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Ductal breast carcinoma in situ and lobular carcinoma in situ

MedGen UID:
83137
•Concept ID:
C0334383
•
Neoplastic Process
Synonyms: Breast Ductal Carcinoma In Situ and Lobular Carcinoma In Situ; DCIS and LCIS of Breast; DCIS and LCIS of breast; DCIS and LCIS of the Breast; DCIS and LCIS of the breast; Ductal and Lobular Breast Carcinoma in situ; ductal and lobular breast carcinoma in situ; Ductal and Lobular Carcinoma in situ of Breast; ductal and lobular carcinoma in situ of breast; Ductal and Lobular Carcinoma in situ of the Breast; ductal and lobular carcinoma in situ of the breast; Ductal Breast Carcinoma In Situ and Lobular Carcinoma In Situ; ductal breast carcinoma in situ and lobular carcinoma in situ; Ductal Carcinoma in situ with Lobular Carcinoma in situ of Breast; ductal carcinoma in situ with lobular carcinoma in situ of breast; Ductal Carcinoma in situ with Lobular Carcinoma in situ of the Breast; ductal carcinoma in situ with lobular carcinoma in situ of the breast; Intraductal and Lobular Breast Carcinoma in situ; intraductal and lobular breast carcinoma in situ; Intraductal and Lobular Carcinoma in situ of Breast; intraductal and lobular carcinoma in situ of breast; Intraductal and Lobular Carcinoma in situ of the Breast; intraductal and lobular carcinoma in situ of the breast; Intraductal carcinoma and lobular carcinoma in situ; Intraductal Carcinoma and Lobular Carcinoma in situ; intraductal carcinoma and lobular carcinoma in situ; Non-Infiltrating Ductal and Non-Infiltrating Lobular Breast Carcinoma; non-infiltrating ductal and non-infiltrating lobular breast carcinoma; Non-Infiltrating Ductal with Non-Infiltrating Lobular Carcinoma of Breast; non-infiltrating ductal with non-infiltrating lobular carcinoma of breast; Non-Infiltrating Ductal with Non-Infiltrating Lobular Carcinoma of the Breast; non-infiltrating ductal with non-infiltrating lobular carcinoma of the breast; Non-Invasive Ductal and Non-Invasive Lobular Breast Carcinoma; non-invasive ductal and non-invasive lobular breast carcinoma; Non-Invasive Ductal and Non-Invasive Lobular Carcinoma; non-invasive ductal and non-invasive lobular carcinoma; Non-Invasive Ductal Breast Carcinoma with Non-Invasive Lobular Breast Carcinoma; non-invasive ductal breast carcinoma with non-invasive lobular breast carcinoma; Non-Invasive Ductal Carcinoma with Non-Invasive Lobular Carcinoma of Breast; non-invasive ductal carcinoma with non-invasive lobular carcinoma of breast; Non-Invasive Ductal Carcinoma with Non-Invasive Lobular Carcinoma of the Breast; non-invasive ductal carcinoma with non-invasive lobular carcinoma of the breast; Non-Invasive Ductal with Non-Invasive Lobular Breast Carcinoma; non-invasive ductal with non-invasive lobular breast carcinoma
SNOMED CT: Intraductal carcinoma and lobular carcinoma in situ (18680006)
 
Monarch Initiative: MONDO:0006184

Definition

The co-existence of ductal and lobular carcinoma in situ in the breast, without evidence of stromal invasion. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVDuctal breast carcinoma in situ and lobular carcinoma in situ

Professional guidelines

PubMed

Management of in situ carcinoma of the breast: lobular and ductal origin.
White RE, Bland KI
R I Med 1995 Sep;78(9):242-5. PMID: 7579718
In situ carcinomas of the female breast. Incidence, clinical findings and DBCG proposals for management.
Graversen HP, Blichert-Toft M, Dyreborg U, Andersen J
Acta Oncol 1988;27(6A):679-82. doi: 10.3109/02841868809091768. PMID: 2851303

Recent clinical studies

Etiology

Papillary lesions of the breast.
Kulka J, Madaras L, Floris G, Lax SF
Virchows Arch 2022 Jan;480(1):65-84. Epub 2021 Nov 3 doi: 10.1007/s00428-021-03182-7. PMID: 34734332Free PMC Article
Management of High-Risk Breast Lesions.
Bahl M
Radiol Clin North Am 2021 Jan;59(1):29-40. doi: 10.1016/j.rcl.2020.08.005. PMID: 33222998
Ductal carcinoma in situ: to treat or not to treat, that is the question.
van Seijen M, Lips EH, Thompson AM, Nik-Zainal S, Futreal A, Hwang ES, Verschuur E, Lane J, Jonkers J, Rea DW, Wesseling J; PRECISION team
Br J Cancer 2019 Aug;121(4):285-292. Epub 2019 Jul 9 doi: 10.1038/s41416-019-0478-6. PMID: 31285590Free PMC Article
Management of Ductal Carcinoma In Situ (DCIS) of the Breast: Present Approaches and Future Directions.
Solin LJ
Curr Oncol Rep 2019 Mar 5;21(4):33. doi: 10.1007/s11912-019-0777-3. PMID: 30834994
Ductal Carcinoma In Situ.
Fu F, Gilmore RC, Jacobs LK
Surg Clin North Am 2018 Aug;98(4):725-745. Epub 2018 May 28 doi: 10.1016/j.suc.2018.03.007. PMID: 30005770

Diagnosis

Advances and controversies in management of breast ductal carcinoma in situ (DCIS).
Farante G, Toesca A, Magnoni F, Lissidini G, Vila J, Mastropasqua M, Viale G, Penco S, Cassano E, Lazzeroni M, Bonanni B, Leonardi MC, Ripoll-Orts F, Curigliano G, Orecchia R, Galimberti V, Veronesi P
Eur J Surg Oncol 2022 Apr;48(4):736-741. Epub 2021 Nov 9 doi: 10.1016/j.ejso.2021.10.030. PMID: 34772587
Papillary lesions of the breast.
Kulka J, Madaras L, Floris G, Lax SF
Virchows Arch 2022 Jan;480(1):65-84. Epub 2021 Nov 3 doi: 10.1007/s00428-021-03182-7. PMID: 34734332Free PMC Article
Overview of breast cancer.
Watkins EJ
JAAPA 2019 Oct;32(10):13-17. doi: 10.1097/01.JAA.0000580524.95733.3d. PMID: 31513033
Ductal carcinoma in situ of breast: update 2019.
Badve SS, Gökmen-Polar Y
Pathology 2019 Oct;51(6):563-569. Epub 2019 Aug 28 doi: 10.1016/j.pathol.2019.07.005. PMID: 31472981Free PMC Article
Ductal carcinoma in situ: to treat or not to treat, that is the question.
van Seijen M, Lips EH, Thompson AM, Nik-Zainal S, Futreal A, Hwang ES, Verschuur E, Lane J, Jonkers J, Rea DW, Wesseling J; PRECISION team
Br J Cancer 2019 Aug;121(4):285-292. Epub 2019 Jul 9 doi: 10.1038/s41416-019-0478-6. PMID: 31285590Free PMC Article

Therapy

Radiation doses and fractionation schedules in non-low-risk ductal carcinoma in situ in the breast (BIG 3-07/TROG 07.01): a randomised, factorial, multicentre, open-label, phase 3 study.
Chua BH, Link EK, Kunkler IH, Whelan TJ, Westenberg AH, Gruber G, Bryant G, Ahern V, Purohit K, Graham PH, Akra M, McArdle O, O'Brien P, Harvey JA, Kirkove C, Maduro JH, Campbell ID, Delaney GP, Martin JD, Vu TTT, Muanza TM, Neal A, Olivotto IA; BIG 3–07/TROG 07.01 trial investigators
Lancet 2022 Aug 6;400(10350):431-440. doi: 10.1016/S0140-6736(22)01246-6. PMID: 35934006
Randomized Phase III Trial Evaluating Radiation Following Surgical Excision for Good-Risk Ductal Carcinoma In Situ: Long-Term Report From NRG Oncology/RTOG 9804.
McCormick B, Winter KA, Woodward W, Kuerer HM, Sneige N, Rakovitch E, Smith BL, Germain I, Hartford AC, O'Rourke MA, Walker EM, Strom EA, Hopkins JO, Pierce LJ, Pu AT, Sumida KNM, Vesprini D, Moughan J, White JR
J Clin Oncol 2021 Nov 10;39(32):3574-3582. Epub 2021 Aug 18 doi: 10.1200/JCO.21.01083. PMID: 34406870Free PMC Article
Management of Ductal Carcinoma In Situ (DCIS) of the Breast: Present Approaches and Future Directions.
Solin LJ
Curr Oncol Rep 2019 Mar 5;21(4):33. doi: 10.1007/s11912-019-0777-3. PMID: 30834994
Ductal Carcinoma In Situ.
Fu F, Gilmore RC, Jacobs LK
Surg Clin North Am 2018 Aug;98(4):725-745. Epub 2018 May 28 doi: 10.1016/j.suc.2018.03.007. PMID: 30005770
Surgical Excision Without Radiation for Ductal Carcinoma in Situ of the Breast: 12-Year Results From the ECOG-ACRIN E5194 Study.
Solin LJ, Gray R, Hughes LL, Wood WC, Lowen MA, Badve SS, Baehner FL, Ingle JN, Perez EA, Recht A, Sparano JA, Davidson NE
J Clin Oncol 2015 Nov 20;33(33):3938-44. Epub 2015 Sep 14 doi: 10.1200/JCO.2015.60.8588. PMID: 26371148Free PMC Article

Prognosis

Advances and controversies in management of breast ductal carcinoma in situ (DCIS).
Farante G, Toesca A, Magnoni F, Lissidini G, Vila J, Mastropasqua M, Viale G, Penco S, Cassano E, Lazzeroni M, Bonanni B, Leonardi MC, Ripoll-Orts F, Curigliano G, Orecchia R, Galimberti V, Veronesi P
Eur J Surg Oncol 2022 Apr;48(4):736-741. Epub 2021 Nov 9 doi: 10.1016/j.ejso.2021.10.030. PMID: 34772587
Immunohistochemistry for diagnosis and prognosis of breast cancer: a review.
Bonacho T, Rodrigues F, Liberal J
Biotech Histochem 2020 Feb;95(2):71-91. Epub 2019 Sep 10 doi: 10.1080/10520295.2019.1651901. PMID: 31502889
Ductal carcinoma in situ of breast: update 2019.
Badve SS, Gökmen-Polar Y
Pathology 2019 Oct;51(6):563-569. Epub 2019 Aug 28 doi: 10.1016/j.pathol.2019.07.005. PMID: 31472981Free PMC Article
Ductal Carcinoma In Situ.
Fu F, Gilmore RC, Jacobs LK
Surg Clin North Am 2018 Aug;98(4):725-745. Epub 2018 May 28 doi: 10.1016/j.suc.2018.03.007. PMID: 30005770
Is DCIS Overrated?
Feinberg J, Wetstone R, Greenstein D, Borgen P
Cancer Treat Res 2018;173:53-72. doi: 10.1007/978-3-319-70197-4_5. PMID: 29349758

Clinical prediction guides

Single-Cell Transcriptome Profiling Reveals Intratumoral Heterogeneity and Molecular Features of Ductal Carcinoma In Situ.
Tokura M, Nakayama J, Prieto-Vila M, Shiino S, Yoshida M, Yamamoto T, Watanabe N, Takayama S, Suzuki Y, Okamoto K, Ochiya T, Kohno T, Yatabe Y, Suto A, Yamamoto Y
Cancer Res 2022 Sep 16;82(18):3236-3248. doi: 10.1158/0008-5472.CAN-22-0090. PMID: 35852797
Papillary lesions of the breast.
Kulka J, Madaras L, Floris G, Lax SF
Virchows Arch 2022 Jan;480(1):65-84. Epub 2021 Nov 3 doi: 10.1007/s00428-021-03182-7. PMID: 34734332Free PMC Article
Immunohistochemistry for diagnosis and prognosis of breast cancer: a review.
Bonacho T, Rodrigues F, Liberal J
Biotech Histochem 2020 Feb;95(2):71-91. Epub 2019 Sep 10 doi: 10.1080/10520295.2019.1651901. PMID: 31502889
Ductal Carcinoma In Situ.
Fu F, Gilmore RC, Jacobs LK
Surg Clin North Am 2018 Aug;98(4):725-745. Epub 2018 May 28 doi: 10.1016/j.suc.2018.03.007. PMID: 30005770
Is DCIS Overrated?
Feinberg J, Wetstone R, Greenstein D, Borgen P
Cancer Treat Res 2018;173:53-72. doi: 10.1007/978-3-319-70197-4_5. PMID: 29349758

Recent systematic reviews

Margin status and survival outcomes after breast cancer conservation surgery: prospectively registered systematic review and meta-analysis.
Bundred JR, Michael S, Stuart B, Cutress RI, Beckmann K, Holleczek B, Dahlstrom JE, Gath J, Dodwell D, Bundred NJ
BMJ 2022 Sep 21;378:e070346. doi: 10.1136/bmj-2022-070346. PMID: 36130770Free PMC Article
Benefits and Harms of Breast Cancer Screening: A Systematic Review.
Myers ER, Moorman P, Gierisch JM, Havrilesky LJ, Grimm LJ, Ghate S, Davidson B, Mongtomery RC, Crowley MJ, McCrory DC, Kendrick A, Sanders GD
JAMA 2015 Oct 20;314(15):1615-34. doi: 10.1001/jama.2015.13183. PMID: 26501537
Post-operative radiotherapy for ductal carcinoma in situ of the breast.
Goodwin A, Parker S, Ghersi D, Wilcken N
Cochrane Database Syst Rev 2013 Nov 21;(11):CD000563. doi: 10.1002/14651858.CD000563.pub7. PMID: 24259251
Breast cancer (non-metastatic).
Stebbing J, Delaney G, Thompson A
BMJ Clin Evid 2011 Feb 8;2011 PMID: 21718560Free PMC Article
Ductal carcinoma in situ of the breast: a systematic review of incidence, treatment, and outcomes.
Virnig BA, Tuttle TM, Shamliyan T, Kane RL
J Natl Cancer Inst 2010 Feb 3;102(3):170-8. Epub 2010 Jan 13 doi: 10.1093/jnci/djp482. PMID: 20071685

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