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Basal cell hyperplasia

MedGen UID:
83097
•Concept ID:
C0333990
•
Pathologic Function
Synonyms: Basal Cell Hyperplasia; Reserve cell hyperplasia
SNOMED CT: Basal cell hyperplasia (89855005); Reserve cell hyperplasia (89855005)

Definition

A pathologic hyperplastic process characterized by the proliferation of the cells of the epithelial layer that resemble the basal cells of the lower part of the epidermis. [from NCI]

Professional guidelines

PubMed

What is the role of endoscopy and oesophageal biopsies in the management of GERD?
Krugmann J, Neumann H, Vieth M, Armstrong D
Best Pract Res Clin Gastroenterol 2013 Jun;27(3):373-85. doi: 10.1016/j.bpg.2013.06.010. PMID: 23998976
Differential diagnosis of glandular proliferations in the prostate. A conventional and immunohistochemical approach.
Helpap B
Virchows Arch 1998 Nov;433(5):397-405. doi: 10.1007/s004280050266. PMID: 9849853
The differential diagnosis of prostatic carcinoma. Its distinction from premalignant and pseudocarcinomatous lesions of the prostate gland.
Jones EC, Young RH
Am J Clin Pathol 1994 Jan;101(1):48-64. doi: 10.1093/ajcp/101.1.48. PMID: 7506479

Recent clinical studies

Etiology

Anemoside B4 prevents chronic obstructive pulmonary disease through alleviating cigarette smoke-induced inflammatory response and airway epithelial hyperplasia.
Ma H, Zhou Z, Chen L, Wang L, Muge Q
Phytomedicine 2022 Dec;107:154431. Epub 2022 Sep 2 doi: 10.1016/j.phymed.2022.154431. PMID: 36115169
Smoking Is Associated With Basal Cell Hyperplasia on Prostate Biopsy Specimens.
Freitas DM, Andriole GL, Freedland SJ, Neto BS, Moreira DM
Am J Clin Pathol 2021 Oct 13;156(5):934-938. doi: 10.1093/ajcp/aqab030. PMID: 33939794
Benign mimics of prostate cancer.
Egevad L, Delahunt B, Furusato B, Tsuzuki T, Yaxley J, Samaratunga H
Pathology 2021 Jan;53(1):26-35. Epub 2020 Oct 16 doi: 10.1016/j.pathol.2020.08.006. PMID: 33070957
Baseline Basal Cell Hyperplasia Is not Associated With Baseline Lower Urinary Tract Symptoms, Baseline Clinical Prostatitis or Prostate Cancer in Repeat Biopsies.
Freitas D, Andriole GL, Freedland SJ, Neto BS, Moreira DM
Urology 2019 Jul;129:160-164. Epub 2019 Mar 23 doi: 10.1016/j.urology.2019.02.034. PMID: 30914334
Seminal vesicle intraepithelial neoplasia versus basal cell hyperplasia in a seminal vesicle.
Montironi R, Lopez-Beltran A, Cheng L, Galosi AB, Montorsi F, Scarpelli M
Eur Urol 2014 Oct;66(4):623-7. Epub 2014 Mar 4 doi: 10.1016/j.eururo.2014.02.054. PMID: 24631410

Diagnosis

Benign mimics of prostate cancer.
Egevad L, Delahunt B, Furusato B, Tsuzuki T, Yaxley J, Samaratunga H
Pathology 2021 Jan;53(1):26-35. Epub 2020 Oct 16 doi: 10.1016/j.pathol.2020.08.006. PMID: 33070957
Respiratory cytology in the era of molecular diagnostics: a review.
Witt BL, Wallander ML, Layfield LJ, Hirschowitz S
Diagn Cytopathol 2012 Jun;40(6):556-63. doi: 10.1002/dc.22858. PMID: 22619130
Eosinophilic oesophagitis versus reflux oesophagitis.
Ensari A
Acta Gastroenterol Belg 2011 Jun;74(2):323-9. PMID: 21861318
Adenoid cystic/basal cell carcinoma of the prostate: review and update.
Begnami MD, Quezado M, Pinto P, Linehan WM, Merino M
Arch Pathol Lab Med 2007 Apr;131(4):637-40. doi: 10.5858/2007-131-637-ABCCOT. PMID: 17425398
Florid basal cell hyperplasia of the prostate: a histological, ultrastructural, and immunohistochemical analysis.
Yang XJ, Tretiakova MS, Sengupta E, Gong C, Jiang Z
Hum Pathol 2003 May;34(5):462-70. doi: 10.1016/s0046-8177(03)00121-7. PMID: 12792920

Therapy

Anemoside B4 prevents chronic obstructive pulmonary disease through alleviating cigarette smoke-induced inflammatory response and airway epithelial hyperplasia.
Ma H, Zhou Z, Chen L, Wang L, Muge Q
Phytomedicine 2022 Dec;107:154431. Epub 2022 Sep 2 doi: 10.1016/j.phymed.2022.154431. PMID: 36115169
Plasminogen Activator Inhibitor-1 as a Marker of Esophageal Functional Changes in Pediatric Eosinophilic Esophagitis.
Williamson P, Proudfoot J, Gharibans A, Dohil L, Newbury R, Barsamian J, Hassan M, Rawson R, Katzka D, Kurten R, Dohil R, Mousa H, Aceves S
Clin Gastroenterol Hepatol 2022 Jan;20(1):57-64.e3. Epub 2020 Sep 30 doi: 10.1016/j.cgh.2020.09.040. PMID: 33007513Free PMC Article
Smoking Is Associated With Basal Cell Hyperplasia on Prostate Biopsy Specimens.
Freitas DM, Andriole GL, Freedland SJ, Neto BS, Moreira DM
Am J Clin Pathol 2021 Oct 13;156(5):934-938. doi: 10.1093/ajcp/aqab030. PMID: 33939794
Baseline Basal Cell Hyperplasia Is not Associated With Baseline Lower Urinary Tract Symptoms, Baseline Clinical Prostatitis or Prostate Cancer in Repeat Biopsies.
Freitas D, Andriole GL, Freedland SJ, Neto BS, Moreira DM
Urology 2019 Jul;129:160-164. Epub 2019 Mar 23 doi: 10.1016/j.urology.2019.02.034. PMID: 30914334
The morphologic changes induced by hormone and radiation therapy on prostate carcinoma.
Roznovanu SL, Rădulescu D, Novac C, Stolnicu S
Rev Med Chir Soc Med Nat Iasi 2005 Apr-Jun;109(2):337-42. PMID: 16607796

Prognosis

Persistent Basal Cell Hyperplasia Is Associated With Clinical and Endoscopic Findings in Patients With Histologically Inactive Eosinophilic Esophagitis.
Whelan KA, Godwin BC, Wilkins B, Elci OU, Benitez A, DeMarshall M, Sharma M, Gross J, Klein-Szanto AJ, Liacouras CA, Dellon ES, Spergel JM, Falk GW, Muir AB, Nakagawa H
Clin Gastroenterol Hepatol 2020 Jun;18(7):1475-1482.e1. Epub 2019 Sep 6 doi: 10.1016/j.cgh.2019.08.055. PMID: 31499251Free PMC Article
Baseline Basal Cell Hyperplasia Is not Associated With Baseline Lower Urinary Tract Symptoms, Baseline Clinical Prostatitis or Prostate Cancer in Repeat Biopsies.
Freitas D, Andriole GL, Freedland SJ, Neto BS, Moreira DM
Urology 2019 Jul;129:160-164. Epub 2019 Mar 23 doi: 10.1016/j.urology.2019.02.034. PMID: 30914334
Seminal vesicle intraepithelial neoplasia versus basal cell hyperplasia in a seminal vesicle.
Montironi R, Lopez-Beltran A, Cheng L, Galosi AB, Montorsi F, Scarpelli M
Eur Urol 2014 Oct;66(4):623-7. Epub 2014 Mar 4 doi: 10.1016/j.eururo.2014.02.054. PMID: 24631410
Respiratory cytology in the era of molecular diagnostics: a review.
Witt BL, Wallander ML, Layfield LJ, Hirschowitz S
Diagn Cytopathol 2012 Jun;40(6):556-63. doi: 10.1002/dc.22858. PMID: 22619130
Adenoid cystic/basal cell carcinoma of the prostate: review and update.
Begnami MD, Quezado M, Pinto P, Linehan WM, Merino M
Arch Pathol Lab Med 2007 Apr;131(4):637-40. doi: 10.5858/2007-131-637-ABCCOT. PMID: 17425398

Clinical prediction guides

Anemoside B4 prevents chronic obstructive pulmonary disease through alleviating cigarette smoke-induced inflammatory response and airway epithelial hyperplasia.
Ma H, Zhou Z, Chen L, Wang L, Muge Q
Phytomedicine 2022 Dec;107:154431. Epub 2022 Sep 2 doi: 10.1016/j.phymed.2022.154431. PMID: 36115169
Prediction of malignant transformation and recurrence of oral epithelial dysplasia using architectural and cytological feature specific prognostic models.
Mahmood H, Bradburn M, Rajpoot N, Islam NM, Kujan O, Khurram SA
Mod Pathol 2022 Sep;35(9):1151-1159. Epub 2022 Mar 31 doi: 10.1038/s41379-022-01067-x. PMID: 35361889Free PMC Article
Premalignant lesions of squamous cell carcinoma of the lung: The molecular make-up and factors affecting their progression.
Denisov EV, Schegoleva AA, Gervas PA, Ponomaryova AA, Tashireva LA, Boyarko VV, Bukreeva EB, Pankova OV, Perelmuter VM
Lung Cancer 2019 Sep;135:21-28. Epub 2019 Jul 5 doi: 10.1016/j.lungcan.2019.07.001. PMID: 31446997
Basal cell hyperplasia in the peripheral zone of the prostate.
Thorson P, Swanson PE, Vollmer RT, Humphrey PA
Mod Pathol 2003 Jun;16(6):598-606. doi: 10.1097/01.MP.0000073526.59270.6E. PMID: 12808066
Unusual morphologic patterns of basal cell hyperplasia of the prostate.
Rioux-Leclercq NC, Epstein JI
Am J Surg Pathol 2002 Feb;26(2):237-43. doi: 10.1097/00000478-200202000-00011. PMID: 11812946

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