U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Basal cell hyperplasia

MedGen UID:
83097
•Concept ID:
C0333990
•
Pathologic Function
Synonyms: Basal Cell Hyperplasia; Reserve cell hyperplasia
SNOMED CT: Basal cell hyperplasia (89855005); Reserve cell hyperplasia (89855005)

Definition

A pathologic hyperplastic process characterized by the proliferation of the cells of the epithelial layer that resemble the basal cells of the lower part of the epidermis. [from NCI]

Professional guidelines

PubMed

Effect of Proton Pump Inhibitor Treatment in "PPI Non-responsive" Patients with Eosinophilic Esophagitis.
Thakkar KP, Philpott H, Lafata S, Fowler M, Keene S, Iuga A, Dellon E
J Gastrointestin Liver Dis 2023 Mar 31;32(1):15-22. doi: 10.15403/jgld-4746. PMID: 37004219Free PMC Article
What is the role of endoscopy and oesophageal biopsies in the management of GERD?
Krugmann J, Neumann H, Vieth M, Armstrong D
Best Pract Res Clin Gastroenterol 2013 Jun;27(3):373-85. doi: 10.1016/j.bpg.2013.06.010. PMID: 23998976
The differential diagnosis of prostatic carcinoma. Its distinction from premalignant and pseudocarcinomatous lesions of the prostate gland.
Jones EC, Young RH
Am J Clin Pathol 1994 Jan;101(1):48-64. doi: 10.1093/ajcp/101.1.48. PMID: 7506479

Recent clinical studies

Etiology

Basal cell carcinoma-clinico-pathological study in Eastern India in correlation with different risk factors.
Jain C, Garg N, Singh S, Chattopadhyay S
Indian J Pathol Microbiol 2022 Oct-Dec;65(4):869-872. doi: 10.4103/ijpm.ijpm_180_21. PMID: 36308196
CD73(+) Epithelial Progenitor Cells That Contribute to Homeostasis and Renewal Are Depleted in Eosinophilic Esophagitis.
Hara T, Kasagi Y, Wang J, Sasaki M, Aaron B, Karami A, Shimonosono M, Shimonosono R, Maekawa H, Dolinsky L, Wilkins B, Klein J, Wei J, Nunes K, Lynch K, Spergel JM, Hamilton KE, Ruffner MA, Karakasheva TA, Whelan KA, Nakagawa H, Muir AB
Cell Mol Gastroenterol Hepatol 2022;13(5):1449-1467. Epub 2022 Jan 30 doi: 10.1016/j.jcmgh.2022.01.018. PMID: 35108658Free PMC Article
Smoking Is Associated With Basal Cell Hyperplasia on Prostate Biopsy Specimens.
Freitas DM, Andriole GL, Freedland SJ, Neto BS, Moreira DM
Am J Clin Pathol 2021 Oct 13;156(5):934-938. doi: 10.1093/ajcp/aqab030. PMID: 33939794
Benign mimics of prostate cancer.
Egevad L, Delahunt B, Furusato B, Tsuzuki T, Yaxley J, Samaratunga H
Pathology 2021 Jan;53(1):26-35. Epub 2020 Oct 16 doi: 10.1016/j.pathol.2020.08.006. PMID: 33070957
Precursor lesions to prostatic adenocarcinoma.
Epstein JI
Virchows Arch 2009 Jan;454(1):1-16. Epub 2008 Dec 2 doi: 10.1007/s00428-008-0707-5. PMID: 19048290

Diagnosis

Benign mimics of prostate cancer.
Egevad L, Delahunt B, Furusato B, Tsuzuki T, Yaxley J, Samaratunga H
Pathology 2021 Jan;53(1):26-35. Epub 2020 Oct 16 doi: 10.1016/j.pathol.2020.08.006. PMID: 33070957
Respiratory cytology in the era of molecular diagnostics: a review.
Witt BL, Wallander ML, Layfield LJ, Hirschowitz S
Diagn Cytopathol 2012 Jun;40(6):556-63. doi: 10.1002/dc.22858. PMID: 22619130
Eosinophilic oesophagitis versus reflux oesophagitis.
Ensari A
Acta Gastroenterol Belg 2011 Jun;74(2):323-9. PMID: 21861318
Precursor lesions to prostatic adenocarcinoma.
Epstein JI
Virchows Arch 2009 Jan;454(1):1-16. Epub 2008 Dec 2 doi: 10.1007/s00428-008-0707-5. PMID: 19048290
Adenoid cystic/basal cell carcinoma of the prostate: review and update.
Begnami MD, Quezado M, Pinto P, Linehan WM, Merino M
Arch Pathol Lab Med 2007 Apr;131(4):637-40. doi: 10.5858/2007-131-637-ABCCOT. PMID: 17425398

Therapy

Allergen-induced NLRP3/caspase1/IL-18 signaling initiate eosinophilic esophagitis and respective inhibitors protect disease pathogenesis.
Yadavalli CS, Upparahalli Venkateshaiah S, Kumar S, Kandikattu HK, Oruganti L, Kathera CS, Mishra A
Commun Biol 2023 Jul 31;6(1):763. doi: 10.1038/s42003-023-05130-4. PMID: 37524769Free PMC Article
Effect of Proton Pump Inhibitor Treatment in "PPI Non-responsive" Patients with Eosinophilic Esophagitis.
Thakkar KP, Philpott H, Lafata S, Fowler M, Keene S, Iuga A, Dellon E
J Gastrointestin Liver Dis 2023 Mar 31;32(1):15-22. doi: 10.15403/jgld-4746. PMID: 37004219Free PMC Article
CD73(+) Epithelial Progenitor Cells That Contribute to Homeostasis and Renewal Are Depleted in Eosinophilic Esophagitis.
Hara T, Kasagi Y, Wang J, Sasaki M, Aaron B, Karami A, Shimonosono M, Shimonosono R, Maekawa H, Dolinsky L, Wilkins B, Klein J, Wei J, Nunes K, Lynch K, Spergel JM, Hamilton KE, Ruffner MA, Karakasheva TA, Whelan KA, Nakagawa H, Muir AB
Cell Mol Gastroenterol Hepatol 2022;13(5):1449-1467. Epub 2022 Jan 30 doi: 10.1016/j.jcmgh.2022.01.018. PMID: 35108658Free PMC Article
Smoking Is Associated With Basal Cell Hyperplasia on Prostate Biopsy Specimens.
Freitas DM, Andriole GL, Freedland SJ, Neto BS, Moreira DM
Am J Clin Pathol 2021 Oct 13;156(5):934-938. doi: 10.1093/ajcp/aqab030. PMID: 33939794
Baseline Basal Cell Hyperplasia Is not Associated With Baseline Lower Urinary Tract Symptoms, Baseline Clinical Prostatitis or Prostate Cancer in Repeat Biopsies.
Freitas D, Andriole GL, Freedland SJ, Neto BS, Moreira DM
Urology 2019 Jul;129:160-164. Epub 2019 Mar 23 doi: 10.1016/j.urology.2019.02.034. PMID: 30914334

Prognosis

Persistent Basal Cell Hyperplasia Is Associated With Clinical and Endoscopic Findings in Patients With Histologically Inactive Eosinophilic Esophagitis.
Whelan KA, Godwin BC, Wilkins B, Elci OU, Benitez A, DeMarshall M, Sharma M, Gross J, Klein-Szanto AJ, Liacouras CA, Dellon ES, Spergel JM, Falk GW, Muir AB, Nakagawa H
Clin Gastroenterol Hepatol 2020 Jun;18(7):1475-1482.e1. Epub 2019 Sep 6 doi: 10.1016/j.cgh.2019.08.055. PMID: 31499251Free PMC Article
Premalignant lesions of squamous cell carcinoma of the lung: The molecular make-up and factors affecting their progression.
Denisov EV, Schegoleva AA, Gervas PA, Ponomaryova AA, Tashireva LA, Boyarko VV, Bukreeva EB, Pankova OV, Perelmuter VM
Lung Cancer 2019 Sep;135:21-28. Epub 2019 Jul 5 doi: 10.1016/j.lungcan.2019.07.001. PMID: 31446997
Baseline Basal Cell Hyperplasia Is not Associated With Baseline Lower Urinary Tract Symptoms, Baseline Clinical Prostatitis or Prostate Cancer in Repeat Biopsies.
Freitas D, Andriole GL, Freedland SJ, Neto BS, Moreira DM
Urology 2019 Jul;129:160-164. Epub 2019 Mar 23 doi: 10.1016/j.urology.2019.02.034. PMID: 30914334
Respiratory cytology in the era of molecular diagnostics: a review.
Witt BL, Wallander ML, Layfield LJ, Hirschowitz S
Diagn Cytopathol 2012 Jun;40(6):556-63. doi: 10.1002/dc.22858. PMID: 22619130
Adenoid cystic/basal cell carcinoma of the prostate: review and update.
Begnami MD, Quezado M, Pinto P, Linehan WM, Merino M
Arch Pathol Lab Med 2007 Apr;131(4):637-40. doi: 10.5858/2007-131-637-ABCCOT. PMID: 17425398

Clinical prediction guides

Neutrophil extracellular traps promote ΔNp63+ basal cell hyperplasia in chronic rhinosinusitis.
Lim S, Khalmuratova R, Lee YY, Kim YS, Lee M, Lee NK, Kim SN, Choy YB, Park CG, Kim DW, Shin HW
J Allergy Clin Immunol 2024 Mar;153(3):705-717.e11. Epub 2023 Nov 22 doi: 10.1016/j.jaci.2023.11.016. PMID: 38000697
Suprabasal cells retain progenitor cell identity programs in eosinophilic esophagitis-driven basal cell hyperplasia.
Clevenger MH, Karami AL, Carlson DA, Kahrilas PJ, Gonsalves N, Pandolfino JE, Winter DR, Whelan KA, Tétreault MP
JCI Insight 2023 Oct 9;8(19) doi: 10.1172/jci.insight.171765. PMID: 37672481Free PMC Article
Anemoside B4 prevents chronic obstructive pulmonary disease through alleviating cigarette smoke-induced inflammatory response and airway epithelial hyperplasia.
Ma H, Zhou Z, Chen L, Wang L, Muge Q
Phytomedicine 2022 Dec;107:154431. Epub 2022 Sep 2 doi: 10.1016/j.phymed.2022.154431. PMID: 36115169
Prediction of malignant transformation and recurrence of oral epithelial dysplasia using architectural and cytological feature specific prognostic models.
Mahmood H, Bradburn M, Rajpoot N, Islam NM, Kujan O, Khurram SA
Mod Pathol 2022 Sep;35(9):1151-1159. Epub 2022 Mar 31 doi: 10.1038/s41379-022-01067-x. PMID: 35361889Free PMC Article
Premalignant lesions of squamous cell carcinoma of the lung: The molecular make-up and factors affecting their progression.
Denisov EV, Schegoleva AA, Gervas PA, Ponomaryova AA, Tashireva LA, Boyarko VV, Bukreeva EB, Pankova OV, Perelmuter VM
Lung Cancer 2019 Sep;135:21-28. Epub 2019 Jul 5 doi: 10.1016/j.lungcan.2019.07.001. PMID: 31446997

Recent systematic reviews

The role of histology in the diagnosis of non-erosive reflux disease: A systematic review and meta-analysis.
Kataria J, Rivera D, Grin A, Reed DE, Rodrigues DM
Neurogastroenterol Motil 2023 Dec;35(12):e14631. Epub 2023 Jul 13 doi: 10.1111/nmo.14631. PMID: 37448170

Supplemental Content

Table of contents

    Practice guidelines

    • PubMed
      See practice and clinical guidelines in PubMed. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.

    Related information

    • PMC Articles
      Related information in PubMed Central Links
    • PubMed
      Related literature resources in PubMed

    Recent activity

    Clear Turn Off Turn On

    Your browsing activity is empty.

    Activity recording is turned off.

    Turn recording back on

    See more...