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High Grade Squamous Intraepithelial Neoplasia

MedGen UID:
83093
•Concept ID:
C0333875
•
Neoplastic Process
Synonyms: High Grade Squamous Intraepithelial Lesion; High Grade Squamous Intraepithelial Lesions; High-Grade Squamous Intraepithelial Lesion; High-Grade Squamous Intraepithelial Lesions; HSIL, High Grade Squamous Intraepithelial Lesion; HSIL, High Grade Squamous Intraepithelial Lesions; HSIL, High-Grade Squamous Intraepithelial Lesions
SNOMED CT: High-grade squamous intraepithelial lesion (22725004); HSIL - high-grade squamous intraepithelial lesion (22725004); High grade SIL (squamous intraepithelial lesion) (22725004)

Definition

A precancerous neoplastic process characterized by the presence of moderate or severe dysplastic cytological changes which extend to the upper part of the squamous epithelium. Maturation at the surface of the squamous epithelium may or may not be present. Representative examples include the high grade esophageal squamous intraepithelial neoplasia, high grade cervical squamous intraepithelial neoplasia, high grade vaginal intraepithelial neoplasia, and high grade vulvar intraepithelial neoplasia. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVHigh Grade Squamous Intraepithelial Neoplasia

Professional guidelines

PubMed

Management of Vulvar Cancer Precursors: A Survey of the International Society for the Study of Vulvovaginal Disease.
Green N, Adedipe T, Dmytryshyn J, Preti M, Selk A
J Low Genit Tract Dis 2020 Oct;24(4):387-391. doi: 10.1097/LGT.0000000000000559. PMID: 32986387
Carcinogenic risk of human papillomavirus (HPV) genotypes and potential effects of HPV vaccines in Korea.
Park E, Kim JY, Choi S, Kim DS, Oh YL
Sci Rep 2019 Aug 29;9(1):12556. doi: 10.1038/s41598-019-49060-w. PMID: 31467383Free PMC Article
Clinical results of infrared coagulation as a treatment of high-grade anal dysplasia: a systematic review.
Corral J, Parés D, García-Cuyás F, Revollo B, Videla S, Chamorro A, Piñol M, Clotet B, Sirera G
Tech Coloproctol 2019 Aug;23(8):707-712. Epub 2019 Jul 23 doi: 10.1007/s10151-019-02041-7. PMID: 31338711

Recent clinical studies

Etiology

Reflectance confocal microscopy as a non-invasive imaging tool in vulvar high-grade squamous intraepithelial lesions and lichen sclerosus: A descriptive morphological study in patients and healthy volunteers.
Huisman BW, Pagan L, Ulrich M, Rissmann R, Damman J, Piek JMJ, Niemeyer-van der Kolk T, van Poelgeest MIE
Exp Dermatol 2023 Oct;32(10):1734-1743. Epub 2023 Jul 24 doi: 10.1111/exd.14888. PMID: 37486173
The crossroads: divergent roles of virus-specific CD4(+) T lymphocytes in determining the outcome for human papillomavirus infection.
van Bockel D, Kelleher A
Immunol Cell Biol 2023 Jul;101(6):525-534. Epub 2023 May 9 doi: 10.1111/imcb.12650. PMID: 37159056
Association of P16, Ki-67, and CD44 expression in high-grade squamous intraepithelial neoplasia and squamous cell carcinoma of the cervix.
Mehdi HK, Raju K, Sheela SR
J Cancer Res Ther 2023 Apr;19(Supplement):S260-S267. doi: 10.4103/jcrt.jcrt_43_21. PMID: 37148002
Lower accuracy of cytological screening for high-grade squamous intraepithelial neoplasia in women over 50 years of age in Japan.
Miki M, Imaeda Y, Takahashi H, Iwata A, Tsukamoto T, Nomura H, Kotani K, Mitani T, Ichikawa R, Fujii T
Int J Clin Oncol 2022 Feb;27(2):427-433. Epub 2021 Dec 6 doi: 10.1007/s10147-021-02065-w. PMID: 34873649Free PMC Article
Prevalence of high-grade squamous intraepithelial neoplasia (HiSIL) in symptomatic women referred to the colposcopy clinic with negative cytology.
Ray P, Kaul V
Arch Gynecol Obstet 2008 Jun;277(6):501-4. doi: 10.1007/s00404-007-0513-3. PMID: 18034351

Diagnosis

Reflectance confocal microscopy as a non-invasive imaging tool in vulvar high-grade squamous intraepithelial lesions and lichen sclerosus: A descriptive morphological study in patients and healthy volunteers.
Huisman BW, Pagan L, Ulrich M, Rissmann R, Damman J, Piek JMJ, Niemeyer-van der Kolk T, van Poelgeest MIE
Exp Dermatol 2023 Oct;32(10):1734-1743. Epub 2023 Jul 24 doi: 10.1111/exd.14888. PMID: 37486173
Lower accuracy of cytological screening for high-grade squamous intraepithelial neoplasia in women over 50 years of age in Japan.
Miki M, Imaeda Y, Takahashi H, Iwata A, Tsukamoto T, Nomura H, Kotani K, Mitani T, Ichikawa R, Fujii T
Int J Clin Oncol 2022 Feb;27(2):427-433. Epub 2021 Dec 6 doi: 10.1007/s10147-021-02065-w. PMID: 34873649Free PMC Article
Performance of three colposcopic images for the identification of squamous and glandular cervical precursor neoplasias.
Fachetti-Machado G, Figueiredo-Alves RR, Moreira MAR
Arch Gynecol Obstet 2022 May;305(5):1319-1327. Epub 2021 Nov 2 doi: 10.1007/s00404-021-06284-4. PMID: 34727221Free PMC Article
Prevalence of high-grade squamous intraepithelial neoplasia (HiSIL) in symptomatic women referred to the colposcopy clinic with negative cytology.
Ray P, Kaul V
Arch Gynecol Obstet 2008 Jun;277(6):501-4. doi: 10.1007/s00404-007-0513-3. PMID: 18034351
Penile squamous cell carcinoma: anatomic, pathologic and viral studies in Paraguay (1993-2007).
Velazquez EF, Cubilla AL
Anal Quant Cytol Histol 2007 Aug;29(4):185-98. PMID: 17879626

Therapy

Reflectance confocal microscopy as a non-invasive imaging tool in vulvar high-grade squamous intraepithelial lesions and lichen sclerosus: A descriptive morphological study in patients and healthy volunteers.
Huisman BW, Pagan L, Ulrich M, Rissmann R, Damman J, Piek JMJ, Niemeyer-van der Kolk T, van Poelgeest MIE
Exp Dermatol 2023 Oct;32(10):1734-1743. Epub 2023 Jul 24 doi: 10.1111/exd.14888. PMID: 37486173
Efficacy of the AS04-Adjuvanted HPV16/18 Vaccine: Pooled Analysis of the Costa Rica Vaccine and PATRICIA Randomized Controlled Trials.
Tota JE, Struyf F, Sampson JN, Gonzalez P, Ryser M, Herrero R, Schussler J, Karkada N, Rodriguez AC, Folschweiller N, Porras C, Schiffman M, Schiller JT, Quint W, Kreimer AR, Wheeler CM, Hildesheim A; Costa Rica Vaccine Trial and PATRICIA Study
J Natl Cancer Inst 2020 Aug 1;112(8):818-828. doi: 10.1093/jnci/djz222. PMID: 31697384Free PMC Article
Clinical results of infrared coagulation as a treatment of high-grade anal dysplasia: a systematic review.
Corral J, Parés D, García-Cuyás F, Revollo B, Videla S, Chamorro A, Piñol M, Clotet B, Sirera G
Tech Coloproctol 2019 Aug;23(8):707-712. Epub 2019 Jul 23 doi: 10.1007/s10151-019-02041-7. PMID: 31338711
Outcomes from a prospective trial of endoscopic radiofrequency ablation of early squamous cell neoplasia of the esophagus.
Bergman JJ, Zhang YM, He S, Weusten B, Xue L, Fleischer DE, Lu N, Dawsey SM, Wang GQ
Gastrointest Endosc 2011 Dec;74(6):1181-90. Epub 2011 Aug 15 doi: 10.1016/j.gie.2011.05.024. PMID: 21839994Free PMC Article
Incidence of squamous neoplasia of the cervix and vagina in women exposed prenatally to diethylstilbestrol (United States).
Hatch EE, Herbst AL, Hoover RN, Noller KL, Adam E, Kaufman RH, Palmer JR, Titus-Ernstoff L, Hyer M, Hartge P, Robboy SJ
Cancer Causes Control 2001 Nov;12(9):837-45. doi: 10.1023/a:1012229112696. PMID: 11714112

Prognosis

Reflectance confocal microscopy as a non-invasive imaging tool in vulvar high-grade squamous intraepithelial lesions and lichen sclerosus: A descriptive morphological study in patients and healthy volunteers.
Huisman BW, Pagan L, Ulrich M, Rissmann R, Damman J, Piek JMJ, Niemeyer-van der Kolk T, van Poelgeest MIE
Exp Dermatol 2023 Oct;32(10):1734-1743. Epub 2023 Jul 24 doi: 10.1111/exd.14888. PMID: 37486173
Lower accuracy of cytological screening for high-grade squamous intraepithelial neoplasia in women over 50 years of age in Japan.
Miki M, Imaeda Y, Takahashi H, Iwata A, Tsukamoto T, Nomura H, Kotani K, Mitani T, Ichikawa R, Fujii T
Int J Clin Oncol 2022 Feb;27(2):427-433. Epub 2021 Dec 6 doi: 10.1007/s10147-021-02065-w. PMID: 34873649Free PMC Article
The Conundrum of an Accumulating Acuminatum.
Cimmino A, Walters E, Gubler A, Ibrahim A
Am J Case Rep 2020 Feb 23;21:e920516. doi: 10.12659/AJCR.920516. PMID: 32088723Free PMC Article
Penile squamous cell carcinoma: anatomic, pathologic and viral studies in Paraguay (1993-2007).
Velazquez EF, Cubilla AL
Anal Quant Cytol Histol 2007 Aug;29(4):185-98. PMID: 17879626
Why is high grade squamous intraepithelial neoplasia under-diagnosed on cytology in a quarter of cases? Analysis of smear characteristics in discrepant cases.
Gupta S, Sodhani P
Indian J Cancer 2004 Jul-Sep;41(3):104-8. PMID: 15472407

Clinical prediction guides

Reflectance confocal microscopy as a non-invasive imaging tool in vulvar high-grade squamous intraepithelial lesions and lichen sclerosus: A descriptive morphological study in patients and healthy volunteers.
Huisman BW, Pagan L, Ulrich M, Rissmann R, Damman J, Piek JMJ, Niemeyer-van der Kolk T, van Poelgeest MIE
Exp Dermatol 2023 Oct;32(10):1734-1743. Epub 2023 Jul 24 doi: 10.1111/exd.14888. PMID: 37486173
Lower accuracy of cytological screening for high-grade squamous intraepithelial neoplasia in women over 50 years of age in Japan.
Miki M, Imaeda Y, Takahashi H, Iwata A, Tsukamoto T, Nomura H, Kotani K, Mitani T, Ichikawa R, Fujii T
Int J Clin Oncol 2022 Feb;27(2):427-433. Epub 2021 Dec 6 doi: 10.1007/s10147-021-02065-w. PMID: 34873649Free PMC Article
Concurrent high expression of human telomerase reverse transcriptase and human nonmetastatic clone 23 in high-grade squamous intraepithelial neoplasia and squamous cell carcinoma of uterine cervix.
Hsu CG, Wang PH, Ko JL, Chen GD, Chang H, Yang SF, Chen SC, Lin LY
Int J Gynecol Cancer 2007 Jul-Aug;17(4):851-7. Epub 2007 Mar 13 doi: 10.1111/j.1525-1438.2007.00894.x. PMID: 17359290
A study of Ki-67, c-erbB2 and cyclin D-1 expression in CIN-I, CIN-III and squamous cell carcinoma of the cervix.
Carreras R, Alameda F, Mancebo G, García-Moreno P, Mariñoso ML, Costa C, Fusté P, Baró T, Serrano S
Histol Histopathol 2007 Jun;22(6):587-92. doi: 10.14670/HH-22.587. PMID: 17357088
Cytologic observations preceding high grade squamous intraepithelial lesions.
Troncone G, Gupta PK
Acta Cytol 1995 Jul-Aug;39(4):659-62. PMID: 7631539

Recent systematic reviews

Clinical results of infrared coagulation as a treatment of high-grade anal dysplasia: a systematic review.
Corral J, Parés D, García-Cuyás F, Revollo B, Videla S, Chamorro A, Piñol M, Clotet B, Sirera G
Tech Coloproctol 2019 Aug;23(8):707-712. Epub 2019 Jul 23 doi: 10.1007/s10151-019-02041-7. PMID: 31338711

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