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DS Stage II Plasma Cell Myeloma

MedGen UID:
82968
Concept ID:
C0278723
Neoplastic Process
Synonyms: DS Stage II Multiple Myeloma; Durie/Salmon Stage II Multiple Myeloma; Durie/Salmon Stage II Plasma Cell Myeloma; Multiple Myeloma Stage II; Stage II Multiple Myeloma; Stage II Plasma Cell Myeloma

Definition

Plasma cell myeloma that fits in neither stage I nor stage III. Estimated myeloma cell mass: 0.6 to 1.2 trillion (1012)/m2 (intermediate burden). The following subclassification of stages is used: a. Creatinine less than 2.0 mg/dL, b. Creatinine greater than or equal to 2.0 mg/dL. Impaired renal function worsens prognosis regardless of stage. Note that the newer International Staging System defines stage II quite differently: Beta-2-microglobulin less than 3.5 and albumin less than 3.5 or beta-2-microglobulin 3.5 to less than 5.5 (median survival of 44 months). (PDQ) [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVDS Stage II Plasma Cell Myeloma

Professional guidelines

PubMed

Liu F, Cheng Q, Song K, Yu H, Li J, Zhang H, Hu G, Zhou M, Wang J, Ding Z, Luo Z, Peng T, Ding L, Zhao L, Liu J, He Y, Peng H
Zhong Nan Da Xue Xue Bao Yi Xue Ban 2022 Apr 28;47(4):497-504. doi: 10.11817/j.issn.1672-7347.2022.210555. PMID: 35545345Free PMC Article

Recent clinical studies

Etiology

Liu F, Cheng Q, Song K, Yu H, Li J, Zhang H, Hu G, Zhou M, Wang J, Ding Z, Luo Z, Peng T, Ding L, Zhao L, Liu J, He Y, Peng H
Zhong Nan Da Xue Xue Bao Yi Xue Ban 2022 Apr 28;47(4):497-504. doi: 10.11817/j.issn.1672-7347.2022.210555. PMID: 35545345Free PMC Article
Li R, Hu Z, Chen H, Lu Y, Qin S, Huang C, Yao Y, Qin X, Wang C
Clin Lab 2021 Jan 1;67(1) doi: 10.7754/Clin.Lab.2020.200341. PMID: 33491432
Xu J, Liu B, Ma S, Zhang J, Ji Y, Xu L, Zhu M, Chen S, Wu X, Wu D
Cell Physiol Biochem 2018;45(4):1631-1640. Epub 2018 Feb 21 doi: 10.1159/000487730. PMID: 29486474
Scudla V, Pika T, Budikova M, Petrova P, Bacovsky J, Srovnalik K, Minarik J, Langova K
Biomed Pap Med Fac Univ Palacky Olomouc Czech Repub 2009 Dec;153(4):275-82. doi: 10.5507/bp.2009.046. PMID: 20208967
Rodon P, Linassier C, Gauvain JB, Benboubker L, Goupille P, Maigre M, Luthier F, Dugay J, Lucas V, Colombat P
Eur J Haematol 2001 Jan;66(1):11-7. doi: 10.1034/j.1600-0609.2001.00301.x. PMID: 11168502

Diagnosis

Liu F, Cheng Q, Song K, Yu H, Li J, Zhang H, Hu G, Zhou M, Wang J, Ding Z, Luo Z, Peng T, Ding L, Zhao L, Liu J, He Y, Peng H
Zhong Nan Da Xue Xue Bao Yi Xue Ban 2022 Apr 28;47(4):497-504. doi: 10.11817/j.issn.1672-7347.2022.210555. PMID: 35545345Free PMC Article
Li R, Hu Z, Chen H, Lu Y, Qin S, Huang C, Yao Y, Qin X, Wang C
Clin Lab 2021 Jan 1;67(1) doi: 10.7754/Clin.Lab.2020.200341. PMID: 33491432
Deng S, Zhang B, Zhou Y, Xu X, Li J, Sang S, Zhang W
Contrast Media Mol Imaging 2018;2018:4198673. Epub 2018 Jul 30 doi: 10.1155/2018/4198673. PMID: 30154686Free PMC Article
Xu J, Liu B, Ma S, Zhang J, Ji Y, Xu L, Zhu M, Chen S, Wu X, Wu D
Cell Physiol Biochem 2018;45(4):1631-1640. Epub 2018 Feb 21 doi: 10.1159/000487730. PMID: 29486474
Rodon P, Linassier C, Gauvain JB, Benboubker L, Goupille P, Maigre M, Luthier F, Dugay J, Lucas V, Colombat P
Eur J Haematol 2001 Jan;66(1):11-7. doi: 10.1034/j.1600-0609.2001.00301.x. PMID: 11168502

Therapy

Liu F, Cheng Q, Song K, Yu H, Li J, Zhang H, Hu G, Zhou M, Wang J, Ding Z, Luo Z, Peng T, Ding L, Zhao L, Liu J, He Y, Peng H
Zhong Nan Da Xue Xue Bao Yi Xue Ban 2022 Apr 28;47(4):497-504. doi: 10.11817/j.issn.1672-7347.2022.210555. PMID: 35545345Free PMC Article
Rodriguez TE, Hari P, Stiff PJ, Smith SE, Sterrenberg D, Vesole DH
Biol Blood Marrow Transplant 2016 Aug;22(8):1391-1396. Epub 2016 May 7 doi: 10.1016/j.bbmt.2016.03.021. PMID: 27164062Free PMC Article
Yang SH, Teng HW, Hong YC, Liu CY, Yu YB, Yang CF, Gau JP, Liu JH, Chang TJ, Yen JJ, Chen PM, Chiou TJ, Tzeng CH, Hsiao LT
Ann Hematol 2012 Jan;91(1):93-102. Epub 2011 May 17 doi: 10.1007/s00277-011-1251-y. PMID: 21584671
Rodon P, Linassier C, Gauvain JB, Benboubker L, Goupille P, Maigre M, Luthier F, Dugay J, Lucas V, Colombat P
Eur J Haematol 2001 Jan;66(1):11-7. doi: 10.1034/j.1600-0609.2001.00301.x. PMID: 11168502

Prognosis

Liu F, Cheng Q, Song K, Yu H, Li J, Zhang H, Hu G, Zhou M, Wang J, Ding Z, Luo Z, Peng T, Ding L, Zhao L, Liu J, He Y, Peng H
Zhong Nan Da Xue Xue Bao Yi Xue Ban 2022 Apr 28;47(4):497-504. doi: 10.11817/j.issn.1672-7347.2022.210555. PMID: 35545345Free PMC Article
Deng S, Zhang B, Zhou Y, Xu X, Li J, Sang S, Zhang W
Contrast Media Mol Imaging 2018;2018:4198673. Epub 2018 Jul 30 doi: 10.1155/2018/4198673. PMID: 30154686Free PMC Article
Yang SH, Teng HW, Hong YC, Liu CY, Yu YB, Yang CF, Gau JP, Liu JH, Chang TJ, Yen JJ, Chen PM, Chiou TJ, Tzeng CH, Hsiao LT
Ann Hematol 2012 Jan;91(1):93-102. Epub 2011 May 17 doi: 10.1007/s00277-011-1251-y. PMID: 21584671
Scudla V, Pika T, Budikova M, Petrova P, Bacovsky J, Srovnalik K, Minarik J, Langova K
Biomed Pap Med Fac Univ Palacky Olomouc Czech Repub 2009 Dec;153(4):275-82. doi: 10.5507/bp.2009.046. PMID: 20208967
Rodon P, Linassier C, Gauvain JB, Benboubker L, Goupille P, Maigre M, Luthier F, Dugay J, Lucas V, Colombat P
Eur J Haematol 2001 Jan;66(1):11-7. doi: 10.1034/j.1600-0609.2001.00301.x. PMID: 11168502

Clinical prediction guides

Deng S, Zhang B, Zhou Y, Xu X, Li J, Sang S, Zhang W
Contrast Media Mol Imaging 2018;2018:4198673. Epub 2018 Jul 30 doi: 10.1155/2018/4198673. PMID: 30154686Free PMC Article
Tu H, He Y, Huang T, Choe S, Lan X, Duan X, Sattar H, Li C, Zhou F
Eur J Haematol 2018 Feb;100(2):189-197. Epub 2017 Dec 29 doi: 10.1111/ejh.13006. PMID: 29226428
Rodriguez TE, Hari P, Stiff PJ, Smith SE, Sterrenberg D, Vesole DH
Biol Blood Marrow Transplant 2016 Aug;22(8):1391-1396. Epub 2016 May 7 doi: 10.1016/j.bbmt.2016.03.021. PMID: 27164062Free PMC Article
Yang SH, Teng HW, Hong YC, Liu CY, Yu YB, Yang CF, Gau JP, Liu JH, Chang TJ, Yen JJ, Chen PM, Chiou TJ, Tzeng CH, Hsiao LT
Ann Hematol 2012 Jan;91(1):93-102. Epub 2011 May 17 doi: 10.1007/s00277-011-1251-y. PMID: 21584671
Rodon P, Linassier C, Gauvain JB, Benboubker L, Goupille P, Maigre M, Luthier F, Dugay J, Lucas V, Colombat P
Eur J Haematol 2001 Jan;66(1):11-7. doi: 10.1034/j.1600-0609.2001.00301.x. PMID: 11168502

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