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Benign Hemangioendothelioma

MedGen UID:
83162
•Concept ID:
C0334536
•
Neoplastic Process
Synonyms: Benign hemangioendothelioma; Hemangioendothelioma, benign
SNOMED CT: Benign hemangioendothelioma (31104000); Hemangioendothelioma, benign (31104000)

Definition

A benign vascular proliferation characterized by the presence of prominent endothelial cells and the formation of vascular channels. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVBenign Hemangioendothelioma

Professional guidelines

PubMed

Benign liver tumours: understanding molecular physiology to adapt clinical management.
Nault JC, Paradis V, Ronot M, Zucman-Rossi J
Nat Rev Gastroenterol Hepatol 2022 Nov;19(11):703-716. Epub 2022 Jul 14 doi: 10.1038/s41575-022-00643-5. PMID: 35835851
A Comprehensive Review of Hepatic Hemangioma Management.
Aziz H, Brown ZJ, Baghdadi A, Kamel IR, Pawlik TM
J Gastrointest Surg 2022 Sep;26(9):1998-2007. Epub 2022 Jun 15 doi: 10.1007/s11605-022-05382-1. PMID: 35705835
Clinical Practice Guideline for the Management of Infantile Hemangiomas.
Krowchuk DP, Frieden IJ, Mancini AJ, Darrow DH, Blei F, Greene AK, Annam A, Baker CN, Frommelt PC, Hodak A, Pate BM, Pelletier JL, Sandrock D, Weinberg ST, Whelan MA; SUBCOMMITTEE ON THE MANAGEMENT OF INFANTILE HEMANGIOMAS
Pediatrics 2019 Jan;143(1) doi: 10.1542/peds.2018-3475. PMID: 30584062

Recent clinical studies

Etiology

Blood group isoantigens in human benign and malignant vascular tumors.
Feigl W, Denk H, Davidovits A, Holzner JH
Virchows Arch A Pathol Anat Histol 1976 Jul 21;370(4):323-32. doi: 10.1007/BF00445777. PMID: 826015

Diagnosis

Angiosarcoma of the liver in children.
Awan S, Davenport M, Portmann B, Howard ER
J Pediatr Surg 1996 Dec;31(12):1729-32. doi: 10.1016/s0022-3468(96)90065-2. PMID: 8987004
Crystalline lamellae in the endothelial cells of a type of hemangioma characterized by the proliferation of immature endothelial cells and pericytes--angioblastoma (Nakagawa).
Kumakiri M, Muramoto F, Tsukinaga I, Yoshida T, Ohura T, Miura Y
J Am Acad Dermatol 1983 Jan;8(1):68-75. doi: 10.1016/s0190-9622(83)70009-5. PMID: 6826810
Benign hemangioendothelioma of the testis: case report with electron microscopic documentation and review of the literature.
Hargreaves HK, Scully RE, Richie JP
Am J Clin Pathol 1982 May;77(5):637-42. doi: 10.1093/ajcp/77.5.637. PMID: 7081155
Two dimensional echocardiography in evaluation of right atrial masses: five cases in pediatric patients.
Riggs T, Paul MH, DeLeon S, Ilbawi M
Am J Cardiol 1981 Nov;48(5):961-6. doi: 10.1016/0002-9149(81)90365-9. PMID: 6272564
Histopathologic studies of benign infantile hemangioendothelioma of the parotid gland.
Nagao K, Matsuzaki O, Shigematsu H, Kaneko T, Katoh T, Kitamura T
Cancer 1980 Nov 15;46(10):2250-6. doi: 10.1002/1097-0142(19801115)46:10<2250::aid-cncr2820461023>3.0.co;2-p. PMID: 7427864

Prognosis

Angiosarcoma of the liver in children.
Awan S, Davenport M, Portmann B, Howard ER
J Pediatr Surg 1996 Dec;31(12):1729-32. doi: 10.1016/s0022-3468(96)90065-2. PMID: 8987004
Benign hemangioendothelioma of the pancreas with obstructive jaundice.
Horie H, Iwasaki I, Iida H, Takizawa J, Itoh F, Kohda S
Acta Pathol Jpn 1985 Jul;35(4):975-9. doi: 10.1111/j.1440-1827.1985.tb00640.x. PMID: 4072679

Clinical prediction guides

Ultrastructural study of hemangiomas. 2. Benign hemangioendothelioma of the hard palate.
Kojimahara M, Koyama M, Igari I, Ooneda G
Acta Pathol Jpn 1981 Mar;31(2):277-88. PMID: 7257768

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