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Typhlitis

MedGen UID:
82756
•Concept ID:
C0267537
•
Disease or Syndrome
Synonym: Cecitis
SNOMED CT: Typhlitis (61564002); Cecitis (61564002)

Definition

Inflammation of the cecum, usually accompanied by neutropenia. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVTyphlitis

Professional guidelines

PubMed

Clostridium difficile colitis: CT findings and differential diagnosis.
Guerri S, Danti G, Frezzetti G, Lucarelli E, Pradella S, Miele V
Radiol Med 2019 Dec;124(12):1185-1198. Epub 2019 Jul 13 doi: 10.1007/s11547-019-01066-0. PMID: 31302848
Surgical management of complications of multimodal therapy.
Chui CH
Pediatr Blood Cancer 2012 Aug;59(2):405-9. Epub 2012 Mar 20 doi: 10.1002/pbc.24147. PMID: 22434785
Management of uncommon chemotherapy-induced emergencies.
Morgan C, Tillett T, Braybrooke J, Ajithkumar T
Lancet Oncol 2011 Aug;12(8):806-14. Epub 2011 Jan 26 doi: 10.1016/S1470-2045(10)70208-4. PMID: 21276754

Recent clinical studies

Etiology

Supportive care in pediatric acute myeloid leukemia:Expert-based recommendations of the NOPHO-DB-SHIP consortium.
Arad-Cohen N, Zeller B, Abrahamsson J, Fernandez Navarro JM, Cheuk D, Palmu S, Costa V, De Moerloose B, Hasle H, Jahnukainen K, Pronk CJ, Gísli Jónsson Ó, Kovalova Z, Lausen B, Munthe-Kaas M, Noren-Nyström U, Palle J, Pasauliene R, Saks K, Kaspers GJ
Expert Rev Anticancer Ther 2022 Nov;22(11):1183-1196. Epub 2022 Oct 28 doi: 10.1080/14737140.2022.2131544. PMID: 36191604
Investigation of typhlitis in bone marrow transplant patients in a stem cell transplant unit.
Deveci B, Kublashvili G, Yilmaz S, Özcan B, Korkmaz HF, Gürsoy O, Toptaş T, Döşemeci L, Saba R
Medicine (Baltimore) 2022 Aug 26;101(34):e30104. doi: 10.1097/MD.0000000000030104. PMID: 36042636Free PMC Article
Neutropenic enterocolitis.
Cloutier RL
Emerg Med Clin North Am 2009 Aug;27(3):415-22. doi: 10.1016/j.emc.2009.04.002. PMID: 19646645
Neutropenic enterocolitis.
Davila ML
Curr Opin Gastroenterol 2006 Jan;22(1):44-7. doi: 10.1097/01.mog.0000198073.14169.3b. PMID: 16319675
Typhlitis in childhood cancer.
McCarville MB, Adelman CS, Li C, Xiong X, Furman WL, Razzouk BI, Pui CH, Sandlund JT
Cancer 2005 Jul 15;104(2):380-7. doi: 10.1002/cncr.21134. PMID: 15952190

Diagnosis

Pediatric Hematologic and Oncologic Emergencies.
Stephanos K, Dubbs SB
Emerg Med Clin North Am 2021 Aug;39(3):555-571. Epub 2021 Jun 9 doi: 10.1016/j.emc.2021.04.007. PMID: 34215402
Ultrasound diagnosis of typhlitis.
Tamburrini S, Setola FR, Belfiore MP, Saturnino PP, Della Casa MG, Sarti G, Abete R, Marano I
J Ultrasound 2019 Mar;22(1):103-106. Epub 2018 Oct 27 doi: 10.1007/s40477-018-0333-2. PMID: 30367357Free PMC Article
Pediatric Oncologic Emergencies.
Stephanos K, Picard L
Emerg Med Clin North Am 2018 Aug;36(3):527-535. Epub 2018 Jun 11 doi: 10.1016/j.emc.2018.04.007. PMID: 30037439
Neutropenic enterocolitis.
Rodrigues FG, Dasilva G, Wexner SD
World J Gastroenterol 2017 Jan 7;23(1):42-47. doi: 10.3748/wjg.v23.i1.42. PMID: 28104979Free PMC Article
Typhlitis.
Urbach DR, Rotstein OD
Can J Surg 1999 Dec;42(6):415-9. PMID: 10593241Free PMC Article

Therapy

Pediatric Hematologic and Oncologic Emergencies.
Stephanos K, Dubbs SB
Emerg Med Clin North Am 2021 Aug;39(3):555-571. Epub 2021 Jun 9 doi: 10.1016/j.emc.2021.04.007. PMID: 34215402
Ultrasound diagnosis of typhlitis.
Tamburrini S, Setola FR, Belfiore MP, Saturnino PP, Della Casa MG, Sarti G, Abete R, Marano I
J Ultrasound 2019 Mar;22(1):103-106. Epub 2018 Oct 27 doi: 10.1007/s40477-018-0333-2. PMID: 30367357Free PMC Article
Neutropenic enterocolitis.
Rodrigues FG, Dasilva G, Wexner SD
World J Gastroenterol 2017 Jan 7;23(1):42-47. doi: 10.3748/wjg.v23.i1.42. PMID: 28104979Free PMC Article
Neutropenic enterocolitis.
Cloutier RL
Emerg Med Clin North Am 2009 Aug;27(3):415-22. doi: 10.1016/j.emc.2009.04.002. PMID: 19646645
Neutropenic enterocolitis.
Davila ML
Curr Opin Gastroenterol 2006 Jan;22(1):44-7. doi: 10.1097/01.mog.0000198073.14169.3b. PMID: 16319675

Prognosis

Pediatric Hematologic and Oncologic Emergencies.
Stephanos K, Dubbs SB
Emerg Med Clin North Am 2021 Aug;39(3):555-571. Epub 2021 Jun 9 doi: 10.1016/j.emc.2021.04.007. PMID: 34215402
Ultrasound diagnosis of typhlitis.
Tamburrini S, Setola FR, Belfiore MP, Saturnino PP, Della Casa MG, Sarti G, Abete R, Marano I
J Ultrasound 2019 Mar;22(1):103-106. Epub 2018 Oct 27 doi: 10.1007/s40477-018-0333-2. PMID: 30367357Free PMC Article
Pediatric Oncologic Emergencies.
Stephanos K, Picard L
Emerg Med Clin North Am 2018 Aug;36(3):527-535. Epub 2018 Jun 11 doi: 10.1016/j.emc.2018.04.007. PMID: 30037439
Neutropenic enterocolitis.
Davila ML
Curr Opin Gastroenterol 2006 Jan;22(1):44-7. doi: 10.1097/01.mog.0000198073.14169.3b. PMID: 16319675
Typhlitis.
Urbach DR, Rotstein OD
Can J Surg 1999 Dec;42(6):415-9. PMID: 10593241Free PMC Article

Clinical prediction guides

Automated Ascertainment of Typhlitis From the Electronic Health Record.
Miller TP, Li Y, Masino AJ, Vallee E, Burrows E, Ramos M, Alonzo TA, Gerbing R, Castellino SM, Hawkins DS, Lash TL, Aplenc R, Grundmeier RW
JCO Clin Cancer Inform 2022 Sep;6:e2200081. doi: 10.1200/CCI.22.00081. PMID: 36198128Free PMC Article
Investigation of typhlitis in bone marrow transplant patients in a stem cell transplant unit.
Deveci B, Kublashvili G, Yilmaz S, Özcan B, Korkmaz HF, Gürsoy O, Toptaş T, Döşemeci L, Saba R
Medicine (Baltimore) 2022 Aug 26;101(34):e30104. doi: 10.1097/MD.0000000000030104. PMID: 36042636Free PMC Article
A surgeon's predicament: Clinical predictors of surgery and mortality in neutropenic enterocolitis.
Shahi N, Kaizer A, Stevens J, Phillips R, Acker SN, Choi YM, Shirek G, Bensard D, Bruny J, Dannull K, Moulton SL
J Pediatr Surg 2022 Mar;57(3):443-449. Epub 2021 Sep 4 doi: 10.1016/j.jpedsurg.2021.08.015. PMID: 34635341
Baseline Gut Microbiota Composition Is Associated with Major Infections Early after Hematopoietic Cell Transplantation.
Murthy HS, Gharaibeh RZ, Al-Mansour Z, Kozlov A, Trikha G, Newsome RC, Gauthier J, Farhadfar N, Wang Y, Kelly DL, Lybarger J, Jobin C, Wang GP, Wingard JR
Biol Blood Marrow Transplant 2020 Nov;26(11):2001-2010. Epub 2020 Jul 24 doi: 10.1016/j.bbmt.2020.07.023. PMID: 32717434
Significance of appendiceal thickening in association with typhlitis in pediatric oncology patients.
McCarville MB, Thompson J, Li C, Adelman CS, Lee MO, Alsammarae D, May MV, Jones SC, Rao BN, Sandlund JT
Pediatr Radiol 2004 Mar;34(3):245-9. Epub 2004 Jan 14 doi: 10.1007/s00247-003-1122-3. PMID: 14722695

Recent systematic reviews

Neutropenic Enterocolitis and Sepsis: Towards the Definition of a Pathologic Profile.
Bertozzi G, Maiese A, Passaro G, Tosoni A, Mirijello A, Simone S, Baldari B, Cipolloni L, La Russa R
Medicina (Kaunas) 2021 Jun 20;57(6) doi: 10.3390/medicina57060638. PMID: 34203105Free PMC Article

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