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Migraine with brainstem aura

MedGen UID:
82857
•Concept ID:
C0270860
•
Disease or Syndrome
Synonyms: Basilar Artery Migraine; Basilar Migraine; Basilar Migraines; Basilar Type Migraine; Basilar-Type Migraine; Migraine, Basilar; Migraine, Basilar Artery; Migraine, Basilar-Type
SNOMED CT: Vertebrobasilar migraine (83351003); Basilar migraine (83351003); Basilar artery migraine (83351003); Bickerstaff's migraine (83351003)
 
Monarch Initiative: MONDO:0043219

Definition

A migraine disorder characterized by episodes that are preceded by focal neurological symptoms originating in the brainstem. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVMigraine with brainstem aura

Professional guidelines

PubMed

Update on diagnosis and differential diagnosis of vestibular migraine.
Shen Y, Qi X
Neurol Sci 2022 Mar;43(3):1659-1666. Epub 2022 Jan 11 doi: 10.1007/s10072-022-05872-9. PMID: 35015204
Migraine Aura: Updates in Pathophysiology and Management.
Lai J, Dilli E
Curr Neurol Neurosci Rep 2020 May 19;20(6):17. doi: 10.1007/s11910-020-01037-3. PMID: 32430657
Episodic Migraine With and Without Aura: Key Differences and Implications for Pathophysiology, Management, and Assessing Risks.
Vgontzas A, Burch R
Curr Pain Headache Rep 2018 Oct 5;22(12):78. doi: 10.1007/s11916-018-0735-z. PMID: 30291554

Recent clinical studies

Etiology

Clinical Features and Burden Scores in Japanese Pediatric Migraines With Brainstem Aura, Hemiplegic Migraine, and Retinal Migraine.
Yamanaka G, Go S, Morichi S, Takeshita M, Morishita N, Suzuki S, Tomoko T, Kasuga A, Daida A, Ishida Y, Oana S, Suganami Y, Nagao R, Kashiwagi Y, Kawashima H
J Child Neurol 2020 Sep;35(10):667-673. Epub 2020 Jun 1 doi: 10.1177/0883073820927840. PMID: 32476572
Getting to the Heart of the Matter: Migraine, Triptans, DHE, Ditans, CGRP Antibodies, First/Second-Generation Gepants, and Cardiovascular Risk.
Mathew PG, Klein BC
Headache 2019 Sep;59(8):1421-1426. Epub 2019 Jul 18 doi: 10.1111/head.13601. PMID: 31318457
Episodic Migraine With and Without Aura: Key Differences and Implications for Pathophysiology, Management, and Assessing Risks.
Vgontzas A, Burch R
Curr Pain Headache Rep 2018 Oct 5;22(12):78. doi: 10.1007/s11916-018-0735-z. PMID: 30291554
Exploding Head Syndrome as Aura of Migraine with Brainstem Aura: A Case Report.
Rossi FH, Gonzalez E, Rossi EM, Tsakadze N
J Oral Facial Pain Headache 2018 Spring;32(2):e34-e36. doi: 10.11607/ofph.1950. PMID: 29694468
Paranasal Sinus Disease in Children With Headache.
Vieira Neto RJ, Teixeira KCS, Guerreiro MM, Montenegro MA
J Child Neurol 2017 Oct;32(12):1014-1017. Epub 2017 Aug 23 doi: 10.1177/0883073817724696. PMID: 28831857

Diagnosis

Migraine with brainstem aura.
Kaniecki R
Handb Clin Neurol 2024;199:367-379. doi: 10.1016/B978-0-12-823357-3.00019-7. PMID: 38307657
Update on diagnosis and differential diagnosis of vestibular migraine.
Shen Y, Qi X
Neurol Sci 2022 Mar;43(3):1659-1666. Epub 2022 Jan 11 doi: 10.1007/s10072-022-05872-9. PMID: 35015204
Migraine Aura: Updates in Pathophysiology and Management.
Lai J, Dilli E
Curr Neurol Neurosci Rep 2020 May 19;20(6):17. doi: 10.1007/s11910-020-01037-3. PMID: 32430657
Migraine with brainstem aura: defining the core syndrome.
Yamani N, Chalmer MA, Olesen J
Brain 2019 Dec 1;142(12):3868-3875. doi: 10.1093/brain/awz338. PMID: 31789370
Complicated Migraines.
Blumenfeld AE, Victorio MC, Berenson FR
Semin Pediatr Neurol 2016 Feb;23(1):18-22. Epub 2016 Jan 22 doi: 10.1016/j.spen.2016.01.007. PMID: 27017017

Therapy

Clinical Features and Burden Scores in Japanese Pediatric Migraines With Brainstem Aura, Hemiplegic Migraine, and Retinal Migraine.
Yamanaka G, Go S, Morichi S, Takeshita M, Morishita N, Suzuki S, Tomoko T, Kasuga A, Daida A, Ishida Y, Oana S, Suganami Y, Nagao R, Kashiwagi Y, Kawashima H
J Child Neurol 2020 Sep;35(10):667-673. Epub 2020 Jun 1 doi: 10.1177/0883073820927840. PMID: 32476572
Getting to the Heart of the Matter: Migraine, Triptans, DHE, Ditans, CGRP Antibodies, First/Second-Generation Gepants, and Cardiovascular Risk.
Mathew PG, Klein BC
Headache 2019 Sep;59(8):1421-1426. Epub 2019 Jul 18 doi: 10.1111/head.13601. PMID: 31318457
A singular association of migraine with brainstem aura and Alice in Wonderland syndrome.
Chirchiglia D, Chirchiglia P, Marotta R
Childs Nerv Syst 2019 Aug;35(8):1435-1437. Epub 2019 May 2 doi: 10.1007/s00381-019-04170-8. PMID: 31049666
Exploding Head Syndrome as Aura of Migraine with Brainstem Aura: A Case Report.
Rossi FH, Gonzalez E, Rossi EM, Tsakadze N
J Oral Facial Pain Headache 2018 Spring;32(2):e34-e36. doi: 10.11607/ofph.1950. PMID: 29694468
Greater Occipital Nerve Blockade: A Safe and Effective Option for the Acute Treatment of Hemiplegic Aura.
Casas-Limón J, Aledo-Serrano Á, Abarrategui B, Cuadrado ML
Headache 2015 Jul-Aug;55(7):1000-3. Epub 2015 Jul 3 doi: 10.1111/head.12607. PMID: 26140423

Prognosis

Migraine with brainstem aura.
Kaniecki R
Handb Clin Neurol 2024;199:367-379. doi: 10.1016/B978-0-12-823357-3.00019-7. PMID: 38307657
Exploding Head Syndrome as Aura of Migraine with Brainstem Aura: A Case Report.
Rossi FH, Gonzalez E, Rossi EM, Tsakadze N
J Oral Facial Pain Headache 2018 Spring;32(2):e34-e36. doi: 10.11607/ofph.1950. PMID: 29694468

Clinical prediction guides

Clinical Features and Burden Scores in Japanese Pediatric Migraines With Brainstem Aura, Hemiplegic Migraine, and Retinal Migraine.
Yamanaka G, Go S, Morichi S, Takeshita M, Morishita N, Suzuki S, Tomoko T, Kasuga A, Daida A, Ishida Y, Oana S, Suganami Y, Nagao R, Kashiwagi Y, Kawashima H
J Child Neurol 2020 Sep;35(10):667-673. Epub 2020 Jun 1 doi: 10.1177/0883073820927840. PMID: 32476572
Neuroimaging for Migraine: The American Headache Society Systematic Review and Evidence-Based Guideline.
Evans RW, Burch RC, Frishberg BM, Marmura MJ, Mechtler LL, Silberstein SD, Turner DP
Headache 2020 Feb;60(2):318-336. Epub 2019 Dec 31 doi: 10.1111/head.13720. PMID: 31891197
Migraine with brainstem aura: Why not a cortical origin?
Demarquay G, Ducros A, Montavont A, Mauguiere F
Cephalalgia 2018 Sep;38(10):1687-1695. Epub 2017 Oct 26 doi: 10.1177/0333102417738251. PMID: 29073774

Recent systematic reviews

Neuroimaging for Migraine: The American Headache Society Systematic Review and Evidence-Based Guideline.
Evans RW, Burch RC, Frishberg BM, Marmura MJ, Mechtler LL, Silberstein SD, Turner DP
Headache 2020 Feb;60(2):318-336. Epub 2019 Dec 31 doi: 10.1111/head.13720. PMID: 31891197

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