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Type A Spindle Cell Melanoma

MedGen UID:
83148
Concept ID:
C0334445
Neoplastic Process
Synonyms: Malignant Spindle Cell Type A Melanoma; Spindle cell melanoma - type A; Spindle cell melanoma, type A; Spindle Cell Type A Malignant Melanoma
SNOMED CT: Spindle cell melanoma - type A (24653009); Spindle cell melanoma, type A (24653009)

Definition

A melanoma characterized by the presence of malignant spindle-shaped melanocytes with slender nuclei and no visible nucleoli. Representative example is the type A spindle cell uveal melanoma. [from NCI]

Term Hierarchy

Professional guidelines

PubMed

Varey AHR, Williams GJ, Lo SN, Taing CY, Maurichi A, Santinami M, Scolyer RA, Thompson JF
J Eur Acad Dermatol Venereol 2023 May;37(5):859-870. Epub 2022 Nov 7 doi: 10.1111/jdv.18665. PMID: 36251355
Aung PP, Mutyambizi KK, Danialan R, Ivan D, Prieto VG
J Clin Pathol 2015 Dec;68(12):963-70. doi: 10.1136/jclinpath-2015-202887. PMID: 26602414
McNichol AM
Endocr Pathol 2001 Winter;12(4):407-15. doi: 10.1385/ep:12:4:407. PMID: 11914474

Recent clinical studies

Etiology

Fumero-Velázquez M, Hagstrom M, Dhillon S, Geraminejad T, Olivares S, Donati M, Nosek D, Waldenbäck P, Kazakov D, Sheffield BS, Tron VA, Gerami P
Am J Surg Pathol 2023 Dec 1;47(12):1438-1448. Epub 2023 Sep 29 doi: 10.1097/PAS.0000000000002131. PMID: 37773074
Shield PW, Ribu DL
Acta Cytol 2023;67(5):557-563. Epub 2023 Mar 30 doi: 10.1159/000530427. PMID: 36996775
Krishna Y, Kalirai H, Thornton S, Damato BE, Heimann H, Coupland SE
Br J Ophthalmol 2016 Jul;100(7):1012-1016. Epub 2016 Apr 20 doi: 10.1136/bjophthalmol-2015-308301. PMID: 27098748
Tariq MU, Ud Din N, Ud Din NF, Fatima S, Ahmad Z
Ann Diagn Pathol 2014 Oct;18(5):275-81. Epub 2014 Aug 8 doi: 10.1016/j.anndiagpath.2014.08.002. PMID: 25163722
Massi G
Virchows Arch 2007 Sep;451(3):623-47. Epub 2007 Jul 26 doi: 10.1007/s00428-007-0459-7. PMID: 17653760

Diagnosis

Chatzopoulos K, Syrnioti A, Linos K
Genes (Basel) 2024 Jan 31;15(2) doi: 10.3390/genes15020195. PMID: 38397186Free PMC Article
Leblebici C, Mod BN, Cin M, Özcan B
Pathol Res Pract 2024 Mar;255:155184. Epub 2024 Feb 1 doi: 10.1016/j.prp.2024.155184. PMID: 38324967
Agaimy A
Semin Diagn Pathol 2023 Jul;40(4):306-312. Epub 2023 Jun 23 doi: 10.1053/j.semdp.2023.06.001. PMID: 37438163
Shield PW, Ribu DL
Acta Cytol 2023;67(5):557-563. Epub 2023 Mar 30 doi: 10.1159/000530427. PMID: 36996775
Massi G
Virchows Arch 2007 Sep;451(3):623-47. Epub 2007 Jul 26 doi: 10.1007/s00428-007-0459-7. PMID: 17653760

Therapy

Lee PJ, Dennis K, Madan R, Fan F
Acta Cytol 2019;63(1):10-16. Epub 2018 Nov 5 doi: 10.1159/000491814. PMID: 30396186
Uitdehaag JC, de Roos JA, van Doornmalen AM, Prinsen MB, Spijkers-Hagelstein JA, de Vetter JR, de Man J, Buijsman RC, Zaman GJ
PLoS One 2015;10(5):e0125021. Epub 2015 May 27 doi: 10.1371/journal.pone.0125021. PMID: 26018524Free PMC Article
Cooper C, Sorrell J, Gerami P
Adv Anat Pathol 2012 Nov;19(6):410-6. doi: 10.1097/PAP.0b013e318271a5cb. PMID: 23060066
Kim J, Lazar AJ, Davies MA, Homsi J, Papadopoulos NE, Hwu WJ, Bedikian AY, Woodman SE, Patel SP, Hwu P, Kim KB
J Cutan Pathol 2012 Sep;39(9):821-5. Epub 2012 Jul 19 doi: 10.1111/j.1600-0560.2012.01950.x. PMID: 22809251Free PMC Article
Vassos N, Agaimy A, Schlabrakowski A, Hohenberger W, Schneider-Stock R, Croner RS
Virchows Arch 2011 Mar;458(3):363-9. Epub 2010 Dec 30 doi: 10.1007/s00428-010-1034-1. PMID: 21191613

Prognosis

Roncati L, Piscioli F
Acta Dermatovenerol Croat 2020 Dec;28(7):236-237. PMID: 33834997
Lee PJ, Dennis K, Madan R, Fan F
Acta Cytol 2019;63(1):10-16. Epub 2018 Nov 5 doi: 10.1159/000491814. PMID: 30396186
Vyas R, Keller JJ, Honda K, Cooper KD, Gerstenblith MR
J Am Acad Dermatol 2015 Dec;73(6):1031-9. Epub 2015 Sep 26 doi: 10.1016/j.jaad.2015.08.016. PMID: 26412164
Lu B, Wang C, Zhang J, Kuiper RP, Song M, Zhang X, Song S, Kessel AGV, Iwamoto A, Wang J, Liu H
Medicine (Baltimore) 2015 Jan;94(3):e393. doi: 10.1097/MD.0000000000000393. PMID: 25621681Free PMC Article
Griewank KG, van de Nes J, Schilling B, Moll I, Sucker A, Kakavand H, Haydu LE, Asher M, Zimmer L, Hillen U, Thompson JF, Scolyer RA, Schadendorf D, Murali R
Mod Pathol 2014 Feb;27(2):175-83. Epub 2013 Jul 26 doi: 10.1038/modpathol.2013.138. PMID: 23887304

Clinical prediction guides

Leblebici C, Mod BN, Cin M, Özcan B
Pathol Res Pract 2024 Mar;255:155184. Epub 2024 Feb 1 doi: 10.1016/j.prp.2024.155184. PMID: 38324967
Szlachta-McGinn A, Chmielowski B, Kang Y, Raman S, Memarzadeh S
Curr Oncol 2021 Oct 21;28(6):4264-4272. doi: 10.3390/curroncol28060362. PMID: 34898540Free PMC Article
Lee PJ, Dennis K, Madan R, Fan F
Acta Cytol 2019;63(1):10-16. Epub 2018 Nov 5 doi: 10.1159/000491814. PMID: 30396186
Tariq MU, Ud Din N, Ud Din NF, Fatima S, Ahmad Z
Ann Diagn Pathol 2014 Oct;18(5):275-81. Epub 2014 Aug 8 doi: 10.1016/j.anndiagpath.2014.08.002. PMID: 25163722
Murali R, Zannino D, Synnott M, McCarthy SW, Thompson JF, Scolyer RA
Histopathology 2011 May;58(6):886-95. Epub 2011 Mar 25 doi: 10.1111/j.1365-2559.2011.03808.x. PMID: 21438911

Recent systematic reviews

Varey AHR, Williams GJ, Lo SN, Taing CY, Maurichi A, Santinami M, Scolyer RA, Thompson JF
J Eur Acad Dermatol Venereol 2023 May;37(5):859-870. Epub 2022 Nov 7 doi: 10.1111/jdv.18665. PMID: 36251355
Pampena R, Lai M, Lombardi M, Mirra M, Raucci M, Lallas A, Apalla Z, Argenziano G, Pellacani G, Longo C
JAMA Dermatol 2020 Apr 1;156(4):430-439. doi: 10.1001/jamadermatol.2019.4912. PMID: 32101255
Vyas R, Keller JJ, Honda K, Cooper KD, Gerstenblith MR
J Am Acad Dermatol 2015 Dec;73(6):1031-9. Epub 2015 Sep 26 doi: 10.1016/j.jaad.2015.08.016. PMID: 26412164

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