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Epulis

MedGen UID:
82751
•Concept ID:
C0266919
•
Disease or Syndrome
Synonym: Epulides
SNOMED CT: Epulis (71708001); Localized gingival enlargement (45676007); Epulis (45676007); Gingival polyp (45676007)
 
Monarch Initiative: MONDO:0003396

Definition

A non-neoplastic nodular lesion that arises from the gingiva. [from NCI]

Professional guidelines

PubMed

Congenital Epulis: Diagnosis and Management.
Lim KH, Toner MB, Millar D, Jackson C
Ulster Med J 2023 Jan;92(1):16-18. Epub 2023 Jan 6 PMID: 36762132Free PMC Article
Histopathological analysis of the differential diagnosis of peripheral odontogenic fibroma from fibrous epulis.
Manabe K, Yakeishi M, Sakaguchi W, Saruta J, Tsukinoki K
J Oral Biosci 2019 Dec;61(4):221-225. Epub 2019 Oct 25 doi: 10.1016/j.job.2019.10.003. PMID: 31669716
New treatment strategy for granulomatous epulis: intralesional injection of propranolol.
Liu C, Qin ZP, Fan ZN, Zhao WJ, Wang YM, Wei FC, Li KL, Liu SH
Med Hypotheses 2012 Feb;78(2):327-9. Epub 2011 Nov 30 doi: 10.1016/j.mehy.2011.11.013. PMID: 22133559

Recent clinical studies

Etiology

Clinical and pathological analysis of congenital granular cell tumor.
Zheng C, Su J, Liang X, Wu J, Gu W, Zhao X
Hua Xi Kou Qiang Yi Xue Za Zhi 2022 Dec 1;40(6):710-715. doi: 10.7518/hxkq.2022.06.013. PMID: 36416325Free PMC Article
Bleeding epulis gravidarum: what to evaluate?
Iorio GG, Carbone L, Donadono V, Rovetto MY, Sarno L, Saccone G, Mazzarelli LL, Sirico A, Esposito G, Buonfantino C, DI Girolamo R, Arduino B, D'Alessandro P, Maruotti GM
Minerva Obstet Gynecol 2022 Apr;74(2):171-177. doi: 10.23736/S2724-606X.21.04960-5. PMID: 35421917
PCR array analysis identified hyperproliferation but not autophagy or apoptosis in fibrous epulis.
Jiang Y, Fang B, Xu B
J Clin Lab Anal 2021 Jun;35(6):e23784. Epub 2021 May 2 doi: 10.1002/jcla.23784. PMID: 33934404Free PMC Article
Periodontal health and gingival diseases and conditions on an intact and a reduced periodontium: Consensus report of workgroup 1 of the 2017 World Workshop on the Classification of Periodontal and Peri-Implant Diseases and Conditions.
Chapple ILC, Mealey BL, Van Dyke TE, Bartold PM, Dommisch H, Eickholz P, Geisinger ML, Genco RJ, Glogauer M, Goldstein M, Griffin TJ, Holmstrup P, Johnson GK, Kapila Y, Lang NP, Meyle J, Murakami S, Plemons J, Romito GA, Shapira L, Tatakis DN, Teughels W, Trombelli L, Walter C, Wimmer G, Xenoudi P, Yoshie H
J Periodontol 2018 Jun;89 Suppl 1:S74-S84. doi: 10.1002/JPER.17-0719. PMID: 29926944
Periodontal health and gingival diseases and conditions on an intact and a reduced periodontium: Consensus report of workgroup 1 of the 2017 World Workshop on the Classification of Periodontal and Peri-Implant Diseases and Conditions.
Chapple ILC, Mealey BL, Van Dyke TE, Bartold PM, Dommisch H, Eickholz P, Geisinger ML, Genco RJ, Glogauer M, Goldstein M, Griffin TJ, Holmstrup P, Johnson GK, Kapila Y, Lang NP, Meyle J, Murakami S, Plemons J, Romito GA, Shapira L, Tatakis DN, Teughels W, Trombelli L, Walter C, Wimmer G, Xenoudi P, Yoshie H
J Clin Periodontol 2018 Jun;45 Suppl 20:S68-S77. doi: 10.1111/jcpe.12940. PMID: 29926499

Diagnosis

Odontogenic and Developmental Oral Lesions in Pediatric Patients.
Bilodeau EA, Hunter KD
Head Neck Pathol 2021 Mar;15(1):71-84. Epub 2021 Mar 15 doi: 10.1007/s12105-020-01284-3. PMID: 33723756Free PMC Article
Non-plaque-induced gingival diseases.
Holmstrup P, Plemons J, Meyle J
J Periodontol 2018 Jun;89 Suppl 1:S28-S45. doi: 10.1002/JPER.17-0163. PMID: 29926945
Periodontal health and gingival diseases and conditions on an intact and a reduced periodontium: Consensus report of workgroup 1 of the 2017 World Workshop on the Classification of Periodontal and Peri-Implant Diseases and Conditions.
Chapple ILC, Mealey BL, Van Dyke TE, Bartold PM, Dommisch H, Eickholz P, Geisinger ML, Genco RJ, Glogauer M, Goldstein M, Griffin TJ, Holmstrup P, Johnson GK, Kapila Y, Lang NP, Meyle J, Murakami S, Plemons J, Romito GA, Shapira L, Tatakis DN, Teughels W, Trombelli L, Walter C, Wimmer G, Xenoudi P, Yoshie H
J Periodontol 2018 Jun;89 Suppl 1:S74-S84. doi: 10.1002/JPER.17-0719. PMID: 29926944
Periodontal health and gingival diseases and conditions on an intact and a reduced periodontium: Consensus report of workgroup 1 of the 2017 World Workshop on the Classification of Periodontal and Peri-Implant Diseases and Conditions.
Chapple ILC, Mealey BL, Van Dyke TE, Bartold PM, Dommisch H, Eickholz P, Geisinger ML, Genco RJ, Glogauer M, Goldstein M, Griffin TJ, Holmstrup P, Johnson GK, Kapila Y, Lang NP, Meyle J, Murakami S, Plemons J, Romito GA, Shapira L, Tatakis DN, Teughels W, Trombelli L, Walter C, Wimmer G, Xenoudi P, Yoshie H
J Clin Periodontol 2018 Jun;45 Suppl 20:S68-S77. doi: 10.1111/jcpe.12940. PMID: 29926499
Non-plaque-induced gingival diseases.
Holmstrup P, Plemons J, Meyle J
J Clin Periodontol 2018 Jun;45 Suppl 20:S28-S43. doi: 10.1111/jcpe.12938. PMID: 29926497

Therapy

Bleeding epulis gravidarum: what to evaluate?
Iorio GG, Carbone L, Donadono V, Rovetto MY, Sarno L, Saccone G, Mazzarelli LL, Sirico A, Esposito G, Buonfantino C, DI Girolamo R, Arduino B, D'Alessandro P, Maruotti GM
Minerva Obstet Gynecol 2022 Apr;74(2):171-177. doi: 10.23736/S2724-606X.21.04960-5. PMID: 35421917
Role of prenatal imaging in the diagnosis and management of fetal facio-cervical masses.
Zheng W, Gai S, Qin J, Qiu F, Li B, Zou Y
Sci Rep 2021 Jan 14;11(1):1385. doi: 10.1038/s41598-021-80976-4. PMID: 33446872Free PMC Article
The clinical application of partial removal periodontal surgery in the therapy of epulis.
Zhu Y, Zhang H, Li C
Medicine (Baltimore) 2019 Jul;98(27):e16107. doi: 10.1097/MD.0000000000016107. PMID: 31277111Free PMC Article
Sclerotherapy for the recurrent granulomatous epulis with pingyangmycin.
Cai Y, Sun R, He KF, Zhao YF, Zhao JH
Med Oral Patol Oral Cir Bucal 2017 Mar 1;22(2):e214-e218. doi: 10.4317/medoral.21422. PMID: 28160580Free PMC Article
MAGE-A antigens in lesions of the oral mucosa.
Krauss E, Rauthe S, Gattenlöhner S, Reuther T, Kochel M, Kriegebaum U, Kübler AC, Müller-Richter UD
Clin Oral Investig 2011 Jun;15(3):315-20. Epub 2010 Feb 20 doi: 10.1007/s00784-010-0387-9. PMID: 20174843

Prognosis

Clinical and pathological analysis of congenital granular cell tumor.
Zheng C, Su J, Liang X, Wu J, Gu W, Zhao X
Hua Xi Kou Qiang Yi Xue Za Zhi 2022 Dec 1;40(6):710-715. doi: 10.7518/hxkq.2022.06.013. PMID: 36416325Free PMC Article
Odontogenic and Developmental Oral Lesions in Pediatric Patients.
Bilodeau EA, Hunter KD
Head Neck Pathol 2021 Mar;15(1):71-84. Epub 2021 Mar 15 doi: 10.1007/s12105-020-01284-3. PMID: 33723756Free PMC Article
Congenital epulis.
Lapid O, Shaco-Levy R, Krieger Y, Kachko L, Sagi A
Pediatrics 2001 Feb;107(2):E22. doi: 10.1542/peds.107.2.e22. PMID: 11158496
Granular cell tumors.
Kershisnik M, Batsakis JG, Mackay B
Ann Otol Rhinol Laryngol 1994 May;103(5 Pt 1):416-9. doi: 10.1177/000348949410300514. PMID: 8179261
Congenital epulis.
Subramaniam R, Shah R, Kapur V
J Postgrad Med 1993 Jan-Mar;39(1):36. PMID: 8295145

Clinical prediction guides

Prenatal diagnosis and multidisciplinary management: a case report of congenital granular cell epulis and literature review.
Ye Y, Tang R, Liu B, Li Y, Mo Y, Zhang Y
J Int Med Res 2021 Oct;49(10):3000605211053769. doi: 10.1177/03000605211053769. PMID: 34719988Free PMC Article
A New Look at the History of Peripheral Ameloblastoma.
Ide F, Ito Y, Miyazaki Y, Nishimura M, Kusama K, Kikuchi K
Head Neck Pathol 2020 Dec;14(4):1052-1057. Epub 2020 May 25 doi: 10.1007/s12105-020-01168-6. PMID: 32451874Free PMC Article
Comparsion of staining characteristics of Toto bodies.
Padala SS, Kiresur MA, Ananthaneni A, Guduru VS, Puneeth HK, Bhavana B
Biotech Histochem 2018;93(5):336-339. Epub 2018 May 21 doi: 10.1080/10520295.2018.1441441. PMID: 29781718
A report on the clinical-pathological correlations of 788 gingival lesion.
Gambino A, Carbone M, Broccoletti R, Carcieri P, Conrotto D, Carrozzo M, Arduino PG
Med Oral Patol Oral Cir Bucal 2017 Nov 1;22(6):e686-e693. doi: 10.4317/medoral.21845. PMID: 29053652Free PMC Article
Congenital granular cell epulis.
Conrad R, Perez MC
Arch Pathol Lab Med 2014 Jan;138(1):128-31. doi: 10.5858/arpa.2012-0306-RS. PMID: 24377822

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