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Disorder of peroxisomal beta oxidation

MedGen UID:
831748
•Concept ID:
CN227598
•
Disease or Syndrome
Synonym: Peroxisomal beta-oxidation disorder
 
Monarch Initiative: MONDO:0019233
Orphanet: ORPHA79188

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVDisorder of peroxisomal beta oxidation
Follow this link to review classifications for Disorder of peroxisomal beta oxidation in Orphanet.

Professional guidelines

PubMed

Glycine-based treatment ameliorates NAFLD by modulating fatty acid oxidation, glutathione synthesis, and the gut microbiome.
Rom O, Liu Y, Liu Z, Zhao Y, Wu J, Ghrayeb A, Villacorta L, Fan Y, Chang L, Wang L, Liu C, Yang D, Song J, Rech JC, Guo Y, Wang H, Zhao G, Liang W, Koike Y, Lu H, Koike T, Hayek T, Pennathur S, Xi C, Wen B, Sun D, Garcia-Barrio MT, Aviram M, Gottlieb E, Mor I, Liu W, Zhang J, Chen YE
Sci Transl Med 2020 Dec 2;12(572) doi: 10.1126/scitranslmed.aaz2841. PMID: 33268508Free PMC Article
The Journey of Thiazolidinediones as Modulators of PPARs for the Management of Diabetes: A Current Perspective.
Ahsan W
Curr Pharm Des 2019;25(23):2540-2554. doi: 10.2174/1381612825666190716094852. PMID: 31333088
n-3 Polyunsaturated fatty acids for the management of alcoholic liver disease: A critical review.
Wang M, Ma LJ, Yang Y, Xiao Z, Wan JB
Crit Rev Food Sci Nutr 2019;59(sup1):S116-S129. Epub 2018 Dec 22 doi: 10.1080/10408398.2018.1544542. PMID: 30580553

Recent clinical studies

Etiology

Emerging views of mitophagy in immunity and autoimmune diseases.
Xu Y, Shen J, Ran Z
Autophagy 2020 Jan;16(1):3-17. Epub 2019 Apr 21 doi: 10.1080/15548627.2019.1603547. PMID: 30951392Free PMC Article
Flow-induced, inflammation-mediated arterial wall remodeling in the formation and progression of intracranial aneurysms.
Frösen J, Cebral J, Robertson AM, Aoki T
Neurosurg Focus 2019 Jul 1;47(1):E21. doi: 10.3171/2019.5.FOCUS19234. PMID: 31261126Free PMC Article
Modulation of Insulin Resistance in Nonalcoholic Fatty Liver Disease.
Khan RS, Bril F, Cusi K, Newsome PN
Hepatology 2019 Aug;70(2):711-724. Epub 2019 Jul 19 doi: 10.1002/hep.30429. PMID: 30556145
Pathogenesis of alcoholic liver disease: role of oxidative metabolism.
Ceni E, Mello T, Galli A
World J Gastroenterol 2014 Dec 21;20(47):17756-72. doi: 10.3748/wjg.v20.i47.17756. PMID: 25548474Free PMC Article
Glutathione transferases.
Hayes JD, Flanagan JU, Jowsey IR
Annu Rev Pharmacol Toxicol 2005;45:51-88. doi: 10.1146/annurev.pharmtox.45.120403.095857. PMID: 15822171

Diagnosis

Acylcarnitines: Nomenclature, Biomarkers, Therapeutic Potential, Drug Targets, and Clinical Trials.
Dambrova M, Makrecka-Kuka M, Kuka J, Vilskersts R, Nordberg D, Attwood MM, Smesny S, Sen ZD, Guo AC, Oler E, Tian S, Zheng J, Wishart DS, Liepinsh E, Schiöth HB
Pharmacol Rev 2022 Jul;74(3):506-551. doi: 10.1124/pharmrev.121.000408. PMID: 35710135
Peroxisomal β-oxidation acts as a sensor for intracellular fatty acids and regulates lipolysis.
Ding L, Sun W, Balaz M, He A, Klug M, Wieland S, Caiazzo R, Raverdy V, Pattou F, Lefebvre P, Lodhi IJ, Staels B, Heim M, Wolfrum C
Nat Metab 2021 Dec;3(12):1648-1661. Epub 2021 Dec 13 doi: 10.1038/s42255-021-00489-2. PMID: 34903883Free PMC Article
Mechanisms of beneficial effects of exercise training on non-alcoholic fatty liver disease (NAFLD): Roles of oxidative stress and inflammation.
Farzanegi P, Dana A, Ebrahimpoor Z, Asadi M, Azarbayjani MA
Eur J Sport Sci 2019 Aug;19(7):994-1003. Epub 2019 Feb 8 doi: 10.1080/17461391.2019.1571114. PMID: 30732555
Pathogenesis of alcoholic liver disease: role of oxidative metabolism.
Ceni E, Mello T, Galli A
World J Gastroenterol 2014 Dec 21;20(47):17756-72. doi: 10.3748/wjg.v20.i47.17756. PMID: 25548474Free PMC Article
Novel insights of dietary polyphenols and obesity.
Wang S, Moustaid-Moussa N, Chen L, Mo H, Shastri A, Su R, Bapat P, Kwun I, Shen CL
J Nutr Biochem 2014 Jan;25(1):1-18. doi: 10.1016/j.jnutbio.2013.09.001. PMID: 24314860Free PMC Article

Therapy

Protective effect of berberine against LPS-induced injury in the intestine: a review.
Izadparast F, Riahi-Zajani B, Yarmohammadi F, Hayes AW, Karimi G
Cell Cycle 2022 Nov;21(22):2365-2378. Epub 2022 Jul 19 doi: 10.1080/15384101.2022.2100682. PMID: 35852392Free PMC Article
Acylcarnitines: Nomenclature, Biomarkers, Therapeutic Potential, Drug Targets, and Clinical Trials.
Dambrova M, Makrecka-Kuka M, Kuka J, Vilskersts R, Nordberg D, Attwood MM, Smesny S, Sen ZD, Guo AC, Oler E, Tian S, Zheng J, Wishart DS, Liepinsh E, Schiöth HB
Pharmacol Rev 2022 Jul;74(3):506-551. doi: 10.1124/pharmrev.121.000408. PMID: 35710135
Therapeutic targeting of hepatic ACSL4 ameliorates NASH in mice.
Duan J, Wang Z, Duan R, Yang C, Zhao R, Feng Q, Qin Y, Jiang J, Gu S, Lv K, Zhang L, He B, Birnbaumer L, Yang S, Chen Z, Yang Y
Hepatology 2022 Jan;75(1):140-153. Epub 2021 Nov 27 doi: 10.1002/hep.32148. PMID: 34510514Free PMC Article
A Review of Human Exposure to Microplastics and Insights Into Microplastics as Obesogens.
Kannan K, Vimalkumar K
Front Endocrinol (Lausanne) 2021;12:724989. Epub 2021 Aug 18 doi: 10.3389/fendo.2021.724989. PMID: 34484127Free PMC Article
Novel insights of dietary polyphenols and obesity.
Wang S, Moustaid-Moussa N, Chen L, Mo H, Shastri A, Su R, Bapat P, Kwun I, Shen CL
J Nutr Biochem 2014 Jan;25(1):1-18. doi: 10.1016/j.jnutbio.2013.09.001. PMID: 24314860Free PMC Article

Prognosis

Modulation of Insulin Resistance in Nonalcoholic Fatty Liver Disease.
Khan RS, Bril F, Cusi K, Newsome PN
Hepatology 2019 Aug;70(2):711-724. Epub 2019 Jul 19 doi: 10.1002/hep.30429. PMID: 30556145
Expanding the concept of peroxisomal diseases and efficient diagnostic system in Japan.
Takashima S, Saitsu H, Shimozawa N
J Hum Genet 2019 Feb;64(2):145-152. Epub 2018 Sep 20 doi: 10.1038/s10038-018-0512-1. PMID: 30237433
SIRT5 inhibits peroxisomal ACOX1 to prevent oxidative damage and is downregulated in liver cancer.
Chen XF, Tian MX, Sun RQ, Zhang ML, Zhou LS, Jin L, Chen LL, Zhou WJ, Duan KL, Chen YJ, Gao C, Cheng ZL, Wang F, Zhang JY, Sun YP, Yu HX, Zhao YZ, Yang Y, Liu WR, Shi YH, Xiong Y, Guan KL, Ye D
EMBO Rep 2018 May;19(5) Epub 2018 Feb 28 doi: 10.15252/embr.201745124. PMID: 29491006Free PMC Article
Pathogenesis of alcoholic liver disease: role of oxidative metabolism.
Ceni E, Mello T, Galli A
World J Gastroenterol 2014 Dec 21;20(47):17756-72. doi: 10.3748/wjg.v20.i47.17756. PMID: 25548474Free PMC Article
Peroxisomal leukoencephalopathy.
Poll-The BT, Engelen M
Semin Neurol 2012 Feb;32(1):42-50. Epub 2012 Mar 15 doi: 10.1055/s-0032-1306385. PMID: 22422205

Clinical prediction guides

Peroxisome Biogenesis Disorders.
Honsho M, Okumoto K, Tamura S, Fujiki Y
Adv Exp Med Biol 2020;1299:45-54. doi: 10.1007/978-3-030-60204-8_4. PMID: 33417206
Hypoxia exacerbates nonalcoholic fatty liver disease via the HIF-2α/PPARα pathway.
Chen J, Chen J, Fu H, Li Y, Wang L, Luo S, Lu H
Am J Physiol Endocrinol Metab 2019 Oct 1;317(4):E710-E722. Epub 2019 Aug 20 doi: 10.1152/ajpendo.00052.2019. PMID: 31430204
Flow-induced, inflammation-mediated arterial wall remodeling in the formation and progression of intracranial aneurysms.
Frösen J, Cebral J, Robertson AM, Aoki T
Neurosurg Focus 2019 Jul 1;47(1):E21. doi: 10.3171/2019.5.FOCUS19234. PMID: 31261126Free PMC Article
Modulation of Insulin Resistance in Nonalcoholic Fatty Liver Disease.
Khan RS, Bril F, Cusi K, Newsome PN
Hepatology 2019 Aug;70(2):711-724. Epub 2019 Jul 19 doi: 10.1002/hep.30429. PMID: 30556145
Glutathione transferases.
Hayes JD, Flanagan JU, Jowsey IR
Annu Rev Pharmacol Toxicol 2005;45:51-88. doi: 10.1146/annurev.pharmtox.45.120403.095857. PMID: 15822171

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