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Gastric adenocarcinoma

MedGen UID:
82961
Concept ID:
C0278701
Neoplastic Process
Synonym: Adenocarcinoma of stomach
SNOMED CT: Adenocarcinoma of stomach (408647009); Cancer of stomach, adenocarcinoma (408647009)
 
HPO: HP:0033770
Monarch Initiative: MONDO:0005036
Orphanet: ORPHA464463

Definition

An adenocarcinoma arising from the stomach glandular epithelium. Gastric carcinoma often produces no specific symptoms when it is superficial and potentially surgically curable, although up to 50% of patients may have nonspecific gastrointestinal complaints such as dyspepsia. [from HPO]

Conditions with this feature

Familial adenomatous polyposis 4
MedGen UID:
934686
Concept ID:
C4310719
Disease or Syndrome
Familial adenomatous polyposis-4 is an autosomal recessive tumor predisposition syndrome characterized by the development of multiple colonic adenomas in adulthood, often with progression to colorectal cancer. Proliferative lesions in other tissues may also occur (summary by Adam et al., 2016). For a discussion of genetic heterogeneity of familial adenomatous polyposis, see FAP1 (175100).
Gastric adenocarcinoma and proximal polyposis of the stomach
MedGen UID:
1657285
Concept ID:
C4749917
Neoplastic Process
APC-associated polyposis conditions include (classic or attenuated) familial adenomatous polyposis (FAP) and gastric adenocarcinoma and proximal polyposis of the stomach (GAPPS). FAP is a colorectal cancer (CRC) predisposition syndrome that can manifest in either classic or attenuated form. Classic FAP is characterized by hundreds to thousands of adenomatous colonic polyps, beginning on average at age 16 years (range 7-36 years). For those with the classic form of FAP, 95% of individuals have polyps by age 35 years; CRC is inevitable without colectomy. The mean age of CRC diagnosis in untreated individuals is 39 years (range 34-43 years). The attenuated form is characterized by multiple colonic polyps (average of 30), more proximally located polyps, and a diagnosis of CRC at a later age than in classic FAP. For those with an attenuated form, there is a 70% lifetime risk of CRC and the mean age of diagnosis is 50-55 years. Extracolonic manifestations are variably present and include polyps of the stomach and duodenum, osteomas, dental abnormalities, congenital hypertrophy of the retinal pigment epithelium (CHRPE), benign cutaneous lesions, desmoid tumors, adrenal masses, and other associated cancers. GAPPS is characterized by proximal gastric polyposis, increased risk of gastric adenocarcinoma, and no duodenal or colonic involvement in most individuals reported.

Professional guidelines

PubMed

Norwood DA, Montalvan-Sanchez E, Dominguez RL, Morgan DR
Gastroenterol Clin North Am 2022 Sep;51(3):501-518. doi: 10.1016/j.gtc.2022.05.001. PMID: 36153107
Joshi SS, Badgwell BD
CA Cancer J Clin 2021 May;71(3):264-279. Epub 2021 Feb 16 doi: 10.3322/caac.21657. PMID: 33592120Free PMC Article
Sexton RE, Al Hallak MN, Diab M, Azmi AS
Cancer Metastasis Rev 2020 Dec;39(4):1179-1203. Epub 2020 Sep 7 doi: 10.1007/s10555-020-09925-3. PMID: 32894370Free PMC Article

Recent clinical studies

Etiology

Xing L, Sun C, Han L, Zhu Z
Appl Biochem Biotechnol 2022 Nov;194(11):5292-5304. Epub 2022 Jun 23 doi: 10.1007/s12010-022-03986-6. PMID: 35737213
Kim J, Wang TC
Gastrointest Endosc Clin N Am 2021 Jul;31(3):451-465. doi: 10.1016/j.giec.2021.03.003. PMID: 34053633
Tacheci I, Repak R, Podhola M, Benesova L, Cyrany J, Bures J, Kohoutova D
Best Pract Res Clin Gastroenterol 2021 Mar-Apr;50-51:101728. Epub 2021 Feb 15 doi: 10.1016/j.bpg.2021.101728. PMID: 33975682
Abdi E, Latifi-Navid S, Zahri S, Yazdanbod A, Pourfarzi F
Cancer Med 2019 Oct;8(13):6114-6126. Epub 2019 Aug 25 doi: 10.1002/cam4.2497. PMID: 31448582Free PMC Article
Russo AE, Strong VE
Annu Rev Med 2019 Jan 27;70:353-367. Epub 2018 Oct 24 doi: 10.1146/annurev-med-081117-043436. PMID: 30355265

Diagnosis

Xing L, Sun C, Han L, Zhu Z
Appl Biochem Biotechnol 2022 Nov;194(11):5292-5304. Epub 2022 Jun 23 doi: 10.1007/s12010-022-03986-6. PMID: 35737213
Kushima R
Pathologe 2022 Feb;43(1):8-15. Epub 2021 Nov 22 doi: 10.1007/s00292-021-01023-7. PMID: 34807275
Hoshi H
Surg Clin North Am 2020 Jun;100(3):523-534. Epub 2020 Mar 18 doi: 10.1016/j.suc.2020.02.004. PMID: 32402298
Johnston FM, Beckman M
Curr Oncol Rep 2019 Jun 24;21(8):67. doi: 10.1007/s11912-019-0820-4. PMID: 31236716
Trieu JA, Bilal M, Saraireh H, Wang AY
Dig Dis Sci 2019 May;64(5):1079-1088. doi: 10.1007/s10620-019-05526-5. PMID: 30771043

Therapy

Tang Z, Gu Y, Shi Z, Min L, Zhang Z, Zhou P, Luo R, Wang Y, Cui Y, Sun Y, Wang X
Cell Rep Med 2023 Feb 21;4(2):100931. Epub 2023 Jan 31 doi: 10.1016/j.xcrm.2023.100931. PMID: 36724786Free PMC Article
Shah MA, Kennedy EB, Alarcon-Rozas AE, Alcindor T, Bartley AN, Malowany AB, Bhadkamkar NA, Deighton DC, Janjigian Y, Karippot A, Khan U, King DA, Klute K, Lacy J, Lee JJ, Mehta R, Mukherjee S, Nagarajan A, Park H, Saeed A, Semrad TJ, Shitara K, Smyth E, Uboha NV, Vincelli M, Wainberg Z, Rajdev L
J Clin Oncol 2023 Mar 1;41(7):1470-1491. Epub 2023 Jan 5 doi: 10.1200/JCO.22.02331. PMID: 36603169
van der Veen A, Brenkman HJF, Seesing MFJ, Haverkamp L, Luyer MDP, Nieuwenhuijzen GAP, Stoot JHMB, Tegels JJW, Wijnhoven BPL, Lagarde SM, de Steur WO, Hartgrink HH, Kouwenhoven EA, Wassenaar EB, Draaisma WA, Gisbertz SS, van der Peet DL, May AM, Ruurda JP, van Hillegersberg R; LOGICA Study Group
J Clin Oncol 2021 Mar 20;39(9):978-989. Epub 2021 Jan 6 doi: 10.1200/JCO.20.01540. PMID: 34581617
Sexton RE, Al Hallak MN, Diab M, Azmi AS
Cancer Metastasis Rev 2020 Dec;39(4):1179-1203. Epub 2020 Sep 7 doi: 10.1007/s10555-020-09925-3. PMID: 32894370Free PMC Article
Johnston FM, Beckman M
Curr Oncol Rep 2019 Jun 24;21(8):67. doi: 10.1007/s11912-019-0820-4. PMID: 31236716

Prognosis

Leijonmarck W, Asplund J, Markar SR, Mattsson F, Lagergren J
Eur J Surg Oncol 2023 Jan;49(1):83-88. Epub 2022 Jul 15 doi: 10.1016/j.ejso.2022.07.011. PMID: 35922280
Gullo I, Grillo F, Mastracci L, Vanoli A, Carneiro F, Saragoni L, Limarzi F, Ferro J, Parente P, Fassan M
Pathologica 2020 Sep;112(3):166-185. doi: 10.32074/1591-951X-166. PMID: 33179620Free PMC Article
Kiladjian JJ, Zachee P, Hino M, Pane F, Masszi T, Harrison CN, Mesa R, Miller CB, Passamonti F, Durrant S, Griesshammer M, Kirito K, Besses C, Moiraghi B, Rumi E, Rosti V, Blau IW, Francillard N, Dong T, Wroclawska M, Vannucchi AM, Verstovsek S
Lancet Haematol 2020 Mar;7(3):e226-e237. Epub 2020 Jan 23 doi: 10.1016/S2352-3026(19)30207-8. PMID: 31982039Free PMC Article
Kemi N, Eskuri M, Herva A, Leppänen J, Huhta H, Helminen O, Saarnio J, Karttunen TJ, Kauppila JH
Br J Cancer 2018 Aug;119(4):435-439. Epub 2018 Jul 30 doi: 10.1038/s41416-018-0202-y. PMID: 30057407Free PMC Article
Thomas RM, Sobin LH
Cancer 1995 Jan 1;75(1 Suppl):154-70. doi: 10.1002/1097-0142(19950101)75:1+<154::aid-cncr2820751305>3.0.co;2-z. PMID: 8000994

Clinical prediction guides

Chang J, Wu H, Wu J, Liu M, Zhang W, Hu Y, Zhang X, Xu J, Li L, Yu P, Zhu J
J Transl Med 2023 Mar 13;21(1):191. doi: 10.1186/s12967-023-04033-6. PMID: 36915111Free PMC Article
Janczewski LM, Shah D, Wells A, Bentrem DJ, Abad JD, Chawla A
J Surg Oncol 2023 Jun;127(7):1116-1124. Epub 2023 Mar 11 doi: 10.1002/jso.27233. PMID: 36905333Free PMC Article
Tang Z, Gu Y, Shi Z, Min L, Zhang Z, Zhou P, Luo R, Wang Y, Cui Y, Sun Y, Wang X
Cell Rep Med 2023 Feb 21;4(2):100931. Epub 2023 Jan 31 doi: 10.1016/j.xcrm.2023.100931. PMID: 36724786Free PMC Article
Ai D, Yao J, Yang F, Huo L, Chen H, Lu W, Soto LMS, Jiang M, Raso MG, Wang S, Bell D, Liu J, Wang H, Tan D, Torres-Cabala C, Gan Q, Wu Y, Albarracin C, Hung MC, Meric-Bernstam F, Wistuba II, Prieto VG, Sahin AA, Ding Q
Mod Pathol 2021 Apr;34(4):710-719. Epub 2020 Oct 3 doi: 10.1038/s41379-020-00692-8. PMID: 33011748
Abdi E, Latifi-Navid S, Zahri S, Yazdanbod A, Pourfarzi F
Cancer Med 2019 Oct;8(13):6114-6126. Epub 2019 Aug 25 doi: 10.1002/cam4.2497. PMID: 31448582Free PMC Article

Recent systematic reviews

Aguiar FJN, Menezes FDS, Fagundes MA, Fernandes GA, Alves FA, Filho JG, Curado MP
Clinics (Sao Paulo) 2024;79:100321. Epub 2024 Jan 31 doi: 10.1016/j.clinsp.2023.100321. PMID: 38301538Free PMC Article
Shah MA, Kennedy EB, Alarcon-Rozas AE, Alcindor T, Bartley AN, Malowany AB, Bhadkamkar NA, Deighton DC, Janjigian Y, Karippot A, Khan U, King DA, Klute K, Lacy J, Lee JJ, Mehta R, Mukherjee S, Nagarajan A, Park H, Saeed A, Semrad TJ, Shitara K, Smyth E, Uboha NV, Vincelli M, Wainberg Z, Rajdev L
J Clin Oncol 2023 Mar 1;41(7):1470-1491. Epub 2023 Jan 5 doi: 10.1200/JCO.22.02331. PMID: 36603169
Hosseini S, Acar A, Sen M, Meeder K, Singh P, Yin K, Sutton JM, Hughes K
Ann Surg Oncol 2023 Mar;30(3):1795-1807. Epub 2022 Dec 17 doi: 10.1245/s10434-022-12829-x. PMID: 36528743
Hirabayashi M, Georges D, Clifford GM, de Martel C
Clin Gastroenterol Hepatol 2023 Apr;21(4):922-930.e21. Epub 2022 Aug 10 doi: 10.1016/j.cgh.2022.07.042. PMID: 35963539
Coburn N, Cosby R, Klein L, Knight G, Malthaner R, Mamazza J, Mercer CD, Ringash J
Cancer Treat Rev 2018 Feb;63:104-115. Epub 2017 Dec 13 doi: 10.1016/j.ctrv.2017.12.006. PMID: 29275224

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