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Giant cell glioblastoma

MedGen UID:
83169
•Concept ID:
C0334588
•
Neoplastic Process
Synonyms: Giant Cell Glioblastoma; Giant Cell Glioblastomas; Glioblastoma, Giant Cell; Glioblastomas, Giant Cell
SNOMED CT: Monstrocellular sarcoma (44529004); Giant cell glioblastoma (44529004)
Modes of inheritance:
Not genetically inherited
MedGen UID:
988794
•Concept ID:
CN307044
•
Finding
Source: Orphanet
clinical entity without genetic inheritance.
See: This record
Not genetically inherited (Orphanet)
 
Monarch Initiative: MONDO:0016682
Orphanet: ORPHA251579

Definition

A rare histological variant of glioblastoma with a predominance of bizarre, multinucleated giant cells, an occasionally abundant stromal reticulin network, and a high frequency of TP53 mutations. (WHO) [from NCI]

Professional guidelines

PubMed

Prognostic Factors and Treatment Patterns in the Management of Giant Cell Glioblastoma.
Jin MC, Wu A, Xiang M, Azad TD, Soltys SG, Li G, Pollom EL
World Neurosurg 2019 Aug;128:e217-e224. Epub 2019 Apr 19 doi: 10.1016/j.wneu.2019.04.103. PMID: 31009783
Survival outcomes of giant cell glioblastoma: institutional experience in the management of 20 patients.
Oh T, Rutkowski MJ, Safaee M, Sun MZ, Sayegh ET, Bloch O, Tihan T, Parsa AT
J Clin Neurosci 2014 Dec;21(12):2129-34. Epub 2014 Jul 16 doi: 10.1016/j.jocn.2014.04.011. PMID: 25037316
Treatment and survival of patients harboring histological variants of glioblastoma.
Ortega A, Nuño M, Walia S, Mukherjee D, Black KL, Patil CG
J Clin Neurosci 2014 Oct;21(10):1709-13. Epub 2014 Jun 26 doi: 10.1016/j.jocn.2014.05.003. PMID: 24980627

Recent clinical studies

Etiology

"De novo replication repair deficient glioblastoma, IDH-wildtype" is a distinct glioblastoma subtype in adults that may benefit from immune checkpoint blockade.
Hadad S, Gupta R, Oberheim Bush NA, Taylor JW, Villanueva-Meyer JE, Young JS, Wu J, Ravindranathan A, Zhang Y, Warrier G, McCoy L, Shai A, Pekmezci M, Perry A, Bollen AW, Phillips JJ, Braunstein SE, Raleigh DR, Theodosopoulos P, Aghi MK, Chang EF, Hervey-Jumper SL, Costello JF, de Groot J, Butowski NA, Clarke JL, Chang SM, Berger MS, Molinaro AM, Solomon DA
Acta Neuropathol 2023 Dec 11;147(1):3. doi: 10.1007/s00401-023-02654-1. PMID: 38079020Free PMC Article
Glioblastoma: Changing concepts in the WHO CNS5 classification.
Chen J, Han P, Dahiya S
Indian J Pathol Microbiol 2022 May;65(Supplement):S24-S32. doi: 10.4103/ijpm.ijpm_1109_21. PMID: 35562131
Differentiating Giant Cell Glioblastoma from Classic Glioblastoma With Diffusion-Weighted Imaging.
Xue C, Zhang B, Deng J, Liu X, Li S, Zhou J
World Neurosurg 2021 Feb;146:e473-e478. Epub 2020 Oct 27 doi: 10.1016/j.wneu.2020.10.125. PMID: 33127573
Association between giant cell glioblastoma and glioblastoma multiforme in the United States: A retrospective cohort study.
Bin Abdulrahman AK, Bin Abdulrahman KA, Bukhari YR, Faqihi AM, Ruiz JG
Brain Behav 2019 Oct;9(10):e01402. Epub 2019 Aug 29 doi: 10.1002/brb3.1402. PMID: 31464386Free PMC Article
Giant cell glioblastoma: a glioblastoma subtype with distinct epidemiology and superior prognosis.
Kozak KR, Moody JS
Neuro Oncol 2009 Dec;11(6):833-41. doi: 10.1215/15228517-2008-123. PMID: 19332771Free PMC Article

Diagnosis

"De novo replication repair deficient glioblastoma, IDH-wildtype" is a distinct glioblastoma subtype in adults that may benefit from immune checkpoint blockade.
Hadad S, Gupta R, Oberheim Bush NA, Taylor JW, Villanueva-Meyer JE, Young JS, Wu J, Ravindranathan A, Zhang Y, Warrier G, McCoy L, Shai A, Pekmezci M, Perry A, Bollen AW, Phillips JJ, Braunstein SE, Raleigh DR, Theodosopoulos P, Aghi MK, Chang EF, Hervey-Jumper SL, Costello JF, de Groot J, Butowski NA, Clarke JL, Chang SM, Berger MS, Molinaro AM, Solomon DA
Acta Neuropathol 2023 Dec 11;147(1):3. doi: 10.1007/s00401-023-02654-1. PMID: 38079020Free PMC Article
Morphogenetic and Imaging Characteristics in Giant Cell Glioblastoma.
Orasanu CI, Aschie M, Deacu M, Mocanu L, Voda RI, Topliceanu TS, Cozaru GC
Curr Oncol 2022 Jul 28;29(8):5316-5323. doi: 10.3390/curroncol29080422. PMID: 36005160Free PMC Article
Glioblastoma: Changing concepts in the WHO CNS5 classification.
Chen J, Han P, Dahiya S
Indian J Pathol Microbiol 2022 May;65(Supplement):S24-S32. doi: 10.4103/ijpm.ijpm_1109_21. PMID: 35562131
Differentiating Giant Cell Glioblastoma from Classic Glioblastoma With Diffusion-Weighted Imaging.
Xue C, Zhang B, Deng J, Liu X, Li S, Zhou J
World Neurosurg 2021 Feb;146:e473-e478. Epub 2020 Oct 27 doi: 10.1016/j.wneu.2020.10.125. PMID: 33127573
Update on Circumscribed Gliomas and Glioneuronal Tumors.
Chen J, Dahiya SM
Surg Pathol Clin 2020 Jun;13(2):249-266. doi: 10.1016/j.path.2020.02.004. PMID: 32389265

Therapy

Prognostic Factors and Treatment Patterns in the Management of Giant Cell Glioblastoma.
Jin MC, Wu A, Xiang M, Azad TD, Soltys SG, Li G, Pollom EL
World Neurosurg 2019 Aug;128:e217-e224. Epub 2019 Apr 19 doi: 10.1016/j.wneu.2019.04.103. PMID: 31009783
Survival outcomes of giant cell glioblastoma: institutional experience in the management of 20 patients.
Oh T, Rutkowski MJ, Safaee M, Sun MZ, Sayegh ET, Bloch O, Tihan T, Parsa AT
J Clin Neurosci 2014 Dec;21(12):2129-34. Epub 2014 Jul 16 doi: 10.1016/j.jocn.2014.04.011. PMID: 25037316
Magnetic resonance imaging and computed tomography findings in pediatric giant cell glioblastoma.
Zipp L, Schwartz KM, Hewer E, Yu Y, Stippich C, Slopis JM
Clin Neuroradiol 2012 Dec;22(4):359-63. doi: 10.1007/s00062-012-0130-9. PMID: 22286149
Inhibition of Aurora-B function increases formation of multinucleated cells in p53 gene deficient cells and enhances anti-tumor effect of temozolomide in human glioma cells.
Tsuno T, Natsume A, Katsumata S, Mizuno M, Fujita M, Osawa H, Nakahara N, Wakabayashi T, Satoh Y, Inagaki M, Yoshida J
J Neurooncol 2007 Jul;83(3):249-58. Epub 2007 Feb 14 doi: 10.1007/s11060-007-9335-1. PMID: 17570035

Prognosis

"De novo replication repair deficient glioblastoma, IDH-wildtype" is a distinct glioblastoma subtype in adults that may benefit from immune checkpoint blockade.
Hadad S, Gupta R, Oberheim Bush NA, Taylor JW, Villanueva-Meyer JE, Young JS, Wu J, Ravindranathan A, Zhang Y, Warrier G, McCoy L, Shai A, Pekmezci M, Perry A, Bollen AW, Phillips JJ, Braunstein SE, Raleigh DR, Theodosopoulos P, Aghi MK, Chang EF, Hervey-Jumper SL, Costello JF, de Groot J, Butowski NA, Clarke JL, Chang SM, Berger MS, Molinaro AM, Solomon DA
Acta Neuropathol 2023 Dec 11;147(1):3. doi: 10.1007/s00401-023-02654-1. PMID: 38079020Free PMC Article
Morphogenetic and Imaging Characteristics in Giant Cell Glioblastoma.
Orasanu CI, Aschie M, Deacu M, Mocanu L, Voda RI, Topliceanu TS, Cozaru GC
Curr Oncol 2022 Jul 28;29(8):5316-5323. doi: 10.3390/curroncol29080422. PMID: 36005160Free PMC Article
Differentiating Giant Cell Glioblastoma from Classic Glioblastoma With Diffusion-Weighted Imaging.
Xue C, Zhang B, Deng J, Liu X, Li S, Zhou J
World Neurosurg 2021 Feb;146:e473-e478. Epub 2020 Oct 27 doi: 10.1016/j.wneu.2020.10.125. PMID: 33127573
Association between giant cell glioblastoma and glioblastoma multiforme in the United States: A retrospective cohort study.
Bin Abdulrahman AK, Bin Abdulrahman KA, Bukhari YR, Faqihi AM, Ruiz JG
Brain Behav 2019 Oct;9(10):e01402. Epub 2019 Aug 29 doi: 10.1002/brb3.1402. PMID: 31464386Free PMC Article
Prognostic Factors and Treatment Patterns in the Management of Giant Cell Glioblastoma.
Jin MC, Wu A, Xiang M, Azad TD, Soltys SG, Li G, Pollom EL
World Neurosurg 2019 Aug;128:e217-e224. Epub 2019 Apr 19 doi: 10.1016/j.wneu.2019.04.103. PMID: 31009783

Clinical prediction guides

"De novo replication repair deficient glioblastoma, IDH-wildtype" is a distinct glioblastoma subtype in adults that may benefit from immune checkpoint blockade.
Hadad S, Gupta R, Oberheim Bush NA, Taylor JW, Villanueva-Meyer JE, Young JS, Wu J, Ravindranathan A, Zhang Y, Warrier G, McCoy L, Shai A, Pekmezci M, Perry A, Bollen AW, Phillips JJ, Braunstein SE, Raleigh DR, Theodosopoulos P, Aghi MK, Chang EF, Hervey-Jumper SL, Costello JF, de Groot J, Butowski NA, Clarke JL, Chang SM, Berger MS, Molinaro AM, Solomon DA
Acta Neuropathol 2023 Dec 11;147(1):3. doi: 10.1007/s00401-023-02654-1. PMID: 38079020Free PMC Article
Differentiating Giant Cell Glioblastoma from Classic Glioblastoma With Diffusion-Weighted Imaging.
Xue C, Zhang B, Deng J, Liu X, Li S, Zhou J
World Neurosurg 2021 Feb;146:e473-e478. Epub 2020 Oct 27 doi: 10.1016/j.wneu.2020.10.125. PMID: 33127573
Prognostic Factors and Treatment Patterns in the Management of Giant Cell Glioblastoma.
Jin MC, Wu A, Xiang M, Azad TD, Soltys SG, Li G, Pollom EL
World Neurosurg 2019 Aug;128:e217-e224. Epub 2019 Apr 19 doi: 10.1016/j.wneu.2019.04.103. PMID: 31009783
Whole-exome sequencing revealed mutational profiles of giant cell glioblastomas.
Shi ZF, Li KK, Kwan JSH, Yang RR, Aibaidula A, Tang Q, Bao Y, Mao Y, Chen H, Ng HK
Brain Pathol 2019 Nov;29(6):782-792. Epub 2019 Apr 10 doi: 10.1111/bpa.12720. PMID: 30861589Free PMC Article
Genetic profile of the giant cell glioblastoma.
Peraud A, Watanabe K, Schwechheimer K, Yonekawa Y, Kleihues P, Ohgaki H
Lab Invest 1999 Feb;79(2):123-9. PMID: 10068201

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