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Silent myocardial infarction

MedGen UID:
83307
Concept ID:
C0340324
Disease or Syndrome
Synonyms: MI - Silent myocardial infarction; Silent Myocardial Infarction; silent myocardial infarction
SNOMED CT: Silent myocardial infarction (233843008); MI - Silent myocardial infarction (233843008)
 
Monarch Initiative: MONDO:0003678

Definition

A history of myocardial infarction in the absence of clinical symptoms and positive electrocardiographic findings. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVSilent myocardial infarction

Professional guidelines

PubMed

Pek PP, Loy EY, Wah W, Ho AFW, Zheng H, Fook-Chong SMC, Chua TSJ, Koh TH, Chow KY, Liu N, Ong MEH
CJEM 2017 Sep;19(5):355-363. Epub 2016 Sep 29 doi: 10.1017/cem.2016.376. PMID: 27681496
Adabag AS, Peterson G, Apple FS, Titus J, King R, Luepker RV
Am Heart J 2010 Jan;159(1):33-9. doi: 10.1016/j.ahj.2009.10.019. PMID: 20102864Free PMC Article
Kato H, Inoue O, Ichinose E, Akagi T, Sato N
Acta Paediatr Jpn 1991 Feb;33(1):27-35. doi: 10.1111/j.1442-200x.1991.tb01516.x. PMID: 1853711

Recent clinical studies

Etiology

Goldberg RB, Orchard TJ, Crandall JP, Boyko EJ, Budoff M, Dabelea D, Gadde KM, Knowler WC, Lee CG, Nathan DM, Watson K, Temprosa M; Diabetes Prevention Program Research Group*
Circulation 2022 May 31;145(22):1632-1641. Epub 2022 May 23 doi: 10.1161/CIRCULATIONAHA.121.056756. PMID: 35603600Free PMC Article
Thygesen K, Alpert JS, Jaffe AS, Chaitman BR, Bax JJ, Morrow DA, White HD; Executive Group on behalf of the Joint European Society of Cardiology (ESC)/American College of Cardiology (ACC)/American Heart Association (AHA)/World Heart Federation (WHF) Task Force for the Universal Definition of Myocardial Infarction
Circulation 2018 Nov 13;138(20):e618-e651. doi: 10.1161/CIR.0000000000000617. PMID: 30571511
Thygesen K, Alpert JS, Jaffe AS, Chaitman BR, Bax JJ, Morrow DA, White HD; Executive Group on behalf of the Joint European Society of Cardiology (ESC)/American College of Cardiology (ACC)/American Heart Association (AHA)/World Heart Federation (WHF) Task Force for the Universal Definition of Myocardial Infarction
J Am Coll Cardiol 2018 Oct 30;72(18):2231-2264. Epub 2018 Aug 25 doi: 10.1016/j.jacc.2018.08.1038. PMID: 30153967
Dormandy JA, Charbonnel B, Eckland DJ, Erdmann E, Massi-Benedetti M, Moules IK, Skene AM, Tan MH, Lefèbvre PJ, Murray GD, Standl E, Wilcox RG, Wilhelmsen L, Betteridge J, Birkeland K, Golay A, Heine RJ, Korányi L, Laakso M, Mokán M, Norkus A, Pirags V, Podar T, Scheen A, Scherbaum W, Schernthaner G, Schmitz O, Skrha J, Smith U, Taton J; PROactive Investigators
Lancet 2005 Oct 8;366(9493):1279-89. doi: 10.1016/S0140-6736(05)67528-9. PMID: 16214598
Dahlöf B, Sever PS, Poulter NR, Wedel H, Beevers DG, Caulfield M, Collins R, Kjeldsen SE, Kristinsson A, McInnes GT, Mehlsen J, Nieminen M, O'Brien E, Ostergren J; ASCOT Investigators
Lancet 2005 Sep 10-16;366(9489):895-906. doi: 10.1016/S0140-6736(05)67185-1. PMID: 16154016

Diagnosis

Kaze AD, Fonarow GC, Echouffo-Tcheugui JB
J Am Heart Assoc 2023 Oct 17;12(20):e029814. Epub 2023 Oct 13 doi: 10.1161/JAHA.123.029814. PMID: 37830346Free PMC Article
Goldberg RB, Orchard TJ, Crandall JP, Boyko EJ, Budoff M, Dabelea D, Gadde KM, Knowler WC, Lee CG, Nathan DM, Watson K, Temprosa M; Diabetes Prevention Program Research Group*
Circulation 2022 May 31;145(22):1632-1641. Epub 2022 May 23 doi: 10.1161/CIRCULATIONAHA.121.056756. PMID: 35603600Free PMC Article
Merkler AE, Bartz TM, Kamel H, Soliman EZ, Howard V, Psaty BM, Okin PM, Safford MM, Elkind MSV, Longstreth WT Jr
Neurology 2021 Aug 3;97(5):e436-e443. Epub 2021 May 24 doi: 10.1212/WNL.0000000000012249. PMID: 34031202Free PMC Article
Thygesen K, Alpert JS, Jaffe AS, Chaitman BR, Bax JJ, Morrow DA, White HD; Executive Group on behalf of the Joint European Society of Cardiology (ESC)/American College of Cardiology (ACC)/American Heart Association (AHA)/World Heart Federation (WHF) Task Force for the Universal Definition of Myocardial Infarction
Circulation 2018 Nov 13;138(20):e618-e651. doi: 10.1161/CIR.0000000000000617. PMID: 30571511
Thygesen K, Alpert JS, Jaffe AS, Chaitman BR, Bax JJ, Morrow DA, White HD; Executive Group on behalf of the Joint European Society of Cardiology (ESC)/American College of Cardiology (ACC)/American Heart Association (AHA)/World Heart Federation (WHF) Task Force for the Universal Definition of Myocardial Infarction
J Am Coll Cardiol 2018 Oct 30;72(18):2231-2264. Epub 2018 Aug 25 doi: 10.1016/j.jacc.2018.08.1038. PMID: 30153967

Therapy

Goldberg RB, Orchard TJ, Crandall JP, Boyko EJ, Budoff M, Dabelea D, Gadde KM, Knowler WC, Lee CG, Nathan DM, Watson K, Temprosa M; Diabetes Prevention Program Research Group*
Circulation 2022 May 31;145(22):1632-1641. Epub 2022 May 23 doi: 10.1161/CIRCULATIONAHA.121.056756. PMID: 35603600Free PMC Article
Li F, Li D, Yu J, Jia Y, Liu Y, Liu Y, Wu Q, Liao X, Zeng Z, Wan Z, Zeng R
Clin Interv Aging 2021;16:1139-1149. Epub 2021 Jun 18 doi: 10.2147/CIA.S315837. PMID: 34168437Free PMC Article
Thygesen K, Alpert JS, Jaffe AS, Chaitman BR, Bax JJ, Morrow DA, White HD; Executive Group on behalf of the Joint European Society of Cardiology (ESC)/American College of Cardiology (ACC)/American Heart Association (AHA)/World Heart Federation (WHF) Task Force for the Universal Definition of Myocardial Infarction
J Am Coll Cardiol 2018 Oct 30;72(18):2231-2264. Epub 2018 Aug 25 doi: 10.1016/j.jacc.2018.08.1038. PMID: 30153967
Dormandy JA, Charbonnel B, Eckland DJ, Erdmann E, Massi-Benedetti M, Moules IK, Skene AM, Tan MH, Lefèbvre PJ, Murray GD, Standl E, Wilcox RG, Wilhelmsen L, Betteridge J, Birkeland K, Golay A, Heine RJ, Korányi L, Laakso M, Mokán M, Norkus A, Pirags V, Podar T, Scheen A, Scherbaum W, Schernthaner G, Schmitz O, Skrha J, Smith U, Taton J; PROactive Investigators
Lancet 2005 Oct 8;366(9493):1279-89. doi: 10.1016/S0140-6736(05)67528-9. PMID: 16214598
Dahlöf B, Sever PS, Poulter NR, Wedel H, Beevers DG, Caulfield M, Collins R, Kjeldsen SE, Kristinsson A, McInnes GT, Mehlsen J, Nieminen M, O'Brien E, Ostergren J; ASCOT Investigators
Lancet 2005 Sep 10-16;366(9489):895-906. doi: 10.1016/S0140-6736(05)67185-1. PMID: 16154016

Prognosis

Li F, Li D, Yu J, Jia Y, Liu Y, Liu Y, Wu Q, Liao X, Zeng Z, Wan Z, Zeng R
Clin Interv Aging 2021;16:1139-1149. Epub 2021 Jun 18 doi: 10.2147/CIA.S315837. PMID: 34168437Free PMC Article
Merkler AE, Bartz TM, Kamel H, Soliman EZ, Howard V, Psaty BM, Okin PM, Safford MM, Elkind MSV, Longstreth WT Jr
Neurology 2021 Aug 3;97(5):e436-e443. Epub 2021 May 24 doi: 10.1212/WNL.0000000000012249. PMID: 34031202Free PMC Article
Cheng YJ, Jia YH, Yao FJ, Mei WY, Zhai YS, Zhang M, Wu SH
J Am Heart Assoc 2021 Jan 5;10(1):e017044. Epub 2020 Dec 29 doi: 10.1161/JAHA.120.017044. PMID: 33372536Free PMC Article
Soliman EZ
Trends Cardiovasc Med 2019 May;29(4):239-244. Epub 2018 Sep 8 doi: 10.1016/j.tcm.2018.09.004. PMID: 30224236
Qureshi WT, Zhang ZM, Chang PP, Rosamond WD, Kitzman DW, Wagenknecht LE, Soliman EZ
J Am Coll Cardiol 2018 Jan 2;71(1):1-8. doi: 10.1016/j.jacc.2017.10.071. PMID: 29301615Free PMC Article

Clinical prediction guides

Li F, Li D, Yu J, Jia Y, Liu Y, Liu Y, Wu Q, Liao X, Zeng Z, Wan Z, Zeng R
Clin Interv Aging 2021;16:1139-1149. Epub 2021 Jun 18 doi: 10.2147/CIA.S315837. PMID: 34168437Free PMC Article
Cheng YJ, Jia YH, Yao FJ, Mei WY, Zhai YS, Zhang M, Wu SH
J Am Heart Assoc 2021 Jan 5;10(1):e017044. Epub 2020 Dec 29 doi: 10.1161/JAHA.120.017044. PMID: 33372536Free PMC Article
Qureshi WT, Zhang ZM, Chang PP, Rosamond WD, Kitzman DW, Wagenknecht LE, Soliman EZ
J Am Coll Cardiol 2018 Jan 2;71(1):1-8. doi: 10.1016/j.jacc.2017.10.071. PMID: 29301615Free PMC Article
Dormandy JA, Charbonnel B, Eckland DJ, Erdmann E, Massi-Benedetti M, Moules IK, Skene AM, Tan MH, Lefèbvre PJ, Murray GD, Standl E, Wilcox RG, Wilhelmsen L, Betteridge J, Birkeland K, Golay A, Heine RJ, Korányi L, Laakso M, Mokán M, Norkus A, Pirags V, Podar T, Scheen A, Scherbaum W, Schernthaner G, Schmitz O, Skrha J, Smith U, Taton J; PROactive Investigators
Lancet 2005 Oct 8;366(9493):1279-89. doi: 10.1016/S0140-6736(05)67528-9. PMID: 16214598
Dahlöf B, Sever PS, Poulter NR, Wedel H, Beevers DG, Caulfield M, Collins R, Kjeldsen SE, Kristinsson A, McInnes GT, Mehlsen J, Nieminen M, O'Brien E, Ostergren J; ASCOT Investigators
Lancet 2005 Sep 10-16;366(9489):895-906. doi: 10.1016/S0140-6736(05)67185-1. PMID: 16154016

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