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Glandular metaplasia

MedGen UID:
83104
•Concept ID:
C0334035
•
Cell or Molecular Dysfunction
Synonym: Glandular Metaplasia
SNOMED CT: Glandular metaplasia (61635003)

Definition

A morphologic finding indicating the alteration of the squamous or transitional epithelial cells to glandular cells. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVGlandular metaplasia

Professional guidelines

PubMed

The spectrum of cervical glandular neoplasia and issues in differential diagnosis.
Loureiro J, Oliva E
Arch Pathol Lab Med 2014 Apr;138(4):453-83. doi: 10.5858/arpa.2012-0493-RA. PMID: 24678677
Newly diagnosed and relapsed epithelial ovarian carcinoma: ESMO Clinical Practice Guidelines for diagnosis, treatment and follow-up.
Ledermann JA, Raja FA, Fotopoulou C, Gonzalez-Martin A, Colombo N, Sessa C; ESMO Guidelines Working Group
Ann Oncol 2013 Oct;24 Suppl 6:vi24-32. doi: 10.1093/annonc/mdt333. PMID: 24078660
Primary adenocarcinoma of the urinary bladder: differential diagnosis and clinical relevance.
Zhong M, Gersbach E, Rohan SM, Yang XJ
Arch Pathol Lab Med 2013 Mar;137(3):371-81. doi: 10.5858/arpa.2012-0076-RA. PMID: 23451748

Recent clinical studies

Etiology

Esophageal abnormalities and the risk for gastroesophageal cancers-a histopathology-register-based study in Sweden.
Ekheden I, Ludvigsson JF, Yin L, Elbe P, Ye W
Eur J Epidemiol 2022 Apr;37(4):401-411. Epub 2022 Jan 3 doi: 10.1007/s10654-021-00833-6. PMID: 34978667Free PMC Article
Necrotizing sialometaplasia-like change of the esophageal submucosal glands is associated with Barrett's esophagus.
Braxton DR, Nickleach DC, Liu Y, Farris AB 3rd
Virchows Arch 2014 Aug;465(2):135-43. Epub 2014 May 27 doi: 10.1007/s00428-014-1590-x. PMID: 24863247Free PMC Article
"Glassy" cells in Barrett's mucosa.
Rubio CA
Anticancer Res 2009 Oct;29(10):4145-6. PMID: 19846963
AGUS in cervical endometriosis.
Symonds DA, Reed TP, Didolkar SM, Graham RR
J Reprod Med 1997 Jan;42(1):39-43. PMID: 9018644
Adenocarcinoma of the urinary bladder.
Gill HS, Dhillon HK, Woodhouse CR
Br J Urol 1989 Aug;64(2):138-42. doi: 10.1111/j.1464-410x.1989.tb05973.x. PMID: 2765779

Diagnosis

Mucinous and secondary tumors of the prostate.
Osunkoya AO
Mod Pathol 2018 Jan;31(S1):S80-S95. doi: 10.1038/modpathol.2017.132. PMID: 29297488
Mucin-producing tumors and tumor-like lesions involving the prostate: a comprehensive review.
Bohman KD, Osunkoya AO
Adv Anat Pathol 2012 Nov;19(6):374-87. doi: 10.1097/PAP.0b013e318271a361. PMID: 23060063
Endometrial coccidiosis.
de Otazu RD, García-Nieto L, Izaguirre-Gondra E, Mayayo E, Ciani S, Nogales FF
J Clin Pathol 2004 Oct;57(10):1104-5. doi: 10.1136/jcp.2004.018283. PMID: 15452171Free PMC Article
Preneoplastic non-papillary lesions and conditions of the urinary bladder: an update based on the Ancona International Consultation.
Lopez-Beltran A, Cheng L, Andersson L, Brausi M, de Matteis A, Montironi R, Sesterhenn I, van det Kwast KT, Mazerolles C
Virchows Arch 2002 Jan;440(1):3-11. doi: 10.1007/s00428-001-0577-6. PMID: 11942574
AGUS in cervical endometriosis.
Symonds DA, Reed TP, Didolkar SM, Graham RR
J Reprod Med 1997 Jan;42(1):39-43. PMID: 9018644

Therapy

AGUS in cervical endometriosis.
Symonds DA, Reed TP, Didolkar SM, Graham RR
J Reprod Med 1997 Jan;42(1):39-43. PMID: 9018644
Comparative pathology of dome and trigone of urinary bladder mucosa in paraplegics and tetraplegics.
van Velzen D, Krishnan KR, Parsons KF, Soni BM, Fraser MH, Howard CV, Vaidyanathan S
Paraplegia 1995 Oct;33(10):565-72. doi: 10.1038/sc.1995.122. PMID: 8848310
Effects of hormone therapy on the endometrium.
Deligdisch L
Mod Pathol 1993 Jan;6(1):94-106. PMID: 8426860
Clinical value of pathologic changes after intravesical BCG therapy of superficial bladder cancer.
Bassi P, Milani C, Meneghini A, Garbeglio A, Aragona F, Zattoni F, Dalla Palma P, Rebuffi A, Pagano F
Urology 1992 Aug;40(2):175-9. doi: 10.1016/0090-4295(92)90523-y. PMID: 1502759
Polyps at the site of ureterosigmoidostomy.
Chiarelli SM, Sandei F
Tumori 1984 Apr 30;70(2):209-15. doi: 10.1177/030089168407000217. PMID: 6730020

Prognosis

Morphology, immunohistochemistry characteristics, and clinical presentation of microcystic urothelial carcinoma: a series of 10 cases.
Su W, Sui W, Cheng X, Zong Y, Qin Y, Cui F
Diagn Pathol 2023 Aug 19;18(1):94. doi: 10.1186/s13000-023-01381-1. PMID: 37598154Free PMC Article
Mucinous and secondary tumors of the prostate.
Osunkoya AO
Mod Pathol 2018 Jan;31(S1):S80-S95. doi: 10.1038/modpathol.2017.132. PMID: 29297488
Mucin-producing tumors and tumor-like lesions involving the prostate: a comprehensive review.
Bohman KD, Osunkoya AO
Adv Anat Pathol 2012 Nov;19(6):374-87. doi: 10.1097/PAP.0b013e318271a361. PMID: 23060063
Primary mucin-producing urothelial-type adenocarcinoma of prostate: report of 15 cases.
Osunkoya AO, Epstein JI
Am J Surg Pathol 2007 Sep;31(9):1323-9. doi: 10.1097/PAS.0b013e31802ff7c4. PMID: 17721186
Adenocarcinoma of the urinary bladder.
Gill HS, Dhillon HK, Woodhouse CR
Br J Urol 1989 Aug;64(2):138-42. doi: 10.1111/j.1464-410x.1989.tb05973.x. PMID: 2765779

Clinical prediction guides

Necrotizing sialometaplasia-like change of the esophageal submucosal glands is associated with Barrett's esophagus.
Braxton DR, Nickleach DC, Liu Y, Farris AB 3rd
Virchows Arch 2014 Aug;465(2):135-43. Epub 2014 May 27 doi: 10.1007/s00428-014-1590-x. PMID: 24863247Free PMC Article
Primary mucin-producing urothelial-type adenocarcinoma of prostate: report of 15 cases.
Osunkoya AO, Epstein JI
Am J Surg Pathol 2007 Sep;31(9):1323-9. doi: 10.1097/PAS.0b013e31802ff7c4. PMID: 17721186
Expression of bcl-2 and p53 oncoproteins in schistosomiasis-associated transitional and squamous cell carcinoma of urinary bladder.
Chaudhary KS, Lu QL, Abel PD, Khandan-Nia N, Shoma AM, el Baz M, Stamp GW, Lalani EN
Br J Urol 1997 Jan;79(1):78-84. doi: 10.1046/j.1464-410x.1997.30717.x. PMID: 9043502
Nature and composition of biliary sludge.
Lee SP, Nicholls JF
Gastroenterology 1986 Mar;90(3):677-86. doi: 10.1016/0016-5085(86)91123-6. PMID: 3943697
Inappropriate mucin production in gall bladder metaplasia and neoplasia--an immunohistological study.
De Boer WG, Ma J, Rees JW, Nayman J
Histopathology 1981 May;5(3):295-303. doi: 10.1111/j.1365-2559.1981.tb01788.x. PMID: 7239450

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