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Nevus anemicus

MedGen UID:
82725
•Concept ID:
C0265982
•
Congenital Abnormality
Synonym: NEVUS ANEMICUS
SNOMED CT: Nevus anemicus et oligemicus (40929003); Nevus oligemicus (40929003); Nevus anemicus (40929003)
 
HPO: HP:0025105
Monarch Initiative: MONDO:0008095
OMIM®: 163050

Definition

A congenital skin lesion characterized by irregular hypopigmented macules that coalesce to form plaques and occur particularly on the chest. It is generally present at birth or develops in the first days of life. It is more common in females. Diagnosis is confirmed by applying gentle friction to the lesion and the surrounding skin and checking that the erythema produced in the healthy skin does not appear in the hypopigmented lesion. This pale macule becomes more conspicuous when the lesion and its surroundings are rubbed. The margin of the naevus is ill-defined and consists of an archipelago of small anemic spots. [from HPO]

Professional guidelines

PubMed

Cutaneous Manifestations not Considered Diagnostic Criteria for Neurofibromatosis Type 1. A Case-Control Study.
García-Martínez FJ, Duat-Rodríguez A, Andrés Esteban E, Torrelo A, Noguera Morel L, Hernández-Martín A
Actas Dermosifiliogr 2022 Nov-Dec;113(10):T923-T929. Epub 2022 Sep 24 doi: 10.1016/j.ad.2022.09.011. PMID: 36162491
Cutaneous Manifestations not Considered Diagnostic Criteria for Neurofibromatosis Type 1. A Case-Control Study.
García-Martínez FJ, Duat-Rodríguez A, Andrés Esteban E, Torrelo A, Noguera Morel L, Hernández-Martín A
Actas Dermosifiliogr 2022 Nov-Dec;113(10):923-929. Epub 2022 May 27 doi: 10.1016/j.ad.2022.05.014. PMID: 35636506

Recent clinical studies

Etiology

Neurofibromatosis Type 1: Diagnostic Timelines in Children.
García-Martínez FJ, Hernández-Martín A
Actas Dermosifiliogr 2023 Mar;114(3):187-193. Epub 2022 Nov 9 doi: 10.1016/j.ad.2022.10.036. PMID: 36370836
Nevus depigmentosus: review of a mark of distinction.
Ullah F, Schwartz RA
Int J Dermatol 2019 Dec;58(12):1366-1370. Epub 2019 Feb 22 doi: 10.1111/ijd.14393. PMID: 30801693
Nevus anemicus: a distinctive cutaneous finding in neurofibromatosis type 1.
Hernández-Martín A, García-Martínez FJ, Duat A, López-Martín I, Noguera-Morel L, Torrelo A
Pediatr Dermatol 2015 May-Jun;32(3):342-7. Epub 2015 Feb 18 doi: 10.1111/pde.12525. PMID: 25690591
Juvenile xanthogranuloma and nevus anemicus in the diagnosis of neurofibromatosis type 1.
Ferrari F, Masurel A, Olivier-Faivre L, Vabres P
JAMA Dermatol 2014 Jan;150(1):42-6. doi: 10.1001/jamadermatol.2013.6434. PMID: 24258576
Nevus anemicus in neurofibromatosis type 1: a potential new diagnostic criterion.
Marque M, Roubertie A, Jaussent A, Carneiro M, Meunier L, Guillot B, Pinson L, Pinson S, Bessis D
J Am Acad Dermatol 2013 Nov;69(5):768-775. Epub 2013 Aug 21 doi: 10.1016/j.jaad.2013.06.039. PMID: 23972508

Diagnosis

Congenital Pigmentary Anomalies in the Newborn.
Habeshian KA, Kirkorian AY
Neoreviews 2021 Oct;22(10):e660-e672. doi: 10.1542/neo.22-10-e660. PMID: 34599064
Nevus depigmentosus: review of a mark of distinction.
Ullah F, Schwartz RA
Int J Dermatol 2019 Dec;58(12):1366-1370. Epub 2019 Feb 22 doi: 10.1111/ijd.14393. PMID: 30801693
Juvenile xanthogranuloma and nevus anemicus in the diagnosis of neurofibromatosis type 1.
Ferrari F, Masurel A, Olivier-Faivre L, Vabres P
JAMA Dermatol 2014 Jan;150(1):42-6. doi: 10.1001/jamadermatol.2013.6434. PMID: 24258576
Nevus anemicus.
Ahkami RN, Schwartz RA
Dermatology 1999;198(4):327-9. doi: 10.1159/000018169. PMID: 10449928
Nevus anemicus.
Mountcastle EA, Diestelmeier MR, Lupton GP
J Am Acad Dermatol 1986 Apr;14(4):628-32. doi: 10.1016/s0190-9622(86)70080-7. PMID: 3007588

Therapy

In vivo reflectance confocal microscopy imaging of vitiligo, nevus depigmentosus and nevus anemicus.
Lai LG, Xu AE
Skin Res Technol 2011 Nov;17(4):404-10. Epub 2011 Mar 24 doi: 10.1111/j.1600-0846.2011.00521.x. PMID: 21429011
Pityriasis alba revisited: perspectives on an enigmatic disorder of childhood.
Jadotte YT, Janniger CK
Cutis 2011 Feb;87(2):66-72. PMID: 21416771
Multiple vascular anomalies: report of a case.
Ratz JL, Roenigk HH Jr
J Dermatol Surg Oncol 1978 Sep;4(9):684-6. doi: 10.1111/j.1524-4725.1978.tb00526.x. PMID: 701589
Nevus anemicus.
Fleisher TL, Zeligman I
Arch Dermatol 1969 Dec;100(6):750-5. PMID: 4188989

Prognosis

Cutaneous Manifestations not Considered Diagnostic Criteria for Neurofibromatosis Type 1. A Case-Control Study.
García-Martínez FJ, Duat-Rodríguez A, Andrés Esteban E, Torrelo A, Noguera Morel L, Hernández-Martín A
Actas Dermosifiliogr 2022 Nov-Dec;113(10):T923-T929. Epub 2022 Sep 24 doi: 10.1016/j.ad.2022.09.011. PMID: 36162491
Cutaneous Manifestations not Considered Diagnostic Criteria for Neurofibromatosis Type 1. A Case-Control Study.
García-Martínez FJ, Duat-Rodríguez A, Andrés Esteban E, Torrelo A, Noguera Morel L, Hernández-Martín A
Actas Dermosifiliogr 2022 Nov-Dec;113(10):923-929. Epub 2022 May 27 doi: 10.1016/j.ad.2022.05.014. PMID: 35636506
Phakomatosis pigmentovascularis type IIb in association with external hydrocephalus.
Okunola P, Ofovwe G, Abiodun M, Isah A, Ikubor J
BMJ Case Rep 2012 Jun 25;2012 doi: 10.1136/bcr.12.2011.5432. PMID: 22736785Free PMC Article
Pityriasis alba revisited: perspectives on an enigmatic disorder of childhood.
Jadotte YT, Janniger CK
Cutis 2011 Feb;87(2):66-72. PMID: 21416771

Clinical prediction guides

Neurofibromatosis Type 1: Diagnostic Timelines in Children.
García-Martínez FJ, Hernández-Martín A
Actas Dermosifiliogr 2023 Mar;114(3):187-193. Epub 2022 Nov 9 doi: 10.1016/j.ad.2022.10.036. PMID: 36370836
Cutaneous Manifestations not Considered Diagnostic Criteria for Neurofibromatosis Type 1. A Case-Control Study.
García-Martínez FJ, Duat-Rodríguez A, Andrés Esteban E, Torrelo A, Noguera Morel L, Hernández-Martín A
Actas Dermosifiliogr 2022 Nov-Dec;113(10):923-929. Epub 2022 May 27 doi: 10.1016/j.ad.2022.05.014. PMID: 35636506
Nevus Anemicus As an Additional Diagnostic Marker of Neurofibromatosis Type 1 in Childhood.
Vaassen P, Rosenbaum T
Neuropediatrics 2016 Jun;47(3):190-3. Epub 2016 Mar 28 doi: 10.1055/s-0036-1579786. PMID: 27019377
Nevus anemicus: a distinctive cutaneous finding in neurofibromatosis type 1.
Hernández-Martín A, García-Martínez FJ, Duat A, López-Martín I, Noguera-Morel L, Torrelo A
Pediatr Dermatol 2015 May-Jun;32(3):342-7. Epub 2015 Feb 18 doi: 10.1111/pde.12525. PMID: 25690591
Juvenile xanthogranuloma and nevus anemicus in the diagnosis of neurofibromatosis type 1.
Ferrari F, Masurel A, Olivier-Faivre L, Vabres P
JAMA Dermatol 2014 Jan;150(1):42-6. doi: 10.1001/jamadermatol.2013.6434. PMID: 24258576

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