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Crypt abscess

MedGen UID:
83075
•Concept ID:
C0333374
•
Pathologic Function
Synonym: Crypt abscesses
SNOMED CT: Crypt abscess (37771006)

Definition

Accumulation of polymorphonuclear neutrophils in the mucosal crypts of the colon. It occurs in ulcerative colitis. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVCrypt abscess

Professional guidelines

PubMed

The role of mesalazine co-treatment in the prevention of recurrence in subjects with subclinical inflammatory bowel disease and perianal fistula who are scheduled for surgical intervention.
Akturk R, Serinsöz S
Ann Ital Chir 2022;93:183-187. PMID: 35311735
Advanced criteria for clinicopathological diagnosis of food protein-induced proctocolitis.
Hwang JB, Park MH, Kang YN, Kim SP, Suh SI, Kam S
J Korean Med Sci 2007 Apr;22(2):213-7. doi: 10.3346/jkms.2007.22.2.213. PMID: 17449926Free PMC Article

Recent clinical studies

Etiology

Gastrointestinal Adverse Events Induced by Immune-Checkpoint Inhibitors.
Yanai S, Toya Y, Sugai T, Matsumoto T
Digestion 2021;102(6):965-973. Epub 2021 Sep 2 doi: 10.1159/000518543. PMID: 34515105
Lymphocytic and collagenous colitis in children and adolescents: Comprehensive clinicopathologic analysis with long-term follow-up.
Windon AL, Almazan E, Oliva-Hemker M, Hutchings D, Assarzadegan N, Salimian K, Montgomery EA, Voltaggio L
Hum Pathol 2020 Dec;106:13-22. Epub 2020 Sep 28 doi: 10.1016/j.humpath.2020.09.011. PMID: 32991931
Clinical features and monocyte/macrophage subsets characterization in granulomatous vs non-granulomatous Crohn's disease.
Zhao L, Tang Y, Lei N, Zhou D, Chen B, Gan T, Yang X, Zhang Y
Scand J Gastroenterol 2020 Apr;55(4):442-448. Epub 2020 Apr 14 doi: 10.1080/00365521.2020.1748222. PMID: 32285715
Endocytoscopic classification can be predictive for relapse in ulcerative colitis.
Ueda N, Isomoto H, Ikebuchi Y, Kurumi H, Kawaguchi K, Yashima K, Ueki M, Matsushima K, Akashi T, Uehara R, Takeshima F, Hayashi T, Nakao K
Medicine (Baltimore) 2018 Mar;97(10):e0107. doi: 10.1097/MD.0000000000010107. PMID: 29517688Free PMC Article
Colitis-related rat colon carcinogenesis induced by 1-hydroxy-anthraquinone and methylazoxymethanol acetate (Review).
Tanaka T, Kohno H, Murakami M, Shimada R, Kagami S
Oncol Rep 2000 May-Jun;7(3):501-8. doi: 10.3892/or.7.3.501. PMID: 10767359

Diagnosis

Gastrointestinal Adverse Events Induced by Immune-Checkpoint Inhibitors.
Yanai S, Toya Y, Sugai T, Matsumoto T
Digestion 2021;102(6):965-973. Epub 2021 Sep 2 doi: 10.1159/000518543. PMID: 34515105
Immune checkpoint inhibitor-induced diarrhea: Clinicopathological study of 11 patients.
Yanai S, Nakamura S, Kawasaki K, Toya Y, Akasaka R, Oizumi T, Ishida K, Sugai T, Matsumoto T
Dig Endosc 2020 May;32(4):616-620. Epub 2019 Nov 12 doi: 10.1111/den.13555. PMID: 31595568
Endocytoscopic classification can be predictive for relapse in ulcerative colitis.
Ueda N, Isomoto H, Ikebuchi Y, Kurumi H, Kawaguchi K, Yashima K, Ueki M, Matsushima K, Akashi T, Uehara R, Takeshima F, Hayashi T, Nakao K
Medicine (Baltimore) 2018 Mar;97(10):e0107. doi: 10.1097/MD.0000000000010107. PMID: 29517688Free PMC Article
The Apoptotic Crypt Abscess: An Underappreciated Histologic Finding in Gastrointestinal Pathology.
Talmon G, Manasek T, Miller R, Muirhead D, Lazenby A
Am J Clin Pathol 2017 Nov 20;148(6):538-544. doi: 10.1093/ajcp/aqx100. PMID: 29140405
Campylobacter colitis.
Lambert ME, Schofield PF, Ironside AG, Mandal BK
Br Med J 1979 Mar 31;1(6167):857-9. doi: 10.1136/bmj.1.6167.857. PMID: 435842Free PMC Article

Therapy

Jianpi Qingchang Bushen decoction improves inflammatory response and metabolic bone disorder in inflammatory bowel disease-induced bone loss.
Zhang YL, Chen Q, Zheng L, Zhang ZW, Chen YJ, Dai YC, Tang ZP
World J Gastroenterol 2022 Apr 7;28(13):1315-1328. doi: 10.3748/wjg.v28.i13.1315. PMID: 35645540Free PMC Article
Immune checkpoint inhibitor-induced diarrhea: Clinicopathological study of 11 patients.
Yanai S, Nakamura S, Kawasaki K, Toya Y, Akasaka R, Oizumi T, Ishida K, Sugai T, Matsumoto T
Dig Endosc 2020 May;32(4):616-620. Epub 2019 Nov 12 doi: 10.1111/den.13555. PMID: 31595568
The Apoptotic Crypt Abscess: An Underappreciated Histologic Finding in Gastrointestinal Pathology.
Talmon G, Manasek T, Miller R, Muirhead D, Lazenby A
Am J Clin Pathol 2017 Nov 20;148(6):538-544. doi: 10.1093/ajcp/aqx100. PMID: 29140405
Systemic lupus erythematosus complicated by Crohn's disease: a case report and literature review.
Yamashita H, Ueda Y, Kawaguchi H, Suzuki A, Takahashi Y, Kaneko H, Kano T, Mimori A
BMC Gastroenterol 2012 Dec 5;12:174. doi: 10.1186/1471-230X-12-174. PMID: 23216789Free PMC Article
Appendices removed at cesarean section: histopathology.
Onuigbo WI, Chukudebelu WO
Dis Colon Rectum 1981 Oct;24(7):507-9. doi: 10.1007/BF02604309. PMID: 7297358

Prognosis

Gastrointestinal Adverse Events Induced by Immune-Checkpoint Inhibitors.
Yanai S, Toya Y, Sugai T, Matsumoto T
Digestion 2021;102(6):965-973. Epub 2021 Sep 2 doi: 10.1159/000518543. PMID: 34515105
Lymphocytic and collagenous colitis in children and adolescents: Comprehensive clinicopathologic analysis with long-term follow-up.
Windon AL, Almazan E, Oliva-Hemker M, Hutchings D, Assarzadegan N, Salimian K, Montgomery EA, Voltaggio L
Hum Pathol 2020 Dec;106:13-22. Epub 2020 Sep 28 doi: 10.1016/j.humpath.2020.09.011. PMID: 32991931
Endocytoscopic classification can be predictive for relapse in ulcerative colitis.
Ueda N, Isomoto H, Ikebuchi Y, Kurumi H, Kawaguchi K, Yashima K, Ueki M, Matsushima K, Akashi T, Uehara R, Takeshima F, Hayashi T, Nakao K
Medicine (Baltimore) 2018 Mar;97(10):e0107. doi: 10.1097/MD.0000000000010107. PMID: 29517688Free PMC Article
Clinical Implications of Histologic Abnormalities in Ileocolonic Biopsies of Patients With Crohn's Disease in Remission.
Brennan GT, Melton SD, Spechler SJ, Feagins LA
J Clin Gastroenterol 2017 Jan;51(1):43-48. doi: 10.1097/MCG.0000000000000507. PMID: 26927490
Intestinal mucosa diamine oxidase activity reflects intestinal involvement in Crohn's disease.
Thompson JS, Burnett DA, Markin RS, Vaughan WP
Am J Gastroenterol 1988 Jul;83(7):756-60. PMID: 3132852

Clinical prediction guides

Computed tomography enterocolongraphy in assessment of degree of ulcerative colitis activity.
Ahmed EA, Abdelatty K, Mahdy RE, Emara DM, Header DA
Int J Clin Pract 2021 Oct;75(10):e14626. Epub 2021 Jul 28 doi: 10.1111/ijcp.14626. PMID: 34258846
Clinical features and monocyte/macrophage subsets characterization in granulomatous vs non-granulomatous Crohn's disease.
Zhao L, Tang Y, Lei N, Zhou D, Chen B, Gan T, Yang X, Zhang Y
Scand J Gastroenterol 2020 Apr;55(4):442-448. Epub 2020 Apr 14 doi: 10.1080/00365521.2020.1748222. PMID: 32285715
Immune checkpoint inhibitor-induced diarrhea: Clinicopathological study of 11 patients.
Yanai S, Nakamura S, Kawasaki K, Toya Y, Akasaka R, Oizumi T, Ishida K, Sugai T, Matsumoto T
Dig Endosc 2020 May;32(4):616-620. Epub 2019 Nov 12 doi: 10.1111/den.13555. PMID: 31595568
Endocytoscopic classification can be predictive for relapse in ulcerative colitis.
Ueda N, Isomoto H, Ikebuchi Y, Kurumi H, Kawaguchi K, Yashima K, Ueki M, Matsushima K, Akashi T, Uehara R, Takeshima F, Hayashi T, Nakao K
Medicine (Baltimore) 2018 Mar;97(10):e0107. doi: 10.1097/MD.0000000000010107. PMID: 29517688Free PMC Article
Crypt abscess-associated microbiota in inflammatory bowel disease and acute self-limited colitis.
Sokol H, Vasquez N, Hoyeau-Idrissi N, Seksik P, Beaugerie L, Lavergne-Slove A, Pochart P, Marteau P
World J Gastroenterol 2010 Feb 7;16(5):583-7. doi: 10.3748/wjg.v16.i5.583. PMID: 20128026Free PMC Article

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