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Dermatitis herpetiformis

MedGen UID:
8327
Concept ID:
C0011608
Disease or Syndrome
Synonyms: Brocq-Duhring disease; Duhring's disease
SNOMED CT: Dermatitis herpetiformis (111196000); Duhring's disease (111196000); Dermatosis herpetiformis (111196000); Duhring-Brocq disease (111196000); DH - Dermatitis herpetiformis (111196000)
Modes of inheritance:
Not genetically inherited
MedGen UID:
988794
Concept ID:
CN307044
Finding
Source: Orphanet
clinical entity without genetic inheritance.
 
Monarch Initiative: MONDO:0015614
Orphanet: ORPHA1656

Definition

A chronic autoimmune subepidermal bullous disease characterized by grouped pruritic lesions such as papules, urticarial plaques, erythema, and herpetiform vesiculae, with a predominantly symmetrical distribution on extensor surfaces of the elbows (90%), knees (30%), shoulders, buttocks, sacral region, and face of children and adults. Erosions, excoriations and hyperpigmentation usually follow. It may also appear as a consequence of gluten intolerance. [from ORDO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVDermatitis herpetiformis
Follow this link to review classifications for Dermatitis herpetiformis in Orphanet.

Professional guidelines

PubMed

Nguyen CN, Kim SJ
Medicina (Kaunas) 2021 Aug 20;57(8) doi: 10.3390/medicina57080843. PMID: 34441049Free PMC Article
Reunala T, Hervonen K, Salmi T
Am J Clin Dermatol 2021 May;22(3):329-338. doi: 10.1007/s40257-020-00584-2. PMID: 33432477Free PMC Article
Al-Toma A, Volta U, Auricchio R, Castillejo G, Sanders DS, Cellier C, Mulder CJ, Lundin KEA
United European Gastroenterol J 2019 Jun;7(5):583-613. Epub 2019 Apr 13 doi: 10.1177/2050640619844125. PMID: 31210940Free PMC Article

Recent clinical studies

Etiology

Reunala T, Hervonen K, Salmi T
Am J Clin Dermatol 2021 May;22(3):329-338. doi: 10.1007/s40257-020-00584-2. PMID: 33432477Free PMC Article
Al-Toma A, Volta U, Auricchio R, Castillejo G, Sanders DS, Cellier C, Mulder CJ, Lundin KEA
United European Gastroenterol J 2019 Jun;7(5):583-613. Epub 2019 Apr 13 doi: 10.1177/2050640619844125. PMID: 31210940Free PMC Article
Salmi TT
Clin Exp Dermatol 2019 Oct;44(7):728-731. Epub 2019 May 15 doi: 10.1111/ced.13992. PMID: 31093998
Glissen Brown JR, Singh P
Paediatr Int Child Health 2019 Feb;39(1):23-31. Epub 2018 Aug 13 doi: 10.1080/20469047.2018.1504431. PMID: 30099930
Ludvigsson JF, Leffler DA, Bai JC, Biagi F, Fasano A, Green PH, Hadjivassiliou M, Kaukinen K, Kelly CP, Leonard JN, Lundin KE, Murray JA, Sanders DS, Walker MM, Zingone F, Ciacci C
Gut 2013 Jan;62(1):43-52. Epub 2012 Feb 16 doi: 10.1136/gutjnl-2011-301346. PMID: 22345659Free PMC Article

Diagnosis

Nguyen CN, Kim SJ
Medicina (Kaunas) 2021 Aug 20;57(8) doi: 10.3390/medicina57080843. PMID: 34441049Free PMC Article
Reunala T, Hervonen K, Salmi T
Am J Clin Dermatol 2021 May;22(3):329-338. doi: 10.1007/s40257-020-00584-2. PMID: 33432477Free PMC Article
Al-Toma A, Volta U, Auricchio R, Castillejo G, Sanders DS, Cellier C, Mulder CJ, Lundin KEA
United European Gastroenterol J 2019 Jun;7(5):583-613. Epub 2019 Apr 13 doi: 10.1177/2050640619844125. PMID: 31210940Free PMC Article
Salmi TT
Clin Exp Dermatol 2019 Oct;44(7):728-731. Epub 2019 May 15 doi: 10.1111/ced.13992. PMID: 31093998
Ludvigsson JF, Leffler DA, Bai JC, Biagi F, Fasano A, Green PH, Hadjivassiliou M, Kaukinen K, Kelly CP, Leonard JN, Lundin KE, Murray JA, Sanders DS, Walker MM, Zingone F, Ciacci C
Gut 2013 Jan;62(1):43-52. Epub 2012 Feb 16 doi: 10.1136/gutjnl-2011-301346. PMID: 22345659Free PMC Article

Therapy

Zingone F, Maimaris S, Auricchio R, Caio GPI, Carroccio A, Elli L, Galliani E, Montagnani M, Valiante F, Biagi F
Dig Liver Dis 2022 Oct;54(10):1304-1319. Epub 2022 Jul 17 doi: 10.1016/j.dld.2022.06.023. PMID: 35858884
Sardana K, Sachdeva S
J Cosmet Dermatol 2022 Jan;21(1):85-98. Epub 2021 Sep 26 doi: 10.1111/jocd.14436. PMID: 34564936
Reunala T, Hervonen K, Salmi T
Am J Clin Dermatol 2021 May;22(3):329-338. doi: 10.1007/s40257-020-00584-2. PMID: 33432477Free PMC Article
Plotnikova N, Miller JL
Skin Therapy Lett 2013 Mar-Apr;18(3):1-3. PMID: 23674144
Ludvigsson JF, Leffler DA, Bai JC, Biagi F, Fasano A, Green PH, Hadjivassiliou M, Kaukinen K, Kelly CP, Leonard JN, Lundin KE, Murray JA, Sanders DS, Walker MM, Zingone F, Ciacci C
Gut 2013 Jan;62(1):43-52. Epub 2012 Feb 16 doi: 10.1136/gutjnl-2011-301346. PMID: 22345659Free PMC Article

Prognosis

Stoj V, Lu J
Clin Dermatol 2022 Mar-Apr;40(2):156-165. Epub 2021 Nov 19 doi: 10.1016/j.clindermatol.2021.10.009. PMID: 34808244
Nguyen CN, Kim SJ
Medicina (Kaunas) 2021 Aug 20;57(8) doi: 10.3390/medicina57080843. PMID: 34441049Free PMC Article
Reunala T, Hervonen K, Salmi T
Am J Clin Dermatol 2021 May;22(3):329-338. doi: 10.1007/s40257-020-00584-2. PMID: 33432477Free PMC Article
Salmi TT
Clin Exp Dermatol 2019 Oct;44(7):728-731. Epub 2019 May 15 doi: 10.1111/ced.13992. PMID: 31093998
Glissen Brown JR, Singh P
Paediatr Int Child Health 2019 Feb;39(1):23-31. Epub 2018 Aug 13 doi: 10.1080/20469047.2018.1504431. PMID: 30099930

Clinical prediction guides

Hopkins ZH, Jimenez A, Taliercio VL, Clarke JT, Hansen CB, Hull CM, Rhoads JLW, Zone JJ, Sahni VN, Kean J, Secrest AM
JAMA Dermatol 2023 Nov 1;159(11):1185-1194. doi: 10.1001/jamadermatol.2023.3121. PMID: 37703003Free PMC Article
Makino T, Shimizu T
Eur J Dermatol 2019 Apr 1;29(2):115-120. doi: 10.1684/ejd.2019.3533. PMID: 31106757
Glissen Brown JR, Singh P
Paediatr Int Child Health 2019 Feb;39(1):23-31. Epub 2018 Aug 13 doi: 10.1080/20469047.2018.1504431. PMID: 30099930
Korponay-Szabó IR, Troncone R, Discepolo V
Best Pract Res Clin Gastroenterol 2015 Jun;29(3):381-98. Epub 2015 May 14 doi: 10.1016/j.bpg.2015.05.003. PMID: 26060104
Elder JT, Nair RP, Guo SW, Henseler T, Christophers E, Voorhees JJ
Arch Dermatol 1994 Feb;130(2):216-24. PMID: 8304761

Recent systematic reviews

Elwenspoek MM, Thom H, Sheppard AL, Keeney E, O'Donnell R, Jackson J, Roadevin C, Dawson S, Lane D, Stubbs J, Everitt H, Watson JC, Hay AD, Gillett P, Robins G, Jones HE, Mallett S, Whiting PF
Health Technol Assess 2022 Oct;26(44):1-310. doi: 10.3310/ZUCE8371. PMID: 36321689Free PMC Article
Kowalski EH, Kneibner D, Patel A, Kridin K, Amber KT
Immunol Res 2019 Jun;67(2-3):265-266. doi: 10.1007/s12026-019-09086-8. PMID: 31313215
Ma C, Sivamani RK
J Altern Complement Med 2015 Sep;21(9):520-9. Epub 2015 Jun 26 doi: 10.1089/acm.2014.0274. PMID: 26115180
Heikkilä K, Koskinen OA, Agarwal A, Tikkinen KAO, Mäki M, Kaukinen K
Nutr Metab Cardiovasc Dis 2015 Sep;25(9):816-831. Epub 2015 May 14 doi: 10.1016/j.numecd.2015.05.004. PMID: 26111459
Haboubi NY, Taylor S, Jones S
Postgrad Med J 2006 Oct;82(972):672-8. doi: 10.1136/pgmj.2006.045443. PMID: 17068278Free PMC Article

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