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Intestinal metaplasia

MedGen UID:
83105
•Concept ID:
C0334037
•
Disease or Syndrome
Synonym: Intestinal Metaplasia
SNOMED CT: Intestinal metaplasia (69310004)

Definition

A morphologic finding indicating the replacement of epithelial tissue outside the intestines by intestinal-type epithelium. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVIntestinal metaplasia

Professional guidelines

PubMed

AGA Clinical Practice Update on the Diagnosis and Management of Atrophic Gastritis: Expert Review.
Shah SC, Piazuelo MB, Kuipers EJ, Li D
Gastroenterology 2021 Oct;161(4):1325-1332.e7. Epub 2021 Aug 26 doi: 10.1053/j.gastro.2021.06.078. PMID: 34454714Free PMC Article
Management of epithelial precancerous conditions and lesions in the stomach (MAPS II): European Society of Gastrointestinal Endoscopy (ESGE), European Helicobacter and Microbiota Study Group (EHMSG), European Society of Pathology (ESP), and Sociedade Portuguesa de Endoscopia Digestiva (SPED) guideline update 2019.
Pimentel-Nunes P, Libânio D, Marcos-Pinto R, Areia M, Leja M, Esposito G, Garrido M, Kikuste I, Megraud F, Matysiak-Budnik T, Annibale B, Dumonceau JM, Barros R, Fléjou JF, Carneiro F, van Hooft JE, Kuipers EJ, Dinis-Ribeiro M
Endoscopy 2019 Apr;51(4):365-388. Epub 2019 Mar 6 doi: 10.1055/a-0859-1883. PMID: 30841008
Treatment of Helicobacter pylori infection in atrophic gastritis.
Lahner E, Carabotti M, Annibale B
World J Gastroenterol 2018 Jun 14;24(22):2373-2380. doi: 10.3748/wjg.v24.i22.2373. PMID: 29904244Free PMC Article

Recent clinical studies

Etiology

Global variations in diagnostic guidelines for Barrett's esophagus.
Kusano C, Singh R, Lee YY, Soh YSA, Sharma P, Ho KY, Gotoda T
Dig Endosc 2022 Nov;34(7):1320-1328. Epub 2022 Jun 5 doi: 10.1111/den.14342. PMID: 35475586
Gastric intestinal metaplasia: when to treat? How to treat?
Abdelfattah T, Shahab O, Shah TU
Curr Opin Gastroenterol 2021 Nov 1;37(6):602-608. doi: 10.1097/MOG.0000000000000784. PMID: 34432654
Guilt by association: intestinal metaplasia does not progress to gastric cancer.
Graham DY, Zou WY
Curr Opin Gastroenterol 2018 Nov;34(6):458-464. doi: 10.1097/MOG.0000000000000472. PMID: 30138135Free PMC Article
Risk of gastric cancer among patients with gastric intestinal metaplasia.
Shao L, Li P, Ye J, Chen J, Han Y, Cai J, Lu X
Int J Cancer 2018 Oct 1;143(7):1671-1677. Epub 2018 Jul 26 doi: 10.1002/ijc.31571. PMID: 29707766
Adenocarcinoma risk in gastric atrophy and intestinal metaplasia: a systematic review.
Spence AD, Cardwell CR, McMenamin ÚC, Hicks BM, Johnston BT, Murray LJ, Coleman HG
BMC Gastroenterol 2017 Dec 11;17(1):157. doi: 10.1186/s12876-017-0708-4. PMID: 29228909Free PMC Article

Diagnosis

Claudin-18.
Wong MT, Singhi AD, Larson BK, Huynh CAT, Balzer BL, Burch M, Dhall D, Gangi A, Gong J, Guindi M, Hendifar AE, Kim SA, de Peralta-Venturina M, Waters KM
Arch Pathol Lab Med 2022 May 1;147(5):559-567. doi: 10.5858/arpa.2021-0428-OA. PMID: 35976638
AGA Clinical Practice Update on the Diagnosis and Management of Atrophic Gastritis: Expert Review.
Shah SC, Piazuelo MB, Kuipers EJ, Li D
Gastroenterology 2021 Oct;161(4):1325-1332.e7. Epub 2021 Aug 26 doi: 10.1053/j.gastro.2021.06.078. PMID: 34454714Free PMC Article
Current Perspectives in Atrophic Gastritis.
Lahner E, Conti L, Annibale B, Corleto VD
Curr Gastroenterol Rep 2020 Jun 15;22(8):38. doi: 10.1007/s11894-020-00775-1. PMID: 32542467
Endoscopic Kyoto classification of Helicobacter pylori infection and gastric cancer risk diagnosis.
Toyoshima O, Nishizawa T, Koike K
World J Gastroenterol 2020 Feb 7;26(5):466-477. doi: 10.3748/wjg.v26.i5.466. PMID: 32089624Free PMC Article
Gastric microbes associated with gastric inflammation, atrophy and intestinal metaplasia 1 year after Helicobacter pylori eradication.
Sung JJY, Coker OO, Chu E, Szeto CH, Luk STY, Lau HCH, Yu J
Gut 2020 Sep;69(9):1572-1580. Epub 2020 Jan 23 doi: 10.1136/gutjnl-2019-319826. PMID: 31974133Free PMC Article

Therapy

Claudin-18.
Wong MT, Singhi AD, Larson BK, Huynh CAT, Balzer BL, Burch M, Dhall D, Gangi A, Gong J, Guindi M, Hendifar AE, Kim SA, de Peralta-Venturina M, Waters KM
Arch Pathol Lab Med 2022 May 1;147(5):559-567. doi: 10.5858/arpa.2021-0428-OA. PMID: 35976638
Gastric microbes associated with gastric inflammation, atrophy and intestinal metaplasia 1 year after Helicobacter pylori eradication.
Sung JJY, Coker OO, Chu E, Szeto CH, Luk STY, Lau HCH, Yu J
Gut 2020 Sep;69(9):1572-1580. Epub 2020 Jan 23 doi: 10.1136/gutjnl-2019-319826. PMID: 31974133Free PMC Article
Treatment of Helicobacter pylori infection in atrophic gastritis.
Lahner E, Carabotti M, Annibale B
World J Gastroenterol 2018 Jun 14;24(22):2373-2380. doi: 10.3748/wjg.v24.i22.2373. PMID: 29904244Free PMC Article
Helicobacter pylori associated chronic gastritis, clinical syndromes, precancerous lesions, and pathogenesis of gastric cancer development.
Watari J, Chen N, Amenta PS, Fukui H, Oshima T, Tomita T, Miwa H, Lim KJ, Das KM
World J Gastroenterol 2014 May 14;20(18):5461-73. doi: 10.3748/wjg.v20.i18.5461. PMID: 24833876Free PMC Article
Chronic gastritis in China: a national multi-center survey.
Du Y, Bai Y, Xie P, Fang J, Wang X, Hou X, Tian D, Wang C, Liu Y, Sha W, Wang B, Li Y, Zhang G, Li Y, Shi R, Xu J, Li Y, Huang M, Han S, Liu J, Ren X, Xie P, Wang Z, Cui L, Sheng J, Luo H, Wang Z, Zhao X, Dai N, Nie Y, Zou Y, Xia B, Fan Z, Chen Z, Lin S, Li ZS; Chinese Chronic Gastritis Research group
BMC Gastroenterol 2014 Feb 7;14:21. doi: 10.1186/1471-230X-14-21. PMID: 24502423Free PMC Article

Prognosis

Controlling Gastric Cancer in a World of Heterogeneous Risk.
Huang RJ, Laszkowska M, In H, Hwang JH, Epplein M
Gastroenterology 2023 Apr;164(5):736-751. Epub 2023 Jan 24 doi: 10.1053/j.gastro.2023.01.018. PMID: 36706842Free PMC Article
The Colombian Chemoprevention Trial: 20-Year Follow-Up of a Cohort of Patients With Gastric Precancerous Lesions.
Piazuelo MB, Bravo LE, Mera RM, Camargo MC, Bravo JC, Delgado AG, Washington MK, Rosero A, Garcia LS, Realpe JL, Cifuentes SP, Morgan DR, Peek RM Jr, Correa P, Wilson KT
Gastroenterology 2021 Mar;160(4):1106-1117.e3. Epub 2020 Nov 18 doi: 10.1053/j.gastro.2020.11.017. PMID: 33220252Free PMC Article
Barrett Esophagus.
Iyer PG, Kaul V
Mayo Clin Proc 2019 Sep;94(9):1888-1901. doi: 10.1016/j.mayocp.2019.01.032. PMID: 31486383
Risk of gastric cancer among patients with gastric intestinal metaplasia.
Shao L, Li P, Ye J, Chen J, Han Y, Cai J, Lu X
Int J Cancer 2018 Oct 1;143(7):1671-1677. Epub 2018 Jul 26 doi: 10.1002/ijc.31571. PMID: 29707766
Gastric Cancer: How Can We Reduce the Incidence of this Disease?
den Hoed CM, Kuipers EJ
Curr Gastroenterol Rep 2016 Jul;18(7):34. doi: 10.1007/s11894-016-0506-0. PMID: 27184043Free PMC Article

Clinical prediction guides

Global variations in diagnostic guidelines for Barrett's esophagus.
Kusano C, Singh R, Lee YY, Soh YSA, Sharma P, Ho KY, Gotoda T
Dig Endosc 2022 Nov;34(7):1320-1328. Epub 2022 Jun 5 doi: 10.1111/den.14342. PMID: 35475586
AGA Clinical Practice Update on the Diagnosis and Management of Atrophic Gastritis: Expert Review.
Shah SC, Piazuelo MB, Kuipers EJ, Li D
Gastroenterology 2021 Oct;161(4):1325-1332.e7. Epub 2021 Aug 26 doi: 10.1053/j.gastro.2021.06.078. PMID: 34454714Free PMC Article
Endoscopic Kyoto classification of Helicobacter pylori infection and gastric cancer risk diagnosis.
Toyoshima O, Nishizawa T, Koike K
World J Gastroenterol 2020 Feb 7;26(5):466-477. doi: 10.3748/wjg.v26.i5.466. PMID: 32089624Free PMC Article
Diagnosis and Management of Gastric Intestinal Metaplasia: Current Status and Future Directions.
Huang RJ, Choi AY, Truong CD, Yeh MM, Hwang JH
Gut Liver 2019 Nov 15;13(6):596-603. doi: 10.5009/gnl19181. PMID: 31394893Free PMC Article
Helicobacter pylori associated gastric intestinal metaplasia: Treatment and surveillance.
Liu KS, Wong IO, Leung WK
World J Gastroenterol 2016 Jan 21;22(3):1311-20. doi: 10.3748/wjg.v22.i3.1311. PMID: 26811668Free PMC Article

Recent systematic reviews

Use of folic acid supplementation to halt and even reverse the progression of gastric precancerous conditions: a meta-analysis.
Lei J, Ren F, Li W, Guo X, Liu Q, Gao H, Pang Y, He Y, Guo J, Zeng J
BMC Gastroenterol 2022 Aug 2;22(1):370. doi: 10.1186/s12876-022-02390-y. PMID: 35918654Free PMC Article
Gastric Cancer Risk of Intestinal Metaplasia Subtypes: A Systematic Review and Meta-Analysis of Cohort Studies.
Du S, Yang Y, Fang S, Guo S, Xu C, Zhang P, Wei W
Clin Transl Gastroenterol 2021 Oct 1;12(10):e00402. doi: 10.14309/ctg.0000000000000402. PMID: 34597278Free PMC Article
Efficacy of Banxia Xiexin decoction for chronic atrophic gastritis: A systematic review and meta-analysis.
Cao Y, Zheng Y, Niu J, Zhu C, Yang D, Rong F, Liu G
PLoS One 2020;15(10):e0241202. Epub 2020 Oct 27 doi: 10.1371/journal.pone.0241202. PMID: 33108375Free PMC Article
Adenocarcinoma risk in gastric atrophy and intestinal metaplasia: a systematic review.
Spence AD, Cardwell CR, McMenamin ÚC, Hicks BM, Johnston BT, Murray LJ, Coleman HG
BMC Gastroenterol 2017 Dec 11;17(1):157. doi: 10.1186/s12876-017-0708-4. PMID: 29228909Free PMC Article
Tobacco smoking and intestinal metaplasia: Systematic review and meta-analysis.
Morais S, Rodrigues S, Amorim L, Peleteiro B, Lunet N
Dig Liver Dis 2014 Nov;46(11):1031-7. Epub 2014 Sep 5 doi: 10.1016/j.dld.2014.08.034. PMID: 25195087

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