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Adenocarcinoid tumor

MedGen UID:
83124
•Concept ID:
C0334302
•
Neoplastic Process
Synonym: Combined carcinoid and adenocarcinoma
SNOMED CT: Adenocarcinoid tumor (86293007); Mixed carcinoid-adenocarcinoma (51465000); Mixed adenoneuroendocrine carcinoma (51465000); MANEC - mixed adenoneuroendocrine carcinoma (51465000); Composite carcinoid (51465000); Combined carcinoid and adenocarcinoma (51465000)
 
Monarch Initiative: MONDO:0021659

Definition

A malignant epithelial neoplasm composed of a mixture of neuroendocrine cells with morphologic and immunohistochemical characteristics of carcinoid tumor and malignant glandular cells. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVAdenocarcinoid tumor

Professional guidelines

PubMed

Mixed Adenoneuroendocrine Carcinoma (MANEC) of the Gallbladder: A Systematic Review of Outcomes Following Surgical Management.
Machairas N, Paspala A, Frountzas M, Tsilimigras DI, Moris D, Ntomi V, Tsapralis D, Schizas D
In Vivo 2019 Nov-Dec;33(6):1721-1726. doi: 10.21873/invivo.11662. PMID: 31662496Free PMC Article
Ampullary Mixed Adenoneuroendocrine Carcinoma: Surprise Histology, Familiar Management.
Mahansaria SS, Agrawal N, Arora A, Bihari C, Appukuttan M, Chattopadhyay TK
Int J Surg Pathol 2017 Oct;25(7):585-591. Epub 2017 May 29 doi: 10.1177/1066896917712454. PMID: 28552015
FOLFOX7 regimen in the first-line treatment of metastatic colorectal cancer.
Koca D, Ünal OÜ, Öztop I, Yılmaz U
Turk J Gastroenterol 2014 Apr;25(2):198-204. doi: 10.5152/tjg.2014.3609. PMID: 25003682

Recent clinical studies

Etiology

Optimal postoperative surveillance strategies for cancer survivors with gastric neuroendocrine carcinoma based on individual risk: a multicenter real-world cohort study.
Xu BB, He XY, Zhou YB, He QL, Tian YT, Hao HK, Qiu XT, Jiang LX, Zhao G, Li Z, Xu YC, Fu WH, Xue FQ, Li SL, Xu ZK, Zhu ZG, Li Y, Li E, Chen JP, Li HL, Cai LS, Wu D, Li P, Zheng CH, Xie JW, Lu J, Huang CM
Int J Surg 2023 Jun 1;109(6):1668-1676. doi: 10.1097/JS9.0000000000000401. PMID: 37076132Free PMC Article
Mixed adenoneuroendocrine carcinoma of the colon and rectum.
Qiu S, Pellino G, Warren OJ, Mills S, Goldin R, Kontovounisios C, Tekkis PP
Acta Chir Belg 2018 Oct;118(5):273-277. Epub 2018 Jun 17 doi: 10.1080/00015458.2018.1482697. PMID: 29911510
Ampullary Mixed Adenoneuroendocrine Carcinoma: Surprise Histology, Familiar Management.
Mahansaria SS, Agrawal N, Arora A, Bihari C, Appukuttan M, Chattopadhyay TK
Int J Surg Pathol 2017 Oct;25(7):585-591. Epub 2017 May 29 doi: 10.1177/1066896917712454. PMID: 28552015
Pathology of gastric cancer and its precursor lesions.
Yakirevich E, Resnick MB
Gastroenterol Clin North Am 2013 Jun;42(2):261-84. Epub 2013 Mar 1 doi: 10.1016/j.gtc.2013.01.004. PMID: 23639640
Discordant histology of primary appendiceal adenocarcinoid neoplasms with peritoneal dissemination.
Yan TD, Brun EA, Sugarbaker PH
Ann Surg Oncol 2008 May;15(5):1440-6. Epub 2008 Feb 26 doi: 10.1245/s10434-007-9754-4. PMID: 18299936

Diagnosis

Optimal postoperative surveillance strategies for cancer survivors with gastric neuroendocrine carcinoma based on individual risk: a multicenter real-world cohort study.
Xu BB, He XY, Zhou YB, He QL, Tian YT, Hao HK, Qiu XT, Jiang LX, Zhao G, Li Z, Xu YC, Fu WH, Xue FQ, Li SL, Xu ZK, Zhu ZG, Li Y, Li E, Chen JP, Li HL, Cai LS, Wu D, Li P, Zheng CH, Xie JW, Lu J, Huang CM
Int J Surg 2023 Jun 1;109(6):1668-1676. doi: 10.1097/JS9.0000000000000401. PMID: 37076132Free PMC Article
Mixed Adenocarcinomatous and Neuroendocrine Tumor of the Urinary Bladder With Concomitant Carcinoma In Situ: A Case Report With a Comprehensive Immunohistochemical Analysis and Review of the Literature.
Tränkenschuh W, Biesdorf AS, Papadimas N, Samara S, Hefty R, Stahl PR
Int J Surg Pathol 2019 Sep;27(6):684-692. Epub 2019 Apr 8 doi: 10.1177/1066896919839781. PMID: 30955388
Mixed adenoneuroendocrine carcinoma of the colon and rectum.
Qiu S, Pellino G, Warren OJ, Mills S, Goldin R, Kontovounisios C, Tekkis PP
Acta Chir Belg 2018 Oct;118(5):273-277. Epub 2018 Jun 17 doi: 10.1080/00015458.2018.1482697. PMID: 29911510
A case of advanced rectal adenocarcinoid tumor with long-term survival.
Wakahara T, Yamamoto S, Fujita S, Akasu T, Onouchi S, Moriya Y
Jpn J Clin Oncol 2010 Jul;40(7):690-3. Epub 2010 Mar 25 doi: 10.1093/jjco/hyq033. PMID: 20338947
Krukenberg tumor from an occult appendiceal adenocarcinoid: a case report and review of the literature.
Mandai M, Konishi I, Tsuruta Y, Suginami N, Kusakari T, Iwasaki T, Fujii S
Eur J Obstet Gynecol Reprod Biol 2001 Jul;97(1):90-5. doi: 10.1016/s0301-2115(00)00503-0. PMID: 11435017

Therapy

Optimal postoperative surveillance strategies for cancer survivors with gastric neuroendocrine carcinoma based on individual risk: a multicenter real-world cohort study.
Xu BB, He XY, Zhou YB, He QL, Tian YT, Hao HK, Qiu XT, Jiang LX, Zhao G, Li Z, Xu YC, Fu WH, Xue FQ, Li SL, Xu ZK, Zhu ZG, Li Y, Li E, Chen JP, Li HL, Cai LS, Wu D, Li P, Zheng CH, Xie JW, Lu J, Huang CM
Int J Surg 2023 Jun 1;109(6):1668-1676. doi: 10.1097/JS9.0000000000000401. PMID: 37076132Free PMC Article
In-vivo multispectral video endoscopy towards in-vivo hyperspectral video endoscopy.
Hohmann M, Kanawade R, Klämpfl F, Douplik A, Mudter J, Neurath MF, Albrecht H
J Biophotonics 2017 Apr;10(4):553-564. Epub 2016 Jul 12 doi: 10.1002/jbio.201600021. PMID: 27403639
Clinicopathological and Prognostic Evaluations of Mixed Adenoneuroendocrine Carcinoma of the Colon and Rectum: A Case-Matched Study.
Watanabe J, Suwa Y, Ota M, Ishibe A, Masui H, Nagahori K, Tsuura Y, Endo I
Dis Colon Rectum 2016 Dec;59(12):1160-1167. doi: 10.1097/DCR.0000000000000702. PMID: 27824701
Discordant histology of primary appendiceal adenocarcinoid neoplasms with peritoneal dissemination.
Yan TD, Brun EA, Sugarbaker PH
Ann Surg Oncol 2008 May;15(5):1440-6. Epub 2008 Feb 26 doi: 10.1245/s10434-007-9754-4. PMID: 18299936
Krukenberg tumor from an occult appendiceal adenocarcinoid: a case report and review of the literature.
Mandai M, Konishi I, Tsuruta Y, Suginami N, Kusakari T, Iwasaki T, Fujii S
Eur J Obstet Gynecol Reprod Biol 2001 Jul;97(1):90-5. doi: 10.1016/s0301-2115(00)00503-0. PMID: 11435017

Prognosis

Mixed adenoneuroendocrine carcinoma of the colon and rectum.
Qiu S, Pellino G, Warren OJ, Mills S, Goldin R, Kontovounisios C, Tekkis PP
Acta Chir Belg 2018 Oct;118(5):273-277. Epub 2018 Jun 17 doi: 10.1080/00015458.2018.1482697. PMID: 29911510
Ampullary Mixed Adenoneuroendocrine Carcinoma: Surprise Histology, Familiar Management.
Mahansaria SS, Agrawal N, Arora A, Bihari C, Appukuttan M, Chattopadhyay TK
Int J Surg Pathol 2017 Oct;25(7):585-591. Epub 2017 May 29 doi: 10.1177/1066896917712454. PMID: 28552015
Discordant histology of primary appendiceal adenocarcinoid neoplasms with peritoneal dissemination.
Yan TD, Brun EA, Sugarbaker PH
Ann Surg Oncol 2008 May;15(5):1440-6. Epub 2008 Feb 26 doi: 10.1245/s10434-007-9754-4. PMID: 18299936
Gastric outlet obstruction and cutaneous metastasis in adenocarcinoid tumor of stomach - unusual presentations with cytologic and ultra structural findings.
Rekhi B, Saxena S; Chintamani
Indian J Cancer 2005 Apr-Jun;42(2):99-101. doi: 10.4103/0019-509x.16700. PMID: 16141510
Krukenberg tumor from an occult appendiceal adenocarcinoid: a case report and review of the literature.
Mandai M, Konishi I, Tsuruta Y, Suginami N, Kusakari T, Iwasaki T, Fujii S
Eur J Obstet Gynecol Reprod Biol 2001 Jul;97(1):90-5. doi: 10.1016/s0301-2115(00)00503-0. PMID: 11435017

Clinical prediction guides

Mixed adenoneuroendocrine carcinoma originating from the appendix and colorectum: a comparative analysis of a large population-based database.
Zhao B, Wang J, Ye H, Cheng X, Meng K, Yang T
Tech Coloproctol 2023 Nov;27(11):1017-1024. Epub 2023 Mar 30 doi: 10.1007/s10151-023-02786-2. PMID: 36995458
Cytoreduction and Hyperthermic Intraperitoneal Chemotherapy (HIPEC) Versus Surgery Without HIPEC for Goblet-Cell Carcinoids and Mixed Adenoneuroendocrine Carcinomas: Propensity Score-Matched Analysis of Centers in the Netherlands and Belgium.
Sluiter NR, van der Bilt JD, Croll DMR, Vriens MR, de Hingh IHJT, Hemmer P, Aalbers AGJ, Bremers AJA, Ceelen W, D'Hoore A, Schoonmade LJ, Coupé V, Verheul H, Kazemier G, Tuynman JB; Dutch Peritoneal Oncology Group
Clin Colorectal Cancer 2020 Sep;19(3):e87-e99. Epub 2020 Jan 30 doi: 10.1016/j.clcc.2020.01.002. PMID: 32651131
High neuroendocrine component is a factor for poor prognosis in gastrointestinal high-grade malignant mixed adenoneuroendocrine neoplasms.
Chen MH, Kuo YJ, Yeh YC, Lin YC, Tzeng CH, Liu CY, Chang PM, Chen MH, Jeng YM, Chao Y
J Chin Med Assoc 2015 Aug;78(8):454-9. Epub 2015 May 19 doi: 10.1016/j.jcma.2015.04.002. PMID: 26002564
Discordant histology of primary appendiceal adenocarcinoid neoplasms with peritoneal dissemination.
Yan TD, Brun EA, Sugarbaker PH
Ann Surg Oncol 2008 May;15(5):1440-6. Epub 2008 Feb 26 doi: 10.1245/s10434-007-9754-4. PMID: 18299936
Krukenberg tumor from an occult appendiceal adenocarcinoid: a case report and review of the literature.
Mandai M, Konishi I, Tsuruta Y, Suginami N, Kusakari T, Iwasaki T, Fujii S
Eur J Obstet Gynecol Reprod Biol 2001 Jul;97(1):90-5. doi: 10.1016/s0301-2115(00)00503-0. PMID: 11435017

Recent systematic reviews

Management and outcomes of mixed adenoneuroendocrine carcinoma of the ampulla of Vater: A systematic review and pooled analysis of 56 patients.
Ziogas IA, Rallis KS, Tasoudis PT, Moris D, Schulick RD, Del Chiaro M
Eur J Surg Oncol 2023 Apr;49(4):682-687. Epub 2023 Jan 9 doi: 10.1016/j.ejso.2023.01.005. PMID: 36646615
MicroRNA-223 in gastrointestinal cancers: A systematic review and diagnostic meta-analysis.
Aalami AH, Abdeahad H, Mesgari M, Sahebkar A
Eur J Clin Invest 2021 Feb;51(2):e13448. Epub 2020 Dec 5 doi: 10.1111/eci.13448. PMID: 33244751
Cytoreduction and Hyperthermic Intraperitoneal Chemotherapy (HIPEC) Versus Surgery Without HIPEC for Goblet-Cell Carcinoids and Mixed Adenoneuroendocrine Carcinomas: Propensity Score-Matched Analysis of Centers in the Netherlands and Belgium.
Sluiter NR, van der Bilt JD, Croll DMR, Vriens MR, de Hingh IHJT, Hemmer P, Aalbers AGJ, Bremers AJA, Ceelen W, D'Hoore A, Schoonmade LJ, Coupé V, Verheul H, Kazemier G, Tuynman JB; Dutch Peritoneal Oncology Group
Clin Colorectal Cancer 2020 Sep;19(3):e87-e99. Epub 2020 Jan 30 doi: 10.1016/j.clcc.2020.01.002. PMID: 32651131
Mixed Adenoneuroendocrine Carcinoma (MANEC) of the Gallbladder: A Systematic Review of Outcomes Following Surgical Management.
Machairas N, Paspala A, Frountzas M, Tsilimigras DI, Moris D, Ntomi V, Tsapralis D, Schizas D
In Vivo 2019 Nov-Dec;33(6):1721-1726. doi: 10.21873/invivo.11662. PMID: 31662496Free PMC Article

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