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Atypical Squamous Cells of the Cervix

MedGen UID:
827178
Concept ID:
C3850084
Finding
Synonym: Atypical Cervical Squamous Cells

Definition

Morphological abnormalities of the cervical EPITHELIUM, usually revealed in PAP SMEAR, which do not meet the criteria for squamous CERVICAL INTRAEPITHELIAL NEOPLASIA or SQUAMOUS CELL CARCINOMAS of the CERVIX . It may be a sign of infection with certain types of human papillomavirus (HPV).or sign of a benign (not cancer) growth, such as a cyst or polyp or, in menopausal women, of low hormone levels. More testing, such as HPV test, may be needed. [from MeSH]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVAtypical Squamous Cells of the Cervix

Professional guidelines

PubMed

Oliveira GG, Oliveira JMDSC, Eleutério RMN, Barbosa RCC, Almeida PRC, Eleutério J Jr
Acta Cytol 2018;62(5-6):386-392. Epub 2018 Jun 13 doi: 10.1159/000489386. PMID: 29898441

Recent clinical studies

Etiology

Velez Torres JM, Zhao J, Epstein JI, Kryvenko ON
Hum Pathol 2022 Dec;130:110-116. Epub 2022 Oct 14 doi: 10.1016/j.humpath.2022.10.006. PMID: 36244465
Cachay ER, Hasteh F, Mathews WC
AIDS 2022 Mar 1;36(3):409-413. doi: 10.1097/QAD.0000000000003123. PMID: 34750293Free PMC Article
Dyhdalo KS, McMeekin E, Brainard JA, Bruening AE, Underwood D, Chute DJ
J Am Soc Cytopathol 2021 Sep-Oct;10(5):517-524. Epub 2021 May 21 doi: 10.1016/j.jasc.2021.05.004. PMID: 34119449
Sharma P, Gupta P, Gupta N, Suri V, Rajwanshi A
Turk Patoloji Derg 2021;37(1):32-38. doi: 10.5146/tjpath.2020.01505. PMID: 33372263Free PMC Article
Oliveira GG, Oliveira JMDSC, Eleutério RMN, Barbosa RCC, Almeida PRC, Eleutério J Jr
Acta Cytol 2018;62(5-6):386-392. Epub 2018 Jun 13 doi: 10.1159/000489386. PMID: 29898441

Diagnosis

Velez Torres JM, Zhao J, Epstein JI, Kryvenko ON
Hum Pathol 2022 Dec;130:110-116. Epub 2022 Oct 14 doi: 10.1016/j.humpath.2022.10.006. PMID: 36244465
Cachay ER, Hasteh F, Mathews WC
AIDS 2022 Mar 1;36(3):409-413. doi: 10.1097/QAD.0000000000003123. PMID: 34750293Free PMC Article
Dyhdalo KS, McMeekin E, Brainard JA, Bruening AE, Underwood D, Chute DJ
J Am Soc Cytopathol 2021 Sep-Oct;10(5):517-524. Epub 2021 May 21 doi: 10.1016/j.jasc.2021.05.004. PMID: 34119449
Sharma P, Gupta P, Gupta N, Suri V, Rajwanshi A
Turk Patoloji Derg 2021;37(1):32-38. doi: 10.5146/tjpath.2020.01505. PMID: 33372263Free PMC Article
Archondakis S, Roma M, Kaladelfou E
Cytopathology 2021 May;32(3):338-343. Epub 2020 Dec 24 doi: 10.1111/cyt.12948. PMID: 33368677

Therapy

Ittiamornlert P, Jareemit N, Phianpiset R, Kuljarusnont S, Hanamornroongruang S, Horthongkham N, Khajorndumrongcherdkul P, Ruengkhachorn I
Sci Rep 2023 Jul 26;13(1):12134. doi: 10.1038/s41598-023-39206-2. PMID: 37495771Free PMC Article
Palmer M, Katanoda K, Saito E, Acuti Martellucci C, Tanaka S, Ikeda S, Sakamoto H, Machelek D, Ml Brotherton J, Hocking JS
Vaccine 2022 Sep 29;40(41):5971-5996. Epub 2022 Sep 6 doi: 10.1016/j.vaccine.2022.07.052. PMID: 36085257
Honarvar Z, Zarisfi Z, Salari Sedigh S, Masoumi Shahrbabak M
J Obstet Gynaecol 2022 Aug;42(6):2320-2324. Epub 2022 May 17 doi: 10.1080/01443615.2022.2049721. PMID: 35579303
Henao AR, Gómez NEM, Gonzalez-Gómez D, Garcés-Palacio IC
Curr Med Res Opin 2020 Apr;36(4):705-712. Epub 2020 Mar 6 doi: 10.1080/03007995.2020.1729709. PMID: 32049551
Cao X, Liu S, Jia M, Chen H, Zhao D, Dong B, Guo Z, Ren L, Zhang S, Sun X
Anal Cell Pathol (Amst) 2019;2019:4324710. Epub 2019 Dec 16 doi: 10.1155/2019/4324710. PMID: 31934532Free PMC Article

Prognosis

Gonzalez AA, Ametorgoh A, Hamele-Bena D, Everest S, Virk R, Cimic A, Tiscornia-Wasserman P
J Am Soc Cytopathol 2021 Nov-Dec;10(6):565-570. Epub 2021 Jun 17 doi: 10.1016/j.jasc.2021.06.004. PMID: 34246617
Dyhdalo KS, McMeekin E, Brainard JA, Bruening AE, Underwood D, Chute DJ
J Am Soc Cytopathol 2021 Sep-Oct;10(5):517-524. Epub 2021 May 21 doi: 10.1016/j.jasc.2021.05.004. PMID: 34119449
Sharma P, Gupta P, Gupta N, Suri V, Rajwanshi A
Turk Patoloji Derg 2021;37(1):32-38. doi: 10.5146/tjpath.2020.01505. PMID: 33372263Free PMC Article
Oliveira GG, Oliveira JMDSC, Eleutério RMN, Barbosa RCC, Almeida PRC, Eleutério J Jr
Acta Cytol 2018;62(5-6):386-392. Epub 2018 Jun 13 doi: 10.1159/000489386. PMID: 29898441
Gomes de Oliveira G, Eleutério RMN, Silveira Gonçalves AK, Giraldo PC, Eleutério J Jr
Acta Cytol 2018;62(1):28-33. Epub 2017 Nov 8 doi: 10.1159/000481654. PMID: 29130974

Clinical prediction guides

Zago RA, Camilo-Júnior DJ, Pires D'Ávilla SCG, Xavier-Júnior JCC
Eur J Obstet Gynecol Reprod Biol 2023 Oct;289:173-176. Epub 2023 Aug 31 doi: 10.1016/j.ejogrb.2023.08.394. PMID: 37688813
Sheng B, Yao D, Du X, Chen D, Zhou L
Eur J Obstet Gynecol Reprod Biol 2023 Feb;281:1-6. Epub 2022 Dec 6 doi: 10.1016/j.ejogrb.2022.12.005. PMID: 36521399
Jiang W, Austin RM, Zhang H, He Y, Xu L, Wu X, Kuang W, Tong L, Li L, Zhao C
Am J Clin Pathol 2022 Oct 6;158(4):472-479. doi: 10.1093/ajcp/aqac073. PMID: 35849091
Dyhdalo KS, McMeekin E, Brainard JA, Bruening AE, Underwood D, Chute DJ
J Am Soc Cytopathol 2021 Sep-Oct;10(5):517-524. Epub 2021 May 21 doi: 10.1016/j.jasc.2021.05.004. PMID: 34119449
Sharma P, Gupta P, Gupta N, Suri V, Rajwanshi A
Turk Patoloji Derg 2021;37(1):32-38. doi: 10.5146/tjpath.2020.01505. PMID: 33372263Free PMC Article

Recent systematic reviews

Palmer M, Katanoda K, Saito E, Acuti Martellucci C, Tanaka S, Ikeda S, Sakamoto H, Machelek D, Ml Brotherton J, Hocking JS
Vaccine 2022 Sep 29;40(41):5971-5996. Epub 2022 Sep 6 doi: 10.1016/j.vaccine.2022.07.052. PMID: 36085257
Terasawa T, Hosono S, Sasaki S, Hoshi K, Hamashima Y, Katayama T, Hamashima C
Sci Rep 2022 Jan 7;12(1):94. doi: 10.1038/s41598-021-04201-y. PMID: 34997127Free PMC Article
Kyrgiou M, Kalliala I, Mitra A, Ng KY, Raglan O, Fotopoulou C, Martin-Hirsch P, Paraskevaidis E, Arbyn M
Int J Cancer 2017 Jan 1;140(1):216-223. Epub 2016 Oct 12 doi: 10.1002/ijc.30419. PMID: 27603593
Chen CC, Huang LW, Bai CH, Lee CC
Ann Saudi Med 2016 Jul-Aug;36(4):245-51. doi: 10.5144/0256-4947.2016.245. PMID: 27478909Free PMC Article
Kisser A, Zechmeister-Koss I
BJOG 2015 Jan;122(1):64-70. Epub 2014 Sep 11 doi: 10.1111/1471-0528.13076. PMID: 25208923

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