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Sarcomatoid transitional cell carcinoma

MedGen UID:
83120
•Concept ID:
C0334271
•
Neoplastic Process
Synonyms: Sarcomatoid Transitional Cell Carcinoma; sarcomatoid transitional cell carcinoma; Transitional cell carcinoma - spindle cell; Transitional cell carcinoma, sarcomatoid; transitional cell carcinoma, sarcomatoid; Transitional cell carcinoma, spindle cell; Transitional Cell Spindle Cell Carcinoma; transitional cell spindle cell carcinoma; Transitional Spindle Cell Carcinoma; transitional spindle cell carcinoma
SNOMED CT: Transitional cell carcinoma - spindle cell (112676006); Transitional cell carcinoma, spindle cell (112676006); Transitional cell carcinoma, sarcomatoid (112676006)
 
Monarch Initiative: MONDO:0002837

Definition

A poorly differentiated transitional cell carcinoma characterized by the presence of malignant cells with spindle cell morphologic features. [from NCI]

Professional guidelines

PubMed

Variant histology: role in management and prognosis of nonmuscle invasive bladder cancer.
Porten SP, Willis D, Kamat AM
Curr Opin Urol 2014 Sep;24(5):517-23. doi: 10.1097/MOU.0000000000000089. PMID: 24921905
Markers of epithelial-mesenchymal transition and epithelial differentiation in sarcomatoid carcinoma: utility in the differential diagnosis with sarcoma.
Cates JM, Dupont WD, Barnes JW, Edmunds HS, Fasig JH, Olson SJ, Black CC
Appl Immunohistochem Mol Morphol 2008 May;16(3):251-62. doi: 10.1097/PAI.0b013e318156e9b4. PMID: 18301244
Histologic variants of adenocarcinoma and other carcinomas of prostate: pathologic criteria and clinical significance.
Randolph TL, Amin MB, Ro JY, Ayala AG
Mod Pathol 1997 Jun;10(6):612-29. PMID: 9195581

Recent clinical studies

Diagnosis

Sarcomatoid carcinoma of the renal pelvis with giant cell tumor-like features: case report with immunohistochemical findings.
Acikalin MF, Kabukcuoglu S, Can C
Int J Urol 2005 Feb;12(2):199-203. doi: 10.1111/j.1442-2042.2005.01002.x. PMID: 15733116
Fine needle aspiration biopsy of primary renal synovial sarcoma. A case report.
Vesoulis Z, Rahmeh T, Nelson R, Clarke R, Lu Y, Dankoff J
Acta Cytol 2003 Jul-Aug;47(4):668-72. doi: 10.1159/000326586. PMID: 12920764
Sarcomatoid transitional cell carcinoma originating from a duplicated renal pelvis.
Hisataki T, Takahashi A, Taguchi K, Shimizu T, Suzuki K, Takatsuka K, Iwaki H
Int J Urol 2001 Dec;8(12):704-6. doi: 10.1046/j.1442-2042.2001.00396.x. PMID: 11851772
Myxoid and sclerosing sarcomatoid transitional cell carcinoma of the urinary bladder: a clinicopathologic and immunohistochemical study of 25 cases.
Jones EC, Young RH
Mod Pathol 1997 Sep;10(9):908-16. PMID: 9310954

Clinical prediction guides

Sarcomatoid transitional cell carcinoma of the renal pelvis. A report of five cases with clinical, pathological, immunohistochemical and DNA ploidy analysis.
Lopez-Beltran A, Escudero AL, Cavazzana AO, Spagnoli LG, Vicioso-Recio L
Pathol Res Pract 1996 Dec;192(12):1218-24. doi: 10.1016/S0344-0338(96)80154-3. PMID: 9182292

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