5):446-455. Epub 2022 Jan 17 doi: 10.1016/j.eururo.2021.12.039. PMID: 35058087Free PMC Article
Reprogramming normal human epithelial tissues to a common, lethal neuroendocrine cancer lineage.
Park JW, Lee JK, Sheu KM, Wang L, Balanis NG, Nguyen K, Smith BA, Cheng C, Tsai BL, Cheng D, Huang J, Kurdistani SK, Graeber TG, Witte ON
Science 2018 Oct 5;362(6410):91-95. doi: 10.1126/science.aat5749. PMID: 30287662Free PMC Article

Clinical prediction guides

Advances in combined neuroendocrine carcinoma of lung cancer.
Han Z, Yang F, Wang F, Zheng H, Chen X, Meng H, Li F
Pathol Oncol Res 2024;30:1611693. Epub 2024 May 14 doi: 10.3389/pore.2024.1611693. PMID: 38807858Free PMC Article
Personalized prognostic prediction tool for high-grade neuroendocrine cervical cancer: a SEER database analysis and single-center validation.
Chen X, Shi W, Wang C, Zhu H
J Cancer Res Clin Oncol 2023 Dec;149(19):17395-17404. Epub 2023 Oct 18 doi: 10.1007/s00432-023-05414-6. PMID: 37853082Free PMC Article
He protec but he also attac - Inflammasomes swinging the sword.
Kattner AA
Biomed J 2023 Oct;46(5):100663. Epub 2023 Sep 28 doi: 10.1016/j.bj.2023.100663. PMID: 37777068Free PMC Article
Small-cell neuroendocrine carcinoma of the ileum: case report and literature review.
Lee JE, Hong SH, Jung HI, Son MW, Ahn TS, Han SW, Cho JH
BMC Surg 2019 Sep 12;19(1):135. doi: 10.1186/s12893-019-0591-8. PMID: 31510991Free PMC Article
Models of neuroendocrine prostate cancer.
Berman-Booty LD, Knudsen KE
Endocr Relat Cancer 2015 Feb;22(1):R33-49. Epub 2014 Oct 27 doi: 10.1530/ERC-14-0393. PMID: 25349195Free PMC Article

Recent systematic reviews

Diagnostic value of four neuroendocrine markers in small cell neuroendocrine carcinomas of the cervix: a meta-analysis.
Huang R, Yu L, Zheng C, Liang Q, Suye S, Yang X, Yin H, Ren Z, Shi L, Zhang Z, Chen H, Fu C
Sci Rep 2020 Sep 11;10(1):14975. doi: 10.1038/s41598-020-72055-x. PMID: 32917946Free PMC Article
Neuroendocrine cells of prostate cancer: biologic functions and molecular mechanisms.
Huang YH, Zhang YQ, Huang JT
Asian J Androl 2019 May-Jun;21(3):291-295. doi: 10.4103/aja.aja_128_18. PMID: 30924452Free PMC Article
A systematic review and meta-analysis on the attribution of human papillomavirus (HPV) in neuroendocrine cancers of the cervix.
Castle PE, Pierz A, Stoler MH
Gynecol Oncol 2018 Feb;148(2):422-429. Epub 2017 Dec 14 doi: 10.1016/j.ygyno.2017.12.001. PMID: 29248196
Neuroendrocrine tumors of the uterine cervix: A therapeutic challenge for gynecologic oncologists.
Gadducci A, Carinelli S, Aletti G
Gynecol Oncol 2017 Mar;144(3):637-646. Epub 2017 Jan 3 doi: 10.1016/j.ygyno.2016.12.003. PMID: 28057354
Sinonasal small cell neuroendocrine carcinoma: a systematic review of 80 patients.
Rivero A, Liang J
Int Forum Allergy Rhinol 2016 Jul;6(7):744-51. Epub 2016 Feb 16 doi: 10.1002/alr.21734. PMID: 26880574

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