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Recurrent Melanoma

MedGen UID:
83003
•Concept ID:
C0278884
•
Neoplastic Process
Synonyms: Recurrent Cutaneous Melanoma; Recurrent Malignant Melanoma; Recurrent Malignant Melanoma of Skin; Recurrent Malignant Melanoma of the Skin; Recurrent Malignant Skin Melanoma; Recurrent Melanoma of Skin; Recurrent Melanoma of the Skin

Definition

The reemergence of a melanoma after a period of remission. [from NCI]

Professional guidelines

PubMed

Treatment of Recurrent Melanoma Following Adjuvant Therapy.
Malissen N, Grob JJ
Am J Clin Dermatol 2023 May;24(3):333-341. Epub 2023 Mar 8 doi: 10.1007/s40257-023-00762-y. PMID: 36890427
Melanoma recurrence patterns and management after adjuvant targeted therapy: a multicentre analysis.
Bhave P, Pallan L, Long GV, Menzies AM, Atkinson V, Cohen JV, Sullivan RJ, Chiarion-Sileni V, Nyakas M, Kahler K, Hauschild A, Plummer R, Trojaniello C, Ascierto PA, Zimmer L, Schadendorf D, Allayous C, Lebbe C, Maurichi A, Santinami M, Roy S, Robert C, Lesimple T, Patel S, Versluis JM, Blank CU, Khattak A, Van der Westhuizen A, Carlino MS, Shackleton M, Haydon A
Br J Cancer 2021 Feb;124(3):574-580. Epub 2020 Oct 22 doi: 10.1038/s41416-020-01121-y. PMID: 33087895Free PMC Article
Treatment of malignant melanoma.
Durán García E, Santolaya R, Requena T
Ann Pharmacother 1999 Jun;33(6):730-8. doi: 10.1345/aph.18190. PMID: 10410188

Recent clinical studies

Etiology

A POT1 Founder Variant Associated with Early Onset Recurrent Melanoma and Various Solid Malignancies.
Abu Shtaya A, Kedar I, Bazak L, Basel-Salmon L, Barhom SF, Naftali M, Eskin-Schwartz M, Birk OS, Polager-Modan S, Keidar N, Reznick Levi G, Levi Z, Yablonski-Peretz T, Mahamid A, Segol O, Matar R, Bareli Y, Azoulay N, Goldberg Y
Genes (Basel) 2024 Mar 13;15(3) doi: 10.3390/genes15030355. PMID: 38540414Free PMC Article
Treatment of Recurrent Melanoma Following Adjuvant Therapy.
Malissen N, Grob JJ
Am J Clin Dermatol 2023 May;24(3):333-341. Epub 2023 Mar 8 doi: 10.1007/s40257-023-00762-y. PMID: 36890427
Efficacy and toxicity of adjuvant radiotherapy in recurrent melanoma after adjuvant immunotherapy.
Bhave P, Hong A, Lo SN, Johnson R, Mangana J, Johnson DB, Dulgar O, Eroglu Z, Yeoh HL, Haydon A, Lodde GC, Livingstone E, Khattak A, Kähler K, Hausschild A, McArthur GA, Menzies AM, Long G, Wang W, Carlino MS
J Immunother Cancer 2023 Mar;11(3) doi: 10.1136/jitc-2022-006629. PMID: 36889810Free PMC Article
Partial lamellar sclerouvectomy surgery for anteriorly located uveal tumour resection: a 20-year experience.
Mirzayev I, Gündüz AK, Okçu Heper A
Eye (Lond) 2022 May;36(5):969-977. Epub 2021 May 3 doi: 10.1038/s41433-021-01545-7. PMID: 33941875Free PMC Article
Treatment of malignant melanoma.
Durán García E, Santolaya R, Requena T
Ann Pharmacother 1999 Jun;33(6):730-8. doi: 10.1345/aph.18190. PMID: 10410188

Diagnosis

Efficacy and toxicity of adjuvant radiotherapy in recurrent melanoma after adjuvant immunotherapy.
Bhave P, Hong A, Lo SN, Johnson R, Mangana J, Johnson DB, Dulgar O, Eroglu Z, Yeoh HL, Haydon A, Lodde GC, Livingstone E, Khattak A, Kähler K, Hausschild A, McArthur GA, Menzies AM, Long G, Wang W, Carlino MS
J Immunother Cancer 2023 Mar;11(3) doi: 10.1136/jitc-2022-006629. PMID: 36889810Free PMC Article
Local and regional therapy for primary and locally recurrent melanoma.
Wilkes JG, Patel A, Zager JS
Clin Adv Hematol Oncol 2021 Apr;19(4):246-260. PMID: 33989273
TERT and TERT promoter in melanocytic neoplasms: Current concepts in pathogenesis, diagnosis, and prognosis.
Motaparthi K, Kim J, Andea AA, Missall TA, Novoa RA, Vidal CI, Fung MA, Emanuel PO
J Cutan Pathol 2020 Aug;47(8):710-719. Epub 2020 Apr 3 doi: 10.1111/cup.13691. PMID: 32202662
Surgical management of primary and recurrent melanoma.
Farma JM, Kulkarni N, Hsu C
Surg Oncol Clin N Am 2015 Apr;24(2):239-47. Epub 2015 Jan 22 doi: 10.1016/j.soc.2014.12.003. PMID: 25769709
FDG imaging.
Coleman RE
Nucl Med Biol 2000 Oct;27(7):689-90. doi: 10.1016/s0969-8051(00)00139-6. PMID: 11091113

Therapy

Treatment of Recurrent Melanoma Following Adjuvant Therapy.
Malissen N, Grob JJ
Am J Clin Dermatol 2023 May;24(3):333-341. Epub 2023 Mar 8 doi: 10.1007/s40257-023-00762-y. PMID: 36890427
Therapy with oncolytic viruses: progress and challenges.
Shalhout SZ, Miller DM, Emerick KS, Kaufman HL
Nat Rev Clin Oncol 2023 Mar;20(3):160-177. Epub 2023 Jan 11 doi: 10.1038/s41571-022-00719-w. PMID: 36631681
Local and regional therapy for primary and locally recurrent melanoma.
Wilkes JG, Patel A, Zager JS
Clin Adv Hematol Oncol 2021 Apr;19(4):246-260. PMID: 33989273
Surgical management of primary and recurrent melanoma.
Farma JM, Kulkarni N, Hsu C
Surg Oncol Clin N Am 2015 Apr;24(2):239-47. Epub 2015 Jan 22 doi: 10.1016/j.soc.2014.12.003. PMID: 25769709
Therapy for unresectable recurrent and in-transit extremity melanoma.
Gimbel MI, Delman KA, Zager JS
Cancer Control 2008 Jul;15(3):225-32. doi: 10.1177/107327480801500305. PMID: 18596674

Prognosis

TERT and TERT promoter in melanocytic neoplasms: Current concepts in pathogenesis, diagnosis, and prognosis.
Motaparthi K, Kim J, Andea AA, Missall TA, Novoa RA, Vidal CI, Fung MA, Emanuel PO
J Cutan Pathol 2020 Aug;47(8):710-719. Epub 2020 Apr 3 doi: 10.1111/cup.13691. PMID: 32202662
What Should Be Done in Inflammatory Bowel Disease Patients with Prior Malignancy?
Cosnes J
Dig Dis 2017;35(1-2):50-55. Epub 2017 Feb 1 doi: 10.1159/000449083. PMID: 28147366
Fear of new or recurrent melanoma after treatment for localised melanoma.
Bell KJL, Mehta Y, Turner RM, Morton RL, Dieng M, Saw R, Guitera P, McCaffery K, Low D, Low C, Jenkins M, Irwig L, Webster AC
Psychooncology 2017 Nov;26(11):1784-1791. Epub 2017 Feb 2 doi: 10.1002/pon.4366. PMID: 28052599
Surgical management of primary and recurrent melanoma.
Farma JM, Kulkarni N, Hsu C
Surg Oncol Clin N Am 2015 Apr;24(2):239-47. Epub 2015 Jan 22 doi: 10.1016/j.soc.2014.12.003. PMID: 25769709
Therapy for unresectable recurrent and in-transit extremity melanoma.
Gimbel MI, Delman KA, Zager JS
Cancer Control 2008 Jul;15(3):225-32. doi: 10.1177/107327480801500305. PMID: 18596674

Clinical prediction guides

Partial lamellar sclerouvectomy surgery for anteriorly located uveal tumour resection: a 20-year experience.
Mirzayev I, Gündüz AK, Okçu Heper A
Eye (Lond) 2022 May;36(5):969-977. Epub 2021 May 3 doi: 10.1038/s41433-021-01545-7. PMID: 33941875Free PMC Article
Role of vitamin D serum levels in prevention of primary and recurrent melanoma.
Lombardo M, Vigezzi A, Ietto G, Franchi C, Iori V, Masci F, Scorza A, Macchi S, Iovino D, Parise C, Carcano G
Sci Rep 2021 Mar 12;11(1):5815. doi: 10.1038/s41598-021-85294-3. PMID: 33712642Free PMC Article
TERT and TERT promoter in melanocytic neoplasms: Current concepts in pathogenesis, diagnosis, and prognosis.
Motaparthi K, Kim J, Andea AA, Missall TA, Novoa RA, Vidal CI, Fung MA, Emanuel PO
J Cutan Pathol 2020 Aug;47(8):710-719. Epub 2020 Apr 3 doi: 10.1111/cup.13691. PMID: 32202662
What Should Be Done in Inflammatory Bowel Disease Patients with Prior Malignancy?
Cosnes J
Dig Dis 2017;35(1-2):50-55. Epub 2017 Feb 1 doi: 10.1159/000449083. PMID: 28147366
Fear of new or recurrent melanoma after treatment for localised melanoma.
Bell KJL, Mehta Y, Turner RM, Morton RL, Dieng M, Saw R, Guitera P, McCaffery K, Low D, Low C, Jenkins M, Irwig L, Webster AC
Psychooncology 2017 Nov;26(11):1784-1791. Epub 2017 Feb 2 doi: 10.1002/pon.4366. PMID: 28052599

Recent systematic reviews

Organ transplantation and outcomes in patients with a past history of melanoma: A systematic review and meta-analysis.
Williams GJ, Webster AC, Thompson JF
Clin Transplant 2021 Jun;35(6):e14287. Epub 2021 Apr 7 doi: 10.1111/ctr.14287. PMID: 33720403
Systemic adjuvant therapy for adult patients at high risk for recurrent melanoma: A systematic review.
Baetz TD, Fletcher GG, Knight G, McWhirter E, Rajagopal S, Song X, Petrella TM
Cancer Treat Rev 2020 Jul;87:102032. Epub 2020 May 27 doi: 10.1016/j.ctrv.2020.102032. PMID: 32473511
Adjuvant interferon therapy for patients at high risk for recurrent melanoma: an updated systematic review and practice guideline.
Petrella T, Verma S, Spithoff K, Quirt I, McCready D; Melanoma Disease Site Group
Clin Oncol (R Coll Radiol) 2012 Aug;24(6):413-23. Epub 2012 Jan 13 doi: 10.1016/j.clon.2011.12.002. PMID: 22245520
What's new in skin cancer? An analysis of guidelines and systematic reviews published in 2008-2009.
Macbeth AE, Grindlay DJ, Williams HC
Clin Exp Dermatol 2011 Jul;36(5):453-8. Epub 2011 Jun 14 doi: 10.1111/j.1365-2230.2011.04087.x. PMID: 21671988
Systematic review of systemic adjuvant therapy for patients at high risk for recurrent melanoma.
Verma S, Quirt I, McCready D, Bak K, Charette M, Iscoe N
Cancer 2006 Apr 1;106(7):1431-42. doi: 10.1002/cncr.21760. PMID: 16511841

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