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Senile dementia

MedGen UID:
8279
•Concept ID:
C0011268
•
Mental or Behavioral Dysfunction
Synonyms: SD - Senile dementia; Senile Dementia
SNOMED CT: SD - Senile dementia (15662003); Senile dementia (15662003)

Definition

Loss of intellectual abilities in an elderly person, interfering with this person''s activities. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVSenile dementia

Professional guidelines

PubMed

Alzheimer's disease: Molecular aspects and treatment opportunities using herbal drugs.
Thakral S, Yadav A, Singh V, Kumar M, Kumar P, Narang R, Sudhakar K, Verma A, Khalilullah H, Jaremko M, Emwas AH
Ageing Res Rev 2023 Jul;88:101960. Epub 2023 May 22 doi: 10.1016/j.arr.2023.101960. PMID: 37224884
Inflammatory Processes in Alzheimer's Disease-Pathomechanism, Diagnosis and Treatment: A Review.
Twarowski B, Herbet M
Int J Mol Sci 2023 Mar 30;24(7) doi: 10.3390/ijms24076518. PMID: 37047492Free PMC Article
The Role of Berberine in the Multi-Target Treatment of Senile Dementia.
Huang M, Chen S, Liang Y, Guo Y
Curr Top Med Chem 2016;16(8):867-73. doi: 10.2174/1568026615666150827095433. PMID: 26311424

Recent clinical studies

Etiology

An evidence-based review of neuronal cholesterol role in dementia and statins as a pharmacotherapy in reducing risk of dementia.
Dutta S, Rahman S, Ahmad R, Kumar T, Dutta G, Banerjee S, Abubakar AR, Rowaiye AB, Dhingra S, Ravichandiran V, Kumar S, Sharma P, Haque M, Charan J
Expert Rev Neurother 2021 Dec;21(12):1455-1472. Epub 2021 Nov 29 doi: 10.1080/14737175.2021.2003705. PMID: 34756134
Alzheimer's Disease: Genomics and Beyond.
Song F, Han G, Bai Z, Peng X, Wang J, Lei H
Int Rev Neurobiol 2015;121:1-24. Epub 2015 Jun 19 doi: 10.1016/bs.irn.2015.05.001. PMID: 26315760
The pathology of paraphrenia.
Casanova MF
Curr Psychiatry Rep 2010 Jun;12(3):196-201. doi: 10.1007/s11920-010-0108-8. PMID: 20425280
Vascular dementia today.
Román GC
Rev Neurol (Paris) 1999;155 Suppl 4:S64-72. PMID: 10637940
Dementias.
Katzman R
Postgrad Med 1978 Aug;64(2):119-25. doi: 10.1080/00325481.1978.11714904. PMID: 757996

Diagnosis

Inflammatory Processes in Alzheimer's Disease-Pathomechanism, Diagnosis and Treatment: A Review.
Twarowski B, Herbet M
Int J Mol Sci 2023 Mar 30;24(7) doi: 10.3390/ijms24076518. PMID: 37047492Free PMC Article
Aging and Alzheimer's disease pathology.
Sengoku R
Neuropathology 2020 Feb;40(1):22-29. Epub 2019 Dec 21 doi: 10.1111/neup.12626. PMID: 31863504
Avicenna (980-1037 CE) and his Early Description and Classification of Dementia.
Taheri-Targhi S, Gjedde A, Araj-Khodaei M, Rikhtegar R, Parsian Z, Zarrintan S, Torbati M, Vafaee MS
J Alzheimers Dis 2019;71(4):1093-1098. doi: 10.3233/JAD-190345. PMID: 31524162
History of Dementia.
Assal F
Front Neurol Neurosci 2019;44:118-126. Epub 2019 Apr 30 doi: 10.1159/000494959. PMID: 31220848
Dementias.
Katzman R
Postgrad Med 1978 Aug;64(2):119-25. doi: 10.1080/00325481.1978.11714904. PMID: 757996

Therapy

The Neuroprotective Potentiality of Flavonoids on Alzheimer's Disease.
Calderaro A, Patanè GT, Tellone E, Barreca D, Ficarra S, Misiti F, Laganà G
Int J Mol Sci 2022 Nov 27;23(23) doi: 10.3390/ijms232314835. PMID: 36499159Free PMC Article
The Role of Berberine in the Multi-Target Treatment of Senile Dementia.
Huang M, Chen S, Liang Y, Guo Y
Curr Top Med Chem 2016;16(8):867-73. doi: 10.2174/1568026615666150827095433. PMID: 26311424
Kampo formulations, chotosan, and yokukansan, for dementia therapy: existing clinical and preclinical evidence.
Matsumoto K, Zhao Q, Niu Y, Fujiwara H, Tanaka K, Sasaki-Hamada S, Oka J
J Pharmacol Sci 2013;122(4):257-69. Epub 2013 Jul 25 doi: 10.1254/jphs.13r03cr. PMID: 23883485
Naftidrofuryl for dementia.
Lu D, Song H, Hao Z, Wu T, McCleery J
Cochrane Database Syst Rev 2011 Dec 7;(12):CD002955. doi: 10.1002/14651858.CD002955.pub4. PMID: 22161372
Formaldehyde stress.
He R, Lu J, Miao J
Sci China Life Sci 2010 Dec;53(12):1399-404. Epub 2010 Dec 23 doi: 10.1007/s11427-010-4112-3. PMID: 21181340

Prognosis

Integrated Positron Emission Tomography/Magnetic Resonance Imaging in clinical diagnosis of Alzheimer's disease.
Gao F
Eur J Radiol 2021 Dec;145:110017. Epub 2021 Nov 3 doi: 10.1016/j.ejrad.2021.110017. PMID: 34826792
Aging and Alzheimer's disease pathology.
Sengoku R
Neuropathology 2020 Feb;40(1):22-29. Epub 2019 Dec 21 doi: 10.1111/neup.12626. PMID: 31863504
Can the retina be used to diagnose and plot the progression of Alzheimer's disease?
Mahajan D, Votruba M
Acta Ophthalmol 2017 Dec;95(8):768-777. Epub 2017 Jun 9 doi: 10.1111/aos.13472. PMID: 29220126
Molecular and Cellular Basis of Neurodegeneration in Alzheimer's Disease.
Jeong S
Mol Cells 2017 Sep 30;40(9):613-620. Epub 2017 Sep 20 doi: 10.14348/molcells.2017.0096. PMID: 28927263Free PMC Article
Dementia: classification and aspects of treatment.
Gottfries CG
Psychopharmacol Ser 1988;5:187-95. doi: 10.1007/978-3-642-73280-5_18. PMID: 3045800

Clinical prediction guides

Macroscopic findings of brain with dementia.
Hashizume Y
Neuropathology 2022 Oct;42(5):353-366. Epub 2022 Apr 21 doi: 10.1111/neup.12785. PMID: 35451141
Integrated Positron Emission Tomography/Magnetic Resonance Imaging in clinical diagnosis of Alzheimer's disease.
Gao F
Eur J Radiol 2021 Dec;145:110017. Epub 2021 Nov 3 doi: 10.1016/j.ejrad.2021.110017. PMID: 34826792
Aging and Alzheimer's disease pathology.
Sengoku R
Neuropathology 2020 Feb;40(1):22-29. Epub 2019 Dec 21 doi: 10.1111/neup.12626. PMID: 31863504
Vitamin D basis of Alzheimer's disease: from genetics to biomarkers.
Dursun E, Gezen-Ak D
Hormones (Athens) 2019 Mar;18(1):7-15. Epub 2018 Nov 27 doi: 10.1007/s42000-018-0086-5. PMID: 30484096
Molecular and Cellular Basis of Neurodegeneration in Alzheimer's Disease.
Jeong S
Mol Cells 2017 Sep 30;40(9):613-620. Epub 2017 Sep 20 doi: 10.14348/molcells.2017.0096. PMID: 28927263Free PMC Article

Recent systematic reviews

Can the retina be used to diagnose and plot the progression of Alzheimer's disease?
Mahajan D, Votruba M
Acta Ophthalmol 2017 Dec;95(8):768-777. Epub 2017 Jun 9 doi: 10.1111/aos.13472. PMID: 29220126
Oral Chinese herbal medicine for kidney nourishment in Alzheimer's disease: a systematic review of the effect on MMSE index measures and safety.
Zeng LF, Wang NS, Wang Q, Zou YP, Liang ZH, Kong LS, Wu HT, Liao NY, Liang XW, Mo YS
Complement Ther Med 2015 Apr;23(2):283-97. Epub 2015 Feb 13 doi: 10.1016/j.ctim.2015.01.014. PMID: 25847567
Estimating the burden of early onset dementia; systematic review of disease prevalence.
Lambert MA, Bickel H, Prince M, Fratiglioni L, Von Strauss E, Frydecka D, Kiejna A, Georges J, Reynish EL
Eur J Neurol 2014 Apr;21(4):563-9. Epub 2014 Jan 13 doi: 10.1111/ene.12325. PMID: 24418291
Naftidrofuryl for dementia.
Lu D, Song H, Hao Z, Wu T, McCleery J
Cochrane Database Syst Rev 2011 Dec 7;(12):CD002955. doi: 10.1002/14651858.CD002955.pub4. PMID: 22161372
Validation therapy for dementia.
Neal M, Briggs M
Cochrane Database Syst Rev 2000;(2):CD001394. doi: 10.1002/14651858.CD001394. PMID: 10796644

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