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Hemorrhage of testis

MedGen UID:
82836
•Concept ID:
C0268969
•
Pathologic Function
Synonyms: Testicular Hemorrhage; Testicular hemorrhage
SNOMED CT: Testicular hemorrhage (77708008); Hemorrhage of testis (77708008)

Definition

Bleeding originating from the testis. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVHemorrhage of testis

Professional guidelines

PubMed

The contemporary management of cancers of the sinonasal tract in adults.
Thawani R, Kim MS, Arastu A, Feng Z, West MT, Taflin NF, Thein KZ, Li R, Geltzeiler M, Lee N, Fuller CD, Grandis JR, Floudas CS, Heinrich MC, Hanna E, Chandra RA
CA Cancer J Clin 2023 Jan;73(1):72-112. Epub 2022 Aug 2 doi: 10.3322/caac.21752. PMID: 35916666Free PMC Article
Testicular involvement of acute lymphoblastic leukemia in children and adolescents: Diagnosis, biology, and management.
Nguyen HTK, Terao MA, Green DM, Pui CH, Inaba H
Cancer 2021 Sep 1;127(17):3067-3081. Epub 2021 May 25 doi: 10.1002/cncr.33609. PMID: 34031876Free PMC Article
Treatment of relapsed/refractory paediatric aggressive B-cell non-Hodgkin lymphoma.
Moleti ML, Testi AM, Foà R
Br J Haematol 2020 Jun;189(5):826-843. Epub 2020 Mar 6 doi: 10.1111/bjh.16461. PMID: 32141616

Recent clinical studies

Etiology

The Role of Mononuclear Phagocytes in the Testes and Epididymis.
Shi X, Zhao H, Kang Y, Dong X, Yu C, Xie Q, Duan Y, Liao A, Huang D
Int J Mol Sci 2022 Dec 20;24(1) doi: 10.3390/ijms24010053. PMID: 36613494Free PMC Article
Моlecular mechanisms of initiation of carcinogenesis in the testis.
Bazalytska SV, Persidsky Y, Romanenko AM
Exp Oncol 2019 Sep;41(3):224-234. doi: 10.32471/exp-oncology.2312-8852.vol-41-no-3.13527. PMID: 31569932
Testicular torsion.
Ringdahl E, Teague L
Am Fam Physician 2006 Nov 15;74(10):1739-43. PMID: 17137004
Testicular injuries.
Cass AS, Luxenberg M
Urology 1991 Jun;37(6):528-30. doi: 10.1016/0090-4295(91)80317-z. PMID: 2038785
Testicular immunoregulatory factors.
Pöllänen P, von Euler M, Söder O
J Reprod Immunol 1990 Aug;18(1):51-76. doi: 10.1016/0165-0378(90)90024-z. PMID: 2170642

Diagnosis

Testomalacia.
Kalra S, Dhingra A, Kapoor N
J Pak Med Assoc 2024 Aug;74(8):1545-1546. doi: 10.47391/JPMA.24-61. PMID: 39160733
Schistosomiasis (bilharziasis) and male infertility.
Abdel-Naser MB, Altenburg A, Zouboulis CC, Wollina U
Andrologia 2019 Feb;51(1):e13165. Epub 2018 Oct 1 doi: 10.1111/and.13165. PMID: 30276841
Testicular torsion.
Ringdahl E, Teague L
Am Fam Physician 2006 Nov 15;74(10):1739-43. PMID: 17137004
Testicular ultrasound.
Blaivas M, Brannam L
Emerg Med Clin North Am 2004 Aug;22(3):723-48, ix. doi: 10.1016/j.emc.2004.04.002. PMID: 15301848
Pubertal gynecomastia.
Lazala C, Saenger P
J Pediatr Endocrinol Metab 2002 May;15(5):553-60. doi: 10.1515/jpem.2002.15.5.553. PMID: 12014513

Therapy

Semaglutide mitigates testicular damage in diabetes by inhibiting ferroptosis.
Zhou L, Dong M, Feng G, Zhang Y, Wang J, Kang H, Dong Z, Ning J, Zhao Z, Wang C
Biochem Biophys Res Commun 2024 Jun 30;715:149996. Epub 2024 Apr 24 doi: 10.1016/j.bbrc.2024.149996. PMID: 38678781
The role of regulatory T Cells in autoimmune orchitis.
Jacobo P
Andrologia 2018 Dec;50(11):e13092. doi: 10.1111/and.13092. PMID: 30569653
Analgesic use in pregnancy and male reproductive development.
Hurtado-Gonzalez P, Mitchell RT
Curr Opin Endocrinol Diabetes Obes 2017 Jun;24(3):225-232. doi: 10.1097/MED.0000000000000338. PMID: 28277341Free PMC Article
The blood-testis barrier and its implications for male contraception.
Cheng CY, Mruk DD
Pharmacol Rev 2012 Jan;64(1):16-64. Epub 2011 Oct 28 doi: 10.1124/pr.110.002790. PMID: 22039149Free PMC Article
Pathogenesis and treatment of varicoceles.
Sandlow J
BMJ 2004 Apr 24;328(7446):967-8. doi: 10.1136/bmj.328.7446.967. PMID: 15105302Free PMC Article

Prognosis

Single-cell sequencing on CD8(+) TILs revealed the nature of exhausted T cells recognizing neoantigen and cancer/testis antigen in non-small cell lung cancer.
Komuro H, Shinohara S, Fukushima Y, Demachi-Okamura A, Muraoka D, Masago K, Matsui T, Sugita Y, Takahashi Y, Nishida R, Takashima C, Ohki T, Shigematsu Y, Watanabe F, Adachi K, Fukuyama T, Hamana H, Kishi H, Miura D, Tanaka Y, Onoue K, Onoguchi K, Yamashita Y, Stratford R, Clancy T, Yamaguchi R, Kuroda H, Doi K, Iwata H, Matsushita H
J Immunother Cancer 2023 Aug;11(8) doi: 10.1136/jitc-2023-007180. PMID: 37544663Free PMC Article
Determination of Intraprostatic and Intratesticular Androgens.
Šimková M, Heráček J, Drašar P, Hampl R
Int J Mol Sci 2021 Jan 5;22(1) doi: 10.3390/ijms22010466. PMID: 33466491Free PMC Article
Ebola survivors: not out of the woods yet.
Harries J, Jacobs M, Davies SC
BMJ 2016 Jan 22;532:i178. doi: 10.1136/bmj.i178. PMID: 26801216
Epidemiology and Diagnosis of Testis Cancer.
Stevenson SM, Lowrance WT
Urol Clin North Am 2015 Aug;42(3):269-75. Epub 2015 Jun 11 doi: 10.1016/j.ucl.2015.04.001. PMID: 26216814
Testicular injuries.
Cass AS, Luxenberg M
Urology 1991 Jun;37(6):528-30. doi: 10.1016/0090-4295(91)80317-z. PMID: 2038785

Clinical prediction guides

Prediction and identification of HLA-A*0201-restricted epitopes from cancer testis antigen CT23.
Zeng X, Nong WX, Zou XQ, Li F, Ge YY, Zhang QM, Luo B, Huang W, Zou JX, Fan R, Xie XX
Hum Vaccin Immunother 2023 Dec 15;19(3):2293299. doi: 10.1080/21645515.2023.2293299. PMID: 38100550Free PMC Article
Single-cell sequencing on CD8(+) TILs revealed the nature of exhausted T cells recognizing neoantigen and cancer/testis antigen in non-small cell lung cancer.
Komuro H, Shinohara S, Fukushima Y, Demachi-Okamura A, Muraoka D, Masago K, Matsui T, Sugita Y, Takahashi Y, Nishida R, Takashima C, Ohki T, Shigematsu Y, Watanabe F, Adachi K, Fukuyama T, Hamana H, Kishi H, Miura D, Tanaka Y, Onoue K, Onoguchi K, Yamashita Y, Stratford R, Clancy T, Yamaguchi R, Kuroda H, Doi K, Iwata H, Matsushita H
J Immunother Cancer 2023 Aug;11(8) doi: 10.1136/jitc-2023-007180. PMID: 37544663Free PMC Article
Determination of Intraprostatic and Intratesticular Androgens.
Šimková M, Heráček J, Drašar P, Hampl R
Int J Mol Sci 2021 Jan 5;22(1) doi: 10.3390/ijms22010466. PMID: 33466491Free PMC Article
Regulation of Male Fertility by the Renin-Angiotensin System.
Gianzo M, Subirán N
Int J Mol Sci 2020 Oct 26;21(21) doi: 10.3390/ijms21217943. PMID: 33114706Free PMC Article
Testicular autoimmunity.
Jacobo P, Guazzone VA, Theas MS, Lustig L
Autoimmun Rev 2011 Feb;10(4):201-4. Epub 2010 Oct 14 doi: 10.1016/j.autrev.2010.09.026. PMID: 20932942

Recent systematic reviews

Impact of COVID-19 on testicular function: a systematic review and meta-analysis.
Cannarella R, Marino M, Crafa A, Bagnara V, La Vignera S, Condorelli RA, Calogero AE
Endocrine 2024 Jul;85(1):44-66. Epub 2024 Feb 12 doi: 10.1007/s12020-024-03705-7. PMID: 38345682Free PMC Article
Gonadotropins for pubertal induction in males with hypogonadotropic hypogonadism: systematic review and meta-analysis.
Alexander EC, Faruqi D, Farquhar R, Unadkat A, Ng Yin K, Hoskyns R, Varughese R, Howard SR
Eur J Endocrinol 2024 Jan 3;190(1):S1-S11. doi: 10.1093/ejendo/lvad166. PMID: 38128110Free PMC Article
Adverse effects of microcystins on sperm: A systematic review.
Zhang Z, Du X, Zhang S, Liu H, Fu Y, Wang F, Zhang H
Toxicology 2023 May 15;490:153507. Epub 2023 Apr 6 doi: 10.1016/j.tox.2023.153507. PMID: 37030550
Orchidopexy for Testicular Torsion: A Systematic Review of Surgical Technique.
Moore SL, Chebbout R, Cumberbatch M, Bondad J, Forster L, Hendry J, Lamb B, MacLennan S, Nambiar A, Shah TT, Stavrinides V, Thurtle D, Pearce I, Kasivisvanathan V
Eur Urol Focus 2021 Nov;7(6):1493-1503. Epub 2020 Aug 27 doi: 10.1016/j.euf.2020.07.006. PMID: 32863201
Urological complications following inguinal hernioplasty.
Gulino G, Antonucci M, Palermo G, Sasso F, Tienforti D, D'Addessi A, Bassi PF
Arch Ital Urol Androl 2012 Sep;84(3):105-10. PMID: 23210400

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