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Adamantinoma

MedGen UID:
83163
•Concept ID:
C0334556
•
Neoplastic Process
Synonym: Adamantinoma of long bones
SNOMED CT: Adamantinoma of long bone (307609003); Adamantinoma of long bones (56763007)
Modes of inheritance:
Not genetically inherited
MedGen UID:
988794
•Concept ID:
CN307044
•
Finding
Source: Orphanet
clinical entity without genetic inheritance.
See: This record
Not genetically inherited (Orphanet)
 
HPO: HP:0034525
Monarch Initiative: MONDO:0002422
OMIM®: 102660
Orphanet: ORPHA55881

Definition

A primary low-grade, malignant bone tumor that is predominantly located in the mid-portion of the tibia. Histologically, classic adamantinoma is a biphasic tumor characterized by epithelial and osteofibrous components that may be intermingled with each other in various proportions and differentiating patterns. [from HPO]

Clinical features

From HPO
Neoplasm
MedGen UID:
10294
•Concept ID:
C0027651
•
Neoplastic Process
An organ or organ-system abnormality that consists of uncontrolled autonomous cell-proliferation which can occur in any part of the body as a benign or malignant neoplasm (tumor).
See: Feature record | Search on this feature

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVAdamantinoma

Professional guidelines

PubMed

Clinicopathologic, immunohistochemical, molecular cytogenetic profile with treatment and outcomes of 34 cases of Ewing sarcoma with epithelial differentiation, including 6 cases with "Adamantinoma-like" features, diagnosed at a single institution, India.
Rekhi B, Shetty O, Vora T, Gulia A, Bajpai J, Laskar S
Ann Diagn Pathol 2020 Dec;49:151625. Epub 2020 Sep 9 doi: 10.1016/j.anndiagpath.2020.151625. PMID: 32932018
Optimal Treatment of Osteofibrous Dysplasia of the Tibia.
Park JW, Lee C, Han I, Cho HS, Kim HS
J Pediatr Orthop 2018 Aug;38(7):e404-e410. doi: 10.1097/BPO.0000000000001197. PMID: 29782394
Clinicopathological features, diagnosis, and treatment of adamantinoma of the long bones.
Papagelopoulos PJ, Mavrogenis AF, Galanis EC, Savvidou OD, Inwards CY, Sim FH
Orthopedics 2007 Mar;30(3):211-5; quiz 216-7. doi: 10.3928/01477447-20070301-04. PMID: 17375547

Recent clinical studies

Etiology

Top 10 Basaloid Neoplasms of the Sinonasal Tract.
Baněčková M, Cox D
Head Neck Pathol 2023 Mar;17(1):16-32. Epub 2023 Mar 16 doi: 10.1007/s12105-022-01508-8. PMID: 36928732Free PMC Article
Small-Cell Malignancies of Thyroid: Challenge Solved?
Canberk S, Thodou E, Bongiovanni M
Acta Cytol 2022;66(4):307-318. Epub 2022 Jan 11 doi: 10.1159/000520876. PMID: 35016187
Comprehensive Molecular Characterization of Adamantinoma and OFD-like Adamantinoma Bone Tumors.
Ali NM, Niada S, Morris MR, Brini AT, Huen D, Sumathi V, Latif F
Am J Surg Pathol 2019 Jul;43(7):965-974. doi: 10.1097/PAS.0000000000001251. PMID: 31021853
Does osteofibrous dysplasia progress to adamantinoma and how should they be treated?
Scholfield DW, Sadozai Z, Ghali C, Sumathi V, Douis H, Gaston L, Grimer RJ, Jeys L
Bone Joint J 2017 Mar;99-B(3):409-416. doi: 10.1302/0301-620X.99B3.38050. PMID: 28249983
Osteofibrous dysplasia and adamantinoma.
Most MJ, Sim FH, Inwards CY
J Am Acad Orthop Surg 2010 Jun;18(6):358-66. doi: 10.5435/00124635-201006000-00008. PMID: 20511441

Diagnosis

Small-Cell Malignancies of Thyroid: Challenge Solved?
Canberk S, Thodou E, Bongiovanni M
Acta Cytol 2022;66(4):307-318. Epub 2022 Jan 11 doi: 10.1159/000520876. PMID: 35016187
Osteofibrous Dysplasia and Adamantinoma.
Nascimento AF, Kilpatrick SE, Reith JD
Surg Pathol Clin 2021 Dec;14(4):723-735. Epub 2021 Oct 7 doi: 10.1016/j.path.2021.06.012. PMID: 34742490
Adamantinoma: An Updated Review.
Varvarousis DN, Skandalakis GP, Barbouti A, Papathanakos G, Filis P, Tepelenis K, Kitsouli A, Kanavaros P, Kitsoulis P
In Vivo 2021 Nov-Dec;35(6):3045-3052. doi: 10.21873/invivo.12600. PMID: 34697136Free PMC Article
Malignant bone tumors.
Weber K, Damron TA, Frassica FJ, Sim FH
Instr Course Lect 2008;57:673-88. PMID: 18399615
Adamantinoma.
Kitsoulis P, Charchanti A, Paraskevas G, Marini A, Karatzias G
Acta Orthop Belg 2007 Aug;73(4):425-31. PMID: 17939469

Therapy

Adamantinoma-like Variant of Ewing Sarcoma in the Metatarsal Bone After Chemotherapy: Report of a Case Successfully Treated with Pedicled Osteocutaneous Fibular Transfer.
Marais YA, Saini AK, Ferreira N, Reddy K, Zühlke A, Rossouw N, Zaharie SD, Schubert PT
Int J Surg Pathol 2021 Oct;29(7):798-803. Epub 2021 Mar 11 doi: 10.1177/10668969211001449. PMID: 33703949
Adamantinomatous tumors: Long-term follow-up study of 20 patients treated at a single institution.
Schwarzkopf E, Tavarez Y, Healey JH, Hameed M, Prince DE
J Surg Oncol 2020 Aug;122(2):273-282. Epub 2020 Apr 25 doi: 10.1002/jso.25950. PMID: 32334443Free PMC Article
Microsurgical reconstruction with vascularized fibula and massive bone allograft for bone tumors.
Errani C, Ceruso M, Donati DM, Manfrini M
Eur J Orthop Surg Traumatol 2019 Feb;29(2):307-311. Epub 2018 Dec 5 doi: 10.1007/s00590-018-2360-2. PMID: 30519732
Vascularized fibular graft for bone reconstruction of the extremities after tumor resection in limb-saving procedures.
Minami A, Kutsumi K, Takeda N, Kaneda K
Microsurgery 1995;16(2):56-64. doi: 10.1002/micr.1920160204. PMID: 7783606
Fibrous dysplasia vs adamantinoma of the tibia: differentiation based on discriminant analysis of clinical and plain film findings.
Bloem JL, van der Heul RO, Schuttevaer HM, Kuipers D
AJR Am J Roentgenol 1991 May;156(5):1017-23. doi: 10.2214/ajr.156.5.2017924. PMID: 2017924

Prognosis

Top 10 Basaloid Neoplasms of the Sinonasal Tract.
Baněčková M, Cox D
Head Neck Pathol 2023 Mar;17(1):16-32. Epub 2023 Mar 16 doi: 10.1007/s12105-022-01508-8. PMID: 36928732Free PMC Article
Comprehensive Molecular Characterization of Adamantinoma and OFD-like Adamantinoma Bone Tumors.
Ali NM, Niada S, Morris MR, Brini AT, Huen D, Sumathi V, Latif F
Am J Surg Pathol 2019 Jul;43(7):965-974. doi: 10.1097/PAS.0000000000001251. PMID: 31021853
Does osteofibrous dysplasia progress to adamantinoma and how should they be treated?
Scholfield DW, Sadozai Z, Ghali C, Sumathi V, Douis H, Gaston L, Grimer RJ, Jeys L
Bone Joint J 2017 Mar;99-B(3):409-416. doi: 10.1302/0301-620X.99B3.38050. PMID: 28249983
Osteofibrous dysplasia and adamantinoma.
Most MJ, Sim FH, Inwards CY
J Am Acad Orthop Surg 2010 Jun;18(6):358-66. doi: 10.5435/00124635-201006000-00008. PMID: 20511441
Malignant bone tumors.
Weber K, Damron TA, Frassica FJ, Sim FH
Instr Course Lect 2008;57:673-88. PMID: 18399615

Clinical prediction guides

Osteofibrous Dysplasia of the Tibia in Children: Outcome Without Resection.
Westacott D, Kannu P, Stimec J, Hopyan S, Howard A
J Pediatr Orthop 2019 Sep;39(8):e614-e621. doi: 10.1097/BPO.0000000000001116. PMID: 31393304
Primary lesions that may imitate metastatic tumors histologically: A selective review.
Wick MR
Semin Diagn Pathol 2018 Mar;35(2):123-142. Epub 2017 Nov 17 doi: 10.1053/j.semdp.2017.11.010. PMID: 29174934
Does osteofibrous dysplasia progress to adamantinoma and how should they be treated?
Scholfield DW, Sadozai Z, Ghali C, Sumathi V, Douis H, Gaston L, Grimer RJ, Jeys L
Bone Joint J 2017 Mar;99-B(3):409-416. doi: 10.1302/0301-620X.99B3.38050. PMID: 28249983
Osteofibrous dysplasia and adamantinoma.
Most MJ, Sim FH, Inwards CY
J Am Acad Orthop Surg 2010 Jun;18(6):358-66. doi: 10.5435/00124635-201006000-00008. PMID: 20511441
Adamantinoma.
Zehr RJ, Recht MP, Bauer TW
Skeletal Radiol 1995 Oct;24(7):553-5. doi: 10.1007/BF00202160. PMID: 8545659

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