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Recurrent Nasopharyngeal Carcinoma

MedGen UID:
83013
•Concept ID:
C0278952
•
Neoplastic Process
Synonyms: Nasopharyngeal Cancer, Recurrent; Recurrent Cancer of Nasopharynx; Recurrent Cancer of the Nasopharynx; Recurrent Carcinoma of Nasopharynx; Recurrent Carcinoma of the Nasopharynx; Recurrent Nasopharyngeal Cancer; Relapsed Cancer of Nasopharynx; Relapsed Cancer of the Nasopharynx; Relapsed Carcinoma of Nasopharynx; Relapsed Carcinoma of the Nasopharynx; Relapsed Nasopharyngeal Cancer; Relapsed Nasopharyngeal Carcinoma; Relapsed Nasopharynx Carcinoma

Definition

The reemergence of nasopharyngeal carcinoma after a period of remission. [from NCI]

Professional guidelines

PubMed

The role of nasopharyngectomy in the management of nasopharyngeal carcinoma.
Wang WH, Yeh CF, Lan MY
Curr Opin Otolaryngol Head Neck Surg 2022 Feb 1;30(1):3-12. doi: 10.1097/MOO.0000000000000780. PMID: 34958319
The Management of rNPC: Salvage Surgery vs. Re-irradiation.
Hao CY, Hao SP
Curr Oncol Rep 2020 Jul 9;22(9):86. doi: 10.1007/s11912-020-00949-0. PMID: 32642860
Management of locally recurrent nasopharyngeal carcinoma.
Lee AWM, Ng WT, Chan JYW, Corry J, Mäkitie A, Mendenhall WM, Rinaldo A, Rodrigo JP, Saba NF, Strojan P, Suárez C, Vermorken JB, Yom SS, Ferlito A
Cancer Treat Rev 2019 Sep;79:101890. Epub 2019 Aug 21 doi: 10.1016/j.ctrv.2019.101890. PMID: 31470314

Recent clinical studies

Etiology

The efficacy and safety of apatinib plus capecitabine in platinum-refractory metastatic and/or recurrent nasopharyngeal carcinoma: a prospective, phase II trial.
Tang LQ, Li XY, Li ZM, Liu ZG, Lin MZ, Zhou H, Yu QW, Zhou J, Zhao C, Chen ZB, Wang XC, Peng JY, Chen QY, Fang WF, Yang YP, Zhang B, Xia LP, Hu PL, Hu WH, Li YJ, Mai HQ, Cai XY
BMC Med 2023 Mar 16;21(1):94. doi: 10.1186/s12916-023-02790-1. PMID: 36927541Free PMC Article
Robotic stereotactic body radiotherapy for recurrent nasopharyngeal carcinoma.
Uysal E, Aksaray F, Dincer S, Altın S
Indian J Cancer 2023 Jul-Sep;60(3):353-358. doi: 10.4103/ijc.IJC_1414_20. PMID: 36861705
Hyperfractionation compared with standard fractionation in intensity-modulated radiotherapy for patients with locally advanced recurrent nasopharyngeal carcinoma: a multicentre, randomised, open-label, phase 3 trial.
You R, Liu YP, Xie YL, Lin C, Duan CY, Chen DP, Pan Y, Qi B, Zou X, Guo L, Cao JY, Zhang YN, Wang ZQ, Liu YL, Ouyang YF, Wen K, Yang Q, Xie RQ, Li HF, Duan XT, Ding X, Peng L, Chen SY, Liang JL, Feng ZK, Xia TL, Xie RL, Jiang R, Gu CM, Liu RZ, Sun R, Yang X, Liu LZ, Ling L, Liu Q, Ng WT, Hua YJ, Huang PY, Chen MY
Lancet 2023 Mar 18;401(10380):917-927. Epub 2023 Feb 23 doi: 10.1016/S0140-6736(23)00269-6. PMID: 36842439
International Recommendations on Reirradiation by Intensity Modulated Radiation Therapy for Locally Recurrent Nasopharyngeal Carcinoma.
Ng WT, Soong YL, Ahn YC, AlHussain H, Choi HCW, Corry J, Grégoire V, Harrington KJ, Hu CS, Jensen K, Kwong DL, Langendijk JA, Le QT, Lee NY, Lin JC, Lu TX, Mendenhall WM, O'Sullivan B, Ozyar E, Pan JJ, Peters LJ, Poh SS, Rosenthal DI, Sanguineti G, Tao Y, Wee JT, Yom SS, Chua MLK, Lee AWM
Int J Radiat Oncol Biol Phys 2021 Jul 1;110(3):682-695. Epub 2021 Feb 9 doi: 10.1016/j.ijrobp.2021.01.041. PMID: 33571626
Management of locally recurrent nasopharyngeal carcinoma.
Lee AWM, Ng WT, Chan JYW, Corry J, Mäkitie A, Mendenhall WM, Rinaldo A, Rodrigo JP, Saba NF, Strojan P, Suárez C, Vermorken JB, Yom SS, Ferlito A
Cancer Treat Rev 2019 Sep;79:101890. Epub 2019 Aug 21 doi: 10.1016/j.ctrv.2019.101890. PMID: 31470314

Diagnosis

Robotic stereotactic body radiotherapy for recurrent nasopharyngeal carcinoma.
Uysal E, Aksaray F, Dincer S, Altın S
Indian J Cancer 2023 Jul-Sep;60(3):353-358. doi: 10.4103/ijc.IJC_1414_20. PMID: 36861705
Image-based diagnosis of residual or recurrent nasopharyngeal carcinoma may be a phantom tumor phenomenon.
Lee CC, Lee JC, Huang WY, Juan CJ, Jen YM, Lin LF
Medicine (Baltimore) 2021 Feb 26;100(8):e24555. doi: 10.1097/MD.0000000000024555. PMID: 33663063Free PMC Article
Management of locally recurrent nasopharyngeal carcinoma.
Lee AWM, Ng WT, Chan JYW, Corry J, Mäkitie A, Mendenhall WM, Rinaldo A, Rodrigo JP, Saba NF, Strojan P, Suárez C, Vermorken JB, Yom SS, Ferlito A
Cancer Treat Rev 2019 Sep;79:101890. Epub 2019 Aug 21 doi: 10.1016/j.ctrv.2019.101890. PMID: 31470314
18F-FDG PET/CT for the Diagnosis of Residual or Recurrent Nasopharyngeal Carcinoma After Radiotherapy: A Metaanalysis.
Zhou H, Shen G, Zhang W, Cai H, Zhou Y, Li L
J Nucl Med 2016 Mar;57(3):342-7. Epub 2015 Nov 5 doi: 10.2967/jnumed.115.165407. PMID: 26541775
Imaging appearances for recurrent nasopharyngeal carcinoma and post-salvage nasopharyngectomy.
Teo PT, Tan NC, Khoo JB
Clin Radiol 2013 Nov;68(11):e629-38. Epub 2013 Aug 12 doi: 10.1016/j.crad.2013.06.003. PMID: 23937825

Therapy

Radiomic signatures reveal multiscale intratumor heterogeneity associated with tissue tolerance and survival in re-irradiated nasopharyngeal carcinoma: a multicenter study.
Liu T, Dong D, Zhao X, Ou XM, Yi JL, Guan J, Zhang Y, Xiao-Fei L, Xie CM, Luo DH, Sun R, Chen QY, Xing L, Guo SS, Liu LT, Lin DF, Chen YZ, Lin JY, Luo MJ, Yan WB, He ML, Mao MY, Zhu MY, Chen WH, Shen BW, Wang SQ, Li HL, Zhong LZ, Hu CS, Wu DH, Mai HQ, Tian J, Tang LQ
BMC Med 2023 Nov 27;21(1):464. doi: 10.1186/s12916-023-03164-3. PMID: 38012705Free PMC Article
The efficacy and safety of apatinib plus capecitabine in platinum-refractory metastatic and/or recurrent nasopharyngeal carcinoma: a prospective, phase II trial.
Tang LQ, Li XY, Li ZM, Liu ZG, Lin MZ, Zhou H, Yu QW, Zhou J, Zhao C, Chen ZB, Wang XC, Peng JY, Chen QY, Fang WF, Yang YP, Zhang B, Xia LP, Hu PL, Hu WH, Li YJ, Mai HQ, Cai XY
BMC Med 2023 Mar 16;21(1):94. doi: 10.1186/s12916-023-02790-1. PMID: 36927541Free PMC Article
Robotic stereotactic body radiotherapy for recurrent nasopharyngeal carcinoma.
Uysal E, Aksaray F, Dincer S, Altın S
Indian J Cancer 2023 Jul-Sep;60(3):353-358. doi: 10.4103/ijc.IJC_1414_20. PMID: 36861705
Hyperfractionation compared with standard fractionation in intensity-modulated radiotherapy for patients with locally advanced recurrent nasopharyngeal carcinoma: a multicentre, randomised, open-label, phase 3 trial.
You R, Liu YP, Xie YL, Lin C, Duan CY, Chen DP, Pan Y, Qi B, Zou X, Guo L, Cao JY, Zhang YN, Wang ZQ, Liu YL, Ouyang YF, Wen K, Yang Q, Xie RQ, Li HF, Duan XT, Ding X, Peng L, Chen SY, Liang JL, Feng ZK, Xia TL, Xie RL, Jiang R, Gu CM, Liu RZ, Sun R, Yang X, Liu LZ, Ling L, Liu Q, Ng WT, Hua YJ, Huang PY, Chen MY
Lancet 2023 Mar 18;401(10380):917-927. Epub 2023 Feb 23 doi: 10.1016/S0140-6736(23)00269-6. PMID: 36842439
Maintenance metronomic chemotherapy for metastatic/recurrent nasopharyngeal carcinoma.
Twu CW, Lin PJ, Tsou HH, Liu YC, Jiang RS, Liang KL, Lin TY, Wang WY, Lin JC
Head Neck 2022 Jun;44(6):1453-1461. Epub 2022 Apr 1 doi: 10.1002/hed.27044. PMID: 35362634

Prognosis

Robotic stereotactic body radiotherapy for recurrent nasopharyngeal carcinoma.
Uysal E, Aksaray F, Dincer S, Altın S
Indian J Cancer 2023 Jul-Sep;60(3):353-358. doi: 10.4103/ijc.IJC_1414_20. PMID: 36861705
Hyperfractionation compared with standard fractionation in intensity-modulated radiotherapy for patients with locally advanced recurrent nasopharyngeal carcinoma: a multicentre, randomised, open-label, phase 3 trial.
You R, Liu YP, Xie YL, Lin C, Duan CY, Chen DP, Pan Y, Qi B, Zou X, Guo L, Cao JY, Zhang YN, Wang ZQ, Liu YL, Ouyang YF, Wen K, Yang Q, Xie RQ, Li HF, Duan XT, Ding X, Peng L, Chen SY, Liang JL, Feng ZK, Xia TL, Xie RL, Jiang R, Gu CM, Liu RZ, Sun R, Yang X, Liu LZ, Ling L, Liu Q, Ng WT, Hua YJ, Huang PY, Chen MY
Lancet 2023 Mar 18;401(10380):917-927. Epub 2023 Feb 23 doi: 10.1016/S0140-6736(23)00269-6. PMID: 36842439
Patterns and prognosis of regional recurrence in nasopharyngeal carcinoma after intensity-modulated radiotherapy.
Xiao XT, Wu YS, Chen YP, Liu X, Guo R, Tang LL, Ma J, Li WF
Cancer Med 2023 Jan;12(2):1399-1408. Epub 2022 Jul 13 doi: 10.1002/cam4.5020. PMID: 35822664Free PMC Article
International Recommendations on Reirradiation by Intensity Modulated Radiation Therapy for Locally Recurrent Nasopharyngeal Carcinoma.
Ng WT, Soong YL, Ahn YC, AlHussain H, Choi HCW, Corry J, Grégoire V, Harrington KJ, Hu CS, Jensen K, Kwong DL, Langendijk JA, Le QT, Lee NY, Lin JC, Lu TX, Mendenhall WM, O'Sullivan B, Ozyar E, Pan JJ, Peters LJ, Poh SS, Rosenthal DI, Sanguineti G, Tao Y, Wee JT, Yom SS, Chua MLK, Lee AWM
Int J Radiat Oncol Biol Phys 2021 Jul 1;110(3):682-695. Epub 2021 Feb 9 doi: 10.1016/j.ijrobp.2021.01.041. PMID: 33571626
Management of locally recurrent nasopharyngeal carcinoma.
Lee AWM, Ng WT, Chan JYW, Corry J, Mäkitie A, Mendenhall WM, Rinaldo A, Rodrigo JP, Saba NF, Strojan P, Suárez C, Vermorken JB, Yom SS, Ferlito A
Cancer Treat Rev 2019 Sep;79:101890. Epub 2019 Aug 21 doi: 10.1016/j.ctrv.2019.101890. PMID: 31470314

Clinical prediction guides

Radiomic signatures reveal multiscale intratumor heterogeneity associated with tissue tolerance and survival in re-irradiated nasopharyngeal carcinoma: a multicenter study.
Liu T, Dong D, Zhao X, Ou XM, Yi JL, Guan J, Zhang Y, Xiao-Fei L, Xie CM, Luo DH, Sun R, Chen QY, Xing L, Guo SS, Liu LT, Lin DF, Chen YZ, Lin JY, Luo MJ, Yan WB, He ML, Mao MY, Zhu MY, Chen WH, Shen BW, Wang SQ, Li HL, Zhong LZ, Hu CS, Wu DH, Mai HQ, Tian J, Tang LQ
BMC Med 2023 Nov 27;21(1):464. doi: 10.1186/s12916-023-03164-3. PMID: 38012705Free PMC Article
The efficacy and safety of apatinib plus capecitabine in platinum-refractory metastatic and/or recurrent nasopharyngeal carcinoma: a prospective, phase II trial.
Tang LQ, Li XY, Li ZM, Liu ZG, Lin MZ, Zhou H, Yu QW, Zhou J, Zhao C, Chen ZB, Wang XC, Peng JY, Chen QY, Fang WF, Yang YP, Zhang B, Xia LP, Hu PL, Hu WH, Li YJ, Mai HQ, Cai XY
BMC Med 2023 Mar 16;21(1):94. doi: 10.1186/s12916-023-02790-1. PMID: 36927541Free PMC Article
Innovative Fudan rT staging in endoscopic surgery for recurrent nasopharyngeal carcinoma.
Li W, Liu Q, Xu H, Wang H, Zhang H, Liu Q, Wang J, Hu L, Li H, Sun X, Yu H, Wang D
Head Neck 2023 Feb;45(2):355-364. Epub 2022 Nov 15 doi: 10.1002/hed.27244. PMID: 36380690
Maintenance metronomic chemotherapy for metastatic/recurrent nasopharyngeal carcinoma.
Twu CW, Lin PJ, Tsou HH, Liu YC, Jiang RS, Liang KL, Lin TY, Wang WY, Lin JC
Head Neck 2022 Jun;44(6):1453-1461. Epub 2022 Apr 1 doi: 10.1002/hed.27044. PMID: 35362634
Establishment of prognostic factors in recurrent nasopharyngeal carcinoma patients who received salvage intensity-modulated radiotherapy: A meta-analysis.
Yue Q, Zhang M, Chen Y, Zheng D, Chen Y, Feng M
Oral Oncol 2018 Jun;81:81-88. Epub 2018 May 2 doi: 10.1016/j.oraloncology.2018.04.017. PMID: 29884418

Recent systematic reviews

Salvage treatments for locally recurrent nasopharyngeal cancer: Systematic review and meta-analysis.
Wang D, Liao M, Wu J, Luo W, Qi S, Liu B, Li J
Head Neck 2023 Feb;45(2):503-520. Epub 2022 Nov 24 doi: 10.1002/hed.27253. PMID: 36420965
Comparing endoscopic surgeries with open surgeries in terms of effectiveness and safety in salvaging residual or recurrent nasopharyngeal cancer: Systematic review and meta-analysis.
Li G, Wang J, Tang H, Han R, Zhao Y, Wang X, Zhou H
Head Neck 2020 Nov;42(11):3415-3426. Epub 2020 Aug 17 doi: 10.1002/hed.26397. PMID: 33463833
Endoscopic nasopharyngectomy in recurrent nasopharyngeal carcinoma: a case series, literature review, and pooled analysis.
Vlantis AC, Lee DL, Wong EW, Chow SM, Ng SK, Chan JY
Int Forum Allergy Rhinol 2017 Apr;7(4):425-432. Epub 2016 Nov 16 doi: 10.1002/alr.21881. PMID: 27865062
Solitary splenic metastasis from nasopharyngeal carcinoma: a case report and systematic review of the literature.
Genova P, Brunetti F, Bequignon E, Landi F, Lizzi V, Esposito F, Charpy C, Calderaro J, Azoulay D, de'Angelis N
World J Surg Oncol 2016 Jul 15;14(1):184. doi: 10.1186/s12957-016-0941-2. PMID: 27422630Free PMC Article
Comparison of 18F-FDG PET/CT, MRI and SPECT in the diagnosis of local residual/recurrent nasopharyngeal carcinoma: A meta-analysis.
Wei J, Pei S, Zhu X
Oral Oncol 2016 Jan;52:11-7. Epub 2015 Nov 4 doi: 10.1016/j.oraloncology.2015.10.010. PMID: 26547126

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